Gene PPH3 in Saccharomyces cerevisiae

Synonym: PPH2, YDL188C, PPH22

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP020_AA protein Get Run
ScerP020_AA_0-288 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 1-288 8.9e-116 380.2 In-house 27-326 (473) alignment 
Range on Protein: 1-288
Range on HMM: 27-326/473.0
MMDLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLR
..|||..|  |. .. .|||....|.   .|.|..| |. ... .....|||||||.||| |.|| |  ...|..||||.|||| .||| ..|||..|..
lldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkik

YPDRITLIRGNHETRQITKVYGFYDEVVRKYgNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDV
||....|.|||||.|... .|||.||. .|| . .......|....| | |.|.. |..||||||||....|.||.|.| .|.|..|...|||||||...
ypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwed

DT--------WSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGG------LVTVWSAPNYCYRCGNVAAVLKIDDDLnREYTIFEAV
|         .  ||||||.|||.. |..||.||.. || |.|. |.|||. .|||.      ..||.||||||.|.|| ||||.||.|| .....|...
dgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdps

QA
. 
ph
subfamily_PPP4C_pd Subfamily PPP4C 2-288 7.1e-164 537.0 In-house 1-287 (288) alignment 
Range on Protein: 2-288
Range on HMM: 1-287/288.0
MDLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRY
.|||. |..||. ..| ||.| .|| ...|.|..|.||..||.|||.|||||||..|||.||. .| |..|.|.||||||||||||.|.|||||..|.||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDVD
||||||||||||.||||.|||||||..||||..||||||.||||||||.|||...||||||||||...|.||||.|||||||||||..||||||||||..
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAVQA
.|..||||||.|||...|.|| |.|..|||.||||||||||| .|.  ..|||||||||||||||||.|..|..|.....||||..|
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaa
subfamily_PPP2C_pd Subfamily PPP2C 2-286 3e-131 429.9 In-house 2-286 (290) alignment 
Range on Protein: 2-286
Range on HMM: 2-286/290.0
MDLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRY
.||||.|. |...|.. |..| .|| . .|.|..| || .| .|||.|||.|||.|||| ||   | . .| |.||||.||||.||.|.  || . |.||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDVD
..|||..|||||.||||.|||||||..|||||.|||.|  ..||||.| |.... |||.|||||| ..|.|.||..|| |||||||..||||||||.| .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAV
 |..||||||. |||   ..| ..|...|||||||||||||. ..|  .||..||||||||||| ||.|..||.|....  |.. 
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
0053225 Metallo-dependent phosphatases 2-286 4.9e-104 340.7 In-house 7-291 (293) alignment 
Range on Protein: 2-286
Range on HMM: 7-291/293.0
MDLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRY
..||..|  |.  |...||....|.|  .|.|..|.|. ... .....|||||.|.||| |.|| | .. .|..||||.|||| .||| ..|||..||.|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDVD
||...|.|||||..... .|||.||..||||....|.........| | |.|...|..||||||||....|.|| |.| ...|.||...||||||| ...
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAV
.|  |.||.|..||   |..||.||...|| |.||.|..||. .|||.||||.|||||..|.||..|||..|..|......|..|
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_PPP7C_pd Subfamily PPP7C 2-181 2.3e-41 134.8 In-house 18-203 (383) alignment 
Range on Protein: 2-181
Range on HMM: 18-203/383.0
MDLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTP----VTICGDIHGQLHDLLTLFEKSGG-VEKTRYIFLGDFVDRGFYSLESFLLLLC
....|.| ...  |..  . |  .  .... | .  |...| |     ||.|||.||.| ||| .. | |   |.  |.| |||||||  |.|  |.||.
deveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillilla

YKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKY--GNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSpDMTTVDEIRTIDRKQ
. | ||  . | |||||   .   |||  ||  ||   .... |   .|| .| |...|...|. ||||.| |.| .. .  |.|..
lllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPP6C_pd Subfamily PPP6C 3-290 2.5e-141 462.9 In-house 1-288 (290) alignment 
Range on Protein: 3-290
Range on HMM: 1-288/290.0
DLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYP
.||| |   .. |..||. . .||   ..||..|.||  | .|||.|||||||..||. || ..| | .|.|.|||||||||.||||.| .||. |..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDVDT
|||||.|||||.||||.||||||| ..||||.|.|.||..||| |...|||.....|||||||||..|.|.||.|.| ||.||.||.|||.|||||||.|
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAVQAQN
|..||||||.|||.. ...|.. ||..||.||||||.||.| |||  ||||||||||||||||||..|...|. .||  .|.||. ..
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdee
0049330 Metallo-dependent phosphatases 3-288 9.3e-107 349.6 In-house 16-301 (309) alignment 
Range on Protein: 3-288
Range on HMM: 16-301/309.0
DLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYP
.||..|  |. .| ..||....|.|  .|.|..|.|. ... .....|||||||.||| |.|| | .  .|..||||.|||| .||| .||||..||.||
lldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllyp

DRITLIRGNHETRQITKVYGFYDEVVRKYGnSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVD
|...|.|||||.|... .|||.||..|||| ...|.........| | |.|...|.|||||||||....|.|| ..| .|.|..| .||||||||  ...
dnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpire

TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAVQA
..  .|||.|..||   |..||.||...|| |.|..|..||. .|||.|.||.||||||.|.||..|||.||.||......||.|. 
gfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
subfamily_PPG1_pd Subfamily PPG1 4-286 6.6e-117 383.1 In-house 1-296 (300) alignment 
Range on Protein: 4-286
Range on HMM: 1-296/300.0
LDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPD
||. .  |.  . .|| ||  |. . .|||..| || .. .|||. ||.|||..|.| .|.  | |  | |.||||.||||.||.|.  ||.. ||||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITLIRGNHETRQITKVYGFYDEVVRKY-GNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE----
||||.|||||.||||.||||| |..||| |||.||.|  |.||||.| |||...|.||||||||.. ..|.|. .|| .|||.|||..||||||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DVDT--WSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAV
      | .   .  |.||||. .||  | .||..|... | |||||..|||. .||. | |||||||||||||| |..|.. . ..| . ..|. 
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeea
subfamily_PPP5C_pd Subfamily PPP5C 5-288 5.6e-86 281.5 In-house 22-311 (322) alignment 
Range on Protein: 5-288
Range on HMM: 22-311/322.0
DKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTP----VTICGDIHGQLHDLLTLFEKSGGV-EKTRYIFLGDFVDRGFYSLESFLLLLCYKL
....  ... |....  .... |...||| ..  .......    .|.||||||| .||| .||. | . |.  |.| ||||||| .|.|  |.||..||
kellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkl

RYPDRITLIRGNHETRQITKVYGFYDEVVRKYgNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGL-SPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE
 ||... | |||||. .. |.||| .||  || ...|     |||..| |. .||.... ||||| | |  |.|..|.||| .. |.||....||||||.
lyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq

DVDTWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKI-DDDLNREYTIFEAVQA
.    | | || |. ||    ..||..||.||| |.|.. .|||. . || |.||.|||||| . || .|.... .|||. ... ||||. 
eanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeaveh
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 12-284 8e-90 293.9 In-house 19-292 (298) alignment 
Range on Protein: 12-284
Range on HMM: 19-292/298.0
RDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGN
.  | | || |..|.  ..... .   . .||.|...|||||||  ||| ||.|.|  ... |.||||.|||| ..||  .|||.||..||... |.|||
kltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGn

HETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPED-VDTWSLSPRGA
||. .| .|||||.|. |.| . ...    .||. | | |.| . |.|.|||||. ....|..|.. | .. ..|    ||||.|||. |  |. . ||.
heceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGv

GFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFE
.. ||. .| ..||| ...|..||||.| .||. . .  |||..|||.|| .  | |||.|.|..|   .... 
svvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlk
subfamily_PPP3C_pd Subfamily PPP3C 15-275 2e-81 267.1 In-house 39-312 (452) alignment 
Range on Protein: 15-275
Range on HMM: 39-312/452.0
KHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHET
 .. ||.. ..  .. .|| .| .. .|..|.|..|||||| .||| ||| .|  ..|.|.||||.|||| .|.|  | |.. |. ||... |.|||||.
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhec

RQITKVYGFYDEVVRKYGNsNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWS-------LS
| .|. . | .|.  ||.. .|.  |.| || | | |..|.  .||||||||.....|.|...|| .|.|. |..||||||||  | .  .        |
rhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpns

PRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFD------GGLVTVWSAPNYCYRCGNVAAVLKIDDD
.||  .... . | .||.||..  | |||.   .||.   .        |.|..|||||.    | |||||....
vrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 15-284 4.9e-78 255.4 In-house 22-292 (299) alignment 
Range on Protein: 15-284
Range on HMM: 22-292/299.0
KHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHET
| . |. . .||  ... ....  . .|..|. .|||||||  ||| .|.|.|   .. ..||||.||||   ||   ||||.|..||.|. ..||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPED-VDTWSLSPRGAGFL
  | .|||||.|. ..|  . .|    . |... |  .|.. |.|.|||||| ..|.| .| . | |. |      ||||.||.. |  |    ||  ..
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFE
||.  | . ... ...|.|||||.| .||. . .  |||..||| || .  | ||..|.|..|   .....
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 15-283 4.1e-67 219.5 In-house 21-292 (297) alignment 
Range on Protein: 15-283
Range on HMM: 21-292/297.0
KHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHET
| | || |..|   . ... .. .. .|..|. .|||||||. ||| || . |    . |.||||.|||| .|.|. .|||.||...|  . |.||||| 
kviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhec

RQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMT---TVDEIRTIDRKQEVpHEGAMCDLLWSDPE-DVDTWSLSPRGA
  . ||||||.|. ..|    ..    .||..| |  .| . |.|.|||||| .|   |.| .| |.| .|  .|. ..||||.||   .  .    |||
efvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrga

GFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIF
|  ||.  | .   . ...|..||||.| .||. .    |||..||| || .  |.||..  |. |.  . |.
gcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeil
subfamily_PPP1C_pd Subfamily PPP1C 16-286 2.5e-101 331.6 In-house 9-279 (282) alignment 
Range on Protein: 16-286
Range on HMM: 9-279/282.0
HIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETR
.. |... .|. ...|.|...  . ... ||.|.||||||..|||.|||.||  ....|.||||.||||  |||  .|||.||..||... |.|||||. 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITKVYGFYDEVVRKYGNSnVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAGFLF
.|...||||||. |.|..  .|.   .||..| | |.... |.||||||||... ...||.| |  |||..| .||||||||. .| .|| . ||  | |
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAV
||. |..||.||...|| ||||.| .||. . .  ||||.|||||| . .| .|||..|..|  ...|. ..
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa
PPP_3 17-284 3.7e-116 379.9 In-house 2-270 (271) alignment 
Range on Protein: 17-284
Range on HMM: 2-270/271.0
IPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQ
..|... .|. . .|.|..| |......|||.||||||||.|||.||...| ...|.|.||||.|||| .||| .||||..|..||....|.|||||.||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDL-LWSDPEDVDTWSLSPRGAGFLFG
|.|||||..||..|.|...|.....|||..|.|.|.|......|||||||.....|.|....||.|||.||...|| |.||||. .... |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

KREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFE
.. ...|||||...||.|||.|..|||. ..|| .|||.||||||.|..|..|.||....|..| ...|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 17-283 1.3e-78 256.9 In-house 6-272 (280) alignment 
Range on Protein: 17-283
Range on HMM: 6-272/280.0
IPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQ
| |  ..|.  . ...|. .  . .||.||..|||.|||  ||| ||.. .    . |.||||.|||| . ||  ||||.||.|||... ..|||||. .
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

ITKVYGFYDEVVRKYGNsNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAGFLFG
| . |||.||| |.| . ...    |..| | | |...  |.|.|||||... ..|... . |  . ..|    ||||.||| .|  |. ..||.  .||
inrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifg

KREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIF
. .| .. || ...|||| ||.| .||. . |  ||||.|||.|.    | ||||..|. |   . ..
anvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevl
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 17-281 3.6e-67 219.8 In-house 3-269 (284) alignment 
Range on Protein: 17-281
Range on HMM: 3-269/284.0
IPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQ
|| | |  | ... ... ..  . .|..|. ||||||||. ||| ||.| |   .. |.||||.|||| . ||. |||..||. .|... ..|||||   
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

ITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAM-CDLLWSDPEDVD-TWSLSPRGAGFLF
| |.||||.|. |.| .  |.     ||  . | |.. . |.|.|||.|  .  | ..|.| |  . |   ..  |.||||| ...  |    ||  ..|
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYT
|   . ..|.. ...|. ||||.| .||. . .  |||..||| || .  | |||. .. .|   . 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfv
PP2Ac_SM00156 18-284 7e-106 346.2 In-house 2-268 (271) alignment 
Range on Protein: 18-284
Range on HMM: 2-268/271.0
PEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQI
 .| |..|. ...|.|..| |...|..|||..|||||||.||| |.|. | .....|.||||.|||| .|.|  |||...|..||....| |||||....
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TKVYGFYDEVVRKYgNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDP-EDVDTWSLSPRGAGFLFGK
.|.|||..|| ||| .....  . |.|..|.|.|.....|.|.||||||.....|.|| ..| .| |.|| ..||||||| ....... | ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

REVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFE
. |..||.|||..|| |||..|.|||. ..|. |||..||||||....|.|||||....|. ..  ..
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlk
PPP_1 19-271 1.2e-109 358.6 In-house 3-263 (264) alignment 
Range on Protein: 19-271
Range on HMM: 3-263/264.0
EETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQIT
||....|. ...|||..| |...|....|.|||||||..|||.||...| ...|.|.||||.|||| .|.| .||||..||.||....|.|||||.||.|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

KVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDL--------LWSDPEDVDTWSLSPRGA
|||||..||..|............|||.|.|.|.|...|..|||||||.....|.||...||.|||.||..|||        |..|.|. .... |.|||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLK
|.||||. ...||.|||..||.|||....|||. .... .||..||.||.....| .|..|
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 19-284 1.3e-80 263.9 In-house 10-281 (284) alignment 
Range on Protein: 19-284
Range on HMM: 10-281/284.0
EETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGV------EKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNH
|. ...||. ..||. .|    ....||.|.||||||  |||.|..  |        ....|.||||.|||| .|.|  .||..|||..||...|.||||
ekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnh

ETRQITKVYGFYDEVVRKYGNsNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAG
|.| . . |||| | ...| . ...      |  . | |.... |.|.|||.| |.  ....  ..|  ..|  | ..|| |.||| .|...  ||||||
esrpvnmqygfyleckkryse.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprgag

FLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFE
 .||.. |..||.| ...|. ||||.||.||. . |  |||..||| || .  |.||||..|..|   .|...
kvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 19-67 1.2e-10 34.1 In-house 11-59 (317) alignment 
Range on Protein: 19-67
Range on HMM: 11-59/317.0
EETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSG
|. .  ||. ..||. .|    ....||||.|||||| .|||.|..  |
ekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_PPZ_pd Subfamily PPZ 20-285 8.5e-78 254.9 In-house 28-293 (300) alignment 
Range on Protein: 20-285
Range on HMM: 28-293/300.0
ETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITK
. ....| ...||.... .. ..  .| | ||.|||  ||| || | |   .. |.||||.||||  |||. |||||||..||. . |.|||||  ..|.
seilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtr

VYGFYDEVVRKyGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDV-DTWSLSPRGAGFLFGKRE
|||||||. |.  | ..|.   . |. | | ||.   |||||||||| . ..|||| . |  .||  | . ||||||| |  . |    ||  . . |  
vygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkva

VDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEA
...||.|  ..|..||| .| .||. . |  ||||.||||||    |  ||. . . |   . ... 
inkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 20-275 4.1e-56 183.3 In-house 9-289 (302) alignment 
Range on Protein: 20-275
Range on HMM: 9-289/302.0
ETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKS-----------GGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLI
. .. |. .  ||| .| ..... .|||| |||||| .||. .. .             .  . ...||||.||||  |.|   |....|. || .  |.
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHETRQITKVYGFYDEVVRKYGNSN---VWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRK-QEVPHEGAMCDLLWSDPEDVDTWS
||||||. |   ||| .|.. ..|...   .|.   ||| .. | |.. . |.|||||.|| ......|. |.|  .|| ..    |||..|| ||..  
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqlla

LS----------PRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDD
             ||  ..| .  | .. .. |..|| |||| . ||.| . |  |.|..|||.|     |  ||||.| .
avsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 20-275 6.6e-56 182.7 In-house 10-290 (302) alignment 
Range on Protein: 20-275
Range on HMM: 10-290/302.0
ETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKS-----------GGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLI
. .. |. .  ||| .| ..... .|||| |||||| .||. .. .             .  . ...||||.||||  |.|   |....|. || .  |.
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHETRQITKVYGFYDEVVRKYGNSN---VWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRK-QEVPHEGAMCDLLWSDPEDVDTWS
||||||. |   ||| .|.. ..|...   .|.   ||| .. | |.. . |.|||||.|| ......|. |.|  .|| ..    |||..|| ||..  
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqlla

LS----------PRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDD
             ||  ..| .  | .. .. |..|| |||| . ||.| . |  |.|..|||.|     |  ||||.| .
avsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 23-282 3.2e-79 258.8 In-house 16-278 (287) alignment 
Range on Protein: 23-282
Range on HMM: 16-278/287.0
FRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYG
. .  . .|.|     . .|..|.||.|||||||.||| .|.. |   |..|.||||.||||  |||  |||...|..|| .. |.||||| ..| |.||
levlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyG

FYDEVVRKYGnSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQE--VPHEGAMCDLLWSDPE-DVDTWSLS-PRGAGFLFGKRE
|..|. ||.. .....   .||..|.| |.... |.|.|||.||.. ..|..... . .     .|| . ||||.||| | .|  |   |.   .|||.|
fkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkke

VDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTI
||..|.| ...|| |||... |||. .||  ||||.||| |. .  |..||..... |.  .. 
vddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvv
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 24-278 2.6e-80 262.7 In-house 15-269 (281) alignment 
Range on Protein: 24-278
Range on HMM: 15-269/281.0
RLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGF
 .  . . ....| .....|.|... ||.|.| .||  |||  | | .....||||.||||  ||| ..||...|.||.||| |.|||||. .. |.|||
nvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygf

YDEVVRKYGNsNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAGFLFGKREVDQF
| | | |||  ..|    . |. | . | |.. . |.||||||..|. ||.| . .  . .. | . ||||.||. .|  |  | ||..|.|||  ||. 
yvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvddv

LEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNR
  . .|||| ||||.|..||. .    |.||.|.||||    | |||||.|..|. 
ckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgi
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 24-283 6e-64 209.1 In-house 27-289 (307) alignment 
Range on Protein: 24-283
Range on HMM: 27-289/307.0
RLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGF
 .  ..| ..  |  . ..| |. . ||.|||. ||. .|   |   .| |.| ||.||||. |||. |||..||. ||. | |.|||||  .. | |||
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygf

YDEVVRKYG--NSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAGFLFGKREVD
|.|.|        ..|     .|. | . |.|   |.|.|||||| .| .||.|   .    |  | . |.||.||.  |  |  | ||.|| ||   .|
yeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnvid

QFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIF
.   .  |||| ||||....||  .    |.|..||| ||    |  .|||.|. |  .   |
dvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvaf
subfamily_PPPLV_pd Subfamily PPPLV 24-274 9.8e-47 152.6 In-house 4-277 (290) alignment 
Range on Protein: 24-274
Range on HMM: 4-277/290.0
RLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTlFEK-----SGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQIT
 ||  . . |..| .. ....|. . ||.||. .||   |||        .  . ..||||.|||| .|.|    ||  |. || .. |.||||| . ..
slcdvavdilaaeerllelksptyvlgdlhgnyrdliy.fekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

KVYGFYDEVVRKYGNS--NVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTV---DEIRTIDRKQEVPHEGA--MCDLLWSDPEDVDTWSL------
. . .. |   |.|.|  .||    .|||.| | |.|.. .||||.|.   . |      |. |  . . . .||    |.|||||..    ||      
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

-------SPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCgNVAAVLKIDD
       . || | .|..  ...||..||.. . |||.   .|..   .| |.||.|. .||    | ||.. .| 
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvdk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 24-67 1.1e-06 21.0 In-house 18-61 (339) alignment 
Range on Protein: 24-67
Range on HMM: 18-61/339.0
RLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSG
 ||  ..||.  |  . ....|. . ||||||. |||....  |
elchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 28-282 7.9e-71 231.4 In-house 27-285 (290) alignment 
Range on Protein: 28-282
Range on HMM: 27-285/290.0
NSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEV
. .|.|     . .| .|..| ||||||| .||  |.. |   | ...||||.||||  |||  |||.|||.||. .. |.|||||.|.. ..|||..|.
kieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeel

VRKYgNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRK--QEVPHEGAMCDLLWSDPED--VDTWSLS-PRGAGFLFGKREVDQF
.||  .|..|.   .||. ||| | ... |.|.|||.|... . . .... .   .   .|| . ||||.||.    || .|   |.   .|||. .|..
arkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddl

LEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTI
|.|  ..|| |||..  ||.. .||  ||||.||| |. .  |. |.... . |. ....
lkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivv
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 30-277 1.2e-67 221.3 In-house 19-266 (280) alignment 
Range on Protein: 30-277
Range on HMM: 19-266/280.0
QELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVR
. ..|.| |. . ..|. . |||| | .|.  ||.  | | . . .||||.||||   .| ..||.| |.|| ||| |.||||||  . |.|||| |.  
eaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqy

KYGNSNVWRYcCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPED-VDTWSLSPRGAGFLFGKREVDQFLEKNNV
|||    | .   .|. . . ..|.. ..|.||||||..  .| || | |  |    | . ||||||| .  . |  | ||  ..|||  |.|  .  ..
kygvglwwdf.qscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqackslei

ELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLN
.|| ||||.| .||. |    |.||.| |||| .  | |||. .. .|.
dliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlq
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 41-277 3.9e-60 196.7 In-house 4-247 (263) alignment 
Range on Protein: 41-277
Range on HMM: 4-247/263.0
QVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNV----
....|. |||| |||  ||| .|.  |   ||.|.||||.|||| .|||  .||.  ||  | .. |.||||| . | | |||. |. ...   .|    
elqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesv

WRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHE-GAMCDLLWSDPEDvDTWSLSP---RGAGFLFGKREVDQFLEKNNVELIA
. .  .|| |. | ||... |.|.|||.|| . ..|.||.|    |  .     |||||.|||  |.  . |   |    .|||.|||.. .. ...|| 
ynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidliv

RAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLN
||||.|  ||  . |  |.||.||  |     | |||. ..  |.
rahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmle
subfamily_YNL217W_pd Subfamily YNL217W 41-126 4.8e-07 22.5 In-house 7-83 (235) alignment 
Range on Protein: 41-126
Range on HMM: 7-83/235.0
QVDTPVTICGDIHGQLHDLLTLFE-KSGGVE-KTRYIFLGDFVDRGFYSLESFLLLlcyklrYPDRITLIRGNHETRQITKVygfydE
.    . . ||.||   .|..|.. | || .     ...||....|  |.|.  ..        |    ..||||   . ..     .
vlgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....k
Metallophos Calcineurin-like phosphoesterase 45-237 4.1e-44 144.2 Pfam-A 2-198 (200) alignment 
Range on Protein: 45-237
Range on HMM: 2-198/200.0
PVTICGDIHGQLHDL----LTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLL--LCYKLRYPDRITLIRGNHETRQITKVYGFYDEVV----------
.....||.||.|.||    | |... .  . . ..||||.|||| .|.| . ||  |..||..|... |.||||| ......|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIrtidrkqevphegamcdllwsdpedvdtwsl
                       ..... .......|.|..|.| |.... |...||.||..  ..| |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGFLFGKREVDQFLEKNNVELIARAHQL
    ...|||..... .|||..| |. |.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 46-237 1.1e-79 259.8 In-house 1-197 (198) alignment 
Range on Protein: 46-237
Range on HMM: 1-197/198.0
VTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFD
||.|||.||||.|||.||.... .....|.||||.|||| .||| .||||..||.||....|.|||||.....|||||..||..|.|...|.....|||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDL-----LWSDPEDVDTWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQL
.|.|.|.|......||||||......|.|....||.|.|.||...||     |....|. .... | ||||.|||.. ....||||...|| |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 46-237 2.1e-75 246.1 In-house 1-196 (197) alignment 
Range on Protein: 46-237
Range on HMM: 1-196/197.0
VTICGDIHGQLHDL-LTLFEKSGGVE-KTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKyGNSNVWRYCCEV
||..|||||||.|| | |....|  . ...|.||||.|||| .||| .||||..||.||....|.|||||.......|||..||..|  ..........|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVP-HEGAMCDL-LWSDPE-DVDTWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQL
||.|.| |.|......||||||......|.|..|.||.|.| .|....|| |||||. . .... | ||||.|||.. ...||||||..|| |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 46-237 5.8e-74 241.4 In-house 1-198 (199) alignment 
Range on Protein: 46-237
Range on HMM: 1-198/199.0
VTICGDIHGQLHDLLTLFEKSGGVEK--TRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEV
||.|||.||||.|||  ..| || ..  ..|.||||.|||| .||| .||||..||.||....|.|||||..|....|||..||..||...........|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVP-HEGAMCDL-LWSDPE-DVDT-WSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQL
||.|.| |.|......|||||||.. ...... |.||.|.| ..| ..|| |||||. .... .  | ||||.|||.. ...||||||..|| |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 48-225 7e-07 21.4 Pfam-A 5-107 (156) alignment 
Range on Protein: 48-225
Range on HMM: 5-107/156.0
ICGDIHGQLHDLLTLFEKSGGveKTRYIFLGDFVDRgfyslesflLLLCYKLRYPdRITLIRGNHETRQITKVYGFYDevvrkygnsnvwryccevF---
| .|.||.|..| .. |.  .     ....||.|..           .. .|.   ..  .||||.  .. | . .                    .   
iiSDlHgnldaleavledike..vdlilhaGDlvep.........eevvelledi.pvlavrGnhDeaelpkelavel..................llaa

-----DylslgaiiNNSIFCVHGGLSPdmttvdeirtidrkqevphegamcdllwsdpedvdtwslsprgagFLFGKREVDQFLEK
     .        ..... |||   .                                             . ....|... |..
aaleie........gdrvllvhgtpls.............................................vqsseeelaellke
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 70-284 7.1e-72 235.2 In-house 99-313 (317) alignment 
Range on Protein: 70-284
Range on HMM: 99-313/317.0
EKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYGNsNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMT
 . .|.||||.|||| .|.|  .||...||.|||...|.|||||.| . . |||| || ..| . ...     .|  | | |..|. |.|.|||.| ...
gykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseell

TVDEIRTIDRKQEVPHEGAMCDLLWSDPE-DVDTWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAA
 .... ...|  ..|  | ..|| |.||. .|...  |.||||..||.. |..||.| ...|. ||||.|..||. . |  |||..|||.|| .  |.||
dlkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaa

VLKIDDDLNREYTIFE
||..|..|.  .....
vlsvdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 71-284 2.9e-58 190.6 In-house 119-332 (339) alignment 
Range on Protein: 71-284
Range on HMM: 119-332/339.0
KTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYgNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTT
  ||.||||.|||| .|.|  .|| . || ||||| |.|||||.| .   |||| ||  .| .....    ..|. . . |.|||.|.|.|||.|  .|.
ykrylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehlts

VDEIRTIDRKQEVPHEGAMCDLLWSDPEDVD-TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYkEMFDG-GLVTVWSAPNYCYRCGNVAA
....  . |  |.|  | . || |.||.  .  .  | ||| |.||   .  ||.| ..... | ||.| .|| |.|||  |||..|||||| .  | ||
fnqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgy.effdgrrlvtifsapnycgqndntaa

VLKIDDDLNREYTIFE
|. ||  |.    .| 
vfsidkklkisinvfr
subfamily_PPP7C_pd Subfamily PPP7C 189-287 1.6e-16 53.1 In-house 237-336 (383) alignment 
Range on Protein: 189-287
Range on HMM: 237-336/383.0
MCDLLWSDPEDVD-TWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAVQ
. |.|||||.  .  .. . ||.|  ||    ...|.| |..|. |.|.  .|||. . |  ..|..|| ||     |  | .|. .||. ..  . | .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqask