Gene PAPL-7 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP088_AA protein Get Run
MbreP088_AA_271-477 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
AAA_25 AAA domain 57-140 2.6e-06 14.3 Pfam-A 12-81 (194) alignment 
Range on Protein: 57-140
Range on HMM: 12-81/194.0
TGRLAVNRSSLQYIATNWHEPVYVVGVVGPFHSGKSFLANRLVDRMAgftlgptvqptT-EGIWTfsvPATDgQRLRVVVLDTEG
...|. .  .|...  ..  .  .. ..|.  .|||.||  |. ..|           | | ...   |.   ...||..|..|.
aedldtppppldwlvkgllprgsltllaGapgtGKStlalqlaaava...........tGepflg...pvvp.epgrVlylsaEd
GBP Guanylate-binding protein, N-terminal domain 59-223 2.4e-38 117.9 Pfam-A 3-165 (260) alignment 
Range on Protein: 59-223
Range on HMM: 3-165/260.0
RLAVNRSSLQYIaTNWHEPVYVVGVVGPFHSGKSFLANRLVDRMAGFTLGPTVQPTTEGIWTFSVPATDGQRLRVVVLDTEGLAA-PGNSPDYDAALFAV
.|..|.  |. . .   .|| ||..|| .. ||||| |.|. .  ||.|..||.  |.||. ...|  ....  .|.||||||     . .  || .||.
qlelneealeil.eaidqpvvvvaivGlyrkGksfLlnklarkkkgFslrstvesetkGiliWcephpkkekvalvLlDteGlgDveksdvkddatiFaL

TTLLSTHLVYNSVRIIDEAAMEYLEVLARRAQLFQFQtaLRSQSQFSPAMLNFPSLTWVVQDFFQE
..|||  .|||||  |.| |.| |...   ..| . .    .  . . ..  ||.| ..| ||  |
avllssvfvYnsvqtinedaleqLqlvtEltelirak..eervadseefvkfFpdlvflvRDfsle
MMR_HSR1 50S ribosome-binding GTPase 81-147 2.6e-06 14.9 Pfam-A 2-63 (116) alignment 
Range on Protein: 81-147
Range on HMM: 2-63/116.0
VGVVGPFHSGKSFLANRLVD--R-MAGFTLGPTVQPtTEGIWTFsvpatDGQRLrvVVLDTEGLAAPGNS
|..||   .||| | |.|..  .   . . | | .. .|. ...     |.|..  ...|| |.. . ..
vaivGrpNvGKStLinaLtnekaakvsdypgtTrdi.ienevel.....dkqei..ilvDtPGiiegase
Metallophos Calcineurin-like phosphoesterase 1142-1353 4.3e-19 62.6 Pfam-A 1-198 (200) alignment 
Range on Protein: 1142-1353
Range on HMM: 1-198/200.0
LRVLVAADVGATEPDHCsyhwiepNaTQTYQHMTDLASSADVVLHIGDISYATGYSAKWELFM-AQAEPLGSVLPIMTALGNHEQDTPDRRSGTYYGSND
||.|| .|.. .  |.          .   ...    . .|.||. ||....  .| ...  .  ....|    |.. ..|||| |  . ..| .   ..
lrilvigDlHgglddle.......d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlk

SGGECAQPTNARFPMpvpshnqfSgwYSFDMGPVHFITINTELEVAPGSDQYDFITDDIAQMNRSETPWLIMMGHRPMYYVRDDVSAI---DPHFQVLES
.    |  ... ..            . . .. . ..... .    ..|.|. .   . |  .|. ... | ..|.|..   . .  |   .   ..|| 
dlrglangeeeyenl........k..itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgpdalek

LMYENKVDLFLVGHVH
| ....||| | ||.|
llekygvdlvlrGHtH
subfamily_ACP5_pd Subfamily ACP5 1148-1354 1.1e-54 177.3 In-house 3-187 (189) alignment 
Range on Protein: 1148-1354
Range on HMM: 3-187/189.0
ADVGATEPDHCSYHWIEPnatqtyqhmtdLASSADVVLHIGDISYATGY--SAKWELFMAQAEPLGSVLPIMTALGNHEQDTpdrrSGTYYgsndsggec
.|.|..|..... .. |             |...|...|.||..||...  .| |. || . ||| | .| |...||||.|     . ..|         
gDlgvseaaslatllkee...........eaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesds....nfsay.........

aqptNARFPMPvpSHNQfsgWYSFDMGPVHFITINTELEVAPGSDQYDFITDDIAQM-NRSETPWLIMMGHRPMYYVRDDVSAI-------D-PHFQVLE
    ..|| ||  |.|.   |||||.||||||...|| ....||.||.....|.... ||..|||.|.|||||||. ..| . .          ... ||
....kkrfsmp..skne...wYsfdygpvhfislstevdfslgseqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresle

SLMYENKVDLFLVGHVHN
.|.|..||||.|.|| |.
dllykykvdlalsgHeHs
PAPL 1149-1354 1.8e-40 131.2 In-house 5-193 (194) alignment 
Range on Protein: 1149-1354
Range on HMM: 5-193/194.0
DVGATEPDHcsyhwiepnaTQTYQHMTDlASSADVVLHIGDISYATGYSAKWELFM--AQAEPLGSVLPIMTALGNHEQDTPDRRSGtyygsndsgGECA
| |.|....          ....|..|.  .. |..||.||..||.... .|. .    | ||| . .| |.| ||||..     .           . .
DlGqtnass..........lkrlqketq.kgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnyk.........arfs

QPTNARFPMpvPSHNQFSGWYSFDMGPVHFITINTELEVAPGSDQYDFITDDIAQMNRSETPWLIMMGHRPMYYVRDDVS---AIDPHFQVLESLMYENK
.|.. . ..  .|..  |  |||. ..||||....| .| . |.||.    | |. |||.|||.|.|||||||   .| .     . ... || |.|...
mpgseeges..nssesgsnsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykyg

VDLFLVGHVHN
|||.|.||.|.
VDlvlaGHeHs
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 1171-1388 1e-06 20.9 Pfam-A 20-139 (156) alignment 
Range on Protein: 1171-1388
Range on HMM: 20-139/156.0
YQHMtdlaSSADVVLHIGDISYatgYsakwelfmAQA-EPLGSVlPIMTALGNHEQDT-PDRRSGTYygsndsggecaqptnarfpmpvpshnqfsgwys
....     ..|..|| ||.               .  | | .. |. .  |||...  |.... ..                                 
ledi....kevdlilhaGDlve...p........eevvelledi.pvlavrGnhDeaelpkelavel.................................

fdmgpvhfitintelevapgsdqydfiT--------DdiaqmnrsetPWLIMMGHRPMYYVRDDVSAidphfqvLESLMYENKVDLFLVGHVHNALVtcp
                           .        .           . ... |.  . |... ..       |..|. |...||...||.|.. |   
...........................llaaaaleie..........gdrvllvhgtplsvqsseee.......laellkeagadlvflGHtHkpkv...

vyngtcaksmdeDLFQGTVHVCVGNGGM
               .||..|..|  |.
............ekrggtlvvnpGsvge
ACP5 1295-1354 3.2e-07 22.2 In-house 140-198 (198) alignment 
Range on Protein: 1295-1354
Range on HMM: 140-198/198.0
ITDDIAQMNRSETPWLIMMGHRPMYYVRDDVSAiDPHFQVLESLMYENKVDLFLVGHVHN
...  .....|.. |.| .|| |.| .    .  .   . |. |. ..|||..| || |.
lkwlekalakstadwkiVvGHhpvySigehgdt.kelverllpllkkykvdaYlnGHdHc
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 1376-1436 2.6e-16 51.1 Pfam-A 1-61 (62) alignment 
Range on Protein: 1376-1436
Range on HMM: 1-61/62.0
QGTVHVCVGNGGMSLDKVPKTAPAWGDFMASDWGYATLDVANKTHLTMSLFEDSTNVELYS
...||..|| .| .|.|..|  | |  |  ||.||..|.|.|.|||... ......  | |
kApvhIvvGaAGnglskfskpqpewsafresdyGysrltvvNrthLhwefvrsddgqvlDs