Gene ACP6 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily ACP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP174_AA protein Get Run
SpurP174_AA_55-441 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0048946 Phosphoglycerate mutase-like 56-441 1.3e-59 195.3 In-house 30-411 (447) alignment 
Range on Protein: 56-441
Range on HMM: 30-411/447.0
AIPLVAREDLELKFVQIFFRHGARTPIGtGCIPNVeEGVWDK-DTIfqgaadlcidyKVCALNGEPQPEWKIENYYRKEPLQGGAFkGQLTAVGMKQAND
 ||  . |..|||.||..||||||||.  ...... | ..|. . .           .|  |.|. .    .. ....||| .  . ||||..|..|. .
gipepvpegcelkqvqvlfRHGaRtPtk.kylkgl.eplldllkna...........nvlelggdlsflndwkyqlkneplwpcgl.gqLTplGreqlye

LGKKLRRHYmekLGFLPqefSPQLVYTRSTNINRTLQSLGCLMGGLYGNIIASKELPVQFYTDEGLG-EVLYPnrqRCNQLSHFYSSVLKGMFSVpGIGH
||| ||..|   ||.||   .|. .| ||....|||||. ... ||... .  .  |....|... . ..|.|    |. . ... . |. ....  .  
lGkrlrkrY...lgllp...npseiyvrssdvdRtlqSaqaflaGlfppepplgyqpipihtvpssndnlllp...sCpafkellkkelaeelke.llke

GTDQIAPVLDASEEQkkKLDFVSMRDDITA-RLEHNMKVPDHLMPVIDLIEKHAVALMRFLIEGGnePGKNIIKFSAGPTMHYICENLEAAKKKEIpyKL
 .......|. ..      |.... | . . .. |..  . .|.   .|   ...| ..|  | |  .| .. . ..|| .. | ..||.| ...   ||
llerlkkllgglnlt..lsdvydlydlllyetaihglsplcslftpeelevleyladlefyyeyg..ygdelarlaggpllneilarledaisgds..kl

HLNSCHDTTLMTLLLALEAFDDVWP------------------PLTASVIFELYEDK-----AGNSFVRTLYQNKELRI---RQSEETLLPLEKFKELLA
.| ..||||...|| ||  ||| .|                  |  ....|||||..      |. .|| ||....|..   . ....| ||..||||| 
ylyfaHdttiaallsaLglfddelplpadnlpfnrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlyngeplplpgCgsgpgglCplddFkellk

PVsYTaqDYADACKV
..     |....|..
kf.lp..dweklCgl
subfamily_HP2-Group1_pd Subfamily HP2-Group1 58-243 2.4e-17 54.4 In-house 12-195 (422) alignment 
Range on Protein: 58-243
Range on HMM: 12-195/422.0
PLVAREDLELKFVQIFFRHGA--RTPIGTGCIPNvEEGVWDKDTIfqgAADLCIdYKVCALNGEPQPEWKIENYYRKEPLQGGAFKGQLTAVGMKQANDL
 |   ||..|| |..  |||   |.     | .  .. .|| | .    |.| .  ||    .  .  ..      .|  .|    .||| .| || .  
slglpedvklkqvivvirhGdrvraaynGscwdG.ddaiwdcdlv...saslpv.ikvekerivvdriyrkiylntreedaGdcavaqltleGykqqeln

GKKLRRHYMEKlGFLPQEFSPQLVYTRSTNINRTLQSLGCLMGGLYGNI-IA-SKELPVQFYTDEGLGEVLYPNRQRCNQLSHFYSSVLK
|. ||. |... |||  ....  || || ...||..|  .|. |.| .  .|  .   |..|| . | . . .| . | .|| .    ||
Gqilrkvyvdt.GflkssldssevylrsddesrtilsaqalilGmypqdtkaedraqvvdlytrdklfdsieanadlcpklseyntqflk
subfamily_MINPP1_pd Subfamily MINPP1 60-201 6e-07 20.6 In-house 24-148 (420) alignment 
Range on Protein: 60-201
Range on HMM: 24-148/420.0
VAREDLELKFVQIFFRHGARTPIGTGC--IPNVEEGVWDKDTIFQGAADLCI-DYKvcalngepqpewkienyyrKEPLQGGAFKGQLTAVGMKQANDLG
 | |  .|. .||..||| | |       | .  | . .   ...|.  ..  |..                   ..     .....|.| | .. . |.
eaeegCklvklqiiaRHGtRypskskikkiqetlekiknyseqldgklsilnedle...................snleyetelekslvaqgqeeleela

KKLRRHYMEKLGflpQEFSPQLVYTRSTNINRTLQSLGCLMGGL--Y
|.| |.. . ..    . .|. .. .||...||..|    . ||   
krlarrfpalfe...evynpdsfsfastakkRtvksaqaFaeGLset
0049059 Phosphoglycerate mutase-like 62-440 3.9e-56 183.8 In-house 38-435 (435) alignment 
Range on Protein: 62-440
Range on HMM: 38-435/435.0
REDLELKFVQIFFRHGARTPIGtgCIPNVEEGVWDKDTIFQGAADlcidykvcalngEPQPEWKIENYYRKeplqggafKGQLTAVGMKQANDLGKKLRR
 |..|||.||..||||||||.    ...  | .|.|.      ..            .| ....  ||  .         |.||..|..|| .|||.||.
pegcelkqvqvlfRHGaRtPts..klikklealwekllslltypn............gplsflndwnyplg........ageLTplGreqayelGkrlrk

HYmeklGFLpqeFSPQLVYTRSTNINRTLQSLGCLMGGLYGNI--------IASKELPVQFYTDEGLGEVLypNRQRCNQLSHFYSSVL-----KGMFsV
.|    |||   ..|. || ||....|||||  ... ||...           .  .||.. |.. .   |  . . |... ......|     . .|  
rY....gfL...ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl..pydscpafdellkellasdeflelf.l

PGIGHGTDQIAPVLDASEEQKKKLDFVSMRDDITARLEHNMKVPdhLMP--VIDLIeKHAVALMRFLIEGGNEPGKNIIKFSAGPTMHYICENLEAAKKK
. |    ....| |. . ..   | ..   | ....  |....|  ...    ... . . .|. . .  .. .| .| | ..|| .. | ..||.| ..
erilkllqellpglgltpsdvldlydlckydtlllgyahglplp..fcslfteeel.evleyladlefyylygygdeiaklaggpllneilarledaing

EI----------------PYKLHLNSCHDTTLMTLLLALEAFDDVWP---------------------PLTASVIFELYEDKAG-NSFVRTLYQNKELRI
.                 ..||.| ..||||...|| ||  ||| .|                     | .....|||||.. | . .|| ||..|.|..
dstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvfElyecpdgneyyVrvlyngkvlpl

RQ---SEETLLPLEKFKELLAPVsyTAQDYADACK
     ....| ||..||||. ..  . .|. | |.
pgcgsgpgglCplddFkelvkkf..lpgddfdeCg
subfamily_PXYLP1_pd Subfamily PXYLP1 62-406 1.5e-19 61.5 In-house 19-371 (419) alignment 
Range on Protein: 62-406
Range on HMM: 19-371/419.0
REDLELKFVQIFFRHGARTPIgtGCIPNVEEGVWDKDtIFQGAADLCIDYKVCALNGEPQP-EWKIE---NYYRKEPL----QGGAFKGQLTAVGMKQAN
.|. .|| | .. ||| |||.    ||. ..  .. | . ..   |   .|    | . .  . ..|     ..  ||    ...  .|||| .|. |  
kegfkLkavlvvirhGDrtPl..sdipkskraeinCd.lsaasknlvdklksfldnssseasgsdfenkvgplkslPllpnheriCelgqLtqkGvvqhL

DLGKKLRRHYMEKLGFL--PQEFSPQLVYTRSTNINRTLQSLGCLMGGLYGNI----IASKELPVQFYTdegLGEVLYP--NRQRCNQLSHfYSSVLKGm
..|. ||. |..||..|  |.|.|   |.  .|. .|||||   |. ||. .     |  .| |   .    |||   |  .|.| .. ..    .|.| 
evGdllrkvYakklklLlkpnelssDevvlettrkrrtlqsalallygllpkaklkairvrespsvafC...lgeCsCPallrkrlekead.kqlLlrg.

fSVPGIghgTDQIAPVLDASEEQKKKLDFVSMRDDITARLEHNMKVPDHLMPVIDLIeKHAVAlMRFLIE-GGNEPGKNIIKFS----AGPTMHYICENL
  |  .     ... .|   . |....      | ... | ||.  |     ... . ...|  .... |   .. .|   | |    | | .. | ...
.kvldv...mksvgetlkgtilqttlngisnpvdalltvlChnvslPcrreGcveps.hvdvl.hkladelsqrsakksyyklsGllraypllrdivsrm

EAAKKKEIPYKLHLNSCHDTTLMTLLLALEAFDDVWPPLTASVIFELYE-DKAGNSFVRTLYQNKEL
  . .     |  |.| || ||  |. ||.  .  ..   . ..||||. ..  . ..| ||. |. 
lkiieGvdkekfvlysghDvtlrplvaaLglseartiayasrlvfelyrreaskeyylrvlynGkDv
0047369 Phosphoglycerate mutase-like 63-440 1e-56 185.9 In-house 40-437 (438) alignment 
Range on Protein: 63-440
Range on HMM: 40-437/438.0
EDLELKFVQIFFRHGARTPigTGCIPNVEEGVWDKDTIFQGAADlcidykvcalngepqpewkiENYYRKEPLQGGAFKGQLTAVGMKQANDLGKKLRRH
|..|||.||..||||||||  |. ... .|..|...    . ..                    ... .   ..|    |||| .|..|| .||| ||..
egcelkqvqvlfRHGaRtP..tksklkkleplwellenattyps....................gplsflndwlgpcgagqLTplGreqayelGkrlrkr

YmeklGFLpqefSPQLV-YTRSTNINRTLQSLGCLMGGLYGNIIASKEL-----PVQFYTDEGLGEVLYP--NRQRCNQLSHFYSSVLKGMFSVPGIghg
|    |.|    .|. | | ||....|||||  ... ||...   .        |. ..|. .  ..|..  . . |. ... ....|     .  .   
Y....glL....npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnllpsdscpafdellkeflasdeflell...

TDQIAPVLDASEE--QKKKLDFVSMRDDITARLEHNMKVPDHLMPVIDLIEKHAVALMRFL----IEGGNEPGKNIIKFSAGPTMHYICENLEAAKKKEI
...|...|    .  .    |.... | ..  . .|. .  .| | ..|. .  .  ...|       .. .|... | ..|| .. | ..||.| ... 
lkdilkrlkkllpglnltpsdvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygnelaklaggpllneilarledaingks

----------------PYKLHLNSCHDTTLMTLLLALEAFDDVWP---------------------PLTASVIFELYED-KAGNSFVRTLYQNKELRIRQ
                ..||.| ..||||...|| ||  ||| ||                     |  ....|||||. . |. .|| ||..|.|..  
tnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivPyasnlvfElyecpsdgeyyVrvlyngkvlplpg

---SEETLLPLEKFKELLAPVSYTaqDYADACK
   ....| ||..||||. .. ..  |....|.
cgsgpgglCplddFkelvkkllpg..dfeelCg
subfamily_ACP2_pd Subfamily ACP2 63-441 6e-55 179.2 In-house 5-358 (361) alignment 
Range on Protein: 63-441
Range on HMM: 5-358/361.0
EDLELKFVQIFFRHGARTPIGtgCIPNVEegvwdkdtifqgaadlcidykvcalngepqpewkienyYRKEPLQGGAfkGQLTAVGMKQANDLGKKLRRH
|. .|||||. ||||.|.|      || .                                      |...  ..|   ||||. ||.|.  ||| ||. 
eerkLkfvqvlfRHGdRsPln..typndk......................................ykedewpqgl..GqLTeeGmqqqyeLGkfLrkr

YMEKLGFLPQEFSPQLVYTRSTNINRTLQSLGCLMGGLYGN---I-----IASKELPVQFYtDEGLGEVLYpNRQRCNQLSHFYSSVLKGmfsvPGIGHG
|.|...||.....|. .| ||...||||.|. ... ||...   .     .  .  ||.   .|    .|  ... |.   .. . . .     | .   
YvedtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfppetgvdypdeqeWqpvPvhtv.seeedlllr.akknCprydellqeakes....pevkkl

TDQIAPVLDASEEQK----KKLDFVSMRDDITARLE-HN-MKVPDHLMP-VIDLIEKHAVALMRFLIEGGNEPGKNIIKFSAGPTMHYICENLEAAKK--
... . .|.. .|..    .. .|. . | .  . . .| ...|. .   ... .|. |   ...  . .||. ... |...|| .... ||.....|  
leenkelleklsestgedidlenfyqlsdtlicerkyanelnlpewandelfekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkce

-KEIPYKLHLNSCHDTTLMTLLLALEAFDDVWPPLTASVIFELYEDKAGNSFVRTLYQNKELRIRQ-------SEETLLPLEKFKELLAPVSYTAqdYAD
 |.   || | | |||||..|| ||. |....|| ....|.||||.. |. .|. ||.|..   ..       ..|.. ||.|||... |. ..   . .
ekkkklklflYSaHDttlaalLeaLgifekkappyasaiivElyeeddgkplvkvlyrnetskdppeltlpgCkgeedCplskfkkivkpfipdd..vde

ACKV
 |..
lCea
0048439 Phosphoglycerate mutase-like 63-431 5.4e-54 177.0 In-house 5-369 (391) alignment 
Range on Protein: 63-431
Range on HMM: 5-369/391.0
EDLELKFVQIFFRHGARTPigTGCIPNVEEGVWDKdtifqgaadlcidykvcalngepqpewkienyyrkEPLQGGAFKGQLTAVGMKQANDLGKKLRRH
...|||.||..||||||||  |  .||.......|                                     ..|.   |.||..|..|. .||..||..
agcelkqvqvlfRHGaRtP..tssypnkldpllnk...................................llpngpcglgeLTplGreqlyelGrrlrkr

YMEkLGFLPQEF--SPQLVYTRSTNINRTLQSLGCLMGGLYGNIiasKELPVQFYTDEGLGEVLYPNrqRCNQLSHFYSSVLKGMFSVPGIGHGT---DQ
| . ||.||. .  .|. || ||....|||||  ... ||....   .  ..   . | ....|.|.   .|. ... .. |. . |..  ..     ..
Yvd.lgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfppl...gltvilvivvesedpllnpl..pintcplledlllldalsalprfylseiler

IAPVLDASEEQKKKL----------------------------DFVSMRDDITARLEHNMKVPDHLMPviDLI----EKHAVALMRFLIEGGNEPGkNII
.|.||.  .. .. .                            |. .. | ....  |....|. |.   .|.     |  ..|. .|. . . .|  | 
laevlnrvlglnltaedvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltd..ellspellkqladlvnelyyyltgsg.eia

KFSAGPTMHYICENLeaAKKKEIPYKLHLNSCHDTTLMTLLLALEAFDD------VWPPLTASVIFELYEDK-AGNSFVRTLYQNKELRIRQsEETLLPL
| ..|| ...| ..|  . . . ..||.| ..||||...|| ||  |.|       .||  ....|||||..  |. .|| ||....| . . . |||.|
klaggpllneilddl..vangpsdpklylyfaHdttiaallsaLglfndtlplpadlppyasnlvfElyecpsdgeyyVrvlynggtldlpr.dltlldl

EKFKEL-LAPVSYT
..|... . |... 
defllrlvlplpgc
subfamily_ACP6_pd Subfamily ACP6 64-442 4.5e-191 626.4 In-house 1-374 (376) alignment 
Range on Protein: 64-442
Range on HMM: 1-374/376.0
DLELKFVQIFFRHGARTPIGTgcIPNVEEGVWDKDtIFQGAADLCIDYKVCALNGEPQPEWKIENYYRKEPLQGGAFKGQLTAVGMKQANDLGKKLRRHY
.||||.||..||||||||| .  .|..||..|||| ......||.|||.|..|||||.||.|||..|.||.|.|||||||||.|||.|..|||.|||..|
sleLkqvqvvfrhGartPiks..lPqeeeveWdkd.lleslpdleidyrvtnlnGepkPeskieekykkeilkGGafkGqLtkvGmqqvfdLGrkLrkrY

MEKLGFLPQEFSPQLVYTRSTNINRTLQSLGCLMGGLYGNIIASKELPVQFYTDEGLGEVLYPNRQRCNQLSHFYSSVLKGMFSVPGIGHGTDQIAPVLD
.|...||.|||.||.||.|||||.|||.|..||..||||.||..||||...||||. .||||||||||..||..|.|| |...|.|||...|.|||.|||
vedikfLsqefnpqevyiRstnieRtlesarclvaGLygkiiiqkelpiilytdeedeevlyPnrqrcpllsrayrsvrksaislpGisedtkqiadvld

ASEEqkKKLDFVSMRDDITARLEHNMKVPDHLMPVIDLIEKHAVALMRFLIEGGNEPGKNIIKFSAGPTMHYICENLEAAKKKEIP-YKLHLNSCHDTTL
.|||  |||||||.||.|.|||.||.|||..|..||||||||||. ...|.|||..|.|.|.|.|.|.....|.||||.||.|||| .||.|.|.|||||
isee..kkldfvslrDniaArlaHnlkvppilkdvidliekhAveelvvlleggdrpekeilklsvGkvlkeilenlekakekeiparklrLysaHDttl

MTLLLALEAFDDVWPPLTASVIFELYEDKAGNSFVRTLYQNKELRIRQSEETLLPLEKFKELLAPVSYtAQDYADACKVA
|||||||..|||.|||..|.||.||||||||..|||.|||.||||.|.|||.|.||||||.|||.... ..|||..||..
mtLLlalgvFDdkWPpfaadvileLyedkageyfvrvlYqekelrlrgseedlvPlekFkallavlvl.pkdyaaeCkle
0046349 Phosphoglycerate mutase-like 64-441 1.8e-61 201.5 In-house 4-392 (409) alignment 
Range on Protein: 64-441
Range on HMM: 4-392/409.0
DLELKFVQIFFRHGARTPIGTgcipnveegvwdkdtifqgaadlcidykvcalngepqpEWKIENYYRKEPLQGGAFKGQLTAVGMKQANDLGKKLRRHY
..|||.||..||||||||. .                                       ....|.  .   .|.   ||||..|..|| .|||.||..|
gceLkqvqvlfRHGaRtPtkk......................................lsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrY

MEkLGFLPQE--FSPQLVYTRSTNINRTLQSLGCLMGGLYGNIIASK--------------ELPVQ---FYTDEGLGEVLYPNRQRCNQLSHFYSSVLKG
 . ||.||..  ..|. .| ||....|||||  ... ||...   .                .|..   ...|..|...|.|. . |..| . ....|| 
vd.lgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkllkenlks

MFSVPG-----------IGHGT-DQIAPVLDASEEQKKKLDFVS-------MRDDITARLEHNMKVPDHLMPVIDLIEKHAVALMRFLIEGGNEPGkNII
.  |             . . | | . .. .   .....|....       . | ..... |... |.    . . . |.  .|...    .. .|  . 
lsevleflvdealldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyylygsg.ela

KFSAGPTMHYICENLEAAKKKEI------PYKLHLNSCHDTTLMTLLLALEAFD-----DVWPPLTASVIFELYED-KAGNSFVRTLYQNKELRIRQSEE
| ..|| .. | ..||.| ...       ..||.| ..||||...|| ||  ||       .||  ....|||||. . |. .|| ||....| . .. |
klaggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLglfdrlfrssdippyasnlvfElyecpsdgeyyVrvlynggplplpgcge

TlLPLEKFKELLAPVSYTAQ--DYADACKV
. .||..||||| ..    .  |... |..
g.cplsefkellkkrlpgcgltdfdklCpl
0049226 Phosphoglycerate mutase-like 66-439 3.4e-59 193.7 In-house 2-340 (342) alignment 
Range on Protein: 66-439
Range on HMM: 2-340/342.0
ELKFVQIFFRHGARTPigtgcipnveegvwdkdtifqgaadlcidykvcalngepqpeW-----------KienyyrkeplqGGAFKGQLTAVGMKQAND
.||.||...|||.|||                                          .           .           .|   |.|| .|..|| .
kLkqvqvliRHGdRtP..........................................lakgpldflnewf...........wgcglgeLTplGreqaye

LGKKLRRHYmekLGFLPQEFSPQLVYTRSTNINRTLQSLGCLMGGLYGNIIASKE--------LPVQfYTDEGLGEVLYPNRQRCNQLSHFYSSVLkgmf
||. ||..|   ||.||. ..|. || ||....|||||. ... ||...  ...         .|.. ...|. . .|... . |. ........|    
lGrrlrkrY...lgllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvplldwqpipii.tepesndtllllpydscpnfdkllkell....

SVPGIGHGTDQIAPVLDASEE-----QKKKLDFVS-MRDDITARLEHNMKVPDhLMPVIDLIEKHAVALMRFLIEGGNEPGKNIIKFSAGPTMHYICENL
. . .   ...|...|..  .      .   |... . | ....| |....|. .  .  | | .|.. . .| . |. .| .| . ..|| .. | ..|
kseevqlfleeildllkklskllglnlstlsdvadtlydlllyelahglplpp.wcslftleelkalyaldllyyygigygeeiarlaggpllneilarl

EAAKKKEIPYKLHLNSCHDTTLMTLLLALEAFDDVWPPLTASVIFELYEDKaGNSFVRTLYQNKE------LRIRQSeETLLPLEKFKELLAPVSYTaqD
|.| .   ..||.| ..||||...|| ||  ||| .||  ....|||||.. |. .|| ||...       |..    ..| ||..||||.... ..  |
eeaiegpsdlklylyfahdttiaallsalglfddqlPpyasnlvfElyecd.geyyVrvlynggvlslpvtlplpgc.dglcpldefkelvkkflpg..d

YADAC
....|
feelC
0053031 Phosphoglycerate mutase-like 66-439 1.2e-58 192.1 In-house 2-340 (342) alignment 
Range on Protein: 66-439
Range on HMM: 2-340/342.0
ELKFVQIFFRHGARTPigtgcipnveegvwdkdtifqgaadlcidykVCALNGEPQPEWKIenyyrkeplqggA-FKGQLTAVGMKQANDLGKKLRRHYm
|||.|....|||||||                               .. .. .| .|| .                |.|| .|..|| .||. ||..| 
eLkqvivlvRHGaRtP...............................lskgpldplnewfy............pcgageLTplGreqayelGrrlrkrY.

ekLGFLPQEFSPQLVYTRSTNINRTLQSLGCLMGGLYGNIIASKE--------LPVQfYTDEGLGEVLYPNRQRCNQlshfYSSVLKGMFSVPGIGHGTD
  ||.||. ..|. || ||....|||||  ... ||...   ..         .|.. . .|. . .|.|| . |      ....||.... . .   ..
..lgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipih.tepessdalllpnydpcpa....fdkllkealaseevkelle

QIAPVLDASEEQKKkLD-------FVSMRDDITARLEHNMKVPDhLMPVIDLIEKHAVALMRFLIEGGNEPGKNIIKFSAGPTMHYICENLEAAKKKEIP
.....|..  .  . |.       . .. | . ..| |....|.  . . .| | .|.. . .| . |. ||  ..| ..|| .. | ..||.. ... .
rylellqklskglg.ltlsdlldlvsdlydlllyelahglplpp.wctlftleelkalyaldllyyyglgpgnelaklaggpllneilarleekisgpld

YKLHLNSCHDTTLMTLLLALEAFDDVWPPLTASVIFELYEDKaGNSFVRTLYQNK------ELRIRQSEEtLLPLEKFKELLAPVSYTaqDYADAC
.|| | ..||||...|| ||  ||| .||  ....||||||. |. .|| ||...      .| .   .. | ||..||||. .. ..  |....|
lklylyfahdttiaallsaLglfddqlPpyasnlvfElyedp.geyyVrvlynggtlseplvlplpgcdg.lcplsefkelvkkllpg..dfeklC
His_Phos_2 Histidine phosphatase superfamily (branch 2) 66-401 3e-31 101.5 Pfam-A 1-346 (347) alignment 
Range on Protein: 66-401
Range on HMM: 1-346/347.0
ELKFVQIFFRHGARTPIGTGCI--------PNVEegvwdkdtifqgaadlcidykvcaLNGEPQPEWKIENYYRKEPLQGGAFKGQLTAVGMKQANDLGK
|||.|.. .|||.|||  .             ..                        |....... .  . .||| ||     |.||  |.|||..||.
eLkgvvvviRHGdRtPkqkfkksvtsekfisllk........................lknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGe

KLRRHYMeklGFLPQEFSPQLVYTRSTNINRTLQSLGCLMGGLYGNII---------ASKELPVQFYTDE----GLGEVLYPNRQRCNQLSH--------
.||..|    |.|. .. .. |. ||.. .|.|.|  ... ||.|.            ..  .. . | .     | |.| .....| ..          
qlrqrYp...gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekr

------FYSSVLKGMFSvpgigHGTDQI----APVLDASEEQKKKLDFVSMRdditarLEHNMKVPDHLMP-VIDLIEKHAVALMRFLIEGgNEPGKNII
      ....|..  ..     .  ...    ...|  .  .|   .|.  .       ....|.|.       |...   .  .. |      .|... 
vvelvnklkkvmdenla.....krlsalctgednllfkerweklfreffeee......kfdiskipelydtmkydalhnrqledleelykl.ygigdeek

KFSAGPTMHYICENLEAAKKKEI---PYKLHLNSCHDTTLMTLLLALEAFD------DVWPPLTASVIFELYED-KAGnSFVRTLY
.  ...... . .... . ...      || | . ||....||| ||  ..        ..|  ....|||||| ..   .|| |.
lkigllllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyedsekk.fyvrllf
His_Phos_2 Histidine phosphatase superfamily (branch 2) 66-401 3e-31 101.5 In-house 1-346 (347) alignment 
Range on Protein: 66-401
Range on HMM: 1-346/347.0
ELKFVQIFFRHGARTPIGTGCI--------PNVEegvwdkdtifqgaadlcidykvcaLNGEPQPEWKIENYYRKEPLQGGAFKGQLTAVGMKQANDLGK
|||.|.. .|||.|||  .             ..                        |....... .  . .||| ||     |.||  |.|||..||.
eLkgvvvviRHGdRtPkqkfkksvtsekfisllk........................lknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGe

KLRRHYMeklGFLPQEFSPQLVYTRSTNINRTLQSLGCLMGGLYGNII---------ASKELPVQFYTDE----GLGEVLYPNRQRCNQLSH--------
.||..|    |.|. .. .. |. ||.. .|.|.|  ... ||.|.            ..  .. . | .     | |.| .....| ..          
qlrqrYp...gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekr

------FYSSVLKGMFSvpgigHGTDQI----APVLDASEEQKKKLDFVSMRdditarLEHNMKVPDHLMP-VIDLIEKHAVALMRFLIEGgNEPGKNII
      ....|..  ..     .  ...    ...|  .  .|   .|.  .       ....|.|.       |...   .  .. |      .|... 
vvelvnklkkvmdenla.....krlsalctgednllfkerweklfreffeee......kfdiskipelydtmkydalhnrqledleelykl.ygigdeek

KFSAGPTMHYICENLEAAKKKEI---PYKLHLNSCHDTTLMTLLLALEAFD------DVWPPLTASVIFELYED-KAGnSFVRTLY
.  ...... . .... . ...      || | . ||....||| ||  ..        ..|  ....|||||| ..   .|| |.
lkigllllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyedsekk.fyvrllf
subfamily_HP2-Group1_pd Subfamily HP2-Group1 325-441 5.3e-12 36.8 In-house 298-418 (422) alignment 
Range on Protein: 325-441
Range on HMM: 298-418/422.0
IKFSAGPTMHYICENLEAAKKKEIPYKLHLNSCHDTTLMTLLLALEAFDDVWPPLTASVIFELYEDKAGNS------FVRTLYQNKELRIRQSEETLLPL
 .   |  .  | ...  . . |   |. | | |||||. || ||.  . .||| .. ...||.|  .  .       || ||. | ...   .    ..
arvGiGfllkdiwkevnesltGedlrkfllysGhdttliqllsalnvdefkwppyasllllellevstapaastpqyavrvlynGklkklpfcdanecsy

EKFKELLAPVSyTAQDYADaCKV
|.|.. |. |    .|. | |||
eqfeaylstvi.phddaed.ckv