Gene ACP2-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily ACP2
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP172_AA protein Get Run
SpurP172_AA_7-456 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0048946 Phosphoglycerate mutase-like 8-295 5.9e-50 163.4 In-house 6-304 (447) alignment 
Range on Protein: 8-295
Range on HMM: 6-304/447.0
QFLKMWSMLlLFFACFSSFLSISS--------CERTIKLVNLLFRHGDRSPTNGY--------------------------PNDNYTEDTW---PQGFGQ
........| |.....| . |...        .. ..|.| .|||||.|.||..|                          ....|. . .   | |.||
aladgfnil.lhlgtlspyfsvpgygipepvpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwpcglgq

LTESGMAQQYELGQWLRKRYvtdLKLFDgiyRPKQFYVHSSPKERTIMSAQSNLQGFFPAEsgggkpssGTPPWPPVPVFTVAEEQDYLLSGskiqNCDT
||. |. |.||||..|||||   |.|..    |...|| ||...||..|||..|.|.|| |        .  .. |.|..||.. .|.||      .|. 
LTplGreqlyelGkrlrkrY...lgllp...npseiyvrssdvdRtlqSaqaflaGlfppe........pplgyqpipihtvpssndnlllp....sCpa

VRdffqyaenSPAEQQYIKDNQIFFDRVHER----AGfSGDVIFENFYHLGDTLIRER--KEGRNLPEWADDETFNRLKATQDYAFEAEFSNMTtDEKRI
          .   . . . ........ ||    .|   .. ....| | |.|  |.      .|... ..| ...|.. .|. |  |...   .  |.
fk........ellkkelaeelkellkellerlkkllg.glnltlsdvydlydlllyetaihglsplcslftpeelevleyladlefyyeygygd.elarl

TSGVLIAAMVANMKAHLNRTNndsRIFMYSG
..|.|. ...|....... ..   ....|..
aggpllneilarledaisgds...klylyfa
0047369 Phosphoglycerate mutase-like 10-295 1.6e-49 162.2 In-house 16-331 (438) alignment 
Range on Protein: 10-295
Range on HMM: 16-331/438.0
LKMWSMLLLFFACFSSFLsISS---CERTIKLVNLLFRHGDRSP-----------------TNGYPNDNYTEDT---WPQGFGQLTESGMAQQYELGQWL
|.....| ..|.... .| ||     . ..|.| .|||||.|.|                 ...||....   .   .|.|.||||. |..|.||||..|
llhlgtlspyfsapgvgl.isldvpegcelkqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrl

RKRYvtdlKLFdgiyRPKQF-YVHSSPKERTIMSAQSNLQGFFPAESGGGKPSsgtPPWPPVPVFTVAEEQDYLLSGSKIQNCDTVRDFFQYAENSPAEQ
||||    .|.     |... || ||...||..|||..|.|.|| |. |  .    . | |.|. |..|..|.||..   ..|. ... ..   .|.  .
rkrY....glL....npedvlyvrssdvdRtlqSAqaflaGlfppegtgelap...ilwqpipihtipesddfllnllpsdscpafdellkeflasdefl

QY-IKDNQIFFDRVHERAGFSGDVIFENFYHLG-DTLIRERKEGRNLP--EWADDETFNRLKATQDYAFEAEFSNmTTDEKRITSGVLIAAMVANMKAHL
.   || . .. .. .  ... . ..  ....  |||...  .. ..|  .. ..| .. |.. .|. |  .. . . . .....|.|. ...|......
elllkdilkrlkkllpglnltpsdvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygy.gnelaklaggpllneilarledai

NRTNN---------------DSRIFMYSG
| ...               | ....|..
ngkstnlnltldsngvtfPldlklylyfa
0049059 Phosphoglycerate mutase-like 12-295 3e-54 177.6 In-house 17-329 (435) alignment 
Range on Protein: 12-295
Range on HMM: 17-329/435.0
MWSMLLLFFACFSsFLSISS---CERTIKLVNLLFRHGDRSPTN-----------------GYPNDNYTEDTW---PQGFGQLTESGMAQQYELGQWLRK
.. .|...|. .. . .||.   .. ..|.| .|||||.|.||.                  |||..... ..   |.|.|.||. |. |.||||..|||
llgtlspyfsapg.vfgisldvpegcelkqvqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrk

RYvTDLklfdgiYRPKQFYVHSSPKERTIMSAQSNLQGFFPAESGGGKPSSGTPPWPPVPVFTVAEEQDYLlsgsKIQNCDTVRDFFQYAENSPAEQQY-
||  .|      |.|...|| ||...||..|||..|.|.|| |. | .  ...... |||. || . .|.|      ..|.   ....   .|.  ..  
rY.gfL......ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl....pydscpafdellkellasdeflelf

IKDNQIFFDRVHERAGFS-GDVIFENFYHLGDTLIRERKEGRNLP--EWADDETFNRLKATQDYAFEAEFsNMTTDEKRITSGVLIAAMVANMKAHLNRT
 .... ..... .. |..  ||   ..... |||.... .|..||  .. ..| ...|.. .|. |  .. . . .  ....|.|. ...|......| .
lerilkllqellpglgltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyladlefyyly.gygdeiaklaggpllneilarledaingd

NN---------------DSRIFMYSG
.                | ....|..
stnlnltldsnpatfpldlklylyfa
subfamily_ACP2_pd Subfamily ACP2 29-296 8.8e-105 343.2 In-house 2-270 (361) alignment 
Range on Protein: 29-296
Range on HMM: 2-270/361.0
ISSCERTIKLVNLLFRHGDRSPTNGYPNDNYTEDTWPQGFGQLTESGMAQQYELGQWLRKRYVTDLKLFDGIYRPKQFYVHSSPKERTIMSAQSNLQGFF
.||.||..|.|..|||||||||.| ||||.|.||.||||.|||||.||.||||||..||||||.|.|..|. |.|||.||.||...||.|||||.|.|.|
ksseerkLkfvqvlfRHGdRsPlntypndkykedewpqglGqLTeeGmqqqyeLGkfLrkrYvedtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglf

PAesGGGKPSSGTPPWPPVPVFTVAEEQDYLLSgsKIQNCDTVRDFFQYAENSPAEQQYIKDNQIFFDRVHERAGfsGDVIFENFYHLGDTLIRERK-EG
|.  ..|.... ...|.||||.||.||.|.||.  ...||.......|.|..||. ......|........|..|   |. .||||.| ||||.||| ..
pp..etgvdypdeqeWqpvPvhtvseeedlllr..akknCprydellqeakespevkklleenkelleklsestg..edidlenfyqlsdtlicerkyan

-RNLPEWADDETFNRLKATQDYAFEAEFS---NMTTDEKRITSGVLIAAMVANMKAHLNRTNND--SRIFMYSGR
 .||||||.||.|..|....|...||||.   ..|.. |....|.|......|||..|......  ...|.||. 
elnlpewandelfekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkceekkkklklflYSaH
0048439 Phosphoglycerate mutase-like 34-295 3.2e-49 161.3 In-house 7-288 (391) alignment 
Range on Protein: 34-295
Range on HMM: 7-288/391.0
RTIKLVNLLFRHGDRSPTNGYPN--DNYTEDTW---PQGFGQLTESGMAQQYELGQWLRKRYVTdLKLFDGIY--RPKQFYVHSSPKERTIMSAQSNLQG
 ..|.| .|||||.|.||..|||  |.... ..   | |.|.||. |. |.||||..||||||  |.|..  |   |...||.||...||..|||..|.|
celkqvqvlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvd.lgllpskytlnpsevyvrssdvdRtlqSAqaflaG

FFPAESGGGKPSSG----TPPWPPVPVFTVAEEQDYLlSGSKIQNCDTV------RDFFQYAENSPAEQQYIKDNQIFFDRVHERAGFSGD-----VIFE
.|| ...            | . |.|. |.   .|.|   . .. .. .      . .... .  .  ... .|.. .||.        |        . 
lfpplgltvilvivvesedpllnplpintcplledll.lldalsalprfylseilerlaevlnrvlglnltaedvlslfdlcaketaalgsllklssplc

NFYHLGDTLIRERKEGRNLPEWADDETFNR--LKATQDYAFEAEFSNMTTDE-KRITSGVLIAAMVANMkahLNRTNNDSRIFMYSG
....| |||. |  .|..||||. ||...   ||.  |.. | .. .  ..|  ....|.|. ......    .. ..| ....|..
dlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsgeiaklaggpllneilddl...vangpsdpklylyfa
0053031 Phosphoglycerate mutase-like 35-295 8.4e-55 179.4 In-house 2-256 (342) alignment 
Range on Protein: 35-295
Range on HMM: 2-256/342.0
TIKLVNLLFRHGDRSPTNGYPNDNYTEDTWPQGFGQLTESGMAQQYELGQWLRKRYvtdLKLFDGIYRPKQFYVHSSPKERTIMSAQSNLQGFFPAESGG
..|.| .|.|||.|.|.. .|.| . | ..| |.|.||. |..|.||||..|||||   |.|....|.|...||.||...||..|||. |.|.|| |...
eLkqvivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrY...lgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtp

GKPSsgTPPWPPVPVFTVAEEQDYLLSGsKIQNCDTVRDFFQYAENSPAEQQYIKDNQIFFDRVHERAGFSGDVIFENFYHLGDTLIRERKEGRNLPEWA
  .   . .| |.|..|..| .|.||..   ..|... .... | .|.  ...... . ..... .. |.. .  . ....| |.|. |   |. ||.| 
ilnp..llgwqpipihtepessdalllp.nydpcpafdkllkealaseevkellerylellqklskglgltlsdlldlvsdlydlllyelahglplppwc

DDETFNRLKATQDYAFEAEF-SNMTTDEKRITSGVLIAAMVANMKAHLNRtNNDSRIFMYSG
...|...|||  .. .  ..  . ...  ....|.|. ...|.......  ..| ....|..
tlftleelkalyaldllyyyglgpgnelaklaggpllneilarleekisg.pldlklylyfa
0049226 Phosphoglycerate mutase-like 35-295 1.8e-54 178.2 In-house 2-256 (342) alignment 
Range on Protein: 35-295
Range on HMM: 2-256/342.0
TIKLVNLLFRHGDRSPTNGYPNDNYTEDTWPQGFGQLTESGMAQQYELGQWLRKRYvtdLKLFDGIYRPKQFYVHSSPKERTIMSAQSNLQGFFPAESGG
..|.| .|.|||||.|.. .|.| . | .|. |.|.||. |. |.||||..|||||   |.|....|.|...||.||...||..|||. |.|.|| |...
kLkqvqvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrY...lgllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltp

GKPSsgTPPWPPVPVFTVAEEQDYLLSGsKIQNCDTVRDFFQYAENSPAEQQYIKDNQIFFDRVHERAGFSGDVIFENFYHLGDTLIRERKEGRNLPEWA
  ..  . .| |.|..|. | .|.|| . . ..|... ....   .|.  |..... . ..... .. |..   . . ...| |.|. |   | .||.| 
ilvp..lldwqpipiitepesndtllll.pydscpnfdkllkellkseevqlfleeildllkklskllglnlstlsdvadtlydlllyelahglplppwc

DDETFNRLKATQDYAFEAEFSNMTT-DEKRITSGVLIAAMVANMKAHLNrTNNDSRIFMYSG
...|.. |||  .. .  .. .  . .  |...|.|. ...|....... . .| ....|..
slftleelkalyaldllyyygigygeeiarlaggpllneilarleeaie.gpsdlklylyfa
0046349 Phosphoglycerate mutase-like 35-295 1.5e-53 175.4 In-house 6-301 (409) alignment 
Range on Protein: 35-295
Range on HMM: 6-301/409.0
TIKLVNLLFRHGDRSP---TNGYPNDNYTEDT-WPQGFGQLTESGMAQQYELGQWLRKRYVTdLKLFDGI--YRPKQFYVHSSPKERTIMSAQSNLQGFF
..|.| .|||||.|.|   .. .||....  | .| |.||||. |. |.||||..||||||  |.|..    |.|...||.||...||..|||..|.|.|
eLkqvqvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvd.lgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlf

PAESGGGK----PSSGTPPWPPVPVFTVAEE-----QDYLLSGSKIqnCDTVRDFFQYAENS-PAEQQ-----------YIKDNQIFFDRVHERA-----
|...|.      ..   ||. |.|. || ..     .|.|| . .   |..  . .. . .| .. ..           . .... ..... ||      
pplggeivpllrqdlldppfqpipidtvpiseddalddtllppdsl..cpaldkllkenlkslsevleflvdealldlelldetkdllkklaerlnselp

GFsgDVI-FENFYH-LGDTLIRERKEGRNLPEW---ADDETFNRLKATQDYAFEAEFSNmTtDEKRITSGVLIAAMVANMKAHLNRTNN-----DSRIFM
|.  ... .....  | |||. |. .|. ||.|    ..| ...| . .|. .  .... . .  ....|.|. ...|....... .|.     | ....
gl..nltdpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyylygs.g.elaklaggpllneilarledaisgknpvtfpldlklyl

YSG
|..
yfa
His_Phos_2 Histidine phosphatase superfamily (branch 2) 36-295 7e-36 116.8 Pfam-A 2-296 (347) alignment 
Range on Protein: 36-295
Range on HMM: 2-296/347.0
IKLVNLLFRHGDRSPTNGYP--------------------NDNYT------EDTWPQGFGQLTESGMAQQYELGQWLRKRYVtdlKLFDGIYRPKQFYVH
.| | ...|||||.|.. ..                    .....      . ... . |.|| ||..|..|||..||.||.   .|.. .. ...... 
LkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYp...gllrdhltyedvkir

SSPKERTIMSAQSNLQGFFPAESG-GGKPSSGTPPWPPVPVFTVAE----EQDYLLSGSkiQNCDTVRD--FFQYAENSPAEQQYIKDNQIFFD-RVHER
|| ..|...|||....|....|     .  .    . .... |. |    ... |. |.  ..| . ..  .    . ... ... |. .  .  |... 
ssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellrega..escpafawppikvekrvvelvnklkkvmdenlakrlsal

-AGFSGDVIFENFYHLGDTLIRER-KEGRNLPEWADD--ETFNRLKATQDYAFEAEFSNMTTDEKRITSGVLIAAMVANMKAHLNRTN--NDSRIFMYSG
  | .    .|. . |   ...|. ... ..||..|.  . .  ..  .|      . . .. ||.   . |. ....... .|..|.  .. ....|..
ctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyft
His_Phos_2 Histidine phosphatase superfamily (branch 2) 36-295 7e-36 116.8 In-house 2-296 (347) alignment 
Range on Protein: 36-295
Range on HMM: 2-296/347.0
IKLVNLLFRHGDRSPTNGYP--------------------NDNYT------EDTWPQGFGQLTESGMAQQYELGQWLRKRYVtdlKLFDGIYRPKQFYVH
.| | ...|||||.|.. ..                    .....      . ... . |.|| ||..|..|||..||.||.   .|.. .. ...... 
LkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYp...gllrdhltyedvkir

SSPKERTIMSAQSNLQGFFPAESG-GGKPSSGTPPWPPVPVFTVAE----EQDYLLSGSkiQNCDTVRD--FFQYAENSPAEQQYIKDNQIFFD-RVHER
|| ..|...|||....|....|     .  .    . .... |. |    ... |. |.  ..| . ..  .    . ... ... |. .  .  |... 
ssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellrega..escpafawppikvekrvvelvnklkkvmdenlakrlsal

-AGFSGDVIFENFYHLGDTLIRER-KEGRNLPEWADD--ETFNRLKATQDYAFEAEFSNMTTDEKRITSGVLIAAMVANMKAHLNRTN--NDSRIFMYSG
  | .    .|. . |   ...|. ... ..||..|.  . .  ..  .|      . . .. ||.   . |. ....... .|..|.  .. ....|..
ctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyft
0048955 Phosphoglycerate mutase-like 42-140 8.6e-06 18.4 In-house 5-72 (240) alignment 
Range on Protein: 42-140
Range on HMM: 5-72/240.0
LFRHGDRSP--TNGYPNdnytedtWPQgfGQLTESGMAQQYELGQWLRKRyvtdlklF---DgiyrpkqfYVHSSPKERTIMSAQSNLQGFfpaesgggk
| ||| ..    . . .       |.    .||| | .|  .||..|...           |        .|.|||  |.| .|.  ....         
LvRHGesewnaegrlqg.......wtD..vpLtelGreqaralgerLadl.......gikfd........lvysSpllRaiqTaeiiaeal.........

pssG
   |
...g
His_Phos_1 Histidine phosphatase superfamily (branch 1) 42-126 9.8e-06 18.6 Pfam-A 4-68 (158) alignment 
Range on Protein: 42-126
Range on HMM: 4-68/158.0
LFRHGDRSptngyPNDNYTEDTWPQgfGQLTESGMAQQYELGQWLRKryvtdlklfdgiyRPKQFY-VHSSPKERTIMSAQSnLQG
| ||| .       | .   . | .   .||| |..|  |||..|..                ..  | .||  |.|  |.. |. 
lvRHGese.....wnkegrlqgwsd..vpLtekGreqarelgkkLkr.............adlpidavytSplkRaiqTaei.lle
His_Phos_1 Histidine phosphatase superfamily (branch 1) 42-126 9.8e-06 18.6 In-house 4-68 (158) alignment 
Range on Protein: 42-126
Range on HMM: 4-68/158.0
LFRHGDRSptngyPNDNYTEDTWPQgfGQLTESGMAQQYELGQWLRKryvtdlklfdgiyRPKQFY-VHSSPKERTIMSAQSnLQG
| ||| .       | .   . | .   .||| |..|  |||..|..                ..  | .||  |.|  |.. |. 
lvRHGese.....wnkegrlqgwsd..vpLtekGreqarelgkkLkr.............adlpidavytSplkRaiqTaei.lle
subfamily_ACP6_pd Subfamily ACP6 63-294 9.6e-16 49.4 In-house 68-289 (376) alignment 
Range on Protein: 63-294
Range on HMM: 68-289/376.0
TWPQG--FGQLTESGMAQQYELGQWLRKRYVTDLKLFDGIYRPKQFYVHSSPKERTIMSAQSNLQGFFPAESGGGKpSsgtppwpPVPVFTVAEEQDYLL
. . |   ||||. || | ..||. |||||| |.|.    . |.. |. |   |||. ||.  . | .  .    .         |. ..|  |... |.
ilkGGafkGqLtkvGmqqvfdLGrkLrkrYvedikfLsqefnpqevyiRstnieRtlesarclvaGLygkiiiqke.l.......piilytdeedeevly

SgsKIQNCDTVRDFFQYAENSPAEQQYIKDnqiFFDRVHERAGFSGDVIFeNFYHLGDTLIRERKEGRNLPEWADdETFNRL--KATQDYAFEAEFSNMT
     | | ... ...  ..|  ... | .   . ...... . | .  . .|  | | .  ... . . |.    . ....  .|...  .  |  . .
P..nrqrcpllsrayrsvrksaislpGise...dtkqiadvldiseekkl.dfvslrDniaArlaHnlkvppilk.dvidliekhAveelvvlleggdrp

T-DEKRITSGVLIAAMVANMKAHLNRTNNDSRIFMYS
  .  ... | ..  .. |...  ... .  .. .||
ekeilklsvGkvlkeilenlekakekeiparklrLys
subfamily_HP2-Group1_pd Subfamily HP2-Group1 67-131 1.5e-09 28.7 In-house 91-154 (422) alignment 
Range on Protein: 67-131
Range on HMM: 91-154/422.0
GFGQLTESGMAQQYELGQWLRKRYVTDlKLFDGIYRPKQFYVHSSPKERTIMSAQSNLQGFFPAE
  .|||  |  ||   || ||| || .  ..   . . . |. |  . |||.|||. ..|..| .
avaqltleGykqqelnGqilrkvyvdt.GflkssldssevylrsddesrtilsaqalilGmypqd
subfamily_PXYLP1_pd Subfamily PXYLP1 68-131 7.1e-08 23.0 In-house 103-168 (419) alignment 
Range on Protein: 68-131
Range on HMM: 103-168/419.0
FGQLTESGMAQQYELGQWLRKRYVTDLKLF--DGIYRPKQFYVHSSPKERTIMSAQSNLQGFFPAE
 ||||. |. |  |.|. ||| |   |||.  .  .   . ....  | ||. || . | |..|..
lgqLtqkGvvqhLevGdllrkvYakklklLlkpnelssDevvlettrkrrtlqsalallygllpka
subfamily_MINPP1_pd Subfamily MINPP1 69-134 3e-06 18.3 In-house 90-146 (420) alignment 
Range on Protein: 69-134
Range on HMM: 90-146/420.0
GQLTESGMAQQYELGQWLRKRYvtdLKLFDGIYRPKQFYVHSSPKERTIMSAQSNLQGFfpaesgG
..|.. | .. .||.. | .|.   ..||.  | |..|.. |. |.||. |||. ..|        
kslvaqgqeeleelakrlarrf...palfeevynpdsfsfastakkRtvksaqaFaeGL......s
0049059 Phosphoglycerate mutase-like 293-452 1.2e-27 90.0 In-house 239-434 (435) alignment 
Range on Protein: 293-452
Range on HMM: 239-434/435.0
YSGRKEGRNLP--EWADDETFNKLKATHDFAFEADFSdMTTDEKRITSGVLLAAMIANMKAHLNRTNN---------------DSRIFMYSGHDDNLAPF
..|. .|..||  .. ..| ...|.. .|. |   ..  . .  ....|.|| ...|......| ..                | ....|..|| ..||.
llgyahglplpfcslfteeelevleyladlefyylyg.ygdeiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapl

LGLFGLFTNVAP---------------------PTASCIMVELYKEDDG-SHTVQLLFrNDtskppYLLKFPECNE----RCPVQNFFHIASPFVVDDVD
|...||| .  |                     | ||....|||. .|| .. |..|. |.     . |..| |..    .||...| .. ..|. .|  
lsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvfElyecpdgneyyVrvly.ng.....kvlplpgcgsgpgglCplddFkelvkkflpgddf

ELC
..|
deC
His_Phos_2 Histidine phosphatase superfamily (branch 2) 297-411 1.4e-16 53.3 Pfam-A 222-346 (347) alignment 
Range on Protein: 297-411
Range on HMM: 222-346/347.0
KEGRNLPEWADD--ETFNKLKATHDFAFEADFSDMTTDEKRITSGVLLAAMIANMKAHLNRTN--NDSRIFMYSGHDDNLAPFLGLFGLFT------NVA
... ..||..|.  . . ...  .|.    ..   .. ||.   . || ....... .|..|.  .. ....|..|| .....| ..||..         
fdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspe

PPTASCIMVELYKEDDGSHTVQLLF
.| ||.|..|||.... .. |.|||
lpyasqivfelyedsekkfyvrllf
His_Phos_2 Histidine phosphatase superfamily (branch 2) 297-411 1.4e-16 53.3 In-house 222-346 (347) alignment 
Range on Protein: 297-411
Range on HMM: 222-346/347.0
KEGRNLPEWADD--ETFNKLKATHDFAFEADFSDMTTDEKRITSGVLLAAMIANMKAHLNRTN--NDSRIFMYSGHDDNLAPFLGLFGLFT------NVA
... ..||..|.  . . ...  .|.    ..   .. ||.   . || ....... .|..|.  .. ....|..|| .....| ..||..         
fdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspe

PPTASCIMVELYKEDDGSHTVQLLF
.| ||.|..|||.... .. |.|||
lpyasqivfelyedsekkfyvrllf
subfamily_ACP2_pd Subfamily ACP2 298-456 1.3e-56 184.7 In-house 194-360 (361) alignment 
Range on Protein: 298-456
Range on HMM: 194-360/361.0
EG-RNLPEWADDETFNKLKATHDFAFEADFS---DMTTDEKRITSGVLLAAMIANMKAHLNRTNND--SRIFMYSGHDDNLAPFLGLFGLFTNVAPPTAS
.. .||||||.||.|.||... | ..|| |.   ..|.. |....|.||.....|||..|......  ...|.||.||..||..| ..|.|...|||.||
anelnlpewandelfekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkceekkkklklflYSaHDttlaalLeaLgifekkappyas

CIMVELYKEDDGSHTVQLLFRNDTSKPPYLLKFPEC--NERCPVQNFFHIASPFVVDDVDELCRGKP
.|.||||.||||...|..|.||.|||.|. |..|.|  .|.||...|..|..||..|||||||..|.
aiivElyeeddgkplvkvlyrnetskdppeltlpgCkgeedCplskfkkivkpfipddvdelCeakt
0048439 Phosphoglycerate mutase-like 298-443 7e-26 84.5 In-house 219-389 (391) alignment 
Range on Protein: 298-443
Range on HMM: 219-389/391.0
EGRNLPEWADDETFNK--LKATHDFAFEADFSDMTTDE-KRITSGVLLAAMIANMkahLNRTNNDSRIFMYSGHDDNLAPFLGLFGLFTN------VAPP
.|..||||. ||....  ||.  |.. |  .    ..|  ....|.|| ......    .. ..| ....|..|| ..|..|...|||..        ||
hglplpewltdellspellkqladlvnelyyyltgsgeiaklaggpllneilddl...vangpsdpklylyfaHdttiaallsaLglfndtlplpadlpp

TASCIMVELYKED-DGSHTVQLLFRNDTSKPPY--------------LLKFPECNE----RCPVQNFFHIASPF
 ||....|||. . ||.. |..|....| ..|.              .|..| |..     ||...|  . ...
yasnlvfElyecpsdgeyyVrvlynggtldlprdltlldldefllrlvlplpgcgsgpgglCplddFvelvkkr
0053031 Phosphoglycerate mutase-like 299-452 9.8e-32 103.7 In-house 188-340 (342) alignment 
Range on Protein: 299-452
Range on HMM: 188-340/342.0
GRNLPEWADDETFNKLKATHDFAFEADF-SDMTTDEKRITSGVLLAAMIANMKAHLNRtNNDSRIFMYSGHDDNLAPFLGLFGLFTNVAPPTASCIMVEL
|. ||.| ...|...|||  .. .   .  . ...  ....|.|| ...|.......  ..| ....|..|| ..|..|...|||..  || ||....||
glplppwctlftleelkalyaldllyyyglgpgnelaklaggpllneilarleekisg.pldlklylyfahdttiaallsaLglfddqlPpyasnlvfEl

YKEDdGSHTVQLLFRNDTSKPPYLLKFPECNERCPVQNFFHIASPFVVDDVDELC
|. . |.. |..|....|  .|. |..| |.. ||...|  . ......| ..||
yedp.geyyVrvlynggtlseplvlplpgcdglcplsefkelvkkllpgdfeklC
0049226 Phosphoglycerate mutase-like 299-453 7.4e-31 100.7 In-house 188-341 (342) alignment 
Range on Protein: 299-453
Range on HMM: 188-341/342.0
GRNLPEWADDETFNKLKATHDFAFEA-DFSDMTTDEKRITSGVLLAAMIANMKAHLNrTNNDSRIFMYSGHDDNLAPFLGLFGLFTNVAPPTASCIMVEL
| .||.| ...|...|||  .. .   ..   . .  |...|.|| ...|....... . .| ....|..|| ..|..|...|||    || ||....||
glplppwcslftleelkalyaldllyyygigygeeiarlaggpllneilarleeaie.gpsdlklylyfahdttiaallsalglfddqlPpyasnlvfEl

YKEDdGSHTVQLLFRNDTSKPPYLLKFPECNERCPVQNFFHIASPFVVDDVDELCR
|. | |.. |..|........|. |..| |...||...|  . ..|...| .||| 
yecd.geyyVrvlynggvlslpvtlplpgcdglcpldefkelvkkflpgdfeelCf
0046349 Phosphoglycerate mutase-like 299-453 8.1e-29 94.0 In-house 227-391 (409) alignment 
Range on Protein: 299-453
Range on HMM: 227-391/409.0
GRNLPEW---ADDETFNKLKATHDFAFEADFSDmTtDEKRITSGVLLAAMIANMKAHLNRTNN-----DSRIFMYSGHDDNLAPFLGLFGLFT-----NV
|. ||.|    ..| ...| . .|. .   ..  . .  ....|.|| ...|....... .|.     | ....|..|| ..|..|...|||.       
glplppwcdlftpeelkvlayladleyyylygs.g.elaklaggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLglfdrlfrssd

APPTASCIMVELYKE-DDGSHTVQLLFRNDtskppyLLKFPECNERCPVQNFFHIASPFVVD----DVDELCR
 || ||....|||.  .|| . |..|....       |..|.|.| ||...| .. ......    |.|.|| 
ippyasnlvfElyecpsdgeyyVrvlyngg......plplpgcgegcplsefkellkkrlpgcgltdfdklCp
0048946 Phosphoglycerate mutase-like 301-456 7.4e-29 94.0 In-house 242-413 (447) alignment 
Range on Protein: 301-456
Range on HMM: 242-413/447.0
NLPEWADDETFNKLKATHDFAFEADFSdMTTDEKRITSGVLLAAMIANMKAHLNRTNndsRIFMYSGHDDNLAPFLGLFGLFTNVAP-------------
.|... ..| ...|.. .|. |   ..  . .  |...|.|| ...|....... ..   ....|..|| ..|..| ..|||..  |             
plcslftpeelevleyladlefyyeyg.ygdelarlaggpllneilarledaisgds...klylyfaHdttiaallsaLglfddelplpadnlpfnrlfr

-----PTASCIMVELYKED-----DGSHTVQLLFrNDTSKPpyllkFPECNE----RCPVQNFFHIASPFvVDDVDELCRGKP
     | ||....|||. .     ||.. |..|. |..  |     .| |.      ||...| .. ..| ..| ..||  . 
sseivPyasnlvfElyecpsslpsdgeyyVrvly.ngeplp.....lpgCgsgpgglCplddFkellkkf.lpdweklCgltl
0047369 Phosphoglycerate mutase-like 301-453 2.3e-27 89.3 In-house 251-437 (438) alignment 
Range on Protein: 301-453
Range on HMM: 251-437/438.0
NLPEWADDETFNKLKATHDFAFEADFSDmTTDEKRITSGVLLAAMIANMKAHLNRTNN---------------DSRIFMYSGHDDNLAPFLGLFGLFTNV
..... ..| ...|.. .|. |   .   . . .....|.|| ...|......| ...               | ....|..|| ..|..|...||| . 
pfcslftpeelevleyladlefyylygy.gnelaklaggpllneilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddt

AP---------------------PTASCIMVELYKE-DDGSHTVQLLFrndtskPPYLLKFPECNE----RCPVQNFFHIASPFVVDDVDELCR
 |                     | ||....|||.  .||.. |..|.       .. |..| |..     ||...| .. ......| .||| 
wplpglpldkialnrlfrsseivPyasnlvfElyecpsdgeyyVrvly......ngkvlplpgcgsgpgglCplddFkelvkkllpgdfeelCg
subfamily_ACP6_pd Subfamily ACP6 332-453 8.7e-16 49.5 In-house 255-372 (376) alignment 
Range on Protein: 332-453
Range on HMM: 255-372/376.0
DEKRITSGVLLAAMIANMKAHLNRTNNDSRIFMYSGHDDNLAPFLGLFGLFTNVAPPTASCIMVELYKEDDGSHTVQLLFRNDTSKPPyllkfpECN-ER
.  ... | .|  .. |...  ... .  .. .|| ||  | . |  .| | .. || |. ...|||....| . |..|..... ...      ... . 
eilklsvGkvlkeilenlekakekeiparklrLysaHDttlmtLLlalgvFDdkWPpfaadvileLyedkageyfvrvlYqekelrlr......gseedl

CPVQNFFHIASPFV-VDDVDELCR
.| . | .. .. |  .|  . |.
vPlekFkallavlvlpkdyaaeCk
subfamily_HP2-Group1_pd Subfamily HP2-Group1 334-453 4e-10 30.6 In-house 298-417 (422) alignment 
Range on Protein: 334-453
Range on HMM: 298-417/422.0
KRITSGVLLAAMIANMKAHLNRTnNDSRIFMYSGHDDNLAPFLGLFGLFTNVAPPTASCIMVELYKEDDGSH--TVQLLFRndTSKPPYLLKFPECNE-R
 |.  | ||  .  ...  |.   .  .. .|||||  | ..|  ...   . || || ...||..     .  | |   |        |.|.| |.   
arvGiGfllkdiwkevnesltGe.dlrkfllysGhdttliqllsalnvdefkwppyasllllellevstapaastpqyavr..vlynGklkklpfcdane

CPVQNFFHIASPFVVDDVDELCR
|....|    |  . .|  | |.
csyeqfeaylstviphddaedck