Gene PAPL-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP141_AA protein Get Run
SpurP141_AA_151-361 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PhoD PhoD-like phosphatase 102-198 2.7e-09 27.5 Pfam-A 57-152 (453) alignment
Range on Protein: 102-198
Range on HMM: 57-152/453.0
KRHTQFIHRVRLIGLKPGELYTYRCGG--DEGWSSQFTFKTFQAGTNWSPRFAVYGDMGNENAQSLARLQIESQErMYDAILHVGDFAYDFSfnDGETG
....... .|.. ||.||. | ||     .|  |    ..| ....  | |.||....  |.    |  .. ..|  .|..||.||. |  .  .|. .
tserdytvkvevtgLepgqeyfYrfraeegesespvGrtrTlpeaaveslrlavvSCsnyeqGyfnayrelaeke.dlDfvlhlGDyiYeyg..egtyk

Metallophos Calcineurin-like phosphoesterase 150-349 5.5e-25 81.8 Pfam-A 2-200 (200) alignment
Range on Protein: 150-349
Range on HMM: 2-200/200.0
RFAVYGDMGNENAQS---LARLQIESQERMYDAILHVGDFAYDFSFNDGETGDEFmRQIESVAGYVPYMTCPGNHEYHYNFSNYKNRFTMPM---YEDTK
|..| ||..  ....   | .|.   .|   |..|. ||. .     ... ..   .. . .. ..|.. ..||||...  | |. . ...    . .  
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang

NLWYSWNvgPahiISISTEVYFYVYYGLHLIIDQINWLKADLFEANKPENRSQRPWIITMGHRPAYCTNNDGDDCtMSVSIIRSALEELFYDNGVDVEFW
   |...  .   | . |  .....      ... .   . |.| . ...|.. ...| ..|.| ... . |||   |.   . |||.|....|||. ..
eeeyenl..k...itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.gselfgpdalekllekygvdlvlr

AHEHSY
.|.| .
GHtHkp

PAPL 152-349 3.5e-73 237.9 In-house 1-194 (194) alignment
Range on Protein: 152-349
Range on HMM: 1-194/194.0
AVYGDMGNENAQSLARLQIESQERMYDAILHVGDFAYDFSFNDGETGDEFMRQIESVAGYVPYMTCPGNHEYHYNFSNYKNRFTMPmyEDTKNLWYSWNV
||.||.|..||.||.||| | |...|||||||||.||. .......|||||||||..| .||||..|||||..|||||||.||.||  ..... ..|.. 
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmp..gseegesnsses

GPAHIiSISTEVYFYVYYGLHLIIDQINWLKADLFEANKPENRSQRPWIITMGHRPAYCTNNDGDDCTMSVSiIRSALEELFYDNGVDVEFWAHEHSY
|.... |..||........ .  ... ..  ..| |.....|||..||||.||||| ||.|.| |||. . . ...|||.|.|..|||.....|||||
gsnsy.sfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekak.mlaaledllykygVDlvlaGHeHsY

subfamily_ACP5_pd Subfamily ACP5 153-350 1.4e-74 242.1 In-house 1-189 (189) alignment
Range on Protein: 153-350
Range on HMM: 1-189/189.0
VYGDMGNENAQSLARLQIESQERMYDAILHVGDFAYDFSFNDGETGDEFMRQIESVAGYVPYMTCPGNHEYHYNFSNYKNRFTMPmyedTKNLWYSWNVG
|.||.|...|.|||.|. |......|.|.||||.||. . ......||||..||..| .||||...||||...|||.||.||.||    .|| |||...|
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp....sknewYsfdyg

PAHIISISTEVYFYVYyglhliIDQINWLKADLFEANkpeNRSQRPWIITMGHRPAYCTNNDGDDCTMSVSIIRS----ALEELFYDNGVDVEFWAHEHS
|.|.||.||||.|..        .|..||..|| |||   ||...||||.||||| ||.|.|.||||.. ...|.    .||.|.|...||. ...||||
pvhfislstevdfslg......seqykWLekdLkean...nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlalsgHeHs

YE
||
Ye

ACP5 153-347 6.5e-11 34.2 In-house 3-197 (198) alignment
Range on Protein: 153-347
Range on HMM: 3-197/198.0
VYGDMGNENAQSLA----RLQIESQERMYDAILHVGDFAYD---FSFNDGETGDEFMRQIESVAGYVPYMTCPGNHEYHYNFSNYKNRFTMPMYEDTKNL
| ||.|.... .       ..   ..  .|..| .||  ||    | .| .  ..| .  .. .  ||.... |||.|. | |   .       .   .|
vvGDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpsl

WYSWNVGpAHIISISTEVYFYVYyGLHLIIDQINWLKADLFEANKPENRSQRPWIITMGHRPAYCTNNDGDDCTMsvsiiRSALEELFYDNGVDVEFWAH
.||...    .... || .   .   .   .. .  .  | . .|  ..|.  |.| .|| | | . . ||  ..      . |. |.  ..||. .  |
ryslskk.evvtelftekkdeks.dqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdtkel.....verllpllkkykvdaYlnGH

EH
.|
dH

subfamily_PAPL_pd Subfamily PAPL 170-348 2.9e-06 18.6 In-house 28-211 (212) alignment
Range on Protein: 170-348
Range on HMM: 28-211/212.0
IESQERMYDAILHVGDFAYDFSFNDgETGDEFMRQIESV----AGYVPYMTCPGNHEYHYN------FSNYKNRFTMPMYEDTKNLWYSWNVGPAHIISI
  ..|   . .|..||  |.   .| ..   | .. | |    .  ||.....|||.|. |      .|.  .|...| .  ||.. .. .    ... |
kvaeeleaqfvlalGDnfYekGvkd.vddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYsklskrWkfpslyytksfkipdsnatvqlvli

STEVYFYVYYG--------LHLIIDQINWLKADLfeankpeNRSQRPWIITMGHRPAYCTNNDGddctmSVSIIRSALEELFYDNGVDVEFWAHEHS
 | .  ..           ..|  .| .||...|       ..|.  ..|. || | . . ..|     . .|... |. |     |.. .  |.|.
dtvllcgksddlklegpvdvslaeeqwawleeeL.......kaseadylivaGhypvwsvaehG.....ptkiLvkrLkPlLekynvtaylsGhDhn

Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 171-376 1e-08 27.3 Pfam-A 22-148 (156) alignment
Range on Protein: 171-376
Range on HMM: 22-148/156.0
ESQErmYDAILHVGDFAYdfsfndgetGDEFMRQIESVagyvPYMTCPGNHEYHYnFSNYKNRFTmpmyedtknlwyswnvgpahiisistevyfyvyyg
. .|  .|.|||.||.            .|.....|..    |  ...|||..   . . ... .                                   
dike..vdlilhaGDlve.........peevvelledi....pvlavrGnhDeae.lpkelavel...................................

lhliidqinwlkadlFEANKPENRSQRPWIITMGHRPAyctnndgddctmsVSIIRSALEELFYDNGVDVEFWAHEHSYERLWPVYNRKVYNGSLSEPYN
               ..|.. ..  .. .... |.. .             |   ...|.||. ..|.|. | .| | ..       . |. ||. ||  
...............llaaaaleiegdrvllvhgtpls.............vqsseeelaellkeagadlvflGHtHkpkvekrggtlvvnpGsvgepre

NPKAPV
...| .
gdeaty

Metallophos_C Iron/zinc purple acid phosphatase-like protein C 373-436 8.3e-23 71.9 Pfam-A 1-62 (62) alignment
Range on Protein: 373-436
Range on HMM: 1-62/62.0
KAPVHLITGSAGCreRRDPFTH-SEPWDAFRSNDYGYHRMHIINNTHINFEQVSDDKgGAVIDKF
|||||...|.||.  . ..|..  ..|.|||..|||| |....|.||...|.|..|. |.|.|.|
kApvhIvvGaAGn..glskfskpqpewsafresdyGysrltvvNrthLhwefvrsdd.gqvlDsf