Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
PAPL | 4-112 | 2.4e-17 | 55.7 | In-house | 98-194 (194) | alignment | |||
Range on Protein: 4-112
Range on HMM: 98-194/194.0
SSEHWYSYDTFGIHVAIVDSMAPHGPGTDQYKWLVQDLAAAqarrtaNPEAHPWIMVMWHFPMYVSHLRGHDHKhdmkpaQMQELRDSLEQVLLDHQVDF
|... ||..| . |. | . .||.|| .|||.. | ...|||.|| | ||| |. .|.| . .. ...||..|....||
sgsnsysfetesvhfivlsseedvkekseqyewleedlakv......nRsktPWiivmgHrpmYcsnkdkddck......ekakmlaaledllykygVDl
LLTGHDHVY
|.|| | |
vlaGHeHsY
|
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subfamily_ACP5_pd | Subfamily ACP5 | 5-112 | 4.2e-32 | 103.6 | In-house | 87-188 (189) | alignment | ||
Range on Protein: 5-112
Range on HMM: 87-188/189.0
SEHWYSYDTFGIHVAIVDSMAPHGPGTDQYKWLVQDLAAAQarrtaNPEAHPWIMVMWHFPMYVSHLRGHDHkHDMKPAQMQELRDSLEQVLLDHQVDFL
...|||.|. ..|. ..... . .|..||||| .||..|. | ...|||.||.| |||.|. ...|. . .. .. ..||.|||..| ...||..
knewYsfdygpvhfislstevdfslgseqykWLekdLkean.....nrkktpwiivmgHrPmYcsnkdeddc.tkeetlvrkglresledllykykvdla
LTGHDHVY
|.||.| |
lsgHeHsY
|
|||||||||
UPF0054 | Uncharacterized protein family UPF0054 | 40-92 | 1.1e-06 | 14.4 | Pfam-A | 91-140 (145) | alignment | ||
Range on Protein: 40-92
Range on HMM: 91-140/145.0
DLAAAQARRTANPEAHPWIMVMWHfpmYVSHLRGHDHKHDMKPAQMQELRDSL
. || .|.. .. .. . .. | . || |.||... . ..|..| . |
etaareakeyghslerelahllvH...GllHllGYDHeeeeeakeMealeeel
|
|||||||||
Metallophos | Calcineurin-like phosphoesterase | 45-112 | 2.9e-08 | 27.2 | Pfam-A | 139-200 (200) | alignment | ||
Range on Protein: 45-112
Range on HMM: 139-200/200.0
QARRTANPEAHPWIMVMWHFPMYVSHLRGHDHkhdmkpAQMQELRDSLEQVLLDHQVDFLLTGHDHVY
. . . . .......| |.. | |.|. . . .| || |....|| .|.||.|..
eflalplralvdgkilltHgplsssggsgddi......gselfgpdalekllekygvdlvlrGHtHkp
|