Gene ACP5-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily ACP5
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP092_AA protein Get Run
MbreP092_AA_46-284 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Metallophos Calcineurin-like phosphoesterase 46-137 7e-08 26.0 Pfam-A 2-84 (200) alignment 
Range on Protein: 46-137
Range on HMM: 2-84/200.0
RFIVFGDFGAGQVGGKdhhqEdVAHLLSSVAAHFQPQFIATTGDIIYDDGIQSIADMQLKtkhrDLYSANSLQVPWHIIPGNHDCHGSLDAM
|..|.|| . |    .      ....|  .||. .|...  .||... .   |   ..|      |    .| .|.. ..|||....  .| 
rilvigDlHgglddle....d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalld....ylvlklllpipvfllrGNHesdpgnsay
ACP5 47-159 1.4e-28 91.9 In-house 1-109 (198) alignment 
Range on Protein: 47-159
Range on HMM: 1-109/198.0
FIVFGDFGagqvGGKDHHQEDVAHLLSSVAAHFQPQFIATTGDIIYDDGIQSIADMQLKTKHRDLYSANSLQVPWHIIPGNHDCHGSLDAMVEYAQLPGN
|.|.||.|    . .  .|..||. ...||.. ...|.  .|| .||||..|. | ..|... . |.|.||||||... ||||..|. .|..|||.   .
flvvGDwG....rkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskd

HWDMPARYYVKTI
.. .. ||.... 
srfpslryslskk
subfamily_PAPL_pd Subfamily PAPL 48-283 2.2e-68 221.6 In-house 1-212 (212) alignment 
Range on Protein: 48-283
Range on HMM: 1-212/212.0
IVFGDFGA-GQVGGKDHHQEDVAHLLSSVAAHFQPQFIATTGDIIYDDGIQSIADMQLKTKHRDLYSANSLQVPWHIIPGNHDCHGSLDAMVEYAQLPgN
.|.||.|. .... ....||.||. |..||.....||....||..|..|.....|...|....|...|.||||||....||||..|...|...|..|. .
lvlgDwGgleeapyttaaqeavakelgkvaeeleaqfvlalGDnfYekGvkdvddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYskls.k

HWDMPARYYVKTISFGDKSARLiylEFQLMhhmfwhiavsmtmphrpDTCLLvCGQMRNFRcedsMRASVNASLRQDELAWLRKELTV-PAQWKLVFGHW
.|..|..||.|.... |..|..   .. |.                 || || ||.  . .    ....|..||.....|||..||.   |....|.||.
rWkfpslyytksfkipdsnatv...qlvli.................dtvll.cgksddlk....legpvdvslaeeqwawleeeLkaseadylivaGhy

GIFSHFGNGPTQELVDDLLPLLREFDVDVYFNGHDHSL
...|.. .|||..||..| |||....|..|..||||.|
pvwsvaehGptkiLvkrLkPlLekynvtaylsGhDhnl
subfamily_ACP5_pd Subfamily ACP5 49-283 3.8e-13 41.8 In-house 1-188 (189) alignment 
Range on Protein: 49-283
Range on HMM: 1-188/189.0
VFGDFGAGQvggkdhhQ-------EDVahllssvaAHFQPQFIATTGDIIYDDGIqsiADMQLKTKHRDLYSANSLQVPWHIIPGNHDCHGsldAMVEYa
||||.|. .       .       ..         .. . ..|   ||. |...     . ..  .. .| .  . .||. ...|||. .     ...| 
vfgDlgvse.......aaslatllkee........eaneldliihvGDlaYalka...kneavwdefmnlieplaskvPymvsiGnhesds...nfsay.

qlpGNHWDMParyyvktisfgDKSArliYLEFQLMHHMFwhIAVSMTMPHRPDtcllvcgqmrnfrcedsmrasvnaslrQDELAWLRKELTV-----PA
    . . ||           .|.    .  |.. .  |  |..|  . . ..                           .. ..||.|.|.        
...kkrfsmp...........skne...wYsfdygpvhf..islstevdfslg...........................seqykWLekdLkeannrkkt

QWKLVFGHWGIFSH--FGNGP--TQE-----LVDDLLPLLREFDVDVYFNGHDHSL
.| .|.|| ...     ..    ..      |.. | .|| ...||... ||.|| 
pwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlalsgHeHsY
PAPL 49-167 7.7e-08 24.7 In-house 2-111 (194) alignment 
Range on Protein: 49-167
Range on HMM: 2-111/194.0
VFGDFGAGQVGGkdhhqedvAHLLSSVAAHFQPQFIATTGDIIYDDGIQSIADMQLKTkhrDLYSANSLQVPWHIIPGNHDCHGSLDAMVEYAQLPGNH-
||||.|. .           .  |.. ... . ..|  .||. |.|. |.  | .      .. .  . .||. ..||||. .   .. ... . ||.. 
vfGDlGqtnass........lkrlqketqkgkydailhvGDlaYaddeqnewdgdefm...rqieplaasvpymvapGNHEeeynfsnykarfsmpgsee

WDMPARY-YVKTISFGDKSAR
....... . ...||  .|. 
gesnssesgsnsysfetesvh
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 77-285 6.3e-06 18.3 Pfam-A 22-123 (156) alignment 
Range on Protein: 77-285
Range on HMM: 22-123/156.0
AHFQPQFIATTGDIIYDdgiqsiadmqlKTKHRDLysaNSLqvPWHIIPGNHDchgsldamveyaqlpgnHWDMPARYYVKTisFGDKSA-RLIYLEFQL
.. ....|   ||..             .. ...|   ...  | ....||||                  ...|... |..  . .. |  .   .. |
dikevdlilhaGDlvep...........eevvell...edi..pvlavrGnhD.................eaelpkelavel..llaaaaleiegdrvll

MHHMFWHiavsmtmphrpdtcllvcgqmrnfrcedsmrasvnaslrqdelawlrkeltvpaqwklvfghwgifshfgngpTQELVDDLLPLLREFDVDVY
.| ....                                                                          |.  ..|  ||.| ..|..
vhgtpls.........................................................................vqsseeelaellkeagadlv

FNGHDHSLQH
| || |  . 
flGHtHkpkv
ACP5 196-282 1.7e-21 68.8 In-house 112-198 (198) alignment 
Range on Protein: 196-282
Range on HMM: 112-198/198.0
CLLVCGQMRNFRCEDSMRAsVNASLRQDELAWLRKELT-VPAQWKLVFGHWGIFSHFGNGPTQELVDDLLPLLREFDVDVYFNGHDHS
.  .. .. ... .....|  . . ....|.||.|.|.   |.||.|.||. ..|   .|.|.|||..|||||.. .||.|.|||||.
vtelftekkdeksdqreva.erekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdtkelverllpllkkykvdaYlnGHdHc
Metallophos Calcineurin-like phosphoesterase 221-282 2.7e-06 20.8 Pfam-A 134-199 (200) alignment 
Range on Protein: 221-282
Range on HMM: 134-199/200.0
RQDELAWLRKELTVPAQWKLVFGHWGIFSHFGNGPT----QELVDDLLPLLREFDVDVYFNGHDHS
.. .  .|...|  .. .|.. .| ...|. |.| .        | | .||.. .||... ||.| 
eeqleeflalplralvdgkilltHgplsssggsgddigselfgpdalekllekygvdlvlrGHtHk