Gene PAPL-6 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP102_AA protein Get Run
NvecP102_AA_141-355 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PhoD PhoD-like phosphatase 97-229 2.2e-09 27.8 Pfam-A 60-184 (453) alignment 
Range on Protein: 97-229
Range on HMM: 60-184/453.0
RQFSIHnVKLTGLQPNTKYYYKVGDV-NQTMSDTFSFSTKENN----IIYAVYGDMGYSNAVsLPQLVQEARDGHFQAVIHVGDLAYDFYqkdadtgD--
|..... |..|||.|...|.|..    ... | . .. | ...    .  ||.... | .    . . . |.. ....|.|.||  |          .  
rdytvk.vevtgLepgqeyfYrfraeegesespvGrtrTlpeaaveslrlavvSCsnyeqGy.fnayrelaekedlDfvlhlGDyiYeyg.......egt

-------NFMNAIQPVATlvpymalpgnhehRFNFSHYKNRFSNMKL
       .  ....|  .              .. ..|..|..  | 
ykneereekgrvvepeke.............ivtladYRkryaqykt
PAPL 142-345 4.2e-49 159.3 In-house 1-194 (194) alignment 
Range on Protein: 142-345
Range on HMM: 1-194/194.0
AVYGDMGYSNAVSLPQLVQEARDGHFQAVIHVGDLAYDFYQKDADTGDNFMNAIQPVATLVPYMALPGNHEHRFNFSHYKNRFSNMKLGPGATSGSD-TS
||.||.|. || ||..| .|...|...|..|||||||. ..... .||.||. |.|.|. ||||..|||||...|||.||.|||...   | .  |. .|
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgs

LWYSFNVGLIHFVAFDTEvfnyfSDVGQIQRQLNWLEADlaKANTNRDKRPWIVSLAHKSKSEEQKCNYLMIwidfMDETNFTHISPLLHKYGVDIHFCG
  |||...  ||... .|     .|| . . |..|||.|  .|. ||.|.|||. ..|.     .| .         ... .... .||.|||||. ..|
nsysfetesvhfivlsse.....edvkekseqyewleed..lakvnRsktPWiivmgHrpmYcsnkdkddck....ekakmlaaledllykygVDlvlaG

HSHNY
| |.|
HeHsY
Metallophos Calcineurin-like phosphoesterase 142-345 4.4e-15 49.5 Pfam-A 4-200 (200) alignment 
Range on Protein: 142-345
Range on HMM: 4-200/200.0
AVYGDMGYSNAVS---LPQLVQEARDGHFQAVIHVGDLAYDFYQKDADTGDNFmNAIQPVATLVPYMALPGNHEHRFNFSHYKNRFSNMKLGPGATSGSD
.| ||... ....   | .| . | .. ...|.. ||| .     .   ..   .  ....  .|...|.|||| ..  | |. .    |.  |   |..
lvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

TSLWYsfnvGlIHFVAFDTEVFNYFSDVGQIQRQLNWLEADLAKANTNRDKRPWIVSLAHKSKSEEQKCNYLMiwidFMDETNFTHISPLLHKYGVDIHF
   .     . | ..    |...  .. .  .   ..   .   |. .| . .... |.|   |.. . ..      .  . .  . ..|| |||||. .
eyenl....k.itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi....gselfgpdalekllekygvdlvl

CGHSHNY
.||.| .
rGHtHkp
subfamily_ACP5_pd Subfamily ACP5 143-346 1.1e-61 200.0 In-house 1-189 (189) alignment 
Range on Protein: 143-346
Range on HMM: 1-189/189.0
VYGDMGYSNAVSLPQLVQEARDGHFQAVIHVGDLAYDFYQKDADTGDNFMNAIQPVATLVPYMALPGNHEHRFNFSHYKNRFSNMklgpgatsgSDTSlW
|.||.|.|.| || .|..|.........||||||||.  .|.. ..|.|||.|.|.|. ||||...||||.. |||.||.|||..         |... |
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp.........skne.w

YSFNVGLIHFVAFDTEVFnYFSDvgqiQRQLNWLEADLAKANtNRDKRPWIVSLAHK----SKSEEQKCNYLMIWID-FmdetNFTHISPLLHKYGVDIH
|||..| .||....|||  .. .    ..|..|||.||..|| ||.|.|||.  .|.    |...|..|..    .       ..... .||.||.||. 
Ysfdygpvhfislstevd.fslg....seqykWLekdLkean.nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkg....lresledllykykvdla

FCGHSHNYQ
..||.|.|.
lsgHeHsYe
ACP5 145-344 2.9e-08 25.6 In-house 5-198 (198) alignment 
Range on Protein: 145-344
Range on HMM: 5-198/198.0
GDMGYSNAVSLP----QLVQEARDGHFQAVIHVGDLAYDFYQKDADTGD---NFMNAIQPVATLVPYMALPGNHEHRFNFSHYKNRFSNMKLGPGATSGS
||.|  ....      |. . |.. . ..|. .||  ||   ...|  .   .| .  .  .. ||.. . |||..| | |   .  .  |        .
GDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpslry

DTSLWYSFnvglIHFVAFDTEVFNYFSDVGQIQRQLNWLEADLAKANTNRDKRPWIVSLAHKSKSEEQKCNylmiwidfmDETNFTHISPLLHKYGVDIH
  | .  .    ....  . .  .  . | . ... ... ..| ||... ...  ||   |  .|  .. .          ..   .. |||.||.||..
slskkevv....telftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgd.........tkelverllpllkkykvdaY

FCGHSHN
..|| |.
lnGHdHc
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 155-358 2.7e-08 26.0 Pfam-A 16-124 (156) alignment 
Range on Protein: 155-358
Range on HMM: 16-124/156.0
LPQLVQEARDghFQAVIHVGDLAYdfyqKdadtgdnfmNA-IQPVATLvPYMALPGNHEHRFNFSHYKNRFsnmklgpgatsgsdtslwysfnvglihfv
| ........   ....|.|||      .         .. .. .... |  |..|||.     .... ..                             
leavledike..vdlilhaGDlve....p.........eevvelledi.pvlavrGnhDeaelpkelavel.............................

afdtevfnyfsdvgqiqrqlnwleaDLAKANTNRDKRPWIVSLAHKSKseeqkcnylmiwidfmDETNFTHISPLLHKYGVDIHFCGHSHNYQRhypyyq
                          ||.|... ... ....  .. .                .. .   .  || ..|.|. |.||.|...       
.........................llaaaaleiegdrvllvhgtpls................vqsseeelaellkeagadlvflGHtHkpkv......

devdR
    .
....e
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 372-419 4.8e-09 27.8 Pfam-A 4-50 (62) alignment 
Range on Protein: 372-419
Range on HMM: 4-50/62.0
TVIVAGSAGSKEKIsHGLGPKRHLAKYIFDYGFGHLQVMNHTHLRWTW
. ||.|.|| ...      ..   |    |||.. |.|.|.|||.|..
vhIvvGaAGnglsk.fskpqpewsafresdyGysrltvvNrthLhwef