Gene ACP5-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily ACP5
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP172_AA protein Get Run
AqueP172_AA_36-254 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PAPL_pd Subfamily PAPL 38-252 1.8e-105 342.8 In-house 1-211 (212) alignment 
Range on Protein: 38-252
Range on HMM: 1-211/212.0
LVIGDWGGMSDEPYYTVGQSKVASVMGEKAEKIDSQFTLAVGDNFYEDGVKDVDDPRFNETFEEVFTAPSLQKRWYAICGNHDYNGNASAQVAYTQKSAR
||.|||||....||.|. |..||...|..||....||.||.||||||.|||||||.||.||||.||||.|||..|| ..|||||.||.|||.||...|.|
lvlgDwGgleeapyttaaqeavakelgkvaeeleaqfvlalGDnfYekGvkdvddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYsklskr

WYMPSFYYTEIFNLSSSNITIQFVFIDTVILCGLSHPkLRhlpPSGPQSSDLADDQWAWIESTLQQSTADWLIVSGHYPVWSAAHHGPTDILVKQLRPLL
|..||.|||. |....||.|.|.|.||||.||| |.. |.   ..||....||..||||.|..|..|.||.|||.|||||||.|.||||.||||.|.|||
Wkfpslyytksfkipdsnatvqlvlidtvllcgksdd.lk...legpvdvslaeeqwawleeeLkaseadylivaGhypvwsvaehGptkiLvkrLkPlL

IKYNVTAYIAGHDHD
.|||||||..||||.
ekynvtaylsGhDhn
ACP5 37-251 4.3e-71 230.7 In-house 1-197 (198) alignment 
Range on Protein: 37-251
Range on HMM: 1-197/198.0
FLVIGDWGGMSDEPyytvgQSKVASVMGEKAEKIDSQFTLAVGDNFYEDGVKDVDDPRFNETFEEVFTAPSLQKRWYAICGNHDYNGNASAQVAYTQKSA
|||.||||...  .     ||.||. ||. ||| | .| |..|||||.|||..||||||.|.||...||.|||. || ..|||||.||.|||..|...| 
flvvGDwGrkgeyn.....qsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrsk

RWYMPSFYYTEIFNLsssnitiqfvfidTVILCGLSHPKLRHLPPSGPQSSDLADDQWAWIESTLQQSTADWLIVSGHYPVWSAAHHGPTDILVKQLRPL
.. .||..|. ...              .|. .  .... ..  ........ | .|..|.|..|..|||||.|| ||.||.|...||.|. ||..|.||
dsrfpslryslskke.............vvtelftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdtkelverllpl

LIKYNVTAYIAGHDH
| ||.|.||..||||
lkkykvdaYlnGHdH
Metallophos Calcineurin-like phosphoesterase 36-252 3.6e-18 59.6 Pfam-A 2-199 (200) alignment 
Range on Protein: 36-252
Range on HMM: 2-199/200.0
NFLVIGDWGGMSDEPYytvgqSkVASVMGEKAEKIDSQFTLAVGDNFYEDGVKDVDDPRFNetfeEVFTAPSLQKRWYAICGNHDYNGNASAQVAYTQKS
..|||||..|. |...       ..  . ..|.. . .. |  ||... .   .    ..           .| ...... |||.. . .||  ..  ..
rilvigDlHgglddle.....d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalld....ylvlklllpipvfllrGNHesdpgnsaygflleql

ARWYMPSFYYTEIFNLsssnitiqfvfiDtVILCGLSHPKLRHLPPSGPQSSDLADDQWAWIESTLQQSTADWLIVSGHYPVWSAAHHGPT----DILVK
 ... . ... | .||            . ..|   | .   .. . .    . .. |. . .  .  . .|. |. .| |..|   .| .    .   .
kdlrglangeeeyenl............k.itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgpd

QLRPLLIKYNVTAYIAGHDHD
 |..|| ||.|.... ||.| 
alekllekygvdlvlrGHtHk
subfamily_ACP5_pd Subfamily ACP5 61-252 1.1e-15 50.1 In-house 14-187 (189) alignment 
Range on Protein: 61-252
Range on HMM: 14-187/189.0
SVMGEKAEKIDSQFTLAVGDNFYEDGVkdvDDPRFNETFEEVFTAPSLQKRWYAICGNHDYNGNASAQvaytqkSARWYMPsfyYTEIfNLSSSNITIQF
.   ...|. . .... |||  |...    .. . ...| ...   . .  . .. |||... | ||       ..|. ||     .    |     ..|
atllkeeeaneldliihvGDlaYalka...kneavwdefmnlieplaskvPymvsiGnhesdsnfsay......kkrfsmp...skne.wYsfdygpvhf

VFIDTVILCGLShpklrhlppsgpqssdlaDDQWAWIESTLQQS----TADWLIVSGHYPVWSAAHHGP----TDILVKQ-----LRPLLIKYNVTAYIA
. ..| .   |.                  ..|..|.|. |..     . .|.|| || |..   ...     .. ||..     | .|| ||.|  ...
islstevdfslg..................seqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlals

GHDHD
||.| 
gHeHs
PAPL 191-251 2e-10 33.1 In-house 125-192 (194) alignment 
Range on Protein: 191-251
Range on HMM: 125-192/194.0
DDQWAWIESTLQQ---STADWLIVSGHYPVWSAAHHG----PTDILVKQLRPLLIKYNVTAYIAGHDH
..|..| |  |..   |  .|.|| || |...  ..      ..  ...| .||.||.|  ..||| |
seqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvlaGHeH
PAPL 54-155 1.1e-06 20.9 In-house 13-106 (194) alignment 
Range on Protein: 54-155
Range on HMM: 13-106/194.0
VgqskvASVMGEKAEKIDSQFTLAVGDNFYEDGVKDVDDPRF-NETFEEVFTapslQKRWYAICGNHDYNGNASAQVAYTQKSARWYMPSFYYTEIFNLS
      .. . ....| . .. | |||  |.|. ..  |     .  |....    .. . .. |||... | |...|..... .....| ..    |  
s.....lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaa....svpymvapGNHEeeynfsnykarfsmpgseegesnssesgsnsy

SSN
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