Gene NEM1 in Saccharomyces cerevisiae

Synonym: YHR004C, NEM1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family FCP
Subfamily DULLARD
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP030_AA protein Get Run
ScerP030_AA_249-411 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
CPDc_SM00577 250-411 4.2e-45 145.3 In-house 1-145 (146) alignment 
Range on Protein: 250-411
Range on HMM: 1-145/146.0
KKKKLVIDLDETLIHS---ASRSTTHSNSSQGHLVEvkfglsgirTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSFpSSFSKRYY
||| ||.||||||.||   |........|.. .|.|         ||....||||.|.||.|..|...|.|||...|.|||...|.|...    .....|
kkkvLVlDLdetLvhsanmaepksfsevsptdslae.........tlvlvlkRPyvdeFLkkaaklfelvifTsaskkyadtildllDpkr.llkyrvly

RSDCVLRDGVgYIKD-LSIVKDseengkgsssSLDDVIIIDNSPVSYAMNVDNAIQVEGWISDPTD
|.||.| .|  ..|| ||..|           .|..|.|||||. |...| .||.... .||...|
Rqdcrlvkgk.llkddlsllkv..........dlskvviiDnseestlvnpenalkikpyisalsd
subfamily_DULLARD_pd Subfamily DULLARD 251-412 2.7e-65 210.8 In-house 1-152 (153) alignment 
Range on Protein: 251-412
Range on HMM: 1-152/153.0
KKKLVIDLDETLIHSASRSTTHSNSSQGHLVE--VKFGLSGIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSfPSSFSKRYYRS
.|.||.||||||||||..|.|.|....|. ..  ||. ......|....|||..||||..|||||||.||||||.|||..|.|.|.|. ......||||.
rktlvlDlDetlihsahdsvtkstvkpgtapdfvvkvlidkepvlfyvykrPhvDlfLdvvskWydlviftasmeeyaaavvdkLdsg.rgilkrryyrq

DCVLRDGvGYIKDLSIVkdseengkgsSSSLDDVIIIDNSPVSYAMNVDNAIQVEGWISDPTDT
.|||..|  |.||||.|          ||.|..|||.|||||.|..|.||||....|.|||.||
hCvlesg.kytkdlslv..........ssdlssviilDnspvayrknpdnaipikswlsdpsdt
NIF NLI interacting factor-like phosphatase 252-431 4.1e-55 178.0 Pfam-A 1-159 (159) alignment 
Range on Protein: 252-431
Range on HMM: 1-159/159.0
KKLVIDLDETLIHSASRSTThsnSSQGHLVevkfglSgIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSfPSSFSKRYYRSDCV
| ||.||||||.|| .....   ...|. |      . ..| ....|||..| ||...||.|...|||||.||||.||.|.|. .    |.||.||..|.
ktLVLDLDetLvhskekkdl...kedgkkv......e.ektkasvkkRPgldeFLkelskayevviftasskeyaepvldkldpk.kklfkkrlyresct

LRDGvGYIKDLSIVkdseengkgsSSSLDDVIIIDNSPVSYAMNVDNAIQVEGWISD-PTDTDLLNLLPFLEAMRYSTDVR
||.|  |.||||..          ...|..|.|.|.|| |.... ||.|..| ...| ..||.||.|||||||...|.|||
lrng.kyvKdLsll..........grdlsrvvivDdsprsfelqpdngipiepfygdsdkdtellkllpflealeksddvr
subfamily_SCP_pd Subfamily SCP 253-412 7.2e-33 105.3 In-house 2-142 (142) alignment 
Range on Protein: 253-412
Range on HMM: 2-142/142.0
KLVIDLDETLIHSASRSTThsnsSQGHLVEVKfgLSGIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSfpSSFSKRYYRSDCVL
 |||||||||.||. .  .    .   .| |.  . |.    .. |||. | || .|.. .....||||.  ||||| | |. .  . ...| .|  || 
clvidldetlvhssfkpvk....nadfvvpve..idgtvhqvyvlkrphvdeflkrvgelfevvlftaslakyadpvadlldkk..kvlrarlfrescvf

RDGvGYIKDLSIVkdseenGKgsssSLDDVIIIDNSPVSYAMNVDNAIQVEGWISDPTDT
  |  |.|||| .      |.    .|..|||.|||| || .  .||. || |..|..||
hkg.nyvkdlsrl......gr....dlkkviivdnspasyifhpenavpveswfddkedt
subfamily_FCP1_pd Subfamily FCP1 253-403 3.4e-17 54.9 In-house 3-140 (146) alignment 
Range on Protein: 253-403
Range on HMM: 3-140/146.0
KLVIDLDETLIHSASRSTTHSNSSQGHLVEvKFGLSGIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSfPSSFSKRYYRSDCVL
 ||.|||.||||... .| ...... . .. || |.  .. |....||..  ||.|.|| |.| |.| . ..||. .   |. .  . ||.|    | .|
vLvvDlDqtlihttkdptievkeekkkdik.kftlpeekevyyvklRpnlkefleklsklyelhiytmgtraYaeqiakilDpe.kklfserilsrdell

rDGVGYIKDLSIVKDSEEngkgsssslDDVIIIDNSPVSYaMNVDNAIQVE
 |    .|.|... ....         . |.|||.    . .  .| |.|.
.dassktkklkklfptdd.........smvviiDDredvW.nfaenlikvk
subfamily_CTDSPL2_pd Subfamily CTDSPL2 254-411 1.3e-30 98.3 In-house 2-141 (142) alignment 
Range on Protein: 254-411
Range on HMM: 2-141/142.0
LVIDLDETLIHSASRSTTHSNSSQghlvEVKFglSGIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSfPSSFSKRYYRSDCVLR
||.||||||.|.. .   ... ..    .|.|  . .    ....||.   || .||| ...|.|||| | ||| ..|.|. .    . .| .| .||  
lvldldetlvhcslekleeatltf....pvlf..enktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpe.kklikhrlfrehcvcv

DGvGYIKDLSIVkdseenGKgsssSLDDVIIIDNSPVSYAMNVDNAIQVEGWISDPTD
||  |||||||.      |.     |. .||.|||| ..|....| | .| | .| .|
dg.nyikdlsil......Gr....dlektiivdnspqafayqlenGipieswfedend
subfamily_TIM50_pd Subfamily TIM50 294-411 6.4e-14 44.2 In-house 21-125 (126) alignment 
Range on Protein: 294-411
Range on HMM: 21-125/126.0
YFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESsfPSSFSKRYYRSDCVLRDGVgYIKDLSIVKdseengkgssSSLDDVIIIDNSPVSYA
.  .|||  | || .... .....||..   .| |.|| |.    .  . | .|  . . ||   .|||| .            .|. ||..|  . |. 
wrfkkrPgvdafleqlaelfeivvftseqgltaaplidkldP..kqlimyrlfrdatkyvdGe.hvkdlskln..........rdlskvivvdldkksvk

MNVDNAIQVEGWISDPTD
.. .||.... |  .  |
lqpenalalkkweGnadd