Gene PAPL-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP140_AA protein Get Run
SpurP140_AA_218-418 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PhoD PhoD-like phosphatase 120-263 9.9e-12 35.5 Pfam-A 3-150 (453) alignment 
Range on Protein: 120-263
Range on HMM: 3-150/453.0
IAYGDMPSEMVIVWSTPSPG---SSEVlYGMAPNNFSLKASGDYEELVDWEGPF--EGVKFIHRVKLEGLSPGASYSYKVQTN--GEQSQTYTFTAMQDG
.| ||  .. |..|.  .|    ..|.    .  .. .. . . ...|. .     .  ... .|...||.|| .| |.....  ...|..  .. ....
vaSGdptadsvvlWTRvapeeeegaep.kapvsvewevaedeefkrvvrsgtvlatserdytvkvevtgLepgqeyfYrfraeegesespvGrtrTlpea

TDWSPTLLVYGDMGLKGGApsLRLLRKAAKENLADAIIHVGDFAYDLHDEE
.  | .|.|....  . |    . .|..|...  |...|.||. |  ....
aveslrlavvSCsnyeqGy..fnayrelaekedlDfvlhlGDyiYeygegt
Metallophos Calcineurin-like phosphoesterase 218-406 6.5e-19 62.0 Pfam-A 2-200 (200) alignment 
Range on Protein: 218-406
Range on HMM: 2-200/200.0
TLLVYGDMGLKGGAP--SLRLLRKAAKENLADAIIHVGDFAYDLHDEEGKVGDDFmNRIQDVAAVLPYMTCPGNHEIAHDFVHYRYRFSMPGSPWPMEDE
. || ||....   .   |..| |.|.|. .|.... ||. .   . ..  ..   .  . ...  |.. ..||||  .    |  .  ..... .   .
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang

MWY----------SFDMGKAHFVSDYLQRSQIEWLRDDLQRANKERAIRPWIIAFGHRPMYCSNADRDDCtKEESRVRTGLEDLFYDFGTDLIIEAHEHS
 .             . .  .  . .|    ...   .   |...||. ...|. .|.|...|    ||  . |   .  ||.|... | ||.. .|.| 
eeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.gselfgpdalekllekygvdlvlrGHtHk

Y
.
p
ACP5 219-404 3.1e-09 28.8 In-house 1-197 (198) alignment 
Range on Protein: 219-404
Range on HMM: 1-197/198.0
LLVYGDMGLKGGAPSL---RLLRKAAKENLADAIIHVGDFAYDLH---DEEGKVGDDFMNRIQDVAAVLPYMTCPGNHEIAHDFVH-YRYRFSMPGSPWP
.|| ||.| || ..     . . |.|... .|... .||  ||      .. .. ..| .  .. .  .|.... |||..  .     .|  .   | .|
flvvGDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfp

MEDEMWY----------SFDMGKAHFVSDYLQRSQIEWLRDDLQRANKErAIRPWIIAFGHRPMYCSNADRDD-CTKEEsrvrtgLEDLFYDFGTDLIIE
.  . ..          . .  | .  ..  .....|.. ..|..|...     |.| .|| |.|      |  .  |.      |. |.   . |. . 
slryslskkevvtelftekkdeksdqrevaerekyaeeqlkwlekalak.stadwkiVvGHhpvySigehgdtkelver......llpllkkykvdaYln

AHEH
 |.|
GHdH
subfamily_ACP5_pd Subfamily ACP5 221-407 1.2e-68 222.7 In-house 1-189 (189) alignment 
Range on Protein: 221-407
Range on HMM: 1-189/189.0
VYGDMGLKGGAPSLRLLRKAaKENLADAIIHVGDFAYDLHDEEGKVGDDFMNRIQDVAAVLPYMTCPGNHEIAHDFVHYRYRFSMPgspwpmEDEMWYSF
|.||.| . .|.  .||... ..| .|.||||||.||.|......|.|.||| |...|. .|||...|||| ...|..|..|||||      ....||||
vfgDlgvseaaslatllkee.eaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp......sknewYsf

DMGKAHFVS------DYLQRSQIEWLRDDLQRANkERAIRPWIIAFGHRPMYCSNADRDDCTKEESRVRTG----LEDLFYDFGTDLIIEAHEHSYE
|.|..||.|       .|...|..||..||..|| .|. .||||..|||||||||.|.|||||||..||.|    ||||.|... ||....||||||
dygpvhfislstevdfslgseqykWLekdLkean.nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlalsgHeHsYe
PAPL 221-406 4.7e-59 191.8 In-house 2-194 (194) alignment 
Range on Protein: 221-406
Range on HMM: 2-194/194.0
VYGDMGLKGGAPsLRLLRKAAKENLADAIIHVGDFAYDLHDEEGKVGDDFMNRIQDVAAVLPYMTCPGNHEIAHDFVHYRYRFSMPGSP---WPMEDE--
|.||.| .  .  |. |.|.....  |||.||||.||.........||.||. |. .|| .|||..||||| ...| .|..|||||||.   .. ..   
vfGDlGqtnass.lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgs

MWYSFDMGKAHFVSD----YLQRSQIEWLRDDLQRANKERAIRPWIIAFGHRPMYCSNADRDDCTKeESRVRTGLEDLFYDFGTDLIIEAHEHSY
  |||. . .||.        .... .. . ....|...|. .||||..|||||||||.|.|||.. .. ....||||.|. | ||.. .|||||
nsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddcke.kakmlaaledllykygVDlvlaGHeHsY
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 427-496 2.8e-17 54.2 Pfam-A 2-62 (62) alignment 
Range on Protein: 427-496
Range on HMM: 2-62/62.0
APVHVISGAAGCNEFDgvcvnpILGPRGEWSAYRSwipGLYGFAHLHIANDTHLHWQQRLAVSDQVQDEF
||||...||||... .         |. ||||.|.     ||.. |...|.|||||..  . . || |.|
ApvhIvvGaAGnglsk......fskpqpewsafre...sdyGysrltvvNrthLhwefvrsddgqvlDsf