Gene ACP5-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily ACP5
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP144_AA protein Get Run
SpurP144_AA_20-263 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Metallophos Calcineurin-like phosphoesterase 20-237 1e-20 67.9 Pfam-A 2-199 (200) alignment 
Range on Protein: 20-237
Range on HMM: 2-199/200.0
NFMVLADWGGQSTSPFvtpceVnVAKQMGILASSYESQFVLALGDNFYYFGVSSVDDPRFNetfeDVFTADSLQVPWYLVAGNHDWHGSVQAQIDYSKVS
...|..|..|.   .        .. ..  .|.. . ..|| |||...    ||    ..           .| .|..|. |||....  .|   . ...
rilvigDlHgglddle.....d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalld....ylvlklllpipvfllrGNHesdpgnsaygflleql

KRWNFPSFYYMLRYQIpssqetvtfimiDtvMLCGNTDDSDVLQQPTKPKDLLMVAKQFAWIEEQLKATMNDTYVIVAGHYPVWSIAEHGPT----DCLV
|... . ....                 .     ..| .  . .   .|..   .. .. .....|..  .. ..|. .| |..|  ..| .    ..  
kdlrglangeeeyenl............k..itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgp

NGLRPMLIKYNVSAYFSGHDHN
. |.. | ||.| ....||.| 
dalekllekygvdlvlrGHtHk
ACP5 21-237 3.7e-69 224.4 In-house 1-198 (198) alignment 
Range on Protein: 21-237
Range on HMM: 1-198/198.0
FMVLADWGGQSTSPFVtpcevNVAKQMGILASSYESQFVLALGDNFYYFGVSSVDDPRFNETFEDVFTADSLQVPWYLVAGNHDWHGSVQAQIDYSKVSK
|.|..|||.......      .|||||| .|.. . .|||.||||||. ||.|||||||.|.||...||.|||||||.|.||||..|.|.|||.|.| ||
flvvGDwGrkgeynqs.....avakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrsk

RWNFPSFYYMLRYQIpssqetvtfimiDTVMLCGNTDDSdVLQQPTKPKDLLMVAKQFAWIEEQLKATmNDTYVIVAGHYPVWSIAEHGPTDCLVNGLRP
...|||..| |. ..            ....|. ...|.   .|......  . ..| .|.|..|..  . ...||.||.||.||.|||.|..||. |.|
dsrfpslryslskke............vvtelftekkde.ksdqrevaerekyaeeqlkwlekalaks.tadwkiVvGHhpvySigehgdtkelverllp

MLIKYNVSAYFSGHDHN
.| ||.|.||..||||.
llkkykvdaYlnGHdHc
subfamily_PAPL_pd Subfamily PAPL 22-238 8.7e-106 343.8 In-house 1-212 (212) alignment 
Range on Protein: 22-238
Range on HMM: 1-212/212.0
MVLADWGGQSTSPFVTPCEVNVAKQMGILASSYESQFVLALGDNFYYFGVSSVDDPRFNETFEDVFTADSLQVPWYLVAGNHDWHGSVQAQIDYSKVSKR
.||.||||....|..|.....|||..| .|...|.|||||||||||. ||..|||.||.|||||||||.|||||||.||||||..|.|.|||.|||.|||
lvlgDwGgleeapyttaaqeavakelgkvaeeleaqfvlalGDnfYekGvkdvddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYsklskr

WNFPSFYYMLRYQIPSSQETVTFIMIDTVMLCGNTDDsDVlqqPTKPKDLLMVAKQFAWIEEQLKAtMNDTYVIVAGHYPVWSIAEHGPTDCLVNGLRPM
|.|||.||. ...||.|..||....||||.|||..|| ..   ...|.|. . ..|.||.||.||| ....|.||||||||||.||||||..||. |.|.
Wkfpslyytksfkipdsnatvqlvlidtvllcgksdd.lk...legpvdvslaeeqwawleeeLka.seadylivaGhypvwsvaehGptkiLvkrLkPl

LIKYNVSAYFSGHDHNL
|.||||.||.|||||||
LekynvtaylsGhDhnl
subfamily_ACP5_pd Subfamily ACP5 52-237 5e-16 51.2 In-house 21-187 (189) alignment 
Range on Protein: 52-237
Range on HMM: 21-187/189.0
SSYESQFVLALGDNFYYFGVssvDDPRFNETFEDVFTADSLQVPWYLVAGNHDWHGsvqaqiDYSKVSKRWNFPSF--YYMLRYqipssqETVTFIMIDT
.. | .... .||  |  .    .. . ...| ...   . .||.  ..|||. .       ..|...||.. ||   .|. .|      . | ||...|
eaneldliihvGDlaYalka...kneavwdefmnlieplaskvPymvsiGnhesds......nfsaykkrfsmpsknewYsfdy......gpvhfislst

VMLCGNTddsdvlqqptkpkdllmvAKQFAWIEEQLKAT---MNDTYVIVAGHYPVWSiAEHGPTDC----------LVNGLRPMLIKYNVSAYFSGHDH
 .   .                    .|..|.|..||.     .. ..||.|| |..   ..   ||          |...| ..| ||.|  ..|||.|
evdfslg..................seqykWLekdLkeannrkktpwiivmgHrPmYc.snkdeddctkeetlvrkglresledllykykvdlalsgHeH

N
.
s
PAPL 52-237 1.9e-10 33.2 In-house 22-193 (194) alignment 
Range on Protein: 52-237
Range on HMM: 22-193/194.0
SSYESQFVLALGDNFYYFGVSSVDDPRF-NETFEDVFTadslQVPWYLVAGNHDWHGSVQAQIDYSKVSKRWNFPSFYYMLRY-QIPSSQETVTFIMIDT
.. . ...| .||  |  . ..  |     .  | ...    .||.  ..|||. .   ...  ... ..... .| .... . ..  ..|.| ||.. .
qkgkydailhvGDlaYaddeqnewdgdefmrqieplaa....svpymvapGNHEeeynfsnykarfsmpgseegesnssesgsnsysfetesvhfivlss

vmlcgntdDSDVLQQPtkpkdllmvaKQFAWIEEQLKA--TMNDTYVIVAGHYPVWSIAEHG----PTDCLVNGLRPMLIKYNVSAYFSGHDHN
        ..|| ..           .| .| ||.|..    .  ..||.|| |...  ..      ..  ...| ..|.||.|  ...|| |.
........eedvkeks..........eqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvlaGHeHs
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 54-254 1.1e-06 20.7 Pfam-A 24-135 (156) alignment 
Range on Protein: 54-254
Range on HMM: 24-135/156.0
YESQFVLALGDnfyyfgvsSVDDprfNETFEDVftadsLQVPWYLVAGNHDWHGsVQAQIDYSKvskrwnfpsfyymlryqipssqetvtfimidtvmlc
 | ...| .||        .|.    .|..|..      ..| . | ||||.   .....   .                                    
kevdlilhaGD........lvep...eevvell.....edipvlavrGnhDeae.lpkelavel....................................

gntdD---------------------SdvlqqptkpkdllmvakqfawieeqlkatmndtyvivaghypvwsiaehgP----TDclvngLRPMLIKYNVS
                          |                                                  .     .     |.  | .....
....llaaaaleiegdrvllvhgtpls..................................................vqsseee.....laellkeagad

AYFSGHDHNLQHIKEDNssVEYFVIG
..|.|| |. .  |...  . ... |
lvflGHtHkpkvekrgg..tlvvnpG