Gene PAPL-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP097_AA protein Get Run
NvecP097_AA_23-240 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Metallophos Calcineurin-like phosphoesterase 22-240 1e-14 48.2 Pfam-A 3-200 (200) alignment 
Range on Protein: 22-240
Range on HMM: 3-200/200.0
FNVFGDMGILPAATP--IANEMVKEAKNGSSFLFHNGDLGYGLGYLHVWEQWQ-NLIEPFVTLMPHMVGVGNHEYDHAF---GGKNDPSGAPGNGFHPWW
. |.||... .. .         . |...  .....||| ..  .   ..    .| ...    |...  ||||.|..    | ..  .. .   .  ..
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

AGPNEygndsygecgvptnmrfhmpdngnsVfwYSFNYGSMHLIMMSTEHDFTKGSPQYQWLQKDLADIDRSVTPWVVIGGHRPMYTSQQIIGDYMISIG
.. |.                         .  . .  .|  |.  | .. ....| |...|...||  .|. ...... .|.|.. | .   |      
eyenl.........................k..itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigself

MRHYFEDLLLQYKVDMAFWAHYHSY
.....|.||..|.||. ...| | .
gpdalekllekygvdlvlrGHtHkp
subfamily_ACP5_pd Subfamily ACP5 24-241 6.9e-64 207.3 In-house 1-189 (189) alignment 
Range on Protein: 24-241
Range on HMM: 1-189/189.0
VFGDMGILPaATPIANEMVKEAKNGSSFLFHNGDLGYGLGY--LHVWEQWQNLIEPFVTLMPHMVGVGNHEYDHAFGGKndpsgapgngfhpwwagpney
||||.|.   |...|... .|..|  ....| |||.| |..   .||....|||||... .|.|| .||||.|. |                        
vfgDlgvse.aaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsay.....................

gndsygecgvptNMRFHMPDNGNsvfWYSFNYGSMHLIMMSTEHDFTKGSPQYQWLQKDLADI-DRSVTPWVVIGGHRPMYTSQQIIGDY-----MISIG
            ..||.||.. .   ||||.||..|.|..|||.||..||.||.||.|||... .|. |||... ||||||.|..  .|.     ... |
............kkrfsmpskne...wYsfdygpvhfislstevdfslgseqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkg

MRHYFEDLLLQYKVDMAFWAHYHSYE
.|. .|||| .||||.|...|.||||
lresledllykykvdlalsgHeHsYe
PAPL 24-118 7.1e-17 54.2 In-house 2-97 (194) alignment 
Range on Protein: 24-118
Range on HMM: 2-97/194.0
VFGDMGILPAATpIANEMVKEAKNGSSFLFHNGDLGYGLGYLHVWEQWQ--NLIEPFVTLMPHMVGVGNHEYDHAFGGKNDPSGAPGNGFHPWWAGP
||||.|   |.. ...   ...|.  ....| ||| | ... . |....  ..|||... .| || .||||... | ...  .  ||.  ... .  
vfGDlGqtnass.lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnsse
PAPL 135-240 2.5e-32 104.6 In-house 89-194 (194) alignment 
Range on Protein: 135-240
Range on HMM: 89-194/194.0
MRFHMPDNGNSVFWYSFNYGSMHLIMMSTEHDFTKGSPQYQWLQKDLADIDRSVTPWVVIGGHRPMYTSQQIIGDYMISIGMRHYFEDLLLQYKVDMAFW
 .  .. . ..   |||...|.|.|..|.|.|... | ||.||..|||. .||.|||... ||||||.|..   |   .  |.. .||||..|.||. ..
eegesnssesgsnsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvla

AHYHSY
.| |||
GHeHsY
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 255-305 8.2e-19 59.1 Pfam-A 2-52 (62) alignment 
Range on Protein: 255-305
Range on HMM: 2-52/62.0
APIHIVVGTAGKELDTEPHWKFSWSEFYMNAYGYGRVTVHDRHSLLWEWIK
||.|||||.|| .|.. .. . .||.| .. |||.|.||..|  | ||...
ApvhIvvGaAGnglskfskpqpewsafresdyGysrltvvNrthLhwefvr