Gene PPH3 in Saccharomyces cerevisiae

Synonym: PPH2, YDL188C, PPH22

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP020_AA protein Get Run
ScerP020_AA_0-288 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 1-288 8.9e-116 380.2 In-house 27-326 (473) alignment
Range on Protein: 1-288
Range on HMM: 27-326/473.0
MMDLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLR
..|||..|  |. .. .|||....|.   .|.|..| |. ... .....|||||||.||| |.|| |  ...|..||||.|||| .||| ..|||..|..
lldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkik

YPDRITLIRGNHETRQITKVYGFYDEVVRKYgNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDV
||....|.|||||.|... .|||.||. .|| . .......|....| | |.|.. |..||||||||....|.||.|.| .|.|..|...|||||||...
ypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwed

DT--------WSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGG------LVTVWSAPNYCYRCGNVAAVLKIDDDLnREYTIFEAV
|         .  ||||||.|||.. |..||.||.. || |.|. |.|||. .|||.      ..||.||||||.|.|| ||||.||.|| .....|...
dgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdps

QA
. 
ph

subfamily_PPP4C_pd Subfamily PPP4C 2-288 7.1e-164 537.0 In-house 1-287 (288) alignment
Range on Protein: 2-288
Range on HMM: 1-287/288.0
MDLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRY
.|||. |..||. ..| ||.| .|| ...|.|..|.||..||.|||.|||||||..|||.||. .| |..|.|.||||||||||||.|.|||||..|.||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDVD
||||||||||||.||||.|||||||..||||..||||||.||||||||.|||...||||||||||...|.||||.|||||||||||..||||||||||..
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAVQA
.|..||||||.|||...|.|| |.|..|||.||||||||||| .|.  ..|||||||||||||||||.|..|..|.....||||..|
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaa

subfamily_PPP2C_pd Subfamily PPP2C 2-286 3e-131 429.9 In-house 2-286 (290) alignment
Range on Protein: 2-286
Range on HMM: 2-286/290.0
MDLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRY
.||||.|. |...|.. |..| .|| . .|.|..| || .| .|||.|||.|||.|||| ||   | . .| |.||||.||||.||.|.  || . |.||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDVD
..|||..|||||.||||.|||||||..|||||.|||.|  ..||||.| |.... |||.|||||| ..|.|.||..|| |||||||..||||||||.| .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAV
 |..||||||. |||   ..| ..|...|||||||||||||. ..|  .||..||||||||||| ||.|..||.|....  |.. 
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa

0053225 Metallo-dependent phosphatases 2-286 4.9e-104 340.7 In-house 7-291 (293) alignment
Range on Protein: 2-286
Range on HMM: 7-291/293.0
MDLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRY
..||..|  |.  |...||....|.|  .|.|..|.|. ... .....|||||.|.||| |.|| | .. .|..||||.|||| .||| ..|||..||.|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDVD
||...|.|||||..... .|||.||..||||....|.........| | |.|...|..||||||||....|.|| |.| ...|.||...||||||| ...
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAV
.|  |.||.|..||   |..||.||...|| |.||.|..||. .|||.||||.|||||..|.||..|||..|..|......|..|
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv

subfamily_PPP7C_pd Subfamily PPP7C 2-181 2.3e-41 134.8 In-house 18-203 (383) alignment
Range on Protein: 2-181
Range on HMM: 18-203/383.0
MDLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTP----VTICGDIHGQLHDLLTLFEKSGG-VEKTRYIFLGDFVDRGFYSLESFLLLLC
....|.| ...  |..  . |  .  .... | .  |...| |     ||.|||.||.| ||| .. | |   |.  |.| |||||||  |.|  |.||.
deveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillilla

YKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKY--GNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSpDMTTVDEIRTIDRKQ
. | ||  . | |||||   .   |||  ||  ||   .... |   .|| .| |...|...|. ||||.| |.| .. .  |.|..
lllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk

subfamily_PPP6C_pd Subfamily PPP6C 3-290 2.5e-141 462.9 In-house 1-288 (290) alignment
Range on Protein: 3-290
Range on HMM: 1-288/290.0
DLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYP
.||| |   .. |..||. . .||   ..||..|.||  | .|||.|||||||..||. || ..| | .|.|.|||||||||.||||.| .||. |..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDVDT
|||||.|||||.||||.||||||| ..||||.|.|.||..||| |...|||.....|||||||||..|.|.||.|.| ||.||.||.|||.|||||||.|
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAVQAQN
|..||||||.|||.. ...|.. ||..||.||||||.||.| |||  ||||||||||||||||||..|...|. .||  .|.||. ..
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdee

0049330 Metallo-dependent phosphatases 3-288 9.3e-107 349.6 In-house 16-301 (309) alignment
Range on Protein: 3-288
Range on HMM: 16-301/309.0
DLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYP
.||..|  |. .| ..||....|.|  .|.|..|.|. ... .....|||||||.||| |.|| | .  .|..||||.|||| .||| .||||..||.||
lldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllyp

DRITLIRGNHETRQITKVYGFYDEVVRKYGnSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVD
|...|.|||||.|... .|||.||..|||| ...|.........| | |.|...|.|||||||||....|.|| ..| .|.|..| .||||||||  ...
dnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpire

TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAVQA
..  .|||.|..||   |..||.||...|| |.|..|..||. .|||.|.||.||||||.|.||..|||.||.||......||.|. 
gfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl

subfamily_PPG1_pd Subfamily PPG1 4-286 6.6e-117 383.1 In-house 1-296 (300) alignment
Range on Protein: 4-286
Range on HMM: 1-296/300.0
LDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPD
||. .  |.  . .|| ||  |. . .|||..| || .. .|||. ||.|||..|.| .|.  | |  | |.||||.||||.||.|.  ||.. ||||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITLIRGNHETRQITKVYGFYDEVVRKY-GNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE----
||||.|||||.||||.||||| |..||| |||.||.|  |.||||.| |||...|.||||||||.. ..|.|. .|| .|||.|||..||||||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DVDT--WSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAV
      | .   .  |.||||. .||  | .||..|... | |||||..|||. .||. | |||||||||||||| |..|.. . ..| . ..|. 
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeea

subfamily_PPP5C_pd Subfamily PPP5C 5-288 5.6e-86 281.5 In-house 22-311 (322) alignment
Range on Protein: 5-288
Range on HMM: 22-311/322.0
DKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTP----VTICGDIHGQLHDLLTLFEKSGGV-EKTRYIFLGDFVDRGFYSLESFLLLLCYKL
....  ... |....  .... |...||| ..  .......    .|.||||||| .||| .||. | . |.  |.| ||||||| .|.|  |.||..||
kellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkl

RYPDRITLIRGNHETRQITKVYGFYDEVVRKYgNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGL-SPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE
 ||... | |||||. .. |.||| .||  || ...|     |||..| |. .||.... ||||| | |  |.|..|.||| .. |.||....||||||.
lyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq

DVDTWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKI-DDDLNREYTIFEAVQA
.    | | || |. ||    ..||..||.||| |.|.. .|||. . || |.||.|||||| . || .|.... .|||. ... ||||. 
eanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeaveh

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 12-284 8e-90 293.9 In-house 19-292 (298) alignment
Range on Protein: 12-284
Range on HMM: 19-292/298.0
RDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGN
.  | | || |..|.  ..... .   . .||.|...|||||||  ||| ||.|.|  ... |.||||.|||| ..||  .|||.||..||... |.|||
kltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGn

HETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPED-VDTWSLSPRGA
||. .| .|||||.|. |.| . ...    .||. | | |.| . |.|.|||||. ....|..|.. | .. ..|    ||||.|||. |  |. . ||.
heceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGv

GFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFE
.. ||. .| ..||| ...|..||||.| .||. . .  |||..|||.|| .  | |||.|.|..|   .... 
svvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlk

subfamily_PPP3C_pd Subfamily PPP3C 15-275 2e-81 267.1 In-house 39-312 (452) alignment
Range on Protein: 15-275
Range on HMM: 39-312/452.0
KHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHET
 .. ||.. ..  .. .|| .| .. .|..|.|..|||||| .||| ||| .|  ..|.|.||||.|||| .|.|  | |.. |. ||... |.|||||.
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhec

RQITKVYGFYDEVVRKYGNsNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWS-------LS
| .|. . | .|.  ||.. .|.  |.| || | | |..|.  .||||||||.....|.|...|| .|.|. |..||||||||  | .  .        |
rhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpns

PRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFD------GGLVTVWSAPNYCYRCGNVAAVLKIDDD
.||  .... . | .||.||..  | |||.   .||.   .        |.|..|||||.    | |||||....
vrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 15-284 4.9e-78 255.4 In-house 22-292 (299) alignment
Range on Protein: 15-284
Range on HMM: 22-292/299.0
KHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHET
| . |. . .||  ... ....  . .|..|. .|||||||  ||| .|.|.|   .. ..||||.||||   ||   ||||.|..||.|. ..||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPED-VDTWSLSPRGAGFL
  | .|||||.|. ..|  . .|    . |... |  .|.. |.|.|||||| ..|.| .| . | |. |      ||||.||.. |  |    ||  ..
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFE
||.  | . ... ...|.|||||.| .||. . .  |||..||| || .  | ||..|.|..|   .....
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlk

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 15-283 4.1e-67 219.5 In-house 21-292 (297) alignment
Range on Protein: 15-283
Range on HMM: 21-292/297.0
KHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHET
| | || |..|   . ... .. .. .|..|. .|||||||. ||| || . |    . |.||||.|||| .|.|. .|||.||...|  . |.||||| 
kviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhec

RQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMT---TVDEIRTIDRKQEVpHEGAMCDLLWSDPE-DVDTWSLSPRGA
  . ||||||.|. ..|    ..    .||..| |  .| . |.|.|||||| .|   |.| .| |.| .|  .|. ..||||.||   .  .    |||
efvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrga

GFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIF
|  ||.  | .   . ...|..||||.| .||. .    |||..||| || .  |.||..  |. |.  . |.
gcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeil

subfamily_PPP1C_pd Subfamily PPP1C 16-286 2.5e-101 331.6 In-house 9-279 (282) alignment
Range on Protein: 16-286
Range on HMM: 9-279/282.0
HIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETR
.. |... .|. ...|.|...  . ... ||.|.||||||..|||.|||.||  ....|.||||.||||  |||  .|||.||..||... |.|||||. 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITKVYGFYDEVVRKYGNSnVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAGFLF
.|...||||||. |.|..  .|.   .||..| | |.... |.||||||||... ...||.| |  |||..| .||||||||. .| .|| . ||  | |
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAV
||. |..||.||...|| ||||.| .||. . .  ||||.|||||| . .| .|||..|..|  ...|. ..
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa

PPP_3 17-284 3.7e-116 379.9 In-house 2-270 (271) alignment
Range on Protein: 17-284
Range on HMM: 2-270/271.0
IPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQ
..|... .|. . .|.|..| |......|||.||||||||.|||.||...| ...|.|.||||.|||| .||| .||||..|..||....|.|||||.||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDL-LWSDPEDVDTWSLSPRGAGFLFG
|.|||||..||..|.|...|.....|||..|.|.|.|......|||||||.....|.|....||.|||.||...|| |.||||. .... |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

KREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFE
.. ...|||||...||.|||.|..|||. ..|| .|||.||||||.|..|..|.||....|..| ...|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 17-283 1.3e-78 256.9 In-house 6-272 (280) alignment
Range on Protein: 17-283
Range on HMM: 6-272/280.0
IPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQ
| |  ..|.  . ...|. .  . .||.||..|||.|||  ||| ||.. .    . |.||||.|||| . ||  ||||.||.|||... ..|||||. .
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

ITKVYGFYDEVVRKYGNsNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAGFLFG
| . |||.||| |.| . ...    |..| | | |...  |.|.|||||... ..|... . |  . ..|    ||||.||| .|  |. ..||.  .||
inrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifg

KREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIF
. .| .. || ...|||| ||.| .||. . |  ||||.|||.|.    | ||||..|. |   . ..
anvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevl

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 17-281 3.6e-67 219.8 In-house 3-269 (284) alignment
Range on Protein: 17-281
Range on HMM: 3-269/284.0
IPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQ
|| | |  | ... ... ..  . .|..|. ||||||||. ||| ||.| |   .. |.||||.|||| . ||. |||..||. .|... ..|||||   
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

ITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAM-CDLLWSDPEDVD-TWSLSPRGAGFLF
| |.||||.|. |.| .  |.     ||  . | |.. . |.|.|||.|  .  | ..|.| |  . |   ..  |.||||| ...  |    ||  ..|
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYT
|   . ..|.. ...|. ||||.| .||. . .  |||..||| || .  | |||. .. .|   . 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfv

PP2Ac_SM00156 18-284 7e-106 346.2 In-house 2-268 (271) alignment
Range on Protein: 18-284
Range on HMM: 2-268/271.0
PEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQI
 .| |..|. ...|.|..| |...|..|||..|||||||.||| |.|. | .....|.||||.|||| .|.|  |||...|..||....| |||||....
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TKVYGFYDEVVRKYgNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDP-EDVDTWSLSPRGAGFLFGK
.|.|||..|| ||| .....  . |.|..|.|.|.....|.|.||||||.....|.|| ..| .| |.|| ..||||||| ....... | ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

REVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFE
. |..||.|||..|| |||..|.|||. ..|. |||..||||||....|.|||||....|. ..  ..
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlk

PPP_1 19-271 1.2e-109 358.6 In-house 3-263 (264) alignment
Range on Protein: 19-271
Range on HMM: 3-263/264.0
EETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQIT
||....|. ...|||..| |...|....|.|||||||..|||.||...| ...|.|.||||.|||| .|.| .||||..||.||....|.|||||.||.|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

KVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDL--------LWSDPEDVDTWSLSPRGA
|||||..||..|............|||.|.|.|.|...|..|||||||.....|.||...||.|||.||..|||        |..|.|. .... |.|||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLK
|.||||. ...||.|||..||.|||....|||. .... .||..||.||.....| .|..|
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 19-284 1.3e-80 263.9 In-house 10-281 (284) alignment
Range on Protein: 19-284
Range on HMM: 10-281/284.0
EETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGV------EKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNH
|. ...||. ..||. .|    ....||.|.||||||  |||.|..  |        ....|.||||.|||| .|.|  .||..|||..||...|.||||
ekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnh

ETRQITKVYGFYDEVVRKYGNsNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAG
|.| . . |||| | ...| . ...      |  . | |.... |.|.|||.| |.  ....  ..|  ..|  | ..|| |.||| .|...  ||||||
esrpvnmqygfyleckkryse.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprgag

FLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFE
 .||.. |..||.| ...|. ||||.||.||. . |  |||..||| || .  |.||||..|..|   .|...
kvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 19-67 1.2e-10 34.1 In-house 11-59 (317) alignment
Range on Protein: 19-67
Range on HMM: 11-59/317.0
EETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSG
|. .  ||. ..||. .|    ....||||.|||||| .|||.|..  |
ekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG

subfamily_PPZ_pd Subfamily PPZ 20-285 8.5e-78 254.9 In-house 28-293 (300) alignment
Range on Protein: 20-285
Range on HMM: 28-293/300.0
ETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITK
. ....| ...||.... .. ..  .| | ||.|||  ||| || | |   .. |.||||.||||  |||. |||||||..||. . |.|||||  ..|.
seilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtr

VYGFYDEVVRKyGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDV-DTWSLSPRGAGFLFGKRE
|||||||. |.  | ..|.   . |. | | ||.   |||||||||| . ..|||| . |  .||  | . ||||||| |  . |    ||  . . |  
vygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkva

VDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEA
...||.|  ..|..||| .| .||. . |  ||||.||||||    |  ||. . . |   . ... 
inkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 20-275 4.1e-56 183.3 In-house 9-289 (302) alignment
Range on Protein: 20-275
Range on HMM: 9-289/302.0
ETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKS-----------GGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLI
. .. |. .  ||| .| ..... .|||| |||||| .||. .. .             .  . ...||||.||||  |.|   |....|. || .  |.
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHETRQITKVYGFYDEVVRKYGNSN---VWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRK-QEVPHEGAMCDLLWSDPEDVDTWS
||||||. |   ||| .|.. ..|...   .|.   ||| .. | |.. . |.|||||.|| ......|. |.|  .|| ..    |||..|| ||..  
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqlla

LS----------PRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDD
             ||  ..| .  | .. .. |..|| |||| . ||.| . |  |.|..|||.|     |  ||||.| .
avsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 20-275 6.6e-56 182.7 In-house 10-290 (302) alignment
Range on Protein: 20-275
Range on HMM: 10-290/302.0
ETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKS-----------GGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLI
. .. |. .  ||| .| ..... .|||| |||||| .||. .. .             .  . ...||||.||||  |.|   |....|. || .  |.
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHETRQITKVYGFYDEVVRKYGNSN---VWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRK-QEVPHEGAMCDLLWSDPEDVDTWS
||||||. |   ||| .|.. ..|...   .|.   ||| .. | |.. . |.|||||.|| ......|. |.|  .|| ..    |||..|| ||..  
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqlla

LS----------PRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDD
             ||  ..| .  | .. .. |..|| |||| . ||.| . |  |.|..|||.|     |  ||||.| .
avsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 23-282 3.2e-79 258.8 In-house 16-278 (287) alignment
Range on Protein: 23-282
Range on HMM: 16-278/287.0
FRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYG
. .  . .|.|     . .|..|.||.|||||||.||| .|.. |   |..|.||||.||||  |||  |||...|..|| .. |.||||| ..| |.||
levlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyG

FYDEVVRKYGnSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQE--VPHEGAMCDLLWSDPE-DVDTWSLS-PRGAGFLFGKRE
|..|. ||.. .....   .||..|.| |.... |.|.|||.||.. ..|..... . .     .|| . ||||.||| | .|  |   |.   .|||.|
fkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkke

VDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTI
||..|.| ...|| |||... |||. .||  ||||.||| |. .  |..||..... |.  .. 
vddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvv

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 24-278 2.6e-80 262.7 In-house 15-269 (281) alignment
Range on Protein: 24-278
Range on HMM: 15-269/281.0
RLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGF
 .  . . ....| .....|.|... ||.|.| .||  |||  | | .....||||.||||  ||| ..||...|.||.||| |.|||||. .. |.|||
nvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygf

YDEVVRKYGNsNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAGFLFGKREVDQF
| | | |||  ..|    . |. | . | |.. . |.||||||..|. ||.| . .  . .. | . ||||.||. .|  |  | ||..|.|||  ||. 
yvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvddv

LEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNR
  . .|||| ||||.|..||. .    |.||.|.||||    | |||||.|..|. 
ckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgi

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 24-283 6e-64 209.1 In-house 27-289 (307) alignment
Range on Protein: 24-283
Range on HMM: 27-289/307.0
RLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGF
 .  ..| ..  |  . ..| |. . ||.|||. ||. .|   |   .| |.| ||.||||. |||. |||..||. ||. | |.|||||  .. | |||
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygf

YDEVVRKYG--NSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAGFLFGKREVD
|.|.|        ..|     .|. | . |.|   |.|.|||||| .| .||.|   .    |  | . |.||.||.  |  |  | ||.|| ||   .|
yeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnvid

QFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIF
.   .  |||| ||||....||  .    |.|..||| ||    |  .|||.|. |  .   |
dvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvaf

subfamily_PPPLV_pd Subfamily PPPLV 24-274 9.8e-47 152.6 In-house 4-277 (290) alignment
Range on Protein: 24-274
Range on HMM: 4-277/290.0
RLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTlFEK-----SGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQIT
 ||  . . |..| .. ....|. . ||.||. .||   |||        .  . ..||||.|||| .|.|    ||  |. || .. |.||||| . ..
slcdvavdilaaeerllelksptyvlgdlhgnyrdliy.fekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

KVYGFYDEVVRKYGNS--NVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTV---DEIRTIDRKQEVPHEGA--MCDLLWSDPEDVDTWSL------
. . .. |   |.|.|  .||    .|||.| | |.|.. .||||.|.   . |      |. |  . . . .||    |.|||||..    ||      
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

-------SPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCgNVAAVLKIDD
       . || | .|..  ...||..||.. . |||.   .|..   .| |.||.|. .||    | ||.. .| 
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvdk

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 24-67 1.1e-06 21.0 In-house 18-61 (339) alignment
Range on Protein: 24-67
Range on HMM: 18-61/339.0
RLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSG
 ||  ..||.  |  . ....|. . ||||||. |||....  |
elchrareliwsepiflkleapicvmgdihgqfddllamldmng

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 28-282 7.9e-71 231.4 In-house 27-285 (290) alignment
Range on Protein: 28-282
Range on HMM: 27-285/290.0
NSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEV
. .|.|     . .| .|..| ||||||| .||  |.. |   | ...||||.||||  |||  |||.|||.||. .. |.|||||.|.. ..|||..|.
kieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeel

VRKYgNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRK--QEVPHEGAMCDLLWSDPED--VDTWSLS-PRGAGFLFGKREVDQF
.||  .|..|.   .||. ||| | ... |.|.|||.|... . . .... .   .   .|| . ||||.||.    || .|   |.   .|||. .|..
arkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddl

LEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTI
|.|  ..|| |||..  ||.. .||  ||||.||| |. .  |. |.... . |. ....
lkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivv

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 30-277 1.2e-67 221.3 In-house 19-266 (280) alignment
Range on Protein: 30-277
Range on HMM: 19-266/280.0
QELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVR
. ..|.| |. . ..|. . |||| | .|.  ||.  | | . . .||||.||||   .| ..||.| |.|| ||| |.||||||  . |.|||| |.  
eaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqy

KYGNSNVWRYcCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPED-VDTWSLSPRGAGFLFGKREVDQFLEKNNV
|||    | .   .|. . . ..|.. ..|.||||||..  .| || | |  |    | . ||||||| .  . |  | ||  ..|||  |.|  .  ..
kygvglwwdf.qscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqackslei

ELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLN
.|| ||||.| .||. |    |.||.| |||| .  | |||. .. .|.
dliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlq

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 41-277 3.9e-60 196.7 In-house 4-247 (263) alignment
Range on Protein: 41-277
Range on HMM: 4-247/263.0
QVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNV----
....|. |||| |||  ||| .|.  |   ||.|.||||.|||| .|||  .||.  ||  | .. |.||||| . | | |||. |. ...   .|    
elqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesv

WRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHE-GAMCDLLWSDPEDvDTWSLSP---RGAGFLFGKREVDQFLEKNNVELIA
. .  .|| |. | ||... |.|.|||.|| . ..|.||.|    |  .     |||||.|||  |.  . |   |    .|||.|||.. .. ...|| 
ynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidliv

RAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLN
||||.|  ||  . |  |.||.||  |     | |||. ..  |.
rahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmle

subfamily_YNL217W_pd Subfamily YNL217W 41-126 4.8e-07 22.5 In-house 7-83 (235) alignment
Range on Protein: 41-126
Range on HMM: 7-83/235.0
QVDTPVTICGDIHGQLHDLLTLFE-KSGGVE-KTRYIFLGDFVDRGFYSLESFLLLlcyklrYPDRITLIRGNHETRQITKVygfydE
.    . . ||.||   .|..|.. | || .     ...||....|  |.|.  ..        |    ..||||   . ..     .
vlgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....k

Metallophos Calcineurin-like phosphoesterase 45-237 4.1e-44 144.2 Pfam-A 2-198 (200) alignment
Range on Protein: 45-237
Range on HMM: 2-198/200.0
PVTICGDIHGQLHDL----LTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLL--LCYKLRYPDRITLIRGNHETRQITKVYGFYDEVV----------
.....||.||.|.||    | |... .  . . ..||||.|||| .|.| . ||  |..||..|... |.||||| ......|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIrtidrkqevphegamcdllwsdpedvdtwsl
                       ..... .......|.|..|.| |.... |...||.||..  ..| |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGFLFGKREVDQFLEKNNVELIARAHQL
    ...|||..... .|||..| |. |.|. 
....gselfgpdalekllekygvdlvlrGHtH

PPP_2 46-237 1.1e-79 259.8 In-house 1-197 (198) alignment
Range on Protein: 46-237
Range on HMM: 1-197/198.0
VTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFD
||.|||.||||.|||.||.... .....|.||||.|||| .||| .||||..||.||....|.|||||.....|||||..||..|.|...|.....|||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDL-----LWSDPEDVDTWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQL
.|.|.|.|......||||||......|.|....||.|.|.||...||     |....|. .... | ||||.|||.. ....||||...|| |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev

PPP_4 46-237 2.1e-75 246.1 In-house 1-196 (197) alignment
Range on Protein: 46-237
Range on HMM: 1-196/197.0
VTICGDIHGQLHDL-LTLFEKSGGVE-KTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKyGNSNVWRYCCEV
||..|||||||.|| | |....|  . ...|.||||.|||| .||| .||||..||.||....|.|||||.......|||..||..|  ..........|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVP-HEGAMCDL-LWSDPE-DVDTWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQL
||.|.| |.|......||||||......|.|..|.||.|.| .|....|| |||||. . .... | ||||.|||.. ...||||||..|| |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel

PPP_5_Dcr2 46-237 5.8e-74 241.4 In-house 1-198 (199) alignment
Range on Protein: 46-237
Range on HMM: 1-198/199.0
VTICGDIHGQLHDLLTLFEKSGGVEK--TRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEV
||.|||.||||.|||  ..| || ..  ..|.||||.|||| .||| .||||..||.||....|.|||||..|....|||..||..||...........|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVP-HEGAMCDL-LWSDPE-DVDT-WSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQL
||.|.| |.|......|||||||.. ...... |.||.|.| ..| ..|| |||||. .... .  | ||||.|||.. ...||||||..|| |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel

Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 48-225 7e-07 21.4 Pfam-A 5-107 (156) alignment
Range on Protein: 48-225
Range on HMM: 5-107/156.0
ICGDIHGQLHDLLTLFEKSGGveKTRYIFLGDFVDRgfyslesflLLLCYKLRYPdRITLIRGNHETRQITKVYGFYDevvrkygnsnvwryccevF---
| .|.||.|..| .. |.  .     ....||.|..           .. .|.   ..  .||||.  .. | . .                    .   
iiSDlHgnldaleavledike..vdlilhaGDlvep.........eevvelledi.pvlavrGnhDeaelpkelavel..................llaa

-----DylslgaiiNNSIFCVHGGLSPdmttvdeirtidrkqevphegamcdllwsdpedvdtwslsprgagFLFGKREVDQFLEK
     .        ..... |||   .                                             . ....|... |..
aaleie........gdrvllvhgtpls.............................................vqsseeelaellke

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 70-284 7.1e-72 235.2 In-house 99-313 (317) alignment
Range on Protein: 70-284
Range on HMM: 99-313/317.0
EKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYGNsNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMT
 . .|.||||.|||| .|.|  .||...||.|||...|.|||||.| . . |||| || ..| . ...     .|  | | |..|. |.|.|||.| ...
gykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseell

TVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAA
 .... ...|  ..|  | ..|| |.||. .|...  |.||||..||.. |..||.| ...|. ||||.|..||. . |  |||..|||.|| .  |.||
dlkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaa

VLKIDDDLNREYTIFE
||..|..|.  .....
vlsvdkklkisinvlr

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 71-284 2.9e-58 190.6 In-house 119-332 (339) alignment
Range on Protein: 71-284
Range on HMM: 119-332/339.0
KTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYgNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTT
  ||.||||.|||| .|.|  .|| . || ||||| |.|||||.| .   |||| ||  .| .....    ..|. . . |.|||.|.|.|||.|  .|.
ykrylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehlts

VDEIRTIDRKQEVPHEGAMCDLLWSDPEDVD-TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYkEMFDG-GLVTVWSAPNYCYRCGNVAA
....  . |  |.|  | . || |.||.  .  .  | ||| |.||   .  ||.| ..... | ||.| .|| |.|||  |||..|||||| .  | ||
fnqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgy.effdgrrlvtifsapnycgqndntaa

VLKIDDDLNREYTIFE
|. ||  |.    .| 
vfsidkklkisinvfr

subfamily_PPP7C_pd Subfamily PPP7C 189-287 1.6e-16 53.1 In-house 237-336 (383) alignment
Range on Protein: 189-287
Range on HMM: 237-336/383.0
MCDLLWSDPEDVD-TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAVQ
. |.|||||.  .  .. . ||.|  ||    ...|.| |..|. |.|.  .|||. . |  ..|..|| ||     |  | .|. .||. ..  . | .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqask