Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| SapB_1 | Saposin-like type B, region 1 | 60-89 | 2.5e-10 | 26.6 | Pfam-A | 10-39 (39) | alignment | ||
Range on Protein: 60-89
Range on HMM: 10-39/39.0
VISDIEAALEANSTQEAIISKLEEICNLLP
|....| |..|||.| || |...|.|||
vvkyvekllkdnsteeeIikaldkvCellP
|
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| PhoD | PhoD-like phosphatase | 154-335 | 3.9e-06 | 17.1 | Pfam-A | 11-156 (453) | alignment | ||
Range on Protein: 154-335
Range on HMM: 11-156/453.0
EMVVMWTTLDA--------TPTPTVIFGTSSTDLNRNVSATQTSySYGGWNGHINTAKLTGLAHNTTYYYRVGDasvapdywmKPAWSQPRELAFTTPlP
. ||.|| ... . . .| . .... ..| ...| . . .. ....|||.....|.||. . . |... ..| |
dsvvlWTRvapeeeegaepkapvsvewevaedeefkrvvrsgtv.latserdytvkvevtgLepgqeyfYrfra.........eegesespvGrtrTl.p
AGPTQSTRIAVIGDAGATDASlltcapvsvfprtpffeakhvarshhhrpmsFRFSRLLIERDsAYQLLLHDGDIGYADGyQAIWDEHMR
.. ..| |.||.... .. |. | | |.. ....|| ||. |..| . .... |
eaaveslrlavvSCsnyeqGy...............................fnayrelaeke.dlDfvlhlGDyiYeyg.egtykneer
|
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| subfamily_ACP5_pd | Subfamily ACP5 | 305-419 | 3e-33 | 107.4 | In-house | 19-122 (189) | alignment | ||
Range on Protein: 305-419
Range on HMM: 19-122/189.0
IERDSAYQLLLHDGDIGYADGY--QAIWDEHMRKMESIAAYVPMMTSPGNHEGFYNFHPYKYRFTMPanesgS--SdplYYSFNYGNMHIVSLNSEGFMG
|......|..| ||..||... .|.|||.|. .|..|..||.|.|.|||| ..||. ||.||.|| | . .|||.||..|..||..|
eeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp.....skne...wYsfdygpvhfislstevdfs
LSaqaitptSPMYTWLAKD
|. |..|.|| ||
lg.......seqykWLekd
|
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| PAPL | 307-398 | 3.5e-23 | 74.7 | In-house | 22-120 (194) | alignment | |||
Range on Protein: 307-398
Range on HMM: 22-120/194.0
RDSAYQLLLHDGDIGYADGYQAIWDEHM--RKMESIAAYVPMMTSPGNHEGFYNFHPYKYRFTMPANE-----SGSSDPLYYSFNYGNMHIVSLNSEGF
... |...|| ||. |||..| ||. |..|..||.||.|..||||| ||| .||.||.|| .| | .|.. .|||... .|.. |.||
qkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgsnsysfetesvhfivlsseed
|
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| subfamily_ACP5_pd | Subfamily ACP5 | 410-454 | 3.2e-09 | 29.0 | In-house | 141-189 (189) | alignment | ||
Range on Protein: 410-454
Range on HMM: 141-189/189.0
SPMYTWLAKDHDCEAEATVLRDG----LEALFVNNSVDLVIQAHRHNYQ
.|||. ....||..| |..|.| || |. ...|||....|.|.|.
rPmYcsnkdeddctkeetlvrkglresledllykykvdlalsgHeHsYe
|
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| PAPL | 411-453 | 7.5e-10 | 31.2 | In-house | 153-194 (194) | alignment | |||
Range on Protein: 411-453
Range on HMM: 153-194/194.0
PMYTWLAKDHDCEAEATVlRDGLEALFVNNSVDLVIQAHRHNY
|||. ....||. .|.. ...|| |.....||||. .| |.|
pmYcsnkdkddckekakm.laaledllykygVDlvlaGHeHsY
|
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| Metallophos_C | Iron/zinc purple acid phosphatase-like protein C | 473-536 | 2e-21 | 67.4 | Pfam-A | 1-62 (62) | alignment | ||
Range on Protein: 473-536
Range on HMM: 1-62/62.0
TAPVYIVNGAAGNKEHTMGPgsCEQSWCRIGLEEYGYAIMTSSDPTKLQWTYYASADGSVLDEF
.|||.||.|||||..... ...|... ..|||...| . |.|.|....| ||.|||.|
kApvhIvvGaAGnglskfsk..pqpewsafresdyGysrltvvNrthLhwefvrsddgqvlDsf
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