Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
PhoD | PhoD-like phosphatase | 165-282 | 7.9e-06 | 16.1 | Pfam-A | 61-149 (453) | alignment | ||
Range on Protein: 165-282
Range on HMM: 61-149/453.0
GYIHEVLLTGLRPDTVYQYSYGStennidggllsslitsfslfP-LQKMSAVRSFHTApiPGPD--VpFKFVVYGDMGVSAPPgsvvtaRLALQEVIA-N
|. .| .|||.|.. | | . . .. | | .. |. |. . ....|.... . .. |..|. . .
dytvkvevtgLepgqeyfYrfra....................eegesespvGrtrTl..peaaves.lrlavvSCsnyeqGy......fnayrelaeke
KAAFIFHVGDISYARGyayvWE
. |..|.||. |..| ..
dlDfvlhlGDyiYeyg....eg
|
|||||||||
Metallophos | Calcineurin-like phosphoesterase | 230-450 | 1.8e-19 | 63.8 | Pfam-A | 1-200 (200) | alignment | ||
Range on Protein: 230-450
Range on HMM: 1-200/200.0
FKFVVYGDMGVSAPPGSVvTARLALQEVIANKAAFIFHVGDISYARGYAYVWEQWH-TLIEPYATLVPYMVGIGNHEQDHTSGGAKDPSGAPGDGFHPWW
....| ||.. .... |. .|. .... ||.... .. .. | .. . .|... .|||| |. . ..| . ...
lrilvigDlHgglddled.lllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglan
GDFGDDSGgecgvpmyqrfrmpdngnalWwYSFDYGSVHFVMMSTEHNFTRGSPQYEWLERDLRGVDRKTTPWVILGGHRPMYTSEISPADYIVSKGMQH
|. ... . . . .|. .. | .. .. .| |.|.|| .|. ..|. ....|| .|.|.. |. | | . .
geeeyenl....................k.itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgpd
AFEDLLSEYHVDLALWGHYHAY
|.|.|| .| ||| |.|| | .
alekllekygvdlvlrGHtHkp
|
|||||||||
PAPL | 233-321 | 6.2e-19 | 60.9 | In-house | 1-87 (194) | alignment | |||
Range on Protein: 233-321
Range on HMM: 1-87/194.0
VVYGDMGVSAPPGsvvtARLALQEVIANKAAFIFHVGDISYARGYAYVWEQWH--TLIEPYATLVPYMVGIGNHEQDHTSGGAKDPSGAPG
.|.||.| . .. .|. .| .|.||||..|| .. |.... .|||.|. ||||| .||||... . . | . ||
avfGDlGqtnass....lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpg
|
|||||||||
subfamily_ACP5_pd | Subfamily ACP5 | 234-451 | 1.3e-67 | 219.4 | In-house | 1-189 (189) | alignment | ||
Range on Protein: 234-451
Range on HMM: 1-189/189.0
VYGDMGVSAppgsVVTARLALQEVIANKAAFIFHVGDISYARGY--AYVWEQWHTLIEPYATLVPYMVGIGNHEQDHtsggA---Kdpsgapgdgfhpww
|.||.|||. ... .|.| ||.. .|.||||..||... ..||.....||||.|. ||||| |||||.|.
vfgDlgvse....aaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesds....nfsay..............
gdfgddsggecgvpmYQRFRMPDNGNalwWYSFDYGSVHFVMMSTEHNFTRGSPQYEWLERDLRGV-DRKTTPWVILGGHRPMYTSEISPADY-----IV
.||.||.. . |||||||.|||...|||..|..||.||.|||.||. . .||.|||.|. ||||||.|. . |. .|
...............kkrfsmpskne...wYsfdygpvhfislstevdfslgseqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlv
SKGMQHAFEDLLSEYHVDLALWGHYHAYE
.||.....|||| .|.|||||.||.|.||
rkglresledllykykvdlalsgHeHsYe
|
|||||||||
Metallophos_2 | Calcineurin-like phosphoesterase superfamily domain | 257-480 | 1.6e-06 | 20.2 | Pfam-A | 22-143 (156) | alignment | ||
Range on Protein: 257-480
Range on HMM: 22-143/156.0
VIaNKAAFIFHVGDIsYARgyayvwEQWHTLIEPYatlvPYMVGIGNHEQDHTSGGAK--Dpsgapgdgfhpwwgdfgddsggecgvpmyqrfrmpdngn
| .....|.|.||. ... |. . |.| . | . |||..... ..
di.kevdlilhaGDl.vep......eevvelledi....pvlavrGnhDeaelpkelavel.......................................
alwwysfdygsvhfvmMSTEHN----------------FtrgspqyewlerdlrgvdrkttpwvilgghrpmytseispadyivSKGMQHAFEDLLSEYH
...... . ...... ||.|..
................llaaaaleiegdrvllvhgtpls.............................................vqsseeelaellkeag
VDLALWGHYHAYERtcpvynqkCQAGATTHIIVGTAGWTLDP
.||.. ||.| .. . |.|... .|..|. .
adlvflGHtHkpkv........ekrggtlvvnpGsvgepreg
|
|||||||||
PAPL | 348-450 | 5.4e-34 | 110.0 | In-house | 92-194 (194) | alignment | |||
Range on Protein: 348-450
Range on HMM: 92-194/194.0
RMPDNGNALWWYSFDYGSVHFVMMSTEHNFTRGSPQYEWLERDLRGVDRKTTPWVILGGHRPMYTSEISPADYIVSKGMQHAFEDLLSEYHVDLALWGHY
.. . . . |||...||||...|.|..... | |||||| ||. |.|. |||.|. ||||||.|. . | .. |..|.|||| .|.||| |.||
esnssesgsnsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvlaGHe
HAY
|.|
HsY
|
|||||||||
ACP5 | 379-448 | 9.2e-06 | 17.4 | In-house | 132-197 (198) | alignment | |||
Range on Protein: 379-448
Range on HMM: 132-197/198.0
RGSPQYEWLERDLRGVDRKTTPWVILGGHRPMYTSEISpadyIVSKGMQHAFEDLLSEYHVDLALWGHYH
| . . |.|. . . ..|. |.| || |.|. .| ... .. ||..|.||. | || |
rekyaeeqlkwlekalakstadwkiVvGHhpvySigeh....gdtkelverllpllkkykvdaYlnGHdH
|
|||||||||
Metallophos_C | Iron/zinc purple acid phosphatase-like protein C | 465-524 | 1.8e-23 | 74.0 | Pfam-A | 2-61 (62) | alignment | ||
Range on Protein: 465-524
Range on HMM: 2-61/62.0
ATTHIIVGTAGWTLDPDRYWKMDWSMYHDNEFGYGRITVHNSTAMYWEWVRNRDNAVVDV
|..||.||.|| |.. . . .|| ......||.|.||.|.|...||.||..|..|.|
ApvhIvvGaAGnglskfskpqpewsafresdyGysrltvvNrthLhwefvrsddgqvlDs
|