Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
ACP5 | 37-257 | 1.2e-54 | 177.0 | In-house | 2-198 (198) | alignment | |||
Range on Protein: 37-257
Range on HMM: 2-198/198.0
VLLGDWGGQDAAPYAEVGQlatvpGLTAVVTQVNAQLALLLGDNFYSSGIHSdEHDARFVETFEQVYNSSVLeAIPYYVIAGNHDHKGNVSAQIAYSQLS
...||||....... .| . .. |... ... | |||||| .|..| ..| || |.||..|... | .|.||..||||..|||||||.|.. |
lvvGDwGrkgeynqsavak.....qmgkvaekldidfvlslGDnfyddGvts.vddprfkesfekiytaksl.qvpWyvvlGNHDyrgnvsaqieyakrs
SRWHFDDYYYKKSFVFspssernmtidiifiDTVLLAGNSDdlEDKFGTLPGPIDADWAETQWSWIQASLRDSTADYLFTAGHYPVWSGCSHGPTDILVD
...| ..|..|. . ... | ... ..| . .. . . ||.|..|....|..||||... .||.||.| ..||.|. ||.
kdsrfpslryslskke...............vvtelftekk..deksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdtkelve
RLKPMLEQYGATGHLSGHDHC
||.|.|..|... .|.|||||
rllpllkkykvdaYlnGHdHc
|
|||||||||
Metallophos | Calcineurin-like phosphoesterase | 37-257 | 2e-15 | 50.6 | Pfam-A | 4-199 (200) | alignment | ||
Range on Protein: 37-257
Range on HMM: 4-199/200.0
VLLGDWGGQDAAPYaevgQlaTVPGLTAVVTQVNAQLALLLGDNFYSSGIHSDEHDARFvetfeqVYNSSVLEAIPYYVIAGNHDHKGNVSAQIAYSQLS
...||..|. . .. . .. | .. . ...| | |||.... | ... . . .|. ||.... |||. .. || .. .
lvigDlHgglddle....d..lllillkiaaeekpdlvlflGDlvdrgdwssetlalld......ylvlklllpipvfllrGNHesdpgnsaygflleql
SRWHFDDYYYKKSFVFspssernmtidiifiDtvLLAGNSDDLEDKFGTLPGPIDADWAETQWSWIQASLRDSTADYLFTAGHYPVWSGCSHGPT----D
... ...... . . .. . | . . . .| |. . | . . .|. . .| |..| .| . .
kdlrglangeeeyenl...............k..itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigsel
ILVDRLKPMLEQYGATGHLSGHDHC
| | . ||.|| . |.||.|.
fgpdalekllekygvdlvlrGHtHk
|
|||||||||
subfamily_PAPL_pd | Subfamily PAPL | 38-258 | 1.9e-92 | 300.3 | In-house | 2-212 (212) | alignment | ||
Range on Protein: 38-258
Range on HMM: 2-212/212.0
LLGDWGGQDAAPYAEVGQLATVPGLTAVVTQVNAQLALLLGDNFYSSGIHsDEHDARFVETFEQVYNSSVLeAIPYYVIAGNHDHKGNVSAQIAYSQLSS
.||||||...|||... | |.. |..|.....||..| ||||||..|.. |..|||| ||||.|.....| ..|.||.|||||.|||||||||||.||.
vlgDwGgleeapyttaaqeavakelgkvaeeleaqfvlalGDnfYekGvk.dvddarfketfedvftaesl.qvpwyvvagnHDykGnvsaqiaYsklsk
RWHFDDYYYKKSFVFSPSserNMTIDIIFIDTVLLAGNSDDleDKfgtLPGPIDADWAETQWSWIQASLRDSTADYLFTAGHYPVWSGCSHGPTDILVDR
||.|...||.||| .. | |.|.....||||||.|.||| .| | ||.|...||.||.|....|..|.||||..|||||||| ..||||.|||.|
rWkfpslyytksfkipds...natvqlvlidtvllcgksdd..lk...legpvdvslaeeqwawleeeLkaseadylivaGhypvwsvaehGptkiLvkr
LKPMLEQYGATGHLSGHDHCL
|||.||.| .|..||||||.|
LkPlLekynvtaylsGhDhnl
|
|||||||||
PAPL | 49-154 | 4e-08 | 25.6 | In-house | 13-107 (194) | alignment | |||
Range on Protein: 49-154
Range on HMM: 13-107/194.0
PyaevgqlatVPGLTAVVTQVNAQLALLLGDNFYSSGIHSDEHDARFVETFEQVYNSsvleaIPYYVIAGNHDHKGNVSAQIAYSQLSSRWHFDDYYYKK
.. |.. ... . .. |..|| | . .. . .|.. |.. .| .|| |..|||... | |.. |... ..... . .....
s.........lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaas.....vpymvapGNHEeeynfsnykarfsmpgseegesnsses
S---FVFSP
. . |.
gsnsysfet
|
|||||||||
subfamily_ACP5_pd | Subfamily ACP5 | 57-258 | 4.2e-12 | 38.4 | In-house | 20-188 (189) | alignment | ||
Range on Protein: 57-258
Range on HMM: 20-188/189.0
AtvpgltavvTQVNAQLALLLGDNFYSSGIhsdeHDARFVETFEQVYNsSVLEAIPYYVIAGNHDHKGNVSAQiaysqlSSRWHFD------DYYYKKSF
. . ...|.. .|| | . .... ..| .. . .. .|| |..|||... |.|| ..|.. . |..
e.........eaneldliihvGDlaYalka....kneavwdefmnlie.plaskvPymvsiGnhesdsnfsay......kkrfsmpsknewYsfdygpvh
VFSPSSERNMTIDiifidtvllagnsddledkfgtlpgpidadwaETQWSWIQASLRDS----TADYLFTAGHYPVWSGCSHGP---------TDILVDR
. | |.| . . . ..|..|... |.. . ......|| |.. ... .. |...
fislstevdfslg................................seqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglres
LKPMLEQYGATGHLSGHDHCL
| ..|..|. ||||.|.
ledllykykvdlalsgHeHsY
|