Gene PPP4C in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP156_AA protein Get Run
SpurP156_AA_3-294 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 4-294 3.3e-123 404.7 In-house 27-329 (473) alignment 
Range on Protein: 4-294
Range on HMM: 27-329/473.0
CSDLDRQIEQLRNCEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVR
 .|||. ||.|.......|.... |. .|.||| .|.|.........|.||||||..||..|..  |  |.....|.||.|||| .|.|...||||||..
lldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkik

YPDRITLIRGNHESRQITQVYGFYDECLRKYgSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPEDT
||....|.|||||.|.....|||.||.|.|| .. ..... | ...| |.|.|.|||..|||||||....|||||.|.| .|.|.||...|||||||...
ypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwed

QG--------WGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNET------VLTVWSAPNYCYRCGNVAAILELDEHLqRDFTIFEAA
 |        .| |||||||||| |.| .|   |..|.|.|.|. | |||...|.        ..||.||||||.|.|| ||.|..||.| . |..|...
dgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdps

PQEVR
|....
phpli
subfamily_PPP7C_pd Subfamily PPP7C 4-184 5.6e-39 126.9 In-house 17-203 (383) alignment 
Range on Protein: 4-184
Range on HMM: 17-203/383.0
CSDLDRQIEQLRNCEIIKESEVKALCAKAREILVEESNVQRVDA----PVTVCGDIHGQFYDLKE-LFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLL
...... ||.... ....   |  .  .|...|..  |..|| .     ||||||.||.. ||   |.| |   .. .|.| |||||||  |||  |.||
kdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillill

ALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKY--GSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSpSITTLDQIRMIDRKQ
|| . ||  . | |||||   .   |||  |   ||   .  . |   ..| .| |...|| ||. ||||.|  .| |. .  |.|..
alllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPP4C_pd Subfamily PPP4C 5-292 1.6e-185 608.0 In-house 1-288 (288) alignment 
Range on Protein: 5-292
Range on HMM: 1-288/288.0
SDLDRQIEQLRNCEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRY
||||||||.||.||.|||.|||||||||||||||||||||||.|||||||||||||||.||||||||||.|||||.||||||||||||||||||||||||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRITLIRGNHESRQITQVYGFYDECLRKYGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPEDTQ
||||||||||||||||||||||||||||||||..|||||||.||||||.||||||||||||||||||.|||.||.|||||||||.||.||||||||||..
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

GWGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAAPQE
||.|||||||||||||||.|||.||.|..||||||||.||||.||||.|||||||||||||||||||||||||.|..||.|||||..|
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaae
subfamily_PPP2C_pd Subfamily PPP2C 5-292 4.6e-157 514.6 In-house 2-289 (290) alignment 
Range on Protein: 5-292
Range on HMM: 2-289/290.0
SDLDRQIEQLRNCEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRY
.|||..||.|..|. ..|||||.|| ||.||| .||||| | .|||||||.||||.|| ||||.||..|||||||.||.||||.|||||  || ||||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRITLIRGNHESRQITQVYGFYDECLRKYGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPEDTQ
..|||..||||||||||||||||||||||||. .||.| |..||||.|.|..|..|||.||||||||.|||.|| .|| |||||.||.||||||||.| .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAAPQE
|||.||||||| || |.  .|| .|.. .| ||||||.|||.| ... | |..||||||||||| |||||||..|.. |  |..||..
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
0049330 Metallo-dependent phosphatases 5-293 1.1e-114 375.5 In-house 15-303 (309) alignment 
Range on Protein: 5-293
Range on HMM: 15-303/309.0
SDLDRQIEQLRNCEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRY
|.||..||.|... ...|.|.. |. ||.||| .|.|.........|.||||||..||..|..  | .|.....|.||.|||| .|.|..|||||||..|
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PDRITLIRGNHESRQITQVYGFYDECLRKYGsITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPE-DT
||...|.|||||.|.....|||.||.||||| . .|..... ...| | |.|.|||.||||||||....|||||...| .|.|.||..||||||||  ..
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

QGWGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAAPQEV
 |.. .|||.|..|| ..| .|   |..|.|.|.|..| .||...|.. ..||.||||||.|.||..|.||.||.| . |..||..|...
egfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll
0053225 Metallo-dependent phosphatases 5-290 4.2e-111 363.9 In-house 7-292 (293) alignment 
Range on Protein: 5-290
Range on HMM: 7-292/293.0
SDLDRQIEQLRNCEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRY
..||..||.|... ...|.|.. |. .|.|||..|.|.........|.|||||...||..|..  | .|.....|.||.|||| .|.|...||||||..|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PDRITLIRGNHESRQITQVYGFYDECLRKYGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPEDTQ
||...|.|||||.......|||.||.|||||.  .|..... ...| |.|.|.|||..|||||||....|||||.|.| ...|..|...||||||| .  
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

GWGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAAP
||. |.||.|..|| ..| .|  .|..|.|.|.||.| .||...|.. ..||.|||||..|.||..|.|.|||.| ..|..|.. .
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP6C_pd Subfamily PPP6C 6-293 3.4e-152 498.6 In-house 1-288 (290) alignment 
Range on Protein: 6-293
Range on HMM: 1-288/290.0
DLDRQIEQLRNCEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYP
.||. ||. ..|. . |...|.||..  ..|.|||||| | .|||||||||||||||.|||. ||.||||.|.|.|||||||.||.||| .||.||..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRITLIRGNHESRQITQVYGFYDECLRKYGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPEDTQG
|||||.||||||||||||||||||||.|||. ..|.|||..|| |...||||....|||||||| ..||||||.|.| ||.||.|..|||.|||||| . 
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAAPQEV
| |||||||||||| |...|.. ||...|||||||| ||.|..|.| . ||||||||||||||||.||.|... .|.. .|.| |.| 
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdee
subfamily_PPG1_pd Subfamily PPG1 7-292 2.1e-137 450.4 In-house 1-299 (300) alignment 
Range on Protein: 7-292
Range on HMM: 1-299/300.0
LDRQIEQLRNCEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPD
||. .|.|...|.. |. ||.|. | .|.||.||||... .|||| ||.||||||. |.||.||.||||||||.||.||||.|||||  ||..||.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITLIRGNHESRQITQVYGFYDECLRKY-GSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPE----
||||.|||||||||||||||| |||||| |  .||.| |||||||.|.|||| .|.|||||||||. ..|||...|| .|||..| ..||||||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DTQG--WGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAAPQE
      | .|  . ||.||||| .| ||| .|   |... | |||||. |||. .|.. . |||||||||||||| |.|||| |...| | ..|.||..
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 10-290 3.9e-96 314.6 In-house 14-295 (298) alignment 
Range on Protein: 10-290
Range on HMM: 14-295/298.0
QIEQLRNCEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRIT
 ... . ...|||..|. |...|..|. . . .  ||||..||||||||. ||  ||. .|  ||.||||.||.|||| ...|. .|||| ||.||... 
slsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnff

LIRGNHESRQITQVYGFYDECLRKYGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPED-TQGWGV
|.|||||  .| .|||||.|| |.| |....    ..|. | | |.| |.|.|.|||||. ...|||.| . | .. ...    ||||.|||. ..||  
llrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwae

SPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAAP
. ||... ||.||| ..    .||...||||.| .||..  .  ..|..|||.|| .  | ||....||.|.  |...  . 
nsrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_PPP5C_pd Subfamily PPP5C 13-290 1e-83 274.0 In-house 27-310 (322) alignment 
Range on Protein: 13-290
Range on HMM: 27-310/322.0
QLRNCEIIKESEVKALCAKAREILVEESNVQRVDA----PVTVCGDIHGQFYDLKELFKVGGDVPD-TNYLFMGDFVDRGFYSVETFLLLLALKVRYPDR
.... . ...  . .. ..|.|.| ... .  ..      .||||||||||||| ..|.. | . .   ||| ||||||| .|||. |.||..|. ||..
lfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnh

ITLIRGNHESRQITQVYGFYDECLRKYGSiTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLS-PSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPEDTQGW
. | |||||| .. ..||| .|.  || . .|    ||.|..| |. .|. |.. |||||      |||..| ||| .. |..| ...||||||....| 
fflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGr

GVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILEL-DEHLQRDFTIFEAAP
. | || |  || || ..|   ||...| |.|..  |||. . .  ..||.|||||| . || .|...| ...|.  |. ||| .
spskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeave
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 16-294 2.8e-85 278.8 In-house 4-280 (280) alignment 
Range on Protein: 16-294
Range on HMM: 4-280/280.0
NCeiIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNH
.|  ||| .....  | ..||. .. .  |||||.||||.|||. ||  ||.  .  ||.||||.||.|||| . .|  ||||| |||||... ..||||
ac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnh

ESRQITQVYGFYDECLRKYgSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPE-DTQGWGVSPRGAG
|  .| . |||.||. |.| |  ..    |..| | | |.. |.|.|.|||||. . .||... . |  . ...    ||||.||| .. ||. ..||. 
evisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

YLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAAPQEVR
..||..|| ..    .||.|.| ||.| .||..  .  ..||.|||.|.    | ||.| .||.|.  | ..  | .||.
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalrevk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 16-287 2.8e-77 252.9 In-house 19-293 (297) alignment 
Range on Protein: 16-287
Range on HMM: 19-293/297.0
NCEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNH
 ...| |  |  |   | ...  . ..  |.||. ||||||||| ||  ||. ||  | .||||.||.|||| .|.|| .|||| ||..|  . |.||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESRQITQVYGFYDECLRKYGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSI---TTLDQIRMIDRKQEVpHDGPMCDLLWSDPED-TQGWGVSPR
|   . .|||||.|| ..| |. ..    ..|..| |. .|  ||.|.|||||| .    ||| .| |.| .|  ... ..||||.||     |.    |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqr

GAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFE
|||  || | | .  .  ..|..|||||.| .||..     ..|..||| || .  |.||..  ||.||  | |. 
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 17-294 1.9e-85 279.7 In-house 21-299 (299) alignment 
Range on Protein: 17-294
Range on HMM: 21-299/299.0
CEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
 . .|| |.. ||| |........ .  |.||. ||||||||. ||  .|.. |  ||.|.||.||.||||   .|.  |||. |..||.|. ..|||||
tksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhe

SRQITQVYGFYDECLRKYGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPEDT-QGWGVSPRGAGY
   | .|||||.|| ..| |  .|    . |... |. .| ..|.|.|||||| ..||||.| . | |. |      ||||.||... ..|    ||  |
cpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsy

LFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAAPQEVR
.|| |||..     .||...||||.| .||..  .  ..|..||| || .  | |||...|| |   |.... .|....
vfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpkslk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 17-285 5.3e-74 242.2 In-house 3-271 (280) alignment 
Range on Protein: 17-285
Range on HMM: 3-271/280.0
CEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
|...   |. |.      |..||||.   .||. | |||| |. |.. || . | ||. . .|.||.||||   .| ..||..||.|| ||| |.|||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGsITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPED-TQGWGVSPRGAGY
.  . ..|||| ||  ||| . .|     .|. . .|..|  ...|.|||||| .  || || | |  |    | . ||||||| .  .||  | ||  |
tpsvnkiygfyvecqykyg.vglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTI
.||  || |   . .||.| ||||.| .||.      ..||.| |||| .  | ||.. |.  ||  |  
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqq
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 17-286 1.9e-64 210.5 In-house 13-286 (290) alignment 
Range on Protein: 17-286
Range on HMM: 13-286/290.0
CEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
 . ......  .  |..|||     . .| ||... ||||||. .| . |.  |  |. ..||.||.||||  |.|  |||. .|.||. .. |.|||||
ldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

SRQITQVYGFYDECLRKYGSiTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQ--EVPHDGPMCDLLWSDPED--TQGWGV-SPR
 |.. ..|||..|  || ||  .|.   ..|. ||| | .. ||.|.|||.|. | . . .. . . .     ..| . ||||.||.   ..   .   |
vrkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqr

GAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIF
.   .|| ... ..     ...| |||..  ||... |.. ..||.||| |. .  |. ||... | |.  ....
aisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 17-70 3.3e-14 45.8 In-house 6-59 (317) alignment 
Range on Protein: 17-70
Range on HMM: 6-59/317.0
CEIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGG
 ...||.|.  || .|||.. .|    ...||||..||||||| ||. |... |
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 18-287 6.3e-83 271.5 In-house 6-281 (284) alignment 
Range on Protein: 18-287
Range on HMM: 6-281/284.0
EIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDV------PDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLI
...|| |.  || .|||.. .|.  . ..|||...||||||| ||. |... |         ...|||.||.|||| .|.|  .||.|.|...||...|.
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQVYGFYDECLRKYgSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPED-TQGWGVSP
||||||| . . |||| || ..| | ...      |  . |.|... ||.|.|||.|  .  |.|.  ..|  ..|  | ..|| |.|||   .|.  ||
rgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFE
|||| .||.. | .|.   ..|.. ||||.|..||..  .  ..|..||| || .  |.||.|..||.|   ||...
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 18-287 6.1e-82 268.0 In-house 5-275 (281) alignment 
Range on Protein: 18-287
Range on HMM: 5-275/281.0
EI-IKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
.. . . |....  ... |..||...  .|.|..| ||.|.|| |||.||.. | ||.. ..|.||.||||  |.|...||..||.||.||| |.|||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

SRQITQVYGFYDECLRKYGsITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPED-TQGWGVSPRGAGY
  .. ..|||| ||  ||| . .|    . |. | .|| |. .. |.|||||| .|.||..| . .  . .. | . ||||.||.. ...|  | ||...
iasvnkiygfyvecvtkyG.eelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssf

LFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFE
.|| .|| .     ....| ||||.| .||.      ..||.|.||||    | ||.| .|| |. ..  . 
tfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalv
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 18-288 2.1e-72 236.5 In-house 8-281 (287) alignment 
Range on Protein: 18-288
Range on HMM: 8-281/287.0
EIIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHES
. ......  .  |..|||   . . .|.||.|..||||||. ||  .|.  |  |...|||.||.||||  |.|  |||..||..|| .. |.||||| 
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

RQITQVYGFYDECLRKYGSiTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQE--VPHDGPMCDLLWSDPE-DTQGWGVS-PRGA
..| ..|||..|  ||...  ...   ..|..|.| |... .|.|.|||.|| . .||... . . .     ..| . ||||.||| |...  .   |. 
kkinklyGfkeelkrkrqe.rlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

GYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEA
  .||  .| ..    .||.| |||... |||.. |.. ..||.||| |. .  |..|.. ... |.  |. .  
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_PPP1C_pd Subfamily PPP1C 19-289 4.3e-108 353.8 In-house 9-279 (282) alignment 
Range on Protein: 19-289
Range on HMM: 9-279/282.0
IIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
 .||.|..||..||||||.... . ...|||...||||||..||  ||. .|  |..||||.||.||||  |.|| .||||.|..||... |.|||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITQVYGFYDECLRKYGsITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPE-DTQGWGVSPRGAGYLF
.|...||||||| |.|. |..|.  |..|..| |.|..| ||.||||||||... |.||| | |  |||..| .||||||||. ...||. . ||  . |
sinriyGfydeckrrys.iklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAA
|.|||..| . |..|.|.||||.| .||... .. ..||.|||||| . .| .|.|..||.|  .|.|. .|
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa
subfamily_PPP3C_pd Subfamily PPP3C 19-278 2.4e-86 283.3 In-house 40-312 (452) alignment 
Range on Protein: 19-278
Range on HMM: 40-312/452.0
IIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
 ..|...  .  .| ..| .|... .|.||.||.|||||||||| .||.||||  .|.|||.||.|||| .|.|. | |.|||. ||... |.|||||.|
rleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecr

QITQVYGFYDECLRKYgSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPEDTQGWGV--------SP
 .|. . | .||  || | .|.  |.| || | |.|..... .|||||||| |..||.|. .|| .|.|. ||.|||||||| .  |           |.
hlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsv

RGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFN------ETVLTVWSAPNYCYRCGNVAAILELDEH
||  |...   |..|  .|..  | |||.   .||. . .       ...|..|||||.    | ||.|.... 
rGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_PPZ_pd Subfamily PPZ 19-286 1.1e-78 257.8 In-house 24-291 (300) alignment 
Range on Protein: 19-286
Range on HMM: 24-291/300.0
IIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
 .|.||.  .| ||||... . ..  .  .| . ||.|||. ||  ||   |  | .||||.||.||||  |.|| ||||. |..||. . |.|||||  
clknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnheca

QITQVYGFYDECLRKyGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPEDT-QGWGVSPRGAGYLF
..|.|||||||| |.   | .|.   . |. | |.||. |||||||||||| . ..|.|| . |  .||  | . ||||||| |. . |    ||  | .
nvtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycy

GSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIF
    . .|     .|..|||| .| .||..  . ...||.||||||    |  |.. . | |   | ..
nkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfell
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 19-69 4e-09 29.0 In-house 10-60 (339) alignment 
Range on Protein: 19-69
Range on HMM: 10-60/339.0
IIKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVG
..  .|.  || .|||..  |  . ...||. | ||||||| ||  .. . 
lfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmn
PPP_3 20-287 1.2e-121 397.9 In-house 2-270 (271) alignment 
Range on Protein: 20-287
Range on HMM: 2-270/271.0
IKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQ
..|.|.| |. |..||| .|||.....||||||||||||..|| ||||.||..|.|.|||.||.|||| .|.|..|||||||..||....|.||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDL-LWSDPEDTQGWGVSPRGAGYLFG
|..||||..|.|.|.|. .|.....|.|..|.|.|.||.|...|||||||||..||||. ..||.|||..|...|| |.||||...|.. |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

SDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFE
.||...|. .|....|.|||.|. |||. .... |.||.||||||.|..|..|||.|.|.|...|...|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 20-286 5.5e-69 225.7 In-house 3-271 (284) alignment 
Range on Protein: 20-286
Range on HMM: 3-271/284.0
IKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQ
|   .|..|  .| .|. ..  .  |..|. .|||||||| ||  ||   |    .||||.||.|||| . .|| |||.| || .|... ..|||||   
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

ITQVYGFYDECLRKYGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPM-CDLLWSDPEDTQ-GWGVSPRGAGYLF
| ..||||.|| |.|   .|.     .|  . |.|..  .|.|.|||.|  .  . |.| | |  . |    .  |.||||| . | ||    ||  |.|
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIF
||| . ..    .||.. ||||.| .||..  |  ..|..||| || .  | ||.. ... |   | ..
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 20-278 3e-53 174.0 In-house 7-290 (302) alignment 
Range on Protein: 20-278
Range on HMM: 7-290/302.0
IKESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVG-----------GDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRI
 ..||. .|. .  | | .|... .. .|||. ||||||| ||  ...                    ..|.||.||||  |.|   |..|||| || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLIRGNHESRQITQVYGFYDECLRKYGSIT---VWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRK-QEVPHDGPMCDLLWSDPEDTQ
 |.|||||.. |   ||| .|   ..|      .|.   |.| .. |.|..  ||.|||||.|| ...|..|. |.|  .|| .|    |||..|| |.|
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGVSP----------RGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEH
.  . .          ||  ..|    | ..    |...| |||| . ||.|.. .. .||..|||.|     |  |.|..|  
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
PPP_1 21-274 3.4e-115 376.8 In-house 2-263 (264) alignment 
Range on Protein: 21-274
Range on HMM: 2-263/264.0
KESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
.|.|...|. |..|.|..|.|...|....||||||||||.|| .||||||..|.|||||.||.|||| .|||..|||||||..||....|.||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDL--------LWSDPEDTQGWGVSPRG
|.||||..|.|.|..| ......|..||.|.|.|.||.||..|||||||....||||| ..||.|||..|..|||        |..|.|.....  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILE
||||||.||...|. .||...|.|||... |||.......|.|..||.||.....| .|...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
PP2Ac_SM00156 21-288 3e-106 347.4 In-house 2-269 (271) alignment 
Range on Protein: 21-288
Range on HMM: 2-269/271.0
KESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
...||..|. ...||| .|.|. .|.|||||.||||||..|| .|.. .| .|...|.|.||.|||| .|.|. |||.|||..||....| ||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDP-EDTQGWGVSPRGAGYLFGS
...|||..|. ||| .  ..  ..|.|..|.|.|..| ||.|.||||||....||.|| ..| .| |..|...||||||| ....|.  | ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEA
|.|..|  .||...|.|||..| |||.. ... ..|..||||||....|.||.|.....|.  .  ...
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 21-278 2e-53 174.5 In-house 7-289 (302) alignment 
Range on Protein: 21-278
Range on HMM: 7-289/302.0
KESEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKV-----------GGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRIT
..||. .|. .  | | .|... .. .|||. ||||||| ||  ...                    ..|.||.||||  |.|   |..|||| || .  
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LIRGNHESRQITQVYGFYDECLRKYGSIT---VWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRK-QEVPHDGPMCDLLWSDPEDTQG
|.|||||.. |   ||| .|   ..|      .|.   |.| .. |.|..  ||.|||||.|| ...|..|. |.|  .|| .|    |||..|| |.|.
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

WGVSP----------RGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEH
  . .          ||  ..|    | ..    |...| |||| . ||.|.. .. .||..|||.|     |  |.|..|  
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 23-292 1.2e-62 204.8 In-house 23-295 (307) alignment 
Range on Protein: 23-292
Range on HMM: 23-295/307.0
SEVKALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQ
 |.. .  .|. |.  |  .  .| |. | ||.|||| || ..| . |  |.| |.| ||.||||. |.|. |||.. |. ||. | |.|||||  .. .
eefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk

VYGFYDECLRKYGS--ITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDLLWSDPEDT-QGWGVSPRGAGYLFGS
 ||||.||.         .|      |. | .||.|  ||.|.||||||..| ||..|   .    |  | . |.||.||. .   |  | ||.|. ||.
kygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgt

DVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAAPQE
.|. .      ...| ||||....||       ..|..||| ||    |  ..| .|| |  .   |  . ..
nviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesen
subfamily_PPPLV_pd Subfamily PPPLV 26-278 1.4e-53 175.1 In-house 3-278 (290) alignment 
Range on Protein: 26-278
Range on HMM: 3-278/290.0
KALCAKAREILVEESNVQRVDAPVTVCGDIHGQFYDL----KELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQIT
 .|| .| .||..| ..  ...|. | ||.||.. ||    | |...| |.  ...||.||.|||| .|||    |||||| || .. |.||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGSI--TVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDR---KQEVPHD-GPM-CDLLWSDPEDTQ----------
. . .. |.  |.|     ||   ...||.| |.|.|| |.||||.|.  .| |  .|  |.    . . . |  |.  |.|||||.. .          
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GWG-VSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCgNVAAILELDEH
  |.   . || |..|..| . .|   ||.. . |||.   .|..   .  .|||.|. .||    | ||.. .|..
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvdkk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 45-294 6.5e-55 179.6 In-house 5-261 (263) alignment 
Range on Protein: 45-294
Range on HMM: 5-261/263.0
VDAPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSI----TVW
..||. .||| |||. ||  .|.  |    |.|||.||.|||| .|.|  .||..||.  | .. |.||||| . | . |||. |  ...       .|.
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

RYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPM-CDLLWSDPE-DTQGWGVS-PRGAGYLFGSDVVSQFNAANNIDMICRA
 .  ..| |. | ||.  .|.|.|||.|| . .||.|| |    |  .  |. |||||.||| |..|.     |    .||   | ..    .||.| ||
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivra

HQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAAPQEVR
||.|  || .  .  ..||.||  |     | ||.. ... |.  |  ..    |||
hqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfevr
Metallophos Calcineurin-like phosphoesterase 48-239 9.7e-48 156.1 Pfam-A 2-197 (200) alignment 
Range on Protein: 48-239
Range on HMM: 2-197/200.0
PVTVCGDIHGQFYDL----KELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLL--LALKVRYPDRITLIRGNHESRQITQVYGFYDECL----------
...|.||.||...||     .|.|.... . ...||.||.|||| .| ||. ||  |.||...|... |.||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLDQIrmidrkqevphdgpmcdllwsdpedtqgwgv
                       ....   ..... |.|..|.| |..||||...||.||.|  . |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYLFGSDVVSQFNAANNIDMICRAHQ
    ...|||.|... .   ...|...|.|.
....gselfgpdalekllekygvdlvlrGHt
PPP_2 49-240 4.4e-83 270.8 In-house 1-197 (198) alignment 
Range on Protein: 49-240
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSITVWRYCTEIFD
||||||.|||..|| .|||.|...|...|||.||.|||| .|.|..|||||||..||....|.||||||.....||||..|.|.|.|. .|.....|.|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVPHDGPMCDL-----LWSDPEDTQGWGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQL
.|.|.|.||.|...||||||..|..||||. ..||.|.|..|...||     |....|.....  | ||||.|||.||....  .|....|.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 49-240 2.2e-78 255.8 In-house 1-196 (197) alignment 
Range on Protein: 49-240
Range on HMM: 1-196/197.0
VTVCGDIHGQFYDL-KELFKVGGDVP-DTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKyGSITVWRYCTEI
|||.||||||..||  .|.|.||. . ...|.|.||.|||| .|.|..|||||||..||....|.||||||......|||..|.|.|  . .........
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVP-HDGPMCDL-LWSDPE-DTQGWGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQL
||.|.|.|.||.|...||||||.....||.|. |.||.|.| ... ..|| |||||. ...|.  | ||||.|||.||...|  .||...|.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 49-240 4.5e-77 251.5 In-house 1-198 (199) alignment 
Range on Protein: 49-240
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-KELFKVGGDVP-DTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSITVWRYCTEI
||||||.|||..||  .||| ||| . ...|.|.||.|||| .|.|..|||||||..||....|.|||||..|....|||..|.|.||..  ........
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLSLSAIIDGKIFCVHGGLSPSITTLDQIRMIDRKQEVP-HDGPMCDL-LWSDPE-DTQG-WGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQL
||.|.|.|.||.|...|||||||.| ...... |.||.|.| ..| ..|| |||||. ...| .  | ||||.||| ||...|   ||...|.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 49-122 5.8e-06 19.0 In-house 12-81 (235) alignment 
Range on Protein: 49-122
Range on HMM: 12-81/235.0
VTVCGDIHGQFYDLKELFK--VGGDVPDTNYLFMGDFVDRGFYSVETFLLLlalkvrYPDRITLIRGNHESRQITQ
. | ||.|| . .| ||..  .||  ..   ...||....|  |||.  ..        |    ..||||   . .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 75-287 2.3e-70 230.3 In-house 101-313 (317) alignment 
Range on Protein: 75-287
Range on HMM: 101-313/317.0
TNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYgSITVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTL
 .|||.||.|||| .|.|  .||.|||..|||...|.||||||| . . |||| |. ..| | ...     .|  | |.|... ||.|.|||.| ... |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIRMIDRKQEVPHDGPMCDLLWSDPEDT-QGWGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAIL
.|.  ..|  ..|  | ..|| |.||. . .|.  |.|||| .||.. | .|.   ..|.. ||||.| .||..  .  ..|..|||.|| .  |.||.|
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

ELDEHLQRDFTIFE
..|..|.  .....
svdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 76-287 5.8e-55 179.7 In-house 121-332 (339) alignment 
Range on Protein: 76-287
Range on HMM: 121-332/339.0
NYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSiTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSITTLD
 |||.||.|||| .|.|  .|| |||. ||||| |.||||||| .   |||| |   .| .  ..    ..|. . . |.|.  |.|.|||.|  .|...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRMIDRKQEVPHDGPMCDLLWSDPEDT-QGWGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILE
|. .. |  |.|  | . || |.||. | .|.  | ||| ..||   .  |    ...|. | ||.| .||..     ..|..|||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDEHLQRDFTIFE
.|..|.    .| 
idkklkisinvfr
subfamily_PPP7C_pd Subfamily PPP7C 192-289 2.1e-19 62.5 In-house 237-335 (383) alignment 
Range on Protein: 192-289
Range on HMM: 237-335/383.0
MCDLLWSDPEDTQG-WGVSPRGAGYLFGSDVVSQFNAANNIDMICRAHQLVIEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQRDFTIFEAA
. |.|||||. ..| .  . ||.|  ||.|| ... .  |.... |.|.   |||..  ...|||..|| ||     |  | . | ..|.  .  . |.
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas