Gene PAPL-13 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP109_AA protein Get Run
NvecP109_AA_80-299 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PhoD PhoD-like phosphatase 32-124 1.1e-08 25.5 Pfam-A 61-148 (453) alignment 
Range on Protein: 32-124
Range on HMM: 61-148/453.0
GFIHDVLLTDLKPSSLYYYQYGTdlV-RIGMSKLKNFTTAplPNPDVS-FKFLVYGDQGISADAHNTARYSLEEilyRNATMVIHLGDIAYAEGY
 ..  | .|.|.|.. |.|.. .    .   |.. ...|.  |. .|. ....|.... . .   |. |   |.    .  .|.||||. |..| 
dytvkvevtgLepgqeyfYrfra..eegesespvGrtrTl..peaaveslrlavvSCsnyeqGyfnayrelaek...edlDfvlhlGDyiYeyge
Metallophos Calcineurin-like phosphoesterase 79-299 3.9e-15 49.7 Pfam-A 1-200 (200) alignment 
Range on Protein: 79-299
Range on HMM: 1-200/200.0
FKFLVYGDQGISADAHN-TARYSLEEILYRNATMVIHLGDIAYAEGYAYQWEKYF-ALIEPYASLVPYMVGIGNHEQDHVSGGEKDPSGAPGEGFHPWFA
...|| || ..  | .. ...  |. . . ....|..|||. ..  ..  .....  | .. .  .|... .|||| |..    .     ..  . ....
lrilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang

PSLFHTDsggecgvpmyhrfhmpdngnhVwwYSFNYGSLHYIMMSTEHNFTRGSRQYKWIENDLRNVDRSVTPWVLIGGHRAMYTSQKYYGDYMLSLGMR
   ...                      .  . .  .|  ..  | .. .. .|.|... | .|....|. ...... .|. .. | ... |    | ..
eeeyenl.....................k..itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgp

HHMDDLLNKYQVDLGLWAHFHSY
.....||.||.||| |..| | .
dalekllekygvdlvlrGHtHkp
subfamily_ACP5_pd Subfamily ACP5 83-300 4.4e-61 198.1 In-house 1-189 (189) alignment 
Range on Protein: 83-300
Range on HMM: 1-189/189.0
VYGDQGISAdAHNTARYSLEEiLYRNATMVIHLGDIAYAEGY--AYQWEKYFALIEPYASLVPYMVGIGNHEQDHvsggekD---Psgapgegfhpwfap
|.|| |.|. |...|... ||   ......||.||.|||...  ...|.... ||||.|| ||||| |||||.|.      .                  
vfgDlgvse.aaslatllkee.eaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesds......nfsay..............

slfhtdsggecgvpmYHRFHMPDNGNhvwWYSFNYGSLHYIMMSTEHNFTRGSRQYKWIENDLRNV-DRSVTPWVLIGGHRAMYTSQKYYGDY-----ML
                .||.||.. .   ||||.||. |.|..|||..|..||.||||.|.||... .|. |||... ||| ||.|.|. .|.     ..
...............kkrfsmpskne...wYsfdygpvhfislstevdfslgseqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlv

SLGMRHHMDDLLNKYQVDLGLWAHFHSYE
. |.|....|||.||.||| |..| ||||
rkglresledllykykvdlalsgHeHsYe
PAPL 83-174 2.1e-17 55.9 In-house 2-93 (194) alignment 
Range on Protein: 83-174
Range on HMM: 2-93/194.0
VYGDQGISADAHntARYSLEEILYRNATMVIHLGDIAYAEGYAYQWEKYF--ALIEPYASLVPYMVGIGNHEQDHVSGGEKDPSGAPGEGFHPW
|.|| |    ..  ..   .|.  ..  ...|.||.||| ..  .|..     .|||.|. ||||| .||||... . ..|  .  ||.  ...
vfGDlGqtnass..lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseeges
PAPL 196-299 2.6e-29 94.7 In-house 83-194 (194) alignment 
Range on Protein: 196-299
Range on HMM: 83-194/194.0
FH--------MPDNGNHVWWYSFNYGSLHYIMMSTEHNFTRGSRQYKWIENDLRNVDRSVTPWVLIGGHRAMYTSQKYYGDYMLSLGMRHHMDDLLNKYQ
|.        .. . .  . |||...| |.|..|.|..... | ||.| |.||..|.||.|||. . ||| ||.|.|   |   .  |.....||| ||.
fsmpgseegesnssesgsnsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykyg

VDLGLWAHFHSY
||| |..| |||
VDlvlaGHeHsY
subfamily_PAPL_pd Subfamily PAPL 220-298 9.9e-06 16.9 In-house 140-211 (212) alignment 
Range on Protein: 220-298
Range on HMM: 140-211/212.0
MSTEHNFTRGSRQYKWIENDLRNvdrSVTPWVLIGGHRAMYTSQKYYGDYMLslgmRHHMDDLLNKYQVDLGLWAHFHS
... .. .  ..|..|.|..|..   |   .....||  ..   .     .|    ..... ||.||.|.  |  | |.
legpvdvslaeeqwawleeeLka...seadylivaGhypvwsvaehGptkiL....vkrLkPlLekynvtaylsGhDhn
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 314-374 2.4e-18 57.6 Pfam-A 2-62 (62) alignment 
Range on Protein: 314-374
Range on HMM: 2-62/62.0
GTVHITVGTAGKQFDTNGFMPMDWSLKQMIEFGYGRITVYSKSALLWEFITNKDKKVADKV
..|||.||.|| . ..    . .||  .. ..||.|.||. ...| |||. ..| .|.|..
ApvhIvvGaAGnglskfskpqpewsafresdyGysrltvvNrthLhwefvrsddgqvlDsf