Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_ACP5_pd | Subfamily ACP5 | 271-484 | 1.4e-61 | 199.7 | In-house | 2-189 (189) | alignment | ||
Range on Protein: 271-484
Range on HMM: 2-189/189.0
YGDLGHGVPDNTLQIKKLEqaslnttknvysEINETELIVHIGDLSYAVGF--SAQWDEYYNEVEKLAANSPYMVCAGNHEADWpNTTSYfqskdsggec
.||||. .... ...| | | ||..||.|.|||.||.. .|.|||..| .|.||.. ||||..|||| |. |...|
fgDlgvseaaslatllkee............eaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesds.nfsay..........
nipyIYRNQMPRVSPvkpWYGFDFGCVHFVIMNSEDNFTMGTEQYRFLVQHLASV-NRTATPWLVFTGHRPMYVDSTSIEEPYGMQPIAKL-LRNNLEDL
.| .||. . || ||.|.|||.....|..|..|.|||..| ..|... ||..|||....||||||..... .. .. ... ||..||||
....kkrfsmpskne...wYsfdygpvhfislstevdfslgseqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledl
LIQYNVSLALWGHHHTYQ
| .|.| |||.||.|.|.
lykykvdlalsgHeHsYe
|
|||||||||
| PAPL | 271-483 | 4.5e-46 | 149.4 | In-house | 3-194 (194) | alignment | |||
Range on Protein: 271-483
Range on HMM: 3-194/194.0
YGDLGHGVPDNtlqikkleqaslNTTKNVYSEINETELIVHIGDLSYAVGFSAQWDEYY--NEVEKLAANSPYMVCAGNHEADWPNTTSYFQSKDSGGEC
.|||| ... ... . . .. ..|.|.|||.|| ... .||. ...|.|||. ||||..||||... .. ........|.|.
fGDlGqtnass............lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgsee
NIPYIYRNQmprvspvKPWYGFDFGCVHFVIMNSEDNFTMGTEQYRFLVQHLASVNRTATPWLVFTGHRPMYVDSTSIEEPYGmqpiAKLLRNNLEDLLI
. . .... . | |....|||. ..||.... |||. | . ||.|||..|||....|||||| ... .. .. ...|||||.
gesnssesg.......snsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddcke....kakmlaaledlly
QYNVSLALWGHHHTY
.|.| | |.||.|.|
kygVDlvlaGHeHsY
|
|||||||||
| Metallophos | Calcineurin-like phosphoesterase | 305-483 | 1.3e-21 | 70.8 | Pfam-A | 31-200 (200) | alignment | ||
Range on Protein: 305-483
Range on HMM: 31-200/200.0
ETELIVHIGDLSYAVGFSAQWDEYY-NEVEKLAANSPYMVCAGNHEADWPNTTSYFQSKDSGGECNIPYIYRNQMPRvspvKpwYGFDFGCVHFVIMNSE
. |... |||... | . . ..|.||... |.... |||| | |. ..| . .. ... . . .. | ... .. . .. ...
kpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeeeyenl....k..itllttsgelyglsgl
DNFTMGTEQYRFLVQHLASVNRTATPWLVFTGHRPMYVDSTSIEEPygmqPIAKLLRNNLEDLLIQYNVSLALWGHHHTY
.. . .|...| . || ..|. ... .. .|.|.. . | . . ...||.|| .|.| | |.|| | .
ypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi....gselfgpdalekllekygvdlvlrGHtHkp
|
|||||||||
| Metallophos_C | Iron/zinc purple acid phosphatase-like protein C | 498-559 | 3.1e-17 | 54.0 | Pfam-A | 2-62 (62) | alignment | ||
Range on Protein: 498-559
Range on HMM: 2-62/62.0
GITHVIIGMAGRpLLQDFEPNRPSYFEYlDDQHYGYTRLQ-ANSTTLTLQYIRNDDLQVHDEV
...|...|.|| |..|. ..|.. .. ....|||.||. .|.|.|.....|.|| ||.|..
ApvhIvvGaAGn.glskfskpqpewsaf.resdyGysrltvvNrthLhwefvrsddgqvlDsf
|
|||||||||
| subfamily_PAPL_pd | Subfamily PAPL | 289-482 | 2.4e-10 | 32.0 | In-house | 19-211 (212) | alignment | ||
Range on Protein: 289-482
Range on HMM: 19-211/212.0
EQASLNTTKNVySEINETELIVHIGDLSYAVGFSAQWDE----YYNEV-EKLAANSPYMVCAGNHEADWPNTTSYFQSKDSgGECNIPYIYRNQMPRVSP
..| .. .| .| |.......|| | | . |. ...| .. . . |..|.||||. . . || | ..| .| .. ...
qeavakelgkv.aeeleaqfvlalGDnfYekGvkdvddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYskls.krWkfpslyytksfkipd
VkpWYGFDFGCVHFVI---------MNSEDNFTMGTEQYRFLVQHLASvnrTATPWLVFTGHRPMYvdSTSIEEPygmqpiAKLLRNNLEDLLIQYNVSL
.. . |. .. . .. .||. .| ..|.. . .|. .|| |.. |.. . | | |...|. ||..|||.
s..natvqlvlidtvllcgksddlklegpvdvslaeeqwawleeeLka...seadylivaGhypvw..svaehGp......tkiLvkrLkPlLekynvta
ALWGHHHT
| || |.
ylsGhDhn
|
|||||||||
| Metallophos_2 | Calcineurin-like phosphoesterase superfamily domain | 293-510 | 2.1e-09 | 29.6 | Pfam-A | 13-140 (156) | alignment | ||
Range on Protein: 293-510
Range on HMM: 13-140/156.0
LNTTKNVYSEINETELIVHIGDLSYAvgfsaqwdeyyNEVEKLAANSPYMVCAGNHEADWPNTTSYFQSkdsggecnipyiyrnqmprvspvkpwygfdf
|.... |. .|.| .||.| ||| .|| .|... | .. |||.... ... ..
ldaleavledikevdlilhaGDlvep...........eevvelledipvlavrGnhDeaelpkelavel...............................
gcvhfvimnsednftmgtE---------QYRFLVQHLASVNrtatpwlvftghrpmyvdstsieepygmqpiAKLLRNNLEDLLIQYNVSLALWGHHHTY
. |.|. | .. . ...|. || .....|.. || | .
..................llaaaaleiegdrvllvhgtpls...............................vqsseeelaellkeagadlvflGHtHkp
QRtckvyrsqCTDNGITHVIIGMAGRP
. . .|...| | .|.|
kv........ekrggtlvvnpGsvgep
|
|||||||||
| PhoD | PhoD-like phosphatase | 218-327 | 2.2e-07 | 21.2 | Pfam-A | 65-153 (453) | alignment | ||
Range on Protein: 218-327
Range on HMM: 65-153/453.0
MdpgtihtVTMDNLSPSTRYYYQFGSN-TWGWSDEFTFKSPPVTGPDTpVRIITYGDLG--HGVpdntlqikkleqaslnttKNVYSEINE---TELIVH
|....|.|...|.|.| .. . | .. | . ... .|. .... .| |.|.|. | ....|
k.......vevtgLepgqeyfYrfraeegesespvGrtrTlpeaaves.lrlavvSCsnyeqGy..................fnayrelaekedlDfvlh
IGDLSYAVGfSAQWDE
.|| |. | . ....
lGDyiYeyg.egtykn
|
|||||||||
| ACP5 | 290-481 | 2.2e-07 | 22.7 | In-house | 15-197 (198) | alignment | |||
Range on Protein: 290-481
Range on HMM: 15-197/198.0
QASLNTTKNVYSEINETELIVHIGDLSYAVGFSAQWDEYYNE-----VEKLAANSPYMVCAGNHEADWPNTTSyFQSKDSGGECNIPYIYRNQMPRVSPV
| . .. . . | .... .. .|| | | . |. .| ... . . |..|..|||. . . . . . |... . . .
qsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaq.ieyakrskdsrfpslryslskkevvt
KPWYGFDFGcvHFVIMNSEDNFTMGTEQYRFLVQHLasvNRTATPWLVFTGHRPMYvdSTSIEEPygmqpiAKLLRNNLEDLLIQYNVSLALWGHHH
. .. . . . ... .. .|| | ..| .. . |.. || |.| |.. ... | | ..|. || .|.|.. | || |
elftekkde..ksdqrevaerekyaeeqlkwlekal...akstadwkiVvGHhpvy..Sigehgd......tkelverllpllkkykvdaYlnGHdH
|
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