Gene PPP7C in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP7C
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP164_AA protein Get Run
SpurP164_AA_104-493 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
IQ IQ calmodulin-binding motif 21-38 6.4e-07 18.2 Pfam-A 2-19 (21) alignment 
Range on Protein: 21-38
Range on HMM: 2-19/21.0
KAALLIQKWYRRYQARLE
|||..||...|.|.|| .
kaaikIQaawRgylaRkr
PPP5 PPP5 TPR repeat region 99-156 3.8e-13 39.7 Pfam-A 32-90 (95) alignment 
Range on Protein: 99-156
Range on HMM: 32-90/95.0
IYSDMEVEEDYDGPHLA-FPLSLDQVEKMMEDFKEQKLLHSKYVLMVLRETEKVMKTKK
 ....|.|.|||||.|    . |. |....|.||.|| || |.|  .| ......|.. 
diesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklp
subfamily_PPP7C_pd Subfamily PPP7C 104-485 2.1e-202 664.9 In-house 1-383 (383) alignment 
Range on Protein: 104-485
Range on HMM: 1-383/383.0
EVEEDYDGPHLAFPLSLDQVEKMMEDFKEQKLLHSKYVLMVLRETEKVMKTKKNINRATTAIAKQITVCGDLHGAIEDLFLVFYKNGLPSAENPYIFNGD
|||..|.||.|..||..|.|||..|.|||.||||.||||..|||..||.|...||.|..|||.|..||||||||...||.|..|||||||.||||.||||
evedsytgprlslpltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

YVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKY---GAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKTDLTFLDNIA
.||||..||||..||....|..|.|||||||||||.||||||||.|||.|||   |..|. ...|.|||||||||||.||||.||||||||||..||.|.
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktdlelldkie

RHKYLSVLKPPLKEGAeELTGEEEDLSLKIDLSEWRQILDILWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKV
|.|. |||.||||||. | . |.|. |.|.| .||||.||||||||....||.|||.||||||||||||||.|.|....||||||||||.||||.| .||
rsklvsvlrpplkege.eaekekeessvkvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkv

LTVFSASNYYEEGSNRGAYIKFGTDLKPRCFQYQTSaKNTKKMTMRQKVSIVEESALRDLREKIGANTTYLRQAFQKYDPGNTGF
||.||||||||||||||||.|.|.||.||..|||.| |.|||.|.||.||||||||||.||||. |....|...|.|.|. ..|.
ltifsasnyyeeGsnrGayvklgkdltprivqyqas.katkkltlrqrvsiveesalrelrekllakksdlleefkkkdekksgl
0045823 Metallo-dependent phosphatases 105-493 3.1e-93 305.9 In-house 12-377 (473) alignment 
Range on Protein: 105-493
Range on HMM: 12-377/473.0
VEEDYDGPHLAFPLSLDQVEKMMEDFKEQKLLHSKYVLMVLRETEKVMKTKKNINRATTaiakQITVCGDLHGAIEDLFLVFYKNGLPSAeNPYIFNGDY
|   ...|.| ..|.| ......| .|...||. ...| .|.|. ...|  .|. . .      |.|.||.|| ..||  .. |.|.|.. . ..|.||.
vlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drlvflGDl

VDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKTdlTFLDNIARHKY
|||| .|.|.  .|.......|. |.| |||||...||  |||..|.  |||...  .|......|||| .|..|||..|||.|.    . || |.... 
vDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl..plldqireier

lsVLKPPLkegaeeltgeeedlslkidlseWRQILDILWSDPRSQDGC-------QPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHG
  .| .|                       ....||.||||| ..||.        .|..|| | .||||.....| |.|.||..|.|.. |.|||....
..pleipd......................dgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfd

DK------VLTVFSASNYYEEGSNRGAYIKFGTDLkPRCFQYQTSAKnTKKMTMRQKVSIVeesALRDLREKIGANTTYLRQAFQKYDPGNTGFITSTQW
.|      ..|||||.||. .| |..|..... || . ..|.. |   ...... ..| ..   .|. |.||.   ...| ..... .  ... |.....
gkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph.plilplfldvfll...slpfllekltellllllnivsddellededilglll

AR
  
le
subfamily_PPP5C_pd Subfamily PPP5C 105-300 5e-66 215.9 In-house 2-197 (322) alignment 
Range on Protein: 105-300
Range on HMM: 2-197/322.0
VEEDYDGPHLAF-PLSLDQVEKMMEDFKEQKLLHSKYVLMVLRETEKVMKTKKNINRATTAIAKQITVCGDLHGAIEDLFLVFYKNGLPSAENPYIFNGD
||..||||.|    .. . |....| ||.|| || ||.|..| |.....|..  .   |.   |..|||||.||   ||. .| .||||| ||||.||||
vedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGd

YVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKTDLTfLDNIA
.|||| .|||....|..| ||.||...|.|||||   .|  |||  ||..|| ....  |...| |||||..|..|.|..|||. .. ..| ||.. 
fvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvt.lddlr
0049330 Metallo-dependent phosphatases 111-437 2.7e-78 256.2 In-house 5-300 (309) alignment 
Range on Protein: 111-437
Range on HMM: 5-300/309.0
GPHLAFPLSLDQVEKMMEDFKEQKLLHSKYVLMVLRETEKVMKTKKNINRATtaiaKQITVCGDLHGAIEDLFLVFYKNGLPSAeNPYIFNGDYVDRGMH
.|.| ..| |. .....| .. .|||. ...|..| .. ...|. .|. . .      |.|.||.|| ..||  .. |.|.|.. . ..|.||.|||| .
dpllllelilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpd

SVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKTdlTFLDNIARHKYlsVLKP
|.|.  .|... ||.|. |.| |||||...||  |||..|.. ||||..  .|.|....|||| .|..|||..|||.|.    . ||.|.. ..  .| .
slevlllllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl..llldqireler..plei

PLKEgaeeltgeeedlslkidlsewrQILDILWSDPR-SQDGCQPNTfRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNY
|| .                       . |.|||||    .|..||. || | .||.......| |.|.||.||.|.. ..||.. ...|..|||||.||
pldg......................llcdllwsdplpiregfapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapny

YEEGSNRGAYIKFGTDLKPRCFQYQTSA
... .|.||..... ||... .... . 
cgrlgnlgavleidedlvisfllfepvp
0053225 Metallo-dependent phosphatases 121-434 1.4e-73 240.8 In-house 7-289 (293) alignment 
Range on Protein: 121-434
Range on HMM: 7-289/293.0
DQVEKMMEDFKEQKLLHSKYVLMVLRETEKVMKTKKNINRATtaiaKQITVCGDLHGAIEDLFLVFYKNGLPSAeNPYIFNGDYVDRGMHSVEIAIILFC
  .....| .. .|||. ...|..| |. ...|. .|. . .      |.|.||.|| ..||  .. | |.|.. . ..|.||.|||| .|.|.  .|..
llldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlellla

FFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKY-GAQIIGQFQDLFAWLPLATLIDSKILICHGGISdkTDLTFLDNIARHKYlsVLKPPlkegaeel
. ||.|. |.| |||||...||  ||| .|.  || .|..  ...|....|||| ||..|||..|||.|   ||. ||.|.. .   .| .|        
lkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGls..pdlslldqireinr..plrip........

tgeeedlslkidlsEWRQILDILWSDPRSQDGCQPNtFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAY
              ... .||.|||||.  .|. |. .|| | .||.......| |.|.||.||.|.. ||||.. ...|..|||||.||... .|.||.
..............legllldllwsdpdlwsgwlps.yrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgav

IKFGTDLKPRCFQYQ
......|... ... 
laldeglvwgfklfa
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 122-301 1.6e-42 138.6 In-house 10-186 (298) alignment 
Range on Protein: 122-301
Range on HMM: 10-186/298.0
QVEKMMEDFKEQKLLHSKYVLMVLRETEKVMKTKKNInratTAIAKQITVCGDLHGAIEDLFLVFYKNGLPSAENpYIFNGDYVDRGMHSVEIAIILFCF
.... ... |  | .... |  ......|..|..| .      .   |.||||.||   ||. .| |.| |  .| |.| ||||||| ...|. ..|...
vlsvslsekkltkvikeedveklielakkifkkqksl....vevdapikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnlevivlllay

FLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKY-GAQIIGQFQDLFAWLPLATLIDSKILICHGGISDK-TDLTFLDNIAR
 . .||...| |||||  ..|  ||| .|.. .|   ..  .|||.|..|||..|| ..||  |||.|.| . |. | .. |
kvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkr
subfamily_PPP3C_pd Subfamily PPP3C 122-300 5.8e-38 123.8 In-house 27-198 (452) alignment 
Range on Protein: 122-300
Range on HMM: 27-198/452.0
QVEKMMEDFKEQKLLHSKYVLMVLRETEKVMKTKKNINRattaIAKQITVCGDLHGAIEDLFLVFYKNGLPSaENPYIFNGDYVDRGMHSVEIAIILFCF
..| . | |...  |... .| ...|. |..|. |.. .    .   |||.||.||   ||. .|  .| |. .  |.| |||||||..|.|. . |.. 
klevlkehflkegrleeeaalkiieeaakllkkektlle....veaPitviGdihGqfydllklfevgGdPa.stkylflGdyvdrGyfsiecvlylyal

FLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKtdLTFLDNIA
 . .|....| |||||   |   . | .|...||. ..  .. . |  ||||.|.. . | .|||.| .  .. ||.| 
kiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspe..ikslddik
subfamily_PPP2C_pd Subfamily PPP2C 122-299 8.1e-35 113.4 In-house 3-174 (290) alignment 
Range on Protein: 122-299
Range on HMM: 3-174/290.0
QVEKMMEDFKEQKLLHSKYVLMVLRETEKVMKTKKNINRattaIAKQITVCGDLHGAIEDLFLVFyKNGLPSAENPYIFNGDYVDRGMHSVEIAIILFCF
...|..| .|| | |. . |  .  ..........|..     .   .|||||.|| . ||. .| | |  | .  |.| ||||||| .|||   .| ..
dldklieklkeckqleesevkelcekakeilskesnvqe....vkcpvtvcgdvhgqfhdllelf.kiggkspdtnylflgdyvdrgyysvetvtllval

FLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGA-QIIGQFQDLFAWLPLATLIDSKILICHGGISDKTDltFLDNI
 . ... . . |||||   .   |||  |.  |||. ..   | ||| .|||..|.|..|.  |||.| . |   ||.|
kvrykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsid..tldki
subfamily_PPP4C_pd Subfamily PPP4C 123-299 5e-35 114.1 In-house 3-173 (288) alignment 
Range on Protein: 123-299
Range on HMM: 3-173/288.0
VEKMMEDFKEQKLLHSKYVLMVLRETEKVMKTKKNINRattaIAKQITVCGDLHGAIEDLFLVFYKNGlPSAENPYIFNGDYVDRGMHSVEIAIILFCFF
.....|. .. .|.. . |  . .......  . |..|    .   .|||||.|| ..||  .|  .|    |. |.| ||.||||..|||  ..| .. 
ldrqieklrrcelikeeevkalcakareilveesnvqr....vdspvtvcgdihgqfydllelfkvgg.dvpetnylflgdfvdrgfysvetfllllalk

LLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQIIGQ-FQDLFAWLPLATLIDSKILICHGGISDktDLTFLDNI
. .|. ..| |||||   .   ||| .|. .|||.. . .   ..| .|.||..|| ||.. |||.|   ... ||.|
vrypdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglsp..sistldei
subfamily_PPP6C_pd Subfamily PPP6C 125-298 1e-31 103.2 In-house 4-171 (290) alignment 
Range on Protein: 125-298
Range on HMM: 4-171/290.0
KMMEDFKEQKLLHSKYVLMVLRETEKVMKTKKNInratTAIAKQITVCGDLHGAIEDLFLVFYKNGLpSAENPYIFNGDYVDRGMHSVEIAIILFCFFLL
| .|  |. | |  . .  .     ...  . |.     ..   .|||||.|| . ||  .| . |    .. |.| ||.|||| .|.|    |... . 
kwielakkckylpendlkklcdlvldllleesnv....qpvsspvtvcgdihgqfydleelfrtggq.vpdtsyvflgdfvdrgyysletftrlltlkak

FPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQIIGQ-FQDLFAWLPLATLIDSKILICHGGISDKtdLTFLDN
.|... | |||||   .   ||| .| ..|||     . . ..|  |..|..|| ..|  |||.| .  .. ||.
ypdritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspd..vktldq
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 133-425 1.6e-43 142.0 In-house 4-290 (302) alignment 
Range on Protein: 133-425
Range on HMM: 4-290/302.0
QKLLHSKYVLMVLRETEKVMKTKKNInratTAIAKQITVCGDLHGAIEDLFLVFYK----------NGLPSAENPYIFNGDYVDRGMHSVEIAIILFCFF
.| .... .|..... .. .|..|..    . |.  .|. ||.||  |||. .. .               ... ..| ||||||| .|.|   ..|.. 
kkeysksellllieaviellkkektl....aeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalk

LLFPNEVYLNRGNHEDYILNLRYGFLKEVQS----KYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKtdLTFLDNIARhkylsvLKPPLKEGAEE
.|.|..  | |||||   .|  ||| .|...    | | .|  .|.. |...|||.|. .|||  |||||.|  |. |..| .      .| |||| .|.
vlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk..lesledikk......ikrplkevted

LTGeeEDLsLKIDLSEWrQILDILWSDPRsqdgCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGA
     .|| |  |  .  | | .  . |.     . |. ||    |     ..|  . ...|..|.|   | |. |    |.||.|||..| .|  |.||
sla..qdl.lfadpldv.qllaavsekPk....yaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGa

YIKFGTD
 .|  |.
vlkvdtn
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 134-426 1.4e-43 142.2 In-house 4-290 (302) alignment 
Range on Protein: 134-426
Range on HMM: 4-290/302.0
KLLHSKYVLMVLRETEKVMKTKKNInratTAIAKQITVCGDLHGAIEDLFLVFYK----------NGLPSAENPYIFNGDYVDRGMHSVEIAIILFCFFL
| .... .|..... .. .|..|..    . |.  .|. ||.||  |||. .. .               ... ..| ||||||| .|.|   ..|.. .
keysksellllieaviellkkektl....aeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkv

LFPNEVYLNRGNHEDYILNLRYGFLKEVQS----KYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKtdLTFLDNIARhkylsvLKPPLKEGAEEL
|.|..  | |||||   .|  ||| .|..     | | .|  .|.. |...|||.|. .|||  |||||.|  |. |..| .      .| |||| .|. 
lyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk..lesledikk......ikrplkevteds

TGeeEDLsLKIDLSEWrQILDILWSDPRsqdgCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAY
    .|| |  |  .  | | .  . |.     . |. ||    |     ..|  . ...|..|.|   | |. |    |.||.|||..| .|  |.|| 
la..qdl.lfadpldv.qllaavsekPk....yaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGav

IKFGTDL
.|  |. 
lkvdtng
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 134-301 3.2e-37 121.5 In-house 6-175 (284) alignment 
Range on Protein: 134-301
Range on HMM: 6-175/284.0
KLLHSKYVL-MVLRETEKVMKtkKNINRattAIAKQITVCGDLHGAIEDLFLVFYKNGLP-----SAENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPN
|||. | .. . .|  |.  |  .....    |   ....||.||  |||  ..  || |     . |. |.| ||||||| .|.|.  .||.. ||.|.
kllkekelielcyrarelfwk..eklkl...eieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpd

EVYLNRGNHEDYILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISD-KTDLTFLDNIAR
 |.| |||||   .| .||| .| . .|  ..   ||  |  .||......||.  |||||.   ||. ||.. |
kvfllrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldkler
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 135-422 3.9e-49 160.5 In-house 22-281 (297) alignment 
Range on Protein: 135-422
Range on HMM: 22-281/297.0
LLHSKYVLMVLRETEKVMKTKKNINRattaIAKQITVCGDLHGAIEDLFLVFYKNGLPSAENpYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRG
..  . || .|  . .|.|..|..      .   | ||||.|| . ||. .|.. | | . | |.| |||||||  |.|  ..|... . || ...| ||
viteervlklldlaldvfkaqksmve....vnapikvcgdihgqfpdllrlfhrggwpptan.ylflgdyvdrgrfsietivlllaykvkfpgnlfllrg

NHEDYILNLRYGFLKEVQSKYGA-QIIGQFQDLFAWLPLATLIDSKILICHGGISDKTDLTFLDNIARHkylsVLKPplKEGAEELtgeeedlslkidls
|||  ..|  ||| .|.| .| . ..   |||.| ||||. || .|||  |||.|      |  .  |.    . ..  .|| |.|              
nhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrk....iers..tegkerl..............

ewrqILDILWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKF
    . |.||.|| |      .  || |  || |   |. ..  .||. |.|.   |||||  | |..|.|||  |  .  |  |..  
....vadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmsc
PP2Ac_SM00156 137-435 2.2e-91 298.6 In-house 2-269 (271) alignment 
Range on Protein: 137-435
Range on HMM: 2-269/271.0
HSKYVLMVLRETEKVMKTKKNINRATtaiaKQITVCGDLHGAIEDLFLVFYKNGlPSAENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNH
....|| .|.|.....| .||. ...    ...||.||.|| ..||. .. ..| ...|..|.|.|||||||..|.|. ..||.. .|.|..|.|.||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

EDYILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDktDLTFLDNIARHKYlsvlkpplkegaeeltgeeedlslKIDLSEWR
|.  .|  ||| .||. |||..|   |...|..||||.|.|||||. |||.|   .|. ||.|...|.                          .  |. 
EsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp..eleslddirklkr........................vkekpeeg

QILDILWSDP-RSQDGCQPNTfRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDLKPRCFQYQT
...|.||||| ....|.||.. || . .||.|..|..| |. ..|.||.||....|||| .  |..|.|||.||..| || .|..|. ..||.. .|.. 
llidllwsdpeqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_PPP1C_pd Subfamily PPP1C 137-427 3.1e-64 209.9 In-house 11-270 (282) alignment 
Range on Protein: 137-427
Range on HMM: 11-270/282.0
HSKYVLMVLRETEKVMKTKKNInratTAIAKQITVCGDLHGAIEDLFLVFYKNGLPSAENpYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNH
... . ..|..........  .      . . ....||.||  .||  .| ..| |...| |.| ||||||| .|.|. ..|... . .|....| ||||
keaeieallkkareillsqpil....leleaPvkivgdihGqyadllrlfetsgaPpesn.ylflGdyvdrGkqsletivlllaykikypenlfllrGnh

EDYILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGisdktdltfldniarhkylsvlkppLKEGAEELTgEEEDLSLKIDLSEWR
|.. .|  |||  |.. .|....  .|.| |..||||.|.|.||| .|||                         | .  ..|  . ....  ....|  
esasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGG.........................lspelksle.qirkiqrPlevpekg

QILDILWSDPRSQD-GCQPNTfRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDLK
 . |.||||| ..  | . |. ||    ||.|| .|.|.|. .||..|.|..  |||||    ...|||||.|| .|  | || ..  ..|.
llcdllWsdpdkevlgwsend.rGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeell
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 138-292 1.7e-35 115.5 In-house 18-167 (290) alignment 
Range on Protein: 138-292
Range on HMM: 18-167/290.0
SKYVLMVLRETEKVMKTKKninrATTAIAKQITVCGDLHGAIEDLFLVFYKNGLPSaENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHE
 | .| .|.. |....       |   . . |.. ||.|| ...|.  | . | |  .  ..| ||||||| .|.|....|||. ......|.| |||||
dkdileilekieeileplp....alleveapivivgdihgqldallryfdavgypp.kvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

DYILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKTD
   .|  ||| .|.  | |...  |.||.|| |.| . .. |||  |||||.| .
vrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkie
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 139-426 4.1e-57 186.3 In-house 13-272 (287) alignment 
Range on Protein: 139-426
Range on HMM: 13-272/287.0
KYVLMVLRETEKVMKTkknINrATTAIAKQITVCGDLHGAIEDLFLVFYKNGLPSaENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHED
| .| ||...|....    .. |   . . ||..||.|| ..||. .| . | .. .  |.| ||||||| .|.|....||.. ...|..|.| ||||| 
kdilevlekieeilep...lp.alleveapitivGdihGqlddllrifnavGaap.kvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

YILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKTDltFLDNIArhkylSVLKPplkegaeeltgeeedlSLKIDLSEwRQI
  .|  ||| .|.. |.. ..  ||.|.|. ||| . .. .||  |||||.| .   ||..      .. ||                . ...  |   .
kkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklk..sldslk.....alkkp................ttplacde.glq

LDILWSDPR-SQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDL
.|.||.||   ... ..|  |.  . ||  .  ..| | .|||..|.|| . .||.|    ...|||||. |  | .| || ..    |
vdllwadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvsksl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 140-300 1.1e-27 90.2 In-house 10-166 (280) alignment 
Range on Protein: 140-300
Range on HMM: 10-166/280.0
YVLMVLRETEKVMKTKKNINRATTAiakqITVCGDLHGAIEDLFLVFYKNGLpSAENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDY
 .. ..|  | ..  . |.  | .     | | ||.|   .|.  .|   |    |.  .| ||||||| . .|. |.|||. . . . .|| |||||  
eiiaiirmveaifmeesnlceaeap....ikvigdihaqyqdmnrlfdligr.vpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetp

ILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDK-TDLTFLDNIA
 .|  |||  |.| |||  .  .||  |  .|.. ||  ..|. |||.| .  .|  . || 
svnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirnip
PPP_3 142-434 3.8e-92 301.1 In-house 4-270 (271) alignment 
Range on Protein: 142-434
Range on HMM: 4-270/271.0
LMVLRETEKVMKTKKNINRATTAIAKQITVCGDLHGAIEDLfLVFYKNGLPSAENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYIL
  .|.|. | .|   . .. .. | ...|||||.||  .|| | ..|||.||.|. |.|.||||||| .|.|. ..|... ...|.||.|.|||||.  .
enelkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

NLRYGFLKEVQ-SKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKTDLTFLDNIARHKYLSVLKPPLKEGAeeltgeeedlslkidlsewrqild
| .||| |||. .|.|...  ..|..|..||||.|||.|.|..|||.|......  ..  ..|  .. . .| .                          
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll........................

ilWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDLKPRCFQYQ
  .|........  |. || | .||||||...| |. ..|.||.||.|..|||..|  ||.|||||.||.|..||.||..|....|...  |..
..lssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
PPP_1 143-421 7.1e-95 310.2 In-house 4-263 (264) alignment 
Range on Protein: 143-421
Range on HMM: 4-263/264.0
MVLRETEKVMKTKKNINRATTAIAKQITVCGDLHGAIEDLfLVFYKNGLPSAENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILN
 .|.|. | .|.  |... .. . ..||||||.||  .|| | ..|.|.||.|. |.|.||||||| .|||| ..|....| .|.|..|.|||||.  ..
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

LRYGFLKEVQ-SKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKTDLTFLDNIARHKYLSVLKPPLKEGAEELtgeeedlslkidlsewrqiLDI
 .||| |||.  ||...|   ..|.|..||||.||| ||||.|||.|...||.  ... |.|  .. . .|..  |.                     ||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekd...................vdi

LWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIK
|.||...|... .|. ||.| .||.|||.|.| |....|.||.||.|..||||.. .||.|.||||||||||||||||.|
llsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 143-302 4.3e-35 114.3 In-house 15-167 (281) alignment 
Range on Protein: 143-302
Range on HMM: 15-167/281.0
MVLRETEKVMKTKKNInratTAIAKQITVCGDLHGAIEDLFLVFYKNGLPSaENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILN
 |.||.| ..  .|..    . | | |.| ||||.  .||  .|   | .. |. ..| |||||||..|.|. |.||.. . ......| |||||   .|
nvireveaifseekaL....veidkPivvvGdlhaqfndlkrlfellgrvp.eevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

LRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISdkTDLTFLDNIARH
 .||| .| . ||| ..  .||  |  ||...||. ..|. |||.|   .|| ||..  .
kiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGls..Peltaldelrnr
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 144-301 8.2e-35 113.3 In-house 14-167 (280) alignment 
Range on Protein: 144-301
Range on HMM: 14-167/280.0
VLRETEKVMKTKKNInratTAIAKQITVCGDLHGAIEDLFLVFYKNGLPSAENpYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNL
|... .|...... .      .   ..|||||||   ||. .| . ..|  .| |.| ||||||| . .|. ..|... . .||. .. |||||   .| 
viekckkiltaqatm....vevdapvavcgdlhgqytdllrlfarvsfppdqn.ylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinr

RYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKT-DLTFLDNIAR
.|||  ||. .|  ..  .||.|.  |||..|.  .||  |||.|.|   |. | .. |
kygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrr
subfamily_PPG1_pd Subfamily PPG1 159-291 6e-30 97.5 In-house 33-166 (300) alignment 
Range on Protein: 159-291
Range on HMM: 33-166/300.0
NRATTAIAKQITVCGDLHGAIEDLFLVFyKNGLPSAENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKY-G-
.     |   .|| ||.|| . |.. .| | | .  .  |.| |||||||..|||  ..| .. | .|  . | |||||   .   |||  |.  || | 
esnvieirspvtvvgdvhgqfydvleif.kiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggn

AQIIGQFQDLFAWLPLATLIDSKILICHGGISDKT
...   . ..| .| ||..|| .|   |||.| ..
srvwkylteifdylvlaaiideeiycvhgglspsv
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 159-303 4.8e-28 91.2 In-house 39-183 (307) alignment 
Range on Protein: 159-303
Range on HMM: 39-183/307.0
NRATTAIAKQITVCGDLHGAIEDLFLVFYKNGLPSaENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQ---SKY
..|   |     | ||||| ..||  .|   | |  |  |.| |||||||. |.|. ..||.. . .|... | |||||   .| .||| .|.     | 
ekalvdidppcvvvgdlhgqfndlinmfillgrpp.etvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkc

GAQIIGQFQDLFAWLPLATLIDSKILICHGGISDktDLTFLDNIARHK
| .|   ||  |  ||...|| .|||  |||.|    || ||..  | 
geeiwalfqrcfnnlpisaliatkilcmhgglsp..altcldelrnhp
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 163-299 2.3e-35 115.3 In-house 47-184 (299) alignment 
Range on Protein: 163-299
Range on HMM: 47-184/299.0
TAIAKQITVCGDLHGAIEDLFLVFYKNGLPSAENpYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGA-QIIG
  .   | ||||.||   ||. .| |.|.|   | ..| |||||||   .|. ..|.|| . .|.. .. |||||   .|  ||| .|.. .| . ..  
leveapiivcgdihgqysdllrifdkagfppdvn.flflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlws

QFQDLFAWLPLATLIDSKILICHGGISDKtdLTFLDN---I
 ||| ||..||. || |.||  |||.| |  |. ||.   .
ifqdafaampltgligsrilcmhgglspk..lqtldqlrdl
subfamily_PPZ_pd Subfamily PPZ 164-299 3.7e-28 91.9 In-house 49-181 (300) alignment 
Range on Protein: 164-299
Range on HMM: 49-181/300.0
AIAKQITVCGDLHGAIEDLFLVFYKNGLPSAENpYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQIIGQF
 .. .. . ||.||   ||. .| | |.| . | |.| ||||||| .|.|  ..|.|. . .|....| |||||   .   |||  |.. .   .|   |
elspsvkivgdvhgqyadllrlftkcgfppsan.ylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktf

QDLFAWLPLATLIDSKILICHGGISDKtdLTFLDNI
 | |  ||||...  ||.  |||.|    |  .|.|
vdtfntlplaaivagkifcvhgglspv..lnsmdei
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 165-290 1.1e-33 109.8 In-house 28-153 (284) alignment 
Range on Protein: 165-290
Range on HMM: 28-153/284.0
IAKQITVCGDLHGAIEDLFLVFYKNGLPSAENpYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGA-QIIGQF
.   | .|||.|| . ||. .| |||.|   | |.| ||||||| | .|  ..||.. ..||| ... |||||  ..|  ||| .|.| .|    .   |
vnspinicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrrynkpsvyvsf

QDLFAWLPLATLIDSKILICHGGISDK
. .|. .||..|.  .||  |||.|  
egvfsvmpltalvgqrilcmhggvskm
subfamily_PPPLV_pd Subfamily PPPLV 167-420 8.6e-38 123.3 In-house 24-273 (290) alignment 
Range on Protein: 167-420
Range on HMM: 24-273/290.0
KQITVCGDLHGAIEDLFL---VFYKNGLPSAENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQI---I
  . | |||||  .||     |... |   .   ..| ||||||| .|||.   |.   .|.|  |.| |||||   .   . .  | . |.| ..    
sptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevw

GQFQDLFAWLPLATLIDSKILICHGGISDKTdLTFLDNIARHKYLSVLKpplkegaeeltgeeedlsLKIDLSEwrQILDILWSDPR------------S
. |.. | .||||. || |.. .|.||   .  |     | .. |  ||                   .|| .     ||||||||              
eafnnvfdalplaavidrkvfcvhagiprai.mtqayisaiqdilerlk..................ddidgap..laldilwsdpaedrdlslrgelvl

QDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYeEGSNRGAYI
..|  .|  || |  |. |  .. | . ... ..|.|| |  |... .. ..|||||.|.|   .||  | |
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssryc.Gssneaali
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 167-299 2.8e-26 85.7 In-house 7-141 (263) alignment 
Range on Protein: 167-299
Range on HMM: 7-141/263.0
KQITVCGDLHGAIEDLFLVFYKNGLpSAENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGA-----QIIG
  | .||| ||  .||. .|   |  ...  |.| ||||||| ||.|. ..|| . | .| ...| |||||   .|  |||  |.. ..        .  
apinicgdthgqyndllrifnacga.atktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvyn

QFQDLFAWLPLATLIDSKILICHGGISDKtdLTFLDNI
.|...|...||....  .||  ||||| .  |  ||.|
hfnqvfsymplcaivskrilcmhggisph..lkslddi
PPP_2 169-388 5.8e-70 228.0 In-house 1-198 (198) alignment 
Range on Protein: 169-388
Range on HMM: 1-198/198.0
ITVCGDLHGAIEDLfLVFYKNGLPSAENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQ-SKYGAQIIGQFQDLF
.||||||||  .|| | ..||||||.|. |.|.||||||| .|.|. ..|... | .|.||.|.|||||.  .| .||| |||. .|.|...  ..|..|
vtvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevf

AWLPLATLIDSKILICHGGISDKTDLTFLDNIARHKYLSVLKPPLKEGAEE-LtgeeedlslkidlsewrqildilWSDPRSQDGCQPNTFRGGGSYFGP
..||||.|||.|.|..|||.|....|.  ..  ..|  |. . .|..  ||                         .|||......  |. ||.| .|||
elLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeek.......................lsdpkekeellansarGagllfgp

DVTKKVLAKHGIDLLIRSHECK
|||...| |. ..|.||.||.|
dvteelleknklkliiRaHevk
PPP_5_Dcr2 169-388 6.3e-69 224.9 In-house 1-199 (199) alignment 
Range on Protein: 169-388
Range on HMM: 1-199/199.0
ITVCGDLHGAIEDLFLVFYKNG-LPSAENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSK-YGAQIIGQFQDL
.|||||||| ..||.| ..|.| .|| |. |.|.||||||| .|.|. ..|... |..|.||.|.||||||  ||..|||.|||.|| .|..|   ..|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FAWLPLATLIDSKILICHGGISDKTDL-TFLDNIARhKYLSvlkpplKEgaeeL-------TgeeedlslkidlsewrqildiLWSDPR-SQDGCQPNTF
| |||||.|||.|.|..|||.|..... . |..|.| |. .      .|            .                     |||||| .|.||. |. 
fdwlPlaalidekvlvvhgglspeiksiellekier.kiei......pe....ekgekadll.....................lwsdprdaqegcklnse

RGGGSYFGPDVTKKVLAKHGIDLLIRSHECK
||.| .||||||.|.| |....|.|||||.|
RGagllfgpdvtekfleknnlkliirshelk
PPP_4 169-388 1e-68 224.3 In-house 1-197 (197) alignment 
Range on Protein: 169-388
Range on HMM: 1-197/197.0
ITVCGDLHGAIEDLFLVFYKNG-LPSAENPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQIIGQFQDLF
.||.||.|| ..||.| ..||| ||| |. |.|.||||||| .|.|. ..|... | .|.||.|.|||||.  |||.||| |||..|.|..|  ..||.|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

AWLPLATLIDSKILICHGGISDKTDLtfLDNIARHKYL--SvlkpplkegaeE--------LTgeeedlslkidlsewrqildiLWSDPR-SQDGcQPNT
..||||.|||.|.|..|||.||...   ||.| |..    |           .        |                      |||||| .|.|   |.
dllplaalidekvlvvhgglsdeles..ldkierierkies...........pleeekrkdll.....................lwsdpreaqeg.lans

FRGGGSYFGPDVTKKVLAKHGIDLLIRSHECK
 ||.| .||||||.|.| |....|.|||||.|
vrGagllFgpdvtekfleknnlkliirshelk
Metallophos Calcineurin-like phosphoesterase 169-389 2.1e-39 128.9 Pfam-A 3-200 (200) alignment 
Range on Protein: 169-389
Range on HMM: 3-200/200.0
ITVCGDLHGAIEDL---FLVFYKNGLPSAENPYIFNGDYVDRGMHSVEIAIIL--FCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQ-----------
|.|.|||||  .||   .| ..|.. ..  ....|.||.|||| .| |.  .|  .. .||.|. |.|.|||||.. .| .||||.|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------SKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKTDLTFLDniarhkylsvlkpplkegaeeltgeeedlslk
                        ..|  .  .... |..|||..|.| |||..||..|. ....                                   
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

idlsewrqildilwsdprsqdgcqpntfrgGGSYFGPDVTKKVLAKHGIDLLIRSHECKP
                              |. .||||.. | | |.|.||..|.|..||
..............................gselfgpdalekllekygvdlvlrGHtHkp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 196-301 4e-31 101.3 In-house 101-207 (317) alignment 
Range on Protein: 196-301
Range on HMM: 101-207/317.0
NPYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDK-TDLT
. |.| ||||||| .|.|. |.||.. ||.|. |.| |||||   .| .||| .||. .| |..   ||  |  |||......|||  |||||.. .||.
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

FLDNIAR
 ||.. |
qldklkr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 197-427 5.8e-38 123.8 In-house 121-325 (339) alignment 
Range on Protein: 197-427
Range on HMM: 121-325/339.0
PYIFNGDYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQIIGQFQDLFAWLPLATLIDSKILICHGGISDKtdLTFL
 |.| |||||||  |.|. |.| .. | .|. .|| |||||   .|  ||| .||. .| ||.   ||..|  .|....|.  |.  |||||..  || .
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggiseh..ltsf

dniarhKYLSVLKPPLkegaeeltgEEEDLSLkidlsewrqILDILWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTH
      . .||.| ||         |  |. .         . |. |.||   .     . ||    |||   . .| |  ....|| |.   |||||  
......nqfsvfkrpl.........eipdvgv.........ltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffd

GDKVLTVFSASNYYEEGSNRGAYIKFGTDLK
| ...|.||| ||  .  |  | .     ||
grrlvtifsapnycgqndntaavfsidkklk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 326-427 8e-16 51.3 In-house 173-274 (284) alignment 
Range on Protein: 326-427
Range on HMM: 173-274/284.0
LSLKIDLSEWRQILDILWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTD
|.  ||...   | |. |.|| ..     .. || |  ||..  |. | |. .||..|.|.   |||||    |..|.|||  |  .  | .| ..  ..
lerpidipdigviadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdee

LK
| 
lv
subfamily_PPZ_pd Subfamily PPZ 328-422 2.5e-13 43.2 In-house 186-280 (300) alignment 
Range on Protein: 328-422
Range on HMM: 186-280/300.0
LKIDLSEWRQILDILWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKF
   |. ..  | |.|||||        .  ||    .     .|.| | |.||. |.|    |||||     ..||||| ||  |  | || .  
rptdvpdfglindllwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 330-427 2.2e-17 56.2 In-house 209-306 (317) alignment 
Range on Protein: 330-427
Range on HMM: 209-306/317.0
IDLSEWRQILDILWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDLK
.|...   . |. |.|| ..     .. || |  ||..  |. | |. .||..|.|.   |||||  . |..|.||| .|  .  | .| ..  ..||
ldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavlsvdkklk
subfamily_PPP4C_pd Subfamily PPP4C 332-429 4e-16 52.1 In-house 182-278 (288) alignment 
Range on Protein: 332-429
Range on HMM: 182-278/288.0
LSEWRQILDILWSDPRSQDGCQpNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDLKPR
. .  .. |.|||||. ..|    . || |  || ||...  .. .|.|..|.|.   .|| .   .|||||.|| ||     |  | ...  .|. .
vphegplcdllwsdpedaegwa.vsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkd
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 336-426 3.6e-19 61.9 In-house 194-284 (298) alignment 
Range on Protein: 336-426
Range on HMM: 194-284/298.0
RQILDILWSDPRS-QDGCQPNTfRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDL
.   |.||.|| . . | ..|. || .  || || |..| |  |||..|.|    |||||  . |..|.||| .| ..  |  | .|   .|
slaidllwadpenavkgwaens.rGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdekl
subfamily_PPP6C_pd Subfamily PPP6C 336-429 2.5e-13 42.8 In-house 185-277 (290) alignment 
Range on Protein: 336-429
Range on HMM: 185-277/290.0
RQILDILWSDPRSQDGCQPnTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDLKPR
  . |..||||   .  .  . || |  ||  |||. ..   ..|..|.|.   .|...   .|. ||.|| ||     |  . ... .. . .
gafcdlvwsdpedvetwav.sprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeere
subfamily_PPP5C_pd Subfamily PPP5C 337-436 2.6e-28 92.0 In-house 210-309 (322) alignment 
Range on Protein: 337-436
Range on HMM: 210-309/322.0
QILDILWSDPRSQDGCQPNTfRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKF-GTDLKPRCFQYQT
.....|||||... | .| . || | .|||||||| | . ...|.||||| | .|||..|  |..||||| || .. .|.||.|.. |.|||..  ....
llvellwsdpqeanGrspsk.rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfea

S
 
v
subfamily_PPP2C_pd Subfamily PPP2C 338-438 2.5e-17 56.0 In-house 189-288 (290) alignment 
Range on Protein: 338-438
Range on HMM: 189-288/290.0
ILDILWSDPRSQDGCQpNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDLKPRCFQYQTSA
. |.|||||  ..| .  . || |  || |...|   . |. |..|.|.   .||...|  .| |.||| ||     |..| ...  .|| .  |.....
lcdllwsdpddrggwg.isprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpap

K
.
r
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 338-425 3.2e-16 52.2 In-house 189-278 (290) alignment 
Range on Protein: 338-425
Range on HMM: 189-278/290.0
ILDILWSDPRS--QDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTD
..|.||.||    .|  . |  |.    || ..  ..| | ...|..|.|| | .|..|   .|..|||||  |  . .| || ..    
qvdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvses
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 338-439 7e-16 51.3 In-house 196-297 (299) alignment 
Range on Protein: 338-439
Range on HMM: 196-297/299.0
ILDILWSDPR-SQDGCQPNTfRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDLKPRCFQYQTS
 .|.||.||  |  . ..|. ||    ||.|| ..|. . .|||. |.|.   |||||    |..|.|||  |  .  |  | .|   .|      .. .
gidllwadpdqsvkdwlanv.rgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt

AKN
.|.
pks
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 338-427 1.8e-15 49.9 In-house 179-268 (281) alignment 
Range on Protein: 338-427
Range on HMM: 179-268/281.0
ILDILWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDLK
. |.||.|| ..     .. || .  || .| ..|  . ...|.||.|    ||||   | |..||||. || .   | .| .|   .|.
viDllwadpdnkveewkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlg
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 338-420 1.5e-14 47.1 In-house 176-258 (284) alignment 
Range on Protein: 338-420
Range on HMM: 176-258/284.0
ILDILWSDPRS-QDGCQPNTfRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYI
 .|||||||   | | .||. ||    || |  .|.| .  |||..|.|.   |||||    ...|.|||  |  .  |  | .
aidilwsdptnfqkgwnpns.rgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavm
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 338-426 5.7e-13 42.0 In-house 177-265 (280) alignment 
Range on Protein: 338-426
Range on HMM: 177-265/280.0
ILDILWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDL
..|.|||||  .      . ||    ||  | ..      |||.||.|.   ||||.  | ...||||  ||  . .|  | . . ..|
lidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanl
subfamily_PPP3C_pd Subfamily PPP3C 338-426 4.4e-11 35.2 In-house 212-313 (452) alignment 
Range on Protein: 338-426
Range on HMM: 212-313/452.0
ILDILWSDPR-------SQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHG------DKVLTVFSASNYYEEGSNRGAYIKFGT
. |.|||||        ...  .||. ||   ...   . . | |  .  .||.||.. .||.  .         ..|.|||.|| .  .|..| .|. .
lcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen

DL
. 
nv
subfamily_PPG1_pd Subfamily PPG1 338-423 4.9e-10 32.1 In-house 187-283 (300) alignment 
Range on Protein: 338-423
Range on HMM: 187-283/300.0
ILDILWSDPR----------SQDG-CQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFG
. |.|||||            ..|    .. || |  .| ||..| | .  .. .||.|.   .||.    .|. ||.|| || .   |. . ..  
ladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilely
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 339-423 2e-16 53.0 In-house 178-262 (280) alignment 
Range on Protein: 339-423
Range on HMM: 178-262/280.0
LDILWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFG
 |.||.|| ..     .. ||    || .| |..  |  |||..| |.   |||||  . |..||||| .| .| .|  | ..  
mdllwadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivd
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 339-443 3.8e-12 39.0 In-house 195-299 (307) alignment 
Range on Protein: 339-443
Range on HMM: 195-299/307.0
LDILWSDPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAYIKFGTDLKPRCFQYQTSAK
 |.||.||         . || |  || .|   |  . |..|.||.|.   |||    | |..|.|||  | .   | |. .|    |  .   .  ...
ndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpese

NTKKM
| .|.
nieki
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 339-419 4.1e-10 32.7 In-house 158-239 (263) alignment 
Range on Protein: 339-419
Range on HMM: 158-239/263.0
LDILWSDPRS-QDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASNYYEEGSNRGAY
 |.||.||     | .||  |     ||      .  .  |||..|.|.    || |    ...|||||| |  |  |  | 
cdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaav
EF-hand_8 EF-hand domain pair 596-622 1.1e-06 17.4 Pfam-A 24-50 (54) alignment 
Range on Protein: 596-622
Range on HMM: 24-50/54.0
KNALETIFRVMDKDHSGCISMEEFQDA
.. ....||..| |..| || ||| ..
eeevdilfrefDtdgdGkisfeEFcvl
EF-hand_7 EF-hand domain pair 599-663 1.2e-15 47.3 Pfam-A 2-66 (66) alignment 
Range on Protein: 599-663
Range on HMM: 2-66/66.0
LETIFRVMDKDHSGCISMEEFQDACQLLSKHIGsnipPETVKDM----AQSIDINKDGNIDFNEFLEAF
|...|. .|||..| ...||.. ... |. ..     .|.|...     . || |.|| ..|.|||.|.
lkeaFkllDkdgdgyldkeeLlrllkhlgspli....deevrevldyifkeiDkngdGvlsfeEflqai
EF-hand_1 EF hand 599-624 2.2e-09 25.9 Pfam-A 2-27 (29) alignment 
Range on Protein: 599-624
Range on HMM: 2-27/29.0
LETIFRVMDKDHSGCISMEEFQDACQ
|. .|...|||..| || |||..|..
lkeaFkefDkDgdGkIsfeEfkealk
EF-hand_6 EF-hand domain 599-624 5.8e-08 22.1 Pfam-A 2-27 (31) alignment 
Range on Protein: 599-624
Range on HMM: 2-27/31.0
LETIFRVMDKDHSGCISMEEFQDACQ
|. .|. .|||..|.|. ||...|..
lreaFklfDkdgdGkidaeELrkaLr
EF-hand_5 EF hand 600-620 2.1e-06 16.2 Pfam-A 2-22 (25) alignment 
Range on Protein: 600-620
Range on HMM: 2-22/25.0
ETIFRVMDKDHSGCISMEEFQ
. .||..||. .| ||.||..
kdtFrafDkNgDGkIsreELk
EF-hand_8 EF-hand domain pair 610-663 2.8e-11 32.1 Pfam-A 1-51 (54) alignment 
Range on Protein: 610-663
Range on HMM: 1-51/54.0
HSGCISMEEFQDACQLLskHIGSnIPPETVKDMAQSIDINKDGNIDFNEFLEAF
..|.|..||...| .||  .... . .|.| ..   .|...|| |.|.||....
ekGlItreeLkralall..glkg.lseeevdilfrefDtdgdGkisfeEFcvll
EF-hand_1 EF hand 639-664 2e-08 22.9 Pfam-A 2-27 (29) alignment 
Range on Protein: 639-664
Range on HMM: 2-27/29.0
VKDMAQSIDINKDGNIDFNEFLEAFR
.|.. . .| ..|| |.|.||.||..
lkeaFkefDkDgdGkIsfeEfkealk
EF-hand_5 EF hand 645-660 8e-06 14.4 Pfam-A 7-22 (25) alignment 
Range on Protein: 645-660
Range on HMM: 7-22/25.0
SIDINKDGNIDFNEFL
 .| |.|| |.. |. 
afDkNgDGkIsreELk