Gene PPP4C-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP103_AA protein Get Run
MbreP103_AA_3-297 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 4-297 1e-117 386.6 In-house 27-330 (473) alignment 
Range on Protein: 4-297
Range on HMM: 27-330/473.0
VEDLDRHIATLRNCEIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVR
  |||. | .|......||.|.. ..|.|.|||  | |.... ..|...||||||..||..|.| .|  ||....|.||.||||..|.|...||| ||..
lldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkik

YPNRMTLLRGNHESRTITQVYGFYDECMRKYGSPtVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPhgE
||....|||||||.| ....|||.||...||| . ... . |... | |||||..|||.|||||||....|||||.|||  |.|..|...|||||||  .
ypgnvfllrGNHElrllnglygfgdetlekyged.lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP..w

EQSG--------WSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQ------ACTVWSAPNYCYRCGNVASVLRIDEHLdHKFVIFQ
|..|        .  ||||||.|||||.|| | ..||| ||.|.|. |.||....|  .       .||.||||||.|.|| |.||.|||.|  .|..|.
eddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfd

AAPTEIRH
..|.....
psphplil
subfamily_PPP2C_pd Subfamily PPP2C 5-293 1.1e-141 464.1 In-house 2-288 (290) alignment 
Range on Protein: 5-293
Range on HMM: 2-288/290.0
EDLDRHIATLRNCEIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRY
.|||..|. |..|. . |..|. .|.||.|||  | |. .. .|.|.|||.||| .||.||| . |..|.|||||.||.||||||||||  ||  |||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PNRMTLLRGNHESRTITQVYGFYDECMRKYGSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHgeE
..|.|.|||||||| |||||||||||.||||...||.. |..|| |.|.|..|..|.|.||||||||..||.||...|  ||| |||.||||||||   .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd..d

QSGWSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAAPT
..||..||||||. || |. | ||..||| || |||||||||..| .... .|..||||||||||| |..| .|..|...|. |..|| 
rggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr
0049330 Metallo-dependent phosphatases 5-296 1.8e-108 355.2 In-house 15-304 (309) alignment 
Range on Protein: 5-296
Range on HMM: 15-304/309.0
EDLDRHIATLRNCEIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRY
..||. | .|... ...|....|...||.|||. |.|.......|...|||||| .||..|.| .|  ||....|.||.||||..|.|..|||| ||..|
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PNRMTLLRGNHESRTITQVYGFYDECMRKYGsPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPhGEE
|....|||||||.| ....|||.||..|||| . .|. ...... | |||||..|||||||||||....||||| .|| .|.| .|..||||||||  ..
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdp.lpi

QSGWSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAAPTEIR
 .|.  .|||.|..||...|| | ..||| ||.|.|..|..|....|... .||.||||||.|.||...||.|||.| . |..|...|....
regfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll
0053225 Metallo-dependent phosphatases 5-291 7.6e-103 336.8 In-house 7-291 (293) alignment 
Range on Protein: 5-291
Range on HMM: 7-291/293.0
EDLDRHIATLRNCEIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRY
 .||. | .|... ...|....|....|.|||. |.|.......|...|||||...||..|.| .|  ||....|.||.||||..|.|...||| ||..|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PNRMTLLRGNHESRTITQVYGFYDECMRKYGSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHgeE
|....|||||||.. ....|||.||..||||.  .|. ...... | |||.|..|||.|||||||.. .||||| |.|  ..| ||...|||||||.  .
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd..l

QSGWSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAA
 |||  |.||.|..||...|. | ..||| ||.|.||.|..|....|... .||.|||||..|.||...|| .||.|  .|..| . 
wsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_PPP4C_pd Subfamily PPP4C 6-293 1.3e-158 519.7 In-house 2-287 (288) alignment 
Range on Protein: 6-293
Range on HMM: 2-287/288.0
DLDRHIATLRNCEIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYP
||||.|..||.||.| |..|. .| ||||||. |.|. .. .|.|.||||||| |||.|||.|.|..|||||||.|||||||.|||||||||| ||||||
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

NRMTLLRGNHESRTITQVYGFYDECMRKYGSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPhgEEQ
.|.||.||||||| |||||||||||.||||| .||..||||||.|||||.||.||.||||||||||..||.||.|.|. ||| |||.||||||||  |..
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdp..eda

SGWSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAAPT
.||.|||||||.||| |||| ||..|.. ||||||||||||.|.||...  ||||||||||||||||..|..||.||..| ||.||..
egwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaa
subfamily_PPP6C_pd Subfamily PPP6C 6-295 2.1e-141 463.2 In-house 1-288 (290) alignment 
Range on Protein: 6-295
Range on HMM: 1-288/290.0
DLDRHIATLRNCEIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYP
.||. | . ..|. .|| |.. .||.  ..|| |.|.. . .|.|.||||||| |||.|||  .||.|.|.|.|.||||||||||.||| .|| ||..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

NRMTLLRGNHESRTITQVYGFYDECMRKYGSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPhgEEQ
.|.|||||||||| |||||||||||..|||. ..|. ||.|||||..||.||...||||||||| .. |||||.|||. |.| .|..|||.||||  |. 
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp..edv

SGWSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAAPTEI
. |.|||||||.|||  |.. |.. | | |||||||||.||.|..|...  |||||||||||||||||.|..... .... .|.| | | 
etwavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdee
subfamily_PPP7C_pd Subfamily PPP7C 6-183 5.2e-37 120.4 In-house 19-202 (383) alignment 
Range on Protein: 6-183
Range on HMM: 19-202/383.0
DLDRHIATLRNCEIIPEHDVRLVCDKAREILLAEGNIVHIG----APITICGDIHGQHYDLMELFEVAGQ-MPETNYLFMGDFVDRGYYSVETFLLLLLL
.... | .... ...  . | |.  .|...| .  || ..       .|.|||.||.  ||. ..   |   .| .|.| |||||||  |||  |.|| |
eveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillal

KVRYPNRMTLLRGNHESRTITQVYGFYDECMRKY--GSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPsIQSLDQIRTIERQ
 . ||. . | |||||   .   |||  | . ||   .  . .|  .||  | ||..||.||| ||||.|  . .|. .  |||.
llvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisd.ktdlelldkiers
subfamily_PPG1_pd Subfamily PPG1 7-293 4.7e-124 406.5 In-house 1-298 (300) alignment 
Range on Protein: 7-293
Range on HMM: 1-298/300.0
LDRHIATLRNCEIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPN
||. .  |...|..||  |. ..|| .|.|. | |...| .|.|. ||.||| ||..|.|.. ||.|.|||||.||.||||.|||||  ||..||.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RMTLLRGNHESRTITQVYGFYDECMRKY-GSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPH----
|.|||||||||| |||||||| ||.||| | ..||.  ||.|| |.|||.||..| |||||||||..|.|||. ..|  ||| || ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

----GEEQSG--WSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAAPT
      ...|  . ||.||||. .| |||| | ..| .  | |||||..||.. .|... .|||||||||||||| ||.| . |.... | ....|| 
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 10-291 4.7e-94 307.8 In-house 14-294 (298) alignment 
Range on Protein: 10-291
Range on HMM: 14-294/298.0
HIATLRNCEIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMT
 ... . ...| |.||  ....|..|. .   .| . |||..|||||||. ||. ||. ||  |..||||.||.|||| ...|. .|||  ||.|||.. 
slsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnff

LLRGNHESRTITQVYGFYDECMRKYGSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHgEEQSGWS
|||||||  .| .|||||.|| |.| | ....   .||. | |.|.| ..|||.|||||. ..||||.|...| .. ..|    ||||.||. . ..||.
llrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpe.navkgwa

VSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAA
 . ||... || |||. . ..  . |..||||.| .|...  ...  |..|||.|| .  | |.|...||.|   |.... .
ensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 14-295 1.1e-82 270.3 In-house 2-279 (280) alignment 
Range on Protein: 14-295
Range on HMM: 2-279/280.0
LRNCeiIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRG
| .|  | | |.  | .| ..||.|.  .| . ||...|||.|||. ||. ||. ..  |..||||.||.|||| . .|  ||||  ||||||.. .|||
llac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrg

NHESRTITQVYGFYDECMRKYgSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHgEEQSGWSVSPR
|||  .| . |||.||..|.| |  ...   |..| | |.|..  .|||.|||||. ..|||... . |  . . |    ||||.||. ....||. ..|
nhevisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpe.nkvtgwaensr

GAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAAPTEI
|.  .|| .||  . ..  . ||.| ||.| .|...  ...  ||.|||.|.    | |.||..||.|   | ... |  |.
gvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalrev
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 16-289 2.9e-74 243.0 In-house 19-293 (297) alignment 
Range on Protein: 16-289
Range on HMM: 19-293/297.0
NCEIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNH
 ...| |. |  . | | ... |. ..| . ||| .|||||||  ||. ||   |  | .||||.||.|||| .|.|| .|||  ||..|  . ||||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESRTITQVYGFYDECMRKYGSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSP---SIQSLDQIRTIERQVEVpSEGPMCDLLWSDPHGeEQSGWSVSP
|   . .|||||.|| ..| |  ..    .||. | |. .| .||||.||||||      .|| .| |||. |   |. ..||||.||     ||.    
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpis.glsgfmenq

RGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQ
||||  || | |     .  | |.|||||.| .|...   ..  |..||| || .  |.|...  ||.|.  | |..
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 17-286 8.7e-68 221.8 In-house 3-270 (280) alignment 
Range on Protein: 17-286
Range on HMM: 3-270/280.0
CEIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHE
|...  |..  .      |.. | |..   ||| . |||| |. |.  ||.. |..|| . .|.||.||||   .| ..||. ||.|| .|. |||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRTITQVYGFYDECMRKYGSPTVWQLCTeVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHGeEQSGWSVSPRGAG
. .. ..|||| ||  |||    |.. . .|. . ....|  ..||.|||||| .  || || | | .|    | . |||||||   .  ||  | ||  
tpsvnkiygfyvecqykygvglwwdfqs.cfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptn.kgegwfhsirgis

FLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFV
..||  |||   .   . || ||||.| .|..    ..  ||.| |||| .  | |.|. ..  |.  | 
ymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfq
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 18-289 2.4e-82 269.6 In-house 6-281 (284) alignment 
Range on Protein: 18-289
Range on HMM: 6-281/284.0
EIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQM------PETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLL
... |...  .| .|||..  |   ..| ||..|.||||||. ||. |... |         |..|||.||.|||| .|.|  .||. .|...|....||
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRTITQVYGFYDECMRKYgSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHGeEQSGWSVS
||||||| . . |||| || ..| | ....     |  . |.||...||.|.|||.|  . .|.|.  .|| ...|  | ..|| |.||.  | .|.  |
rgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpea.evegykes

PRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQ
||||| .||.. |. |...  | |. ||||.||.|...  ...  |..||| || .  |.|.||..||.|   |....
prgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 18-295 1.2e-81 267.3 In-house 22-298 (299) alignment 
Range on Protein: 18-295
Range on HMM: 22-298/299.0
EIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHES
. . |.... .|. |..... .  .. . ||| .|||||||. ||. .|..||  |..|.||.||.||||   .|.  |||  |..||.|. .|||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RTITQVYGFYDECMRKYGSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHgEEQSGWSVSPRGAGF
 .| .|||||.|| ..| |  .| .  . |. . |. .|  .|||.|||||| .|.|||.| . |  . |.     ||||.||  .   .|    ||  .
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpd.qsvkdwlanvrgvsy

LFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAAPTEI
.||.|||.   .. .. |..||||.| .|...  ...  |..||| || .  | |.....|| |   ||... .| ..
vfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpksl
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 18-289 1.3e-69 227.4 In-house 14-287 (290) alignment 
Range on Protein: 18-289
Range on HMM: 14-287/290.0
EIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHES
. . ..|.  . .|..|||     .... |||.| ||||||  .|.. |.  |. |. ..||.||.||||  |.|  |||. .|.||.... ||||||| 
dafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhev

RTITQVYGFYDECMRKYGSpTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQ-V-EVPSEGPMCDLLWSDPHGEEQSGWSVS-PRG
| . ..|||..| .|| ||  .|.   .||. ||| | .. ||||.|||.|. |.| . ......  |     || . ||||.||  . .   ..   |.
rkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqra

AGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQ
   .|| .... . .. .| || |||..  |||.. |...  ||.||| |. .  |. ..... | |. ..|...
isvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 18-70 4.2e-12 38.9 In-house 7-59 (317) alignment 
Range on Protein: 18-70
Range on HMM: 7-59/317.0
EIIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAG
... |...  .| .|||..  |   ... ||.||.||||||. ||. |... |
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_PPP1C_pd Subfamily PPP1C 19-291 3.7e-107 350.7 In-house 9-279 (282) alignment 
Range on Protein: 19-291
Range on HMM: 9-279/282.0
IIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESR
 . |.... ...|||||||..  .... ||..|.||||||..||. ||| .|  ||.||||.||.||||  |.|| .||| .|..||... |||||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

TITQVYGFYDECMRKYGSPtVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPhGEEQSGWSVSPRGAGFL
 |...||||||| |.|..  .|.  |.||. | |||..|.|||||||||||...||.|||.|.| .|||..| .||||||||  .|. ||| . ||  | 
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdp.dkevlgwsendrGvsft

FGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAA
||.|||| | |.| | ||.||||.| .|.... ..|  ||.|||||| . .| ..||..||.|  .| |...|
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 19-289 4e-71 232.7 In-house 2-272 (284) alignment 
Range on Protein: 19-289
Range on HMM: 2-272/284.0
IIPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESR
.|| .||  .  .| .|.  .  .. . .|| ||||||||  ||. ||.  |    .||||.||.|||| . .|| |||.  || .||.. .||||||  
lippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecs

TITQVYGFYDECMRKYGSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPM-CDLLWSDPHgEEQSGWSVSPRGAGF
 | ..||||.|| |.|  |.|..    ||  . |.|.. ..|||.|||.|  .| . |.|.|.| .. |    .  |.|||||  . | ||    ||  .
linkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdpt.nfqkgwnpnsrgvsy

LFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQ
.|| | .  . ..  . |. ||||.| .|...  ...  |..||| || .  | |.|. ... |   ||...
vfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlr
PPP_3 20-289 1.7e-115 377.7 In-house 2-270 (271) alignment 
Range on Protein: 20-289
Range on HMM: 2-270/271.0
IPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRT
..|.... ...|..|||  | |.|.| ||.|.||||||| .||.|||...|..|||.|||.||.||||..|.|..|||| ||..||....|||||||||.
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECMRKYGSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHgEEQSGWSVSPRGAGFLF
|..||||..|...|.|. .|.. ..|||.||.|||.||.|.|.|||||||||.|||||...||. |||.||...|||.|... |...|.. |.||||.||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdp.ekeeglenskrGagllF

GPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQ
||||.| |...| | ||.|||.|..||.. .....  ||.||||||.|..|....|...|.| ..|....
gpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 20-291 6.1e-79 258.1 In-house 8-277 (281) alignment 
Range on Protein: 20-291
Range on HMM: 8-277/281.0
IPEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRT
. ....  |  ... |.  | ..| | .||.. ||.|.|. || .|||. |..||. ..|.||.||||  |.|...||. ||.||..|. |||||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

ITQVYGFYDECMRKYGSpTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHGeEQSGWSVSPRGAGFLF
. ..|||| ||. |||   .| |  . |. | ..| |. ..||.|||||| . .||..| . . .. .  | . ||||.||.  .  .|  | ||..|.|
vnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdn.kveewkassrGssftf

GPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAA
| .||.   .. .. || ||||.|..|..    ..  ||.|.||||    | |.||..|| |. ..| .  |
GknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
PP2Ac_SM00156 21-290 3.2e-106 347.3 In-house 2-269 (271) alignment 
Range on Protein: 21-290
Range on HMM: 2-269/271.0
PEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTI
 ...|. ......||| .| |.|.. ||.|..|||||| .||..|.| ||..||..|.|.||.||||..|.|. |||. ||..||....||||||||. .
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECMRKYgSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPhGEEQSGWSVSPRGAGFLFG
...|||..|..||| .  ... ..|.|.||.|||..|.||||.||||||...|||.|| ..|. | | ||...|||||||  ....|.. | ||....||
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp.eqkekgfqpskrglsvvFg

PDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQA
.|.|. | ..| | ||.|||..|.||... ....  |..||||||....|.|.||.....|..... ...
edavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_PPP3C_pd Subfamily PPP3C 21-280 3.1e-85 279.6 In-house 42-312 (452) alignment 
Range on Protein: 21-280
Range on HMM: 42-312/452.0
PEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTI
 |...  . ..| ..|  | ..... ||||..||||||.|||..||||.|.  .|.|||.||.|||||.|.|. | |. ||. ||... |||||||.| .
eeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhl

TQVYGFYDECMRKYGSpTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHGEEQSG------WSVSPRG
|. . | .||  ||.  .|.. |.| || | |||..... ||||||||| |.|||.|....|  |.|. ||.||||||||. . ..          |.||
teyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrG

AGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQA------CTVWSAPNYCYRCGNVASVLRIDEH
  ....   |  | |.| |  | |||.   .|.. . ...|       |..|||||.    | |.||.... 
csyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 21-290 1.2e-76 250.4 In-house 11-281 (287) alignment 
Range on Protein: 21-290
Range on HMM: 11-281/287.0
PEHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTI
 ..|.  | .|..|||     .... |||||.||||||  ||. .|.  |. |...|||.||.||||  |.|  |||. ||..||... ||||||| . |
sdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkki

TQVYGFYDECMRKYGsPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQ-VEVP-SEGPMCDLLWSDPHGEEQSGWSVSPRGAGFL
 ..|||..| .||..   ...   .||. |.| | .. .|||.|||.|| ..|||.......  ...   || . ||||.||. . ..      |.   .
nklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

FGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQA
||  .|. . .. .. || |||... ||... |...  ||.||| |. .  |...|. ... |. .|| .. 
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_PPZ_pd Subfamily PPZ 22-287 4.6e-76 249.2 In-house 27-290 (300) alignment 
Range on Protein: 22-287
Range on HMM: 27-290/300.0
EHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTIT
. ..  .| ||||..||. ... .  .. | ||.|||. ||. ||  .|  | .||||.||.||||  |.|| ||||  |..||. . |||||||   .|
nseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvt

QVYGFYDECMRKYgSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHgEEQSGWSVSPRGAGFLFGP
.|||||||| |.     .|.   . |. | |||..  ||.|||||||| ..|.|.|| . |  .||  | . |||||||  . .  |    ||  . .  
rvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdpt.dssnewednergvsycynk

DVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVI
  .. | .. |. |.|||| .| .|...  ..   ||.||||||    |  .|. . | |   | .
vainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfel
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 22-280 1.7e-52 171.5 In-house 9-290 (302) alignment 
Range on Protein: 22-280
Range on HMM: 9-290/302.0
EHDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAG------Q-----MPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTL
.... |....  | |  | ....| .|.|| ||||||. ||. ..          .       .  ..|.||.||||. |.|   |.. ||| ||..  |
ksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyil

LRGNHESRTITQVYGFYDECMRKYGSPT---VWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSE-GPMCDLLWSDPHGEEQS
||||||...|   ||| .|   ..|      .|.   |||  . |||.. .||||||||.|| ..||..|. |.| ..  .|     |||..||   .. 
lrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqll

-GWSV-------SPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEH
   |          ||  ..|    |. . .. .| || |||| . ||||.. ... .|..|||.|     |  .||..|  
aavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
PPP_1 23-275 1.4e-107 351.9 In-house 4-262 (264) alignment 
Range on Protein: 23-275
Range on HMM: 4-262/264.0
HDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTITQ
. .. ...|..|.|  | |.... ..||.||||||| .||..||.|.|. |||||||.||.||||..|||..|||| ||..||....|||||||||..|.
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtk

VYGFYDECMRKYGSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLL-------WSDPHGeEQSGWSVSPRGA
||||..|...|..| ......|.|||.|.|||.||.|||.|||||||....|||||...|. |||.||..||||       .||..  ...... |.|||
vygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddke.qeeavansiRGa

GFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVL
|.|||.||.| |.|.|.| ||.|||....||........  |..||.||.....| ....
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 23-280 1.2e-52 172.0 In-house 9-289 (302) alignment 
Range on Protein: 23-280
Range on HMM: 9-289/302.0
HDVRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAG------Q-----MPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLL
... |....  | |  | ....| .|.|| ||||||. ||. ..          .       .  ..|.||.||||. |.|   |.. ||| ||..  ||
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHESRTITQVYGFYDECMRKYGSPT---VWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSE-GPMCDLLWSDPHGEEQS-
|||||...|   ||| .|   ..|      .|.   |||  . |||.. .||||||||.|| ..||..|. |.| ..  .|     |||..||   ..  
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqlla

GWSV-------SPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEH
  |          ||  ..|    |. . .. .| || |||| . ||||.. ... .|..|||.|     |  .||..|  
avsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 25-70 6.1e-08 25.1 In-house 16-61 (339) alignment 
Range on Protein: 25-70
Range on HMM: 16-61/339.0
VRLVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAG
.  .| .|||.. .|  .... ||| . ||||||  ||. .... |
laelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-295 6.7e-64 209.0 In-house 27-296 (307) alignment 
Range on Protein: 27-295
Range on HMM: 27-296/307.0
LVCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTITQVYGF
 |  .|. |. .|  .| |  |  . ||.|||  ||...| . |. ||| |.| ||.||||  |.|. |||.  |. ||. . |||||||   . . |||
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygf

YDECMRKYG--SPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHGEeQSGWSVSPRGAGFLFGPDVV
|.||.         .| |   .|. | ..|.|  ||||.||||||..  ||..|   . .  |  | . |.||.||       |  | ||.|| || .|.
yeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdps.vfewkassrgsgftfgtnvi

EIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAAPTEI
.   .. |. || ||||....|.     ..  |..||| ||    |   ||..|| |  . | |  .  .|
ddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpeseni
subfamily_PPPLV_pd Subfamily PPPLV 28-280 1.5e-50 165.1 In-house 5-278 (290) alignment 
Range on Protein: 28-280
Range on HMM: 5-278/290.0
VCDKAREILLAEGNIVHIGAPITICGDIHGQHYDLME----LFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTITQV
.||.| .||.|| ..... .|. . ||.||.. ||.     |. .  ..  ...||.||.|||| .|||    || ||| || .. ||||||| ..... 
lcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqes

YGFYDECMRKYGSP--TVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLD---QIRTIERQVEVPSEG-PM-CDLLWSDPHGEEQ----------S
. .. |.. |.|     ||.  ..||| | ||||||.|..|||.|.  .|..      |. |  ... . .| |.  |.|||||  ...           
ieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlne

GWS-VSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCgNVASVLRIDEH
|.   . || | .|. | .| | ..|.|  . |||.   .|..   . .  ||.|. .||    | |... .|..
GfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvdkk
subfamily_PPP5C_pd Subfamily PPP5C 30-292 3.1e-83 272.4 In-house 44-310 (322) alignment 
Range on Protein: 30-292
Range on HMM: 44-310/322.0
DKAREILLAEGNIVHIG----APITICGDIHGQHYDLMELFEVAGQMPET-NYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTITQVY
 .|.|.| ..  .|.|       .|.|||||||.|||...||. |.  |.  ||| ||||||| .|||. |.|| .|. |||.. | |||||| .. ..|
leakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkly

GFYDECMRKYGSpTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSP-SIQSLDQIRTIERQVEVPSEGPMCDLLWSDPHgeEQSGWSVSPRGAGFLFGPDV
|| .|.  || . .| .| ||||. | || ||..|.| |||||      .||..|.|.|. . |.|| ...||||||.  |..| | | || |. |||||
Gfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq..eanGrspskrGvgvqfGpdv

VEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRI-DEHLDHKFVIFQAAP
 . | ..|.| || |.|.. .||.. . . .  ||.|||||| . || ...... ...|. ||  |.| .
tkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeave
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 43-296 4.3e-56 183.5 In-house 3-261 (263) alignment 
Range on Protein: 43-296
Range on HMM: 3-261/263.0
VHIGAPITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTITQVYGFYDECMRKYGSPT----
. . ||| |||| |||. ||. .|. .|   .|.|||.||.|||| .|.|  .||. ||.  | .| ||||||| ..| . |||. |  ...        
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPM-CDLLWSDPHGEEQSGWSVSPRGAGFLFGPDVVEIFNQQNGLGLIC
|..   .||  . |.|..  .|||.|||.|| ..|||.||.|   .|     |. |||||.||  . .       |    .||   |. . ..  . || 
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidliv

RAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAAPTEIR
||||.|  |. .  ...  ||.||  |     | |.|. ... |.  || ..    |.|
rahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfevr
Metallophos Calcineurin-like phosphoesterase 48-242 1.4e-47 155.6 Pfam-A 2-198 (200) alignment 
Range on Protein: 48-242
Range on HMM: 2-198/200.0
PITICGDIHGQHYDL----MELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLL--LLLKVRYPNRMTLLRGNHESRTITQVYGFYDECM----------
.|...||.||...||    ..|...|.. . ...||.||.|||| .| ||. ||  |.||...|..  ||||||||. ....|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLDQIrtierqvevpsegpmcdllwsdphgeeqsgw
                       .... . ... . |.|..|.|.| .| |||..||.||.| .| |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

svsprgAGFLFGPDVVEIFNQQNGLGLICRAHQL
      ...|||||..| . ...|. |..|.|. 
......gselfgpdalekllekygvdlvlrGHtH
subfamily_YNL217W_pd Subfamily YNL217W 48-121 1.6e-06 20.8 In-house 11-80 (235) alignment 
Range on Protein: 48-121
Range on HMM: 11-80/235.0
PITICGDIHGQHYDLMELFE--VAGQMPETNYLFMGDFVDRGYYSVETFLLLlllkvRYpNRMTLLRGNHESRTIT
 . . ||.||   .|.||..  . |. ..   ...||....|  |||.  ..     |  .    ..||||  .. 
rllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv.....rk.dqvkcvkGnheelvll
PPP_2 49-242 3.3e-81 264.7 In-house 1-197 (198) alignment 
Range on Protein: 49-242
Range on HMM: 1-197/198.0
ITICGDIHGQHYDLMELFEVAGQMPETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTITQVYGFYDECMRKYGSPTVWQLCTEVFD
.|.|||.||| .||..||......||..|||.||.||||..|.|..|||| ||..||....||||||||.....||||..|...|.|. .|.. ..|||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

LLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVPSEGPMCDLL----WSDPHgEEQSGWSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQL
||.|||.||.|.|.||||||..|..||||...||..|.|.||...|||    .|||. |...... | ||||.||||||.| . ..| | ||.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpk.ekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 49-242 3.1e-77 252.1 In-house 1-196 (197) alignment 
Range on Protein: 49-242
Range on HMM: 1-196/197.0
ITICGDIHGQHYDL-MELFEVAGQMP-ETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTITQVYGFYDECMRKyGSPTVWQLCTEV
.|..|||||| .|| ..|....|. . |..|.|.||.||||..|.|..|||| ||..||....||||||||. ....|||..|...|  . .... ...|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVP-SEGPMCDL-LWSDPHgEEQSGWSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQL
||||.|||.||.|.|.||||||....|||.|..|||..|.| .|. ..|| |||||  |.|.|.. | ||||.||||||.| | ..|.| ||.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr.eaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 49-242 2e-75 246.2 In-house 1-198 (199) alignment 
Range on Protein: 49-242
Range on HMM: 1-198/199.0
ITICGDIHGQHYDL-MELFEVAGQMP-ETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTITQVYGFYDECMRKYGSPTVWQLCTEV
.|.|||.||| .|| ..||. .|. . |..|.|.||.||||..|.|..|||| ||..||....|||||||.. ....|||..|...||..  ... ...|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDLLSLAAVIDDKILCVHGGLSPSIQSLDQIRTIERQVEVP-SEGPMCDL-LWSDPHgEEQSG-WSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQL
|| |.|||.||.|.|.|||||||.|.|..... |||..|.| ..| ..|| |||||  ..|.| .  | ||||.||||||.| | ..|.| ||.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr.daqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 74-289 7.4e-72 235.2 In-house 100-313 (317) alignment 
Range on Protein: 74-289
Range on HMM: 100-313/317.0
ETNYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTITQVYGFYDECMRKYgSPTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQS
  .|||.||.|||| .|.|  .||. ||..||....|||||||||.. . |||| |. ..| | ....    .|  | |.||...||||.|||.| .. .
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDQIRTIERQVEVPSEGPMCDLLWSDPHGEEqSGWSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVAS
|.|. ...| ...|  | ..|| |.||. |. .|.  |.||||..||.. |. |...  | |. ||||.|..|...  ...  |..|||.|| .  |.|.
lkqldklkrpldipdvGvladltwadpdaev.kgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaa

VLRIDEHLDHKFVIFQ
||..|..|   . ...
vlsvdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 76-289 2.3e-55 181.1 In-house 121-332 (339) alignment 
Range on Protein: 76-289
Range on HMM: 121-332/339.0
NYLFMGDFVDRGYYSVETFLLLLLLKVRYPNRMTLLRGNHESRTITQVYGFYDECMRKYGSpTVWQLCTEVFDLLSLAAVIDDKILCVHGGLSPSIQSLD
 |||.||.|||| .|.|  .||  ||. ||.|. |||||||||..   |||| |   .| .  ...   ..|... ..|||.. |.|.|||.|  . |..
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRTIERQVEVPSEGPMCDLLWSDPHGEEQsGWSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVL
|.  ..| .|.|  | . || |.||   |. |.  | ||| |.|||  .  | ..  | .. | ||.| .|...   ..  |..|||||| .  | |.|.
qfsvfkrpleipdvgvltdltwadpdptek.gykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavf

RIDEHLDHKFVIFQ
 ||..|     .|.
sidkklkisinvfr
subfamily_PPP7C_pd Subfamily PPP7C 192-295 1e-17 56.9 In-house 237-339 (383) alignment 
Range on Protein: 192-295
Range on HMM: 237-339/383.0
MCDLLWSDPHGEEqSGWSVSPRGAGFLFGPDVVEIFNQQNGLGLICRAHQLVMEGFKWHFQQQACTVWSAPNYCYRCGNVASVLRIDEHLDHKFVIFQAA
. |.|||||. .|   .. . ||.|  ||||| . . |. .| |. |.|.  .||...  ...  |..|| ||     |  . ... ..|  ..| .||.
vldilwsdpkake.GckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas

PTEI
 .. 
katk