Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| PhoD | PhoD-like phosphatase | 102-198 | 2.7e-09 | 27.5 | Pfam-A | 57-152 (453) | alignment | ||
Range on Protein: 102-198
Range on HMM: 57-152/453.0
KRHTQFIHRVRLIGLKPGELYTYRCGG--DEGWSSQFTFKTFQAGTNWSPRFAVYGDMGNENAQSLARLQIESQErMYDAILHVGDFAYDFSfnDGETG
....... .|.. ||.||. | || .| | ..| .... | |.||.... |. | .. ..| .|..||.||. | . .|. .
tserdytvkvevtgLepgqeyfYrfraeegesespvGrtrTlpeaaveslrlavvSCsnyeqGyfnayrelaeke.dlDfvlhlGDyiYeyg..egtyk
|
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| Metallophos | Calcineurin-like phosphoesterase | 150-349 | 5.5e-25 | 81.8 | Pfam-A | 2-200 (200) | alignment | ||
Range on Protein: 150-349
Range on HMM: 2-200/200.0
RFAVYGDMGNENAQS---LARLQIESQERMYDAILHVGDFAYDFSFNDGETGDEFmRQIESVAGYVPYMTCPGNHEYHYNFSNYKNRFTMPM---YEDTK
|..| ||.. .... | .|. .| |..|. ||. . ... .. .. . .. ..|.. ..||||... | |. . ... . .
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang
NLWYSWNvgPahiISISTEVYFYVYYGLHLIIDQINWLKADLFEANKPENRSQRPWIITMGHRPAYCTNNDGDDCtMSVSIIRSALEELFYDNGVDVEFW
|... . | . | ..... ... . . |.| . ...|.. ...| ..|.| ... . ||| |. . |||.|....|||. ..
eeeyenl..k...itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.gselfgpdalekllekygvdlvlr
AHEHSY
.|.| .
GHtHkp
|
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| PAPL | 152-349 | 3.5e-73 | 237.9 | In-house | 1-194 (194) | alignment | |||
Range on Protein: 152-349
Range on HMM: 1-194/194.0
AVYGDMGNENAQSLARLQIESQERMYDAILHVGDFAYDFSFNDGETGDEFMRQIESVAGYVPYMTCPGNHEYHYNFSNYKNRFTMPmyEDTKNLWYSWNV
||.||.|..||.||.||| | |...|||||||||.||. .......|||||||||..| .||||..|||||..|||||||.||.|| ..... ..|..
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmp..gseegesnsses
GPAHIiSISTEVYFYVYYGLHLIIDQINWLKADLFEANKPENRSQRPWIITMGHRPAYCTNNDGDDCTMSVSiIRSALEELFYDNGVDVEFWAHEHSY
|.... |..||........ . ... .. ..| |.....|||..||||.||||| ||.|.| |||. . . ...|||.|.|..|||.....|||||
gsnsy.sfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekak.mlaaledllykygVDlvlaGHeHsY
|
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| subfamily_ACP5_pd | Subfamily ACP5 | 153-350 | 1.4e-74 | 242.1 | In-house | 1-189 (189) | alignment | ||
Range on Protein: 153-350
Range on HMM: 1-189/189.0
VYGDMGNENAQSLARLQIESQERMYDAILHVGDFAYDFSFNDGETGDEFMRQIESVAGYVPYMTCPGNHEYHYNFSNYKNRFTMPmyedTKNLWYSWNVG
|.||.|...|.|||.|. |......|.|.||||.||. . ......||||..||..| .||||...||||...|||.||.||.|| .|| |||...|
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp....sknewYsfdyg
PAHIISISTEVYFYVYyglhliIDQINWLKADLFEANkpeNRSQRPWIITMGHRPAYCTNNDGDDCTMSVSIIRS----ALEELFYDNGVDVEFWAHEHS
|.|.||.||||.|.. .|..||..|| ||| ||...||||.||||| ||.|.|.||||.. ...|. .||.|.|...||. ...||||
pvhfislstevdfslg......seqykWLekdLkean...nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlalsgHeHs
YE
||
Ye
|
|||||||||
| ACP5 | 153-347 | 6.5e-11 | 34.2 | In-house | 3-197 (198) | alignment | |||
Range on Protein: 153-347
Range on HMM: 3-197/198.0
VYGDMGNENAQSLA----RLQIESQERMYDAILHVGDFAYD---FSFNDGETGDEFMRQIESVAGYVPYMTCPGNHEYHYNFSNYKNRFTMPMYEDTKNL
| ||.|.... . .. .. .|..| .|| || | .| . ..| . .. . ||.... |||.|. | | . . .|
vvGDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpsl
WYSWNVGpAHIISISTEVYFYVYyGLHLIIDQINWLKADLFEANKPENRSQRPWIITMGHRPAYCTNNDGDDCTMsvsiiRSALEELFYDNGVDVEFWAH
.||... .... || . . . .. . . | . .| ..|. |.| .|| | | . . || .. . |. |. ..||. . |
ryslskk.evvtelftekkdeks.dqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdtkel.....verllpllkkykvdaYlnGH
EH
.|
dH
|
|||||||||
| subfamily_PAPL_pd | Subfamily PAPL | 170-348 | 2.9e-06 | 18.6 | In-house | 28-211 (212) | alignment | ||
Range on Protein: 170-348
Range on HMM: 28-211/212.0
IESQERMYDAILHVGDFAYDFSFNDgETGDEFMRQIESV----AGYVPYMTCPGNHEYHYN------FSNYKNRFTMPMYEDTKNLWYSWNVGPAHIISI
..| . .|..|| |. .| .. | .. | | . ||.....|||.|. | .|. .|...| . ||.. .. . ... |
kvaeeleaqfvlalGDnfYekGvkd.vddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYsklskrWkfpslyytksfkipdsnatvqlvli
STEVYFYVYYG--------LHLIIDQINWLKADLfeankpeNRSQRPWIITMGHRPAYCTNNDGddctmSVSIIRSALEELFYDNGVDVEFWAHEHS
| . .. ..| .| .||...| ..|. ..|. || | . . ..| . .|... |. | |.. . |.|.
dtvllcgksddlklegpvdvslaeeqwawleeeL.......kaseadylivaGhypvwsvaehG.....ptkiLvkrLkPlLekynvtaylsGhDhn
|
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| Metallophos_2 | Calcineurin-like phosphoesterase superfamily domain | 171-376 | 1e-08 | 27.3 | Pfam-A | 22-148 (156) | alignment | ||
Range on Protein: 171-376
Range on HMM: 22-148/156.0
ESQErmYDAILHVGDFAYdfsfndgetGDEFMRQIESVagyvPYMTCPGNHEYHYnFSNYKNRFTmpmyedtknlwyswnvgpahiisistevyfyvyyg
. .| .|.|||.||. .|.....|.. | ...|||.. . . ... .
dike..vdlilhaGDlve.........peevvelledi....pvlavrGnhDeae.lpkelavel...................................
lhliidqinwlkadlFEANKPENRSQRPWIITMGHRPAyctnndgddctmsVSIIRSALEELFYDNGVDVEFWAHEHSYERLWPVYNRKVYNGSLSEPYN
..|.. .. .. .... |.. . | ...|.||. ..|.|. | .| | .. . |. ||. ||
...............llaaaaleiegdrvllvhgtpls.............vqsseeelaellkeagadlvflGHtHkpkvekrggtlvvnpGsvgepre
NPKAPV
...| .
gdeaty
|
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| Metallophos_C | Iron/zinc purple acid phosphatase-like protein C | 373-436 | 8.3e-23 | 71.9 | Pfam-A | 1-62 (62) | alignment | ||
Range on Protein: 373-436
Range on HMM: 1-62/62.0
KAPVHLITGSAGCreRRDPFTH-SEPWDAFRSNDYGYHRMHIINNTHINFEQVSDDKgGAVIDKF
|||||...|.||. . ..|.. ..|.|||..|||| |....|.||...|.|..|. |.|.|.|
kApvhIvvGaAGn..glskfskpqpewsafresdyGysrltvvNrthLhwefvrsdd.gqvlDsf
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