Gene ACP5-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily ACP5
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP145_AA protein Get Run
SpurP145_AA_89-301 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Metallophos Calcineurin-like phosphoesterase 89-301 1.3e-23 77.4 Pfam-A 2-199 (200) alignment 
Range on Protein: 89-301
Range on HMM: 2-199/200.0
RFLVLGDIGGLGEPPYttddqEdVAWAAGKVADNFKADFIVELGDNFYENGVKDVHDPRFRqtfeDVYTAESLQVPWYIVPGNHDWDGNITAQIEYSKIS
|.||.||..|  . ..       .. .  |.| . |.|... |||... .   .    ...          .| .|.. ..|||..|.  .|   . ...
rilvigDlHgglddle.....d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalld....ylvlklllpipvfllrGNHesdpgnsaygflleql

ERWHFPSLYYTKEFRIsdspdaKlfmVVIDTMLLCGMGTPPTGPWNVSAAEDQWIWLEHQLNATKEANYVIVAGHYPVRSMGSHGPT----RCLVERLEP
 ..  .  .. ...        |   . . |.  .. |    .| .   |.... . . .|.. . ....|. .| |. | | .| .     .  . ||.
kdlrglangeeeyenl......k...itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgpdalek

LLKQYNVSAYFAGHDHN
||..|.| ... ||.| 
llekygvdlvlrGHtHk
ACP5 90-301 1.3e-70 229.1 In-house 1-198 (198) alignment 
Range on Protein: 90-301
Range on HMM: 1-198/198.0
FLVLGDIGGLGEPPYTtddqeDVAWAAGKVADNFKADFIVELGDNFYENGVKDVHDPRFRQTFEDVYTAESLQVPWYIVPGNHDWDGNITAQIEYSKISE
|||.||.|. ||....     .|| . ||||.. ..||.. ||||||..||..|.||||...||..|||.|||||||.| ||||. ||..|||||.|.|.
flvvGDwGrkgeynqs.....avakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrsk

RWHFPSLYYTKEFRIsdspdaklFMVVIDTMLLCGMGTPPTGPWNVSAAEDQWIWLEHQLNAtKEANYVIVAGHYPVRSMGSHGPTRCLVERLEPLLKQY
...||||.|......        ... . |         .... . ..||.|. |||..|.. ..|...||.||.||.|.|.||.|..|||||.||||.|
dsrfpslryslskke........vvtelftekkdeksdqrevaerekyaeeqlkwlekalak.stadwkiVvGHhpvySigehgdtkelverllpllkky

NVSAYFAGHDHN
.|.||..||||.
kvdaYlnGHdHc
subfamily_PAPL_pd Subfamily PAPL 91-302 2e-104 339.4 In-house 1-212 (212) alignment 
Range on Protein: 91-302
Range on HMM: 1-212/212.0
LVLGDIGGLGEPPYTTDDQEDVAWAAGKVADNFKADFIVELGDNFYENGVKDVHDPRFRQTFEDVYTAESLQVPWYIVPGNHDWDGNITAQIEYSKISER
|||||.|||.| ||||. ||.||.. ||||....|.|...|||||||.|||||.|.||..|||||.||||||||||.|.||||..||..|||.|||.|.|
lvlgDwGgleeapyttaaqeavakelgkvaeeleaqfvlalGDnfYekGvkdvddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYsklskr

WHFPSLYYTKEFRISDSpDAKLFMVVIDTMLLCGMGTP--PTGPWNVSAAEDQWIWLEHQLNAtKEANYVIVAGHYPVRSMGSHGPTRCLVERLEPLLKQ
|.||||||||.|.|.|| .|.. .|.|||.||||. ..  ..||..||.||.|| |||..|.| .||.|.|||||||| |...||||..||.||.|||..
Wkfpslyytksfkipds.natvqlvlidtvllcgksddlklegpvdvslaeeqwawleeeLka.seadylivaGhypvwsvaehGptkiLvkrLkPlLek

YNVSAYFAGHDHNL
|||.||..||||||
ynvtaylsGhDhnl
subfamily_ACP5_pd Subfamily ACP5 106-301 1.7e-17 56.0 In-house 15-187 (189) alignment 
Range on Protein: 106-301
Range on HMM: 15-187/189.0
TDDQEDvawaagkvaDNFKADFIVELGDNFYENGVkdvHDPRFRQTFEDVYTAESLQVPWYIVPGNHDWDGnitaqiEYSKISERWHFPslyYTKEFRIS
|  .|          .. ..|.|. .||  |. .    .. .   .| ..    . .||. ...|||. |       ..|....|.. |     .|.   
tllkee.........eaneldliihvGDlaYalka...kneavwdefmnlieplaskvPymvsiGnhesds......nfsaykkrfsmp...sknewYsf

DSpdAKLFMVVIDTMLLCGMGtpptgpwnvsaaEDQWIWLEHQLNAT---KEANYVIVAGHYPVRS--MGSHGP--TRC-----LVERLEPLLKQYNVSA
|    .  .....|.    .|            ..|. |||..|..    |. ...||.|| |.    . ..    ..      |.|.||.||..|.|  
dy..gpvhfislstevdfslg............seqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdl

YFAGHDHN
...||.|.
alsgHeHs
PAPL 113-301 2.3e-14 46.0 In-house 14-193 (194) alignment 
Range on Protein: 113-301
Range on HMM: 14-193/194.0
AWAAGKVADNFKADFIVELGDNFYENGVKDVHDPRF-RQTFEDVYTaeslQVPWYIVPGNHDWDGNITAQIEYSKISERWHFPSLYYTKEF-RISDSPDA
...  | ... | |.|. .||  |. . .. .|     .  | . .    .||. ..||||. . | ... .... ..... .| .. ..  ..| . . 
lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaa....svpymvapGNHEeeynfsnykarfsmpgseegesnssesgsnsysfetes

KLFMVVIDTMllcgmgtpptgpwNVSAAEDQWIWLEHQLNAT--KEANYVIVAGHYPVRSMGSHGP----TRCLVERLEPLLKQYNVSAYFAGHDHN
  |.|  .               .|.  ..|. |||..|..   ..  ..||.|| |. .  ..      ..  .. ||.|| .|.|  ..||| |.
vhfivlssee.............dvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvlaGHeHs
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 122-306 5.2e-08 25.1 Pfam-A 23-125 (156) alignment 
Range on Protein: 122-306
Range on HMM: 23-125/156.0
NFKADFIVELGDnF-YEngvkdvhdprfRQTFEDVytaESLqvPWYIVPGNHDWDGnITAQIEYSKiserwhfpslyytkefrisdspdaklfmvvidtm
  ..|.|. .|| .  .           ....|..   |..  | ..|.||||..  . ....  .                                  
ikevdlilhaGD.lvep...........eevvell...edi..pvlavrGnhDeae.lpkelavel..................................

llcgmgtpptgpwnvsaaedqwiwLEHQLN--ATKEaNYVIVAGH-YPvrsmgshgptrC--LVERLEPLLKQYNVSAYFAGHDHNLQHIH
                        |.....  .... . ..| |. ..           .    |.|. |||.......| || |. .   
........................llaaaaleiegd.rvllvhgtpls...........vqsseeelaellkeagadlvflGHtHkpkvek