Gene ACP2-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily ACP2
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP194_AA protein Get Run
AqueP194_AA_14-370 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP2_pd Subfamily ACP2 20-366 3.9e-119 390.4 In-house 7-358 (361) alignment 
Range on Protein: 20-366
Range on HMM: 7-358/361.0
DKLEFVSIVFRHGARSPTGPYKNDIYKEYDWPQGYGQLSIEGMKEEYNLGKLFQSRYL-ESGFMNATYNRTQIYVRSTQYDRTIMSAQCVLAAMYPPtEE
.||.||...||||.|||. .|.|| ||| .||||.|||. |||...|.|||....||. ...|..|.||..||||||....||.||||.|||...|| |.
rkLkfvqvlfRHGdRsPlntypndkykedewpqglGqLTeeGmqqqyeLGkfLrkrYvedtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfpp.et

EVEFQPGLDWQPIPVHS-TIGPDYLLRgfASKLCPRYELLKNQTEKSSGYLATWNDNKELFVELSNYTGEPVNLTNIWHIQDTLFQQWY-AN-YTTPYWY
.|....  .|||.|||.     |.|||  |.| ||||. |......|. . .  ..||||. .||..|||...| |.....|||...   || .. | |.
gvdypdeqeWqpvPvhtvseeedlllr..akknCprydellqeakespevkklleenkelleklsestgedidlenfyqlsdtlicerkyanelnlpewa

TTELMDKLQELANYVLSLLFD-----STMKKQLTGGLWANEVIENMEDKSS-KESNLTQRMILYSAHDTTVAAMLSVFNLFDKKQPLFSAAFVIELYSND
. ||..||.|||..| .. |.     .. .|.|.||.. ||..|||..|.. .|.. .....||||||||.||.|.....|.||.| ...|...|||..|
ndelfekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkceekkkklklflYSaHDttlaalLeaLgifekkappyasaiivElyeed

DNGHYVKFLYHNETKSDQFhELTHPNC--ETNCPLGKLKQIMKPYLVSNisqIEELCSL
|. ..||.||.|||..|.. |||.|.|  |. ||| |.|.|.||.....   ..|||  
dgkplvkvlyrnetskdpp.eltlpgCkgeedCplskfkkivkpfipdd...vdelCea
0049226 Phosphoglycerate mutase-like 21-364 4.5e-85 278.8 In-house 2-340 (342) alignment 
Range on Protein: 21-364
Range on HMM: 2-340/342.0
KLEFVSIVFRHGARSPTGPYKNDIYKEYDWPQGYGQLSIEGMKEEYNLGKLFQSRYleSGFMNATYNRTQIYVRSTQYDRTIMSAQCVLAAMYPPTEEEV
||..| ...|||.|.|.  ...| ..|. |. |.|.|. .|....|.||. . .||   |... |||....||||. .|||..|||..||...||.  ..
kLkqvqvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrY..lgllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpi

EFQpGLDWQPIPVHST-IGPDYLLRGfASKLCPRYELLKNQTEKSSGYLATWNDNKELFVELSNYTGEPV-NLTNIWH-IQDTLFQQWYANYTTPYWYTT
 ..  |||||||....  . |.||..  .. ||... | ... ||. . .  .. ..|. .||...| .. .|....  ..|.|  ... ... | |.. 
lvp.lldwqpipiitepesndtllll.pydscpnfdkllkellkseevqlfleeildllkklskllglnlstlsdvadtlydlllyelahglplppwcsl

ELMDKLQELANYVLS---LLFDSTMKKQLTGGLWANEVIENMEDKSSkeSNLTQRMILYSAHDTTVAAMLSVFNLFDKKQPLFSAAFVIELYSNDdNGHY
.....|..|....|    .....    .|.|| ..||.....|.. .    ......||.|||||.||.||...||| ..| .....|.|||..| ...|
ftleelkalyaldllyyygigygeeiarlaggpllneilarleeaie..gpsdlklylyfahdttiaallsalglfddqlPpyasnlvfElyecd.geyy

VKFLYHNETKsDQFHELTHPNCETNCPLGKLKQIMKPYLVSNisqIEELC
|..||....  .....|. |.|.. ||| ..|...|..|...   .||||
Vrvlynggvl.slpvtlplpgcdglcpldefkelvkkflpgd...feelC
0046349 Phosphoglycerate mutase-like 15-368 7.3e-85 278.5 In-house 2-394 (409) alignment 
Range on Protein: 15-368
Range on HMM: 2-394/409.0
PPvrGDKLEFVSIVFRHGARSPTGP----YKNDIYKEYDWPQGYGQLSIEGMKEEYNLGKLFQSRYLESGFMNAT--YNRTQIYVRSTQYDRTIMSAQCV
.|  | .|..| ..||||||.||       . . .. . .| |.|||. .|... |.||| . .|| ..|... .  ||...|||||. .|||..|||..
vP..gceLkqvqvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaf

LAAMYPPTEEEVEF-----QPGLDWQPIPVHSTIGP-----DYLLRGFASKlCPRYELLKNQTEKS-SGYLA-----------TWNDNKELFVELSNYT-
||...|| . |. .      . . .||||.. .. .     |. |  . |  ||... | ... || | .|            .....|.|. .|.... 
laGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdsl.cpaldkllkenlkslsevleflvdealldlelldetkdllkklaerln

----GEPVN-LTNIWH-IQDTLFQQWYANYTTPYW---YTTELMDKLQELANYVLSLLFDSTMKKQLTGGLWANEVIENMEDKSSKESNL----TQRMIL
    | ... .....  ..|||. ... ... | |   .| |....| .||..   .|..|.   .|.|| ..||.....||. |....     .....|
selpglnltdpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyylygsgelaklaggpllneilarledaisgknpvtfpldlklyl

YSAHDTTVAAMLSVFNLFD-----KKQPLFSAAFVIELYSN-DDNGHYVKFLYHNEtksdqfhELTHPNCETNCPLGKLKQIMKPYLVSN-ISQIEELCS
|.|||||.||.||...|||      . | ... .|.|||.. .|...||..||...       .|. |.| . ||| ..|...|..|... .  ...||.
yfaHdttiaallsaLglfdrlfrssdippyasnlvfElyecpsdgeyyVrvlyngg.......plplpgcgegcplsefkellkkrlpgcgltdfdklCp

LDE
|..
led
0053031 Phosphoglycerate mutase-like 20-364 1.4e-82 270.7 In-house 1-340 (342) alignment 
Range on Protein: 20-364
Range on HMM: 1-340/342.0
DKLEFVSIVFRHGARSPTGPYKNDIYKEYDWPQGYGQLSIEGMKEEYNLGKLFQSRYleSGFMNATYNRTQIYVRSTQYDRTIMSAQCVLAAMYPPTEEE
..|..| ...|||||.|.  ...| ..|. .| |.|.|. .|... |.||. . .||  .|... |||....||||. .|||..|||..||...||   .
eeLkqvivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrY..lgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtp

VEFQpGLDWQPIPVHST-IGPDYLLRGfASKLCPRYELLKNQTEKSSGYLATWNDNKELFVELSNYTGepVNLTN----IWHIQDTLFQQWYANYTTPYW
. ..  |.|||||.|.   ..|.||..  .. ||... | ... .|. .  .... .||. .||...|  ..|..    .....|.|. ... ... | |
ilnp.llgwqpipihtepessdalllp.nydpcpafdkllkealaseevkellerylellqklskglg..ltlsdlldlvsdlydlllyelahglplppw

YTTELMDKLQELANYVLSL---LFDSTMKKQLTGGLWANEVIENMEDKSSKesNLTQRMILYSAHDTTVAAMLSVFNLFDKKQPLFSAAFVIELYSNDdN
.| .....|. |....|     |. ..   .|.|| ..||.....|.| |.  .|.....||.|||||.||.||...||| . | ... .|.|||... .
ctlftleelkalyaldllyyyglgpgnelaklaggpllneilarleekisg..pldlklylyfahdttiaallsaLglfddqlPpyasnlvfElyedp.g

GHYVKFLYHNETKSdQFHELTHPNCETNCPLGKLKQIMKPYLVSnisQIEELC
..||..||...| | ....|. |.|.  ||| ..|...|..|..    .|.||
eyyVrvlynggtls.eplvlplpgcdglcplsefkelvkkllpg...dfeklC
0048439 Phosphoglycerate mutase-like 16-352 2.9e-81 266.7 In-house 3-389 (391) alignment 
Range on Protein: 16-352
Range on HMM: 3-389/391.0
PVRGDKLEFVSIVFRHGARSPTGPYKN--DIYKEYDW---PQGYGQLSIEGMKEEYNLGKLFQSRYLESGFMNATY--NRTQIYVRSTQYDRTIMSAQCV
.. | .|..| ..||||||.||  |.|  | . ....   | |.|.|. .|... |.||. . .|| ..|... .|  |....||||. .|||..|||..
vpagcelkqvqvlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaf

LAAMYPPTEEEVEFQP-----GLDWQPIPVHSTIGPDYLLRGFASKLCPRY------ELLKNQTEKSSGYLATWNDNKELFVELSNYTGEP-------VN
||...||..  |  ..     .. ..|.|...   .. ||. .|.. .||.      | |.. ... .|.. |..|...||  ....|           .
laGlfpplgltvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevlnrvlglnltaedvlslfdlcaketaalgsllklssp

LTNIWHIQDTLFQQWYANYTTPYWYTTEL-----MDKLQELANYVLSLLFDSTMKKQLTGGLWANEVIENMedksSKESNLTQRMILYSAHDTTVAAMLS
|...... |||. ... ... |.|.|.||     ...| .|.|... .|..|    .|.|| ..||.....      .........||.|||||.||.||
lcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsgeiaklaggpllneilddl....vangpsdpklylyfaHdttiaalls

VFNLFDK------KQPLFSAAFVIELYSND-DNGHYVKFLYHNETKSDqFH--------------ELTHPNCETN----CPLGKLKQIMKPY
...||.       ..| ... .|.|||... |...||..||...| .   .               |. |.|...    ||| ......|..
aLglfndtlplpadlppyasnlvfElyecpsdgeyyVrvlynggtldl.prdltlldldefllrlvlplpgcgsgpgglCplddFvelvkkr
0048946 Phosphoglycerate mutase-like 15-370 1.9e-79 260.6 In-house 34-415 (447) alignment 
Range on Protein: 15-370
Range on HMM: 34-415/447.0
PPVRGDKLEFVSIVFRHGARSPT-----------------------------GPYKNDIYKEYDWPQGYGQLSIEGMKEEYNLGKLFQSRYleSGFMNat
|.. | .|..| ..||||||.||                               .| ....|. || |.|||. .|... |.||| . .||  .|...  
pvpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwpcglgqLTplGreqlyelGkrlrkrY..lgllp..

yNRTQIYVRSTQYDRTIMSAQCVLAAMYPPTeeevefqPGLDWQPIPVHSTIGPD-YLLRGfaskLCPRYEllknqtEKSSGYLATWND--NKELFVELS
 |...|||||. .|||..|||..||...||.       | |..||||.|.. ..  .||.      ||...      |.  ..|| ...  .|||.  |.
.npseiyvrssdvdRtlqSaqaflaGlfppe.......pplgyqpipihtvpssndnlllp....sCpafk......ellkkelaeelkellkellerlk

NYTGE-PVNLTNIWHIQDTLFQQWYANYT--TPYWYTTELMDKLQELANYVLSLLFD-STMKKQLTGGLWANEVIENMEDKSSKESnltqRMILYSAHDT
...|   ..|.... ..|.|.......     . ..| |....|..||...  ...  .    .|.|| ..||.....||. |..|    ...||.||||
kllgglnltlsdvydlydlllyetaihglsplcslftpeelevleyladlefyyeygygdelarlaggpllneilarledaisgds....klylyfaHdt

TVAAMLSVFNLFDKKQPL------------------FSAAFVIELYSND-----DNGHYVKFLYHNEtksdqfhELTHPNCETN----CPLGKLKQIMKP
|.||.||...||| ..||                  ... .|.|||...     |...||..|| .|       .|. |.|...    ||| ..|...|.
tiaallsaLglfddelplpadnlpfnrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlynge.......plplpgCgsgpgglCplddFkellkk

YlVSnisQIEELCSLDEPT
. ..   ..|.|| |....
f.lp...dweklCgltlsv
0047369 Phosphoglycerate mutase-like 15-358 2.4e-76 250.6 In-house 37-433 (438) alignment 
Range on Protein: 15-358
Range on HMM: 37-433/438.0
PPVRGDKLEFVSIVFRHGARSP-----------------TGPYKNDI---YKEYDWPQGYGQLSIEGMKEEYNLGKLFQSRYlesGFMnatyNRTQI-YV
... | .|..| ..||||||.|                 ...|...    .... .|.|.|||. .|... |.||| . .||   |..    |. .. ||
dvpegcelkqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrY...glL....npedvlyv

RSTQYDRTIMSAQCVLAAMYPPTEEEVEFQpgLDWQPIPVHSTIGP-DYLLRGFASKLCPRYELLKNQTEKSSGYLAT-WNDNKELFVELSNYTGepVNL
||. .|||..|||..|| ..||. ... .   . |||||.|. ..  |.||... |. ||... |....  |. .| .  .| .... .| ....  .. 
rssdvdRtlqSAqaflaGlfppegtgelap..ilwqpipihtipesddfllnllpsdscpafdellkeflasdeflelllkdilkrlkkllpgln..ltp

TNIWHIQDTLFQQWYANYT-----TP--YWYTTELMDKLQELANYVLSLLF-DSTMKKQLTGGLWANEVIENMEDKSSKESNL--------------TQR
.... ..|... . .|| .      |   ..| |....|. ||...   |.  .   ..|.|| ..||.....||. ...|.               ...
sdvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygnelaklaggpllneilarledaingkstnlnltldsngvtfPldlk

MILYSAHDTTVAAMLSVFNLFDKKQ----------------------PlFSAAFVIELYSN-DDNGHYVKFLYhnetksdQFHELTHPNCETN----CPL
..||.|||||.||.||...||| ..                      | ... .|.|||.. .|...||..||       . ..|. |.|...    |||
lylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivP.yasnlvfElyecpsdgeyyVrvly.......ngkvlplpgcgsgpgglCpl

GKLKQIMKPYLVSNIS
 ..|...|..|.... 
ddFkelvkkllpgdfe
0049059 Phosphoglycerate mutase-like 15-364 5.4e-76 249.2 In-house 36-434 (435) alignment 
Range on Protein: 15-364
Range on HMM: 36-434/435.0
PPVRGDKLEFVSIVFRHGARSPTGPY-----------------KN---DIYKEYDWPQGYGQLSIEGMKEEYNLGKLFQSRYlesGFMnatYNRTQIYVR
....| .|..| ..||||||.||  .                  |   ........|.|.|.|. .|... |.||| . .||   ||.   ||....|||
dvpegcelkqvqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrY...gfL...ynpdevyvr

STQYDRTIMSAQCVLAAMYPPT-EEEVEFQPGLDWQPIPVHSTIGPDYLLrgfASKLCPRYELLKNQTEKSSGYLAT-WNDNKELFVELSNYTGEP---V
|. .|||..|||..||...||   ..  ..|  ..||.|...    . .|    .. ||... |...  .|. .| .  .....|. ||....| .   |
ssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl...pydscpafdellkellasdeflelflerilkllqellpglgltpsdv

NLTNIWHIQDTLFQQWYANYTTP--YWYTTELMDKLQELANYVLSLLFD-STMKKQLTGGLWANEVIENMEDKSSKES--------------NLTQRMIL
.  . ... |||. ... ... |   . | |....|..||...  .|.  .    .|.|| ..||.....||. ...|               |.....|
ldlydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygdeiaklaggpllneilarledaingdstnlnltldsnpatfpldlklyl

YSAHDTTVAAMLSVFNLFDKKQ----------------------PlFSAAFVIELYSNDDN-GHYVKFLYhNEtksdqfHELTHPNCETN----CPLGKL
|.|||||.|..||...||| ..                      | ... .|.|||...|. ..||..|| |.      ..|. |.|...    ||| ..
yfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivP.yasnlvfElyecpdgneyyVrvly.ng......kvlplpgcgsgpgglCplddF

KQIMKPYLVSniSQIEElC
|...|..| .  .. .| |
kelvkkflpg..ddfde.C
His_Phos_2 Histidine phosphatase superfamily (branch 2) 21-320 3.2e-50 164.0 Pfam-A 1-347 (347) alignment 
Range on Protein: 21-320
Range on HMM: 1-347/347.0
KLEFVSIVFRHGARSPTGPYKNDIYKEY--------------------------DWPQGYGQLSIEGMKEEYNLGKLFQSRYLesGFMNATYNRTQIYVR
.|..| .|.|||.|.|.  .| .. .|.                          ... ..|.|  .|.|....||. . .||   |...  ... ....|
eLkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYp..gllrdhltyedvkir

STQYDRTIMSAQCVLAAMYPPTEE--EVEFQPGLDWQPIPVHSTIG----PDYLLRGFAsKLCPRYEL--LKNQTEKSSGYLATWNDNKELFV-ELSNY-
|....|...|||...|....| .|    . .. ||.......         . |||  | . ||...   .|......       .. .| .  .||.. 
ssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellrega.escpafawppikvekrvvelvnklkkvmdenlakrlsalc

TGE-PVNLTNIWHIQDTLFQQWY--ANYTTPYWYTT-----ELMDKLQELANyVLSLLFDSTMKKQLTGGLWANEVIENMEDKSSKES-NLTQRMILYSA
||| ...  . |   .. | .     . . | .|.|     . ...|..| .    |   ..  |.  |.|..|......... ...  . .....||..
tgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledlee.lyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyft

HDTTVAAMLSVFNLFD------KKQPLFSAAFVIELYS-NDDNgHYVKFLYH
||......|....|..       ... .... |.|||. .... .||. |..
hDshiytllnaLgleekiareaspelpyasqivfelyedsekk.fyvrllfs
His_Phos_2 Histidine phosphatase superfamily (branch 2) 21-320 3.2e-50 164.0 In-house 1-347 (347) alignment 
Range on Protein: 21-320
Range on HMM: 1-347/347.0
KLEFVSIVFRHGARSPTGPYKNDIYKEY--------------------------DWPQGYGQLSIEGMKEEYNLGKLFQSRYLesGFMNATYNRTQIYVR
.|..| .|.|||.|.|.  .| .. .|.                          ... ..|.|  .|.|....||. . .||   |...  ... ....|
eLkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYp..gllrdhltyedvkir

STQYDRTIMSAQCVLAAMYPPTEE--EVEFQPGLDWQPIPVHSTIG----PDYLLRGFAsKLCPRYEL--LKNQTEKSSGYLATWNDNKELFV-ELSNY-
|....|...|||...|....| .|    . .. ||.......         . |||  | . ||...   .|......       .. .| .  .||.. 
ssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellrega.escpafawppikvekrvvelvnklkkvmdenlakrlsalc

TGE-PVNLTNIWHIQDTLFQQWY--ANYTTPYWYTT-----ELMDKLQELANyVLSLLFDSTMKKQLTGGLWANEVIENMEDKSSKES-NLTQRMILYSA
||| ...  . |   .. | .     . . | .|.|     . ...|..| .    |   ..  |.  |.|..|......... ...  . .....||..
tgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledlee.lyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyft

HDTTVAAMLSVFNLFD------KKQPLFSAAFVIELYS-NDDNgHYVKFLYH
||......|....|..       ... .... |.|||. .... .||. |..
hDshiytllnaLgleekiareaspelpyasqivfelyedsekk.fyvrllfs
subfamily_ACP6_pd Subfamily ACP6 54-366 5.7e-36 116.0 In-house 75-373 (376) alignment 
Range on Protein: 54-366
Range on HMM: 75-373/376.0
YGQLSIEGMKEEYNLGKLFQSRYLES-GFMNATYNRTQIYVRSTQYDRTIMSAQCVLAAMYPPTEEEVEFQPGLdWQPIPVHSTIGPDYLlrgFASKLCP
 |||   ||.. ..||.  . ||.|  .|.  ..|  ..|.|||  .||. ||.|..| .|     . | .  | .     . .. |..    .  .|  
kGqLtkvGmqqvfdLGrkLrkrYvedikfLsqefnpqevyiRstnieRtlesarclvaGLygkiiiqkelpiil.ytdeedeevlyPnrq...rcpllsr

RYELLKNQTEKSSGYLATWNDnkeLFVELSNYTGepVNLtNIWHIQDTLFQQWYANYTTPYwYTTELMDKLQELANYVLSLLFDSTMK-----KQLTGGL
.|.  .... .  |.    .    .  .|        .| .   ..| .  .   | . |   . ...| ... |   | .|.    .      .|. | 
ayrsvrksaislpGisedtkq...iadvldisee..kkl.dfvslrDniaArlaHnlkvpp.ilkdvidliekhAveelvvlleggdrpekeilklsvGk

WANEVIENMEDKSSKESNLtQRMILYSAHDTTVAAMLSVFNLFDKKQPLFSAAFVIELYSNDDNGHYVKFLYHNEtksdqfhELTHPNCE-TNCPLGKLK
  .|..||.|..  ||..  ... ||||||||. ..|  .. ||.| | |.|  ..||| .... ..|. ||...       ||  ...| . .|| | |
vlkeilenlekakekeipa.rklrLysaHDttlmtLLlalgvFDdkWPpfaadvileLyedkageyfvrvlYqek.......elrlrgseedlvPlekFk

QIMKPYLVsnISQIEELCSL
...... .    . .. |.|
allavlvl..pkdyaaeCkl
subfamily_HP2-Group1_pd Subfamily HP2-Group1 55-325 1.3e-21 68.5 In-house 93-386 (422) alignment 
Range on Protein: 55-325
Range on HMM: 93-386/422.0
GQLSIEGMKEEYNLGKLFQSRYLESGFMNATYNRTQIYVRSTQYDRTIMSAQCVLAAMYPPTEEEVEFqpgldWQPIPVHsTIGPDYLLRGFASKLCPRY
.||..|| |..   |. ... |...||...... ...|.|| .  |||.|||...  |||.     .       | .... |    .      ..|||. 
aqltleGykqqelnGqilrkvyvdtGflkssldssevylrsddesrtilsaqalilGmypqdtkaedr.....aqvvdly.trdklfdsieanadlcpkl

ELLKNQTEKSSGYLATWN-DNKELFVELSNYTGEPVN---------------------LTNIWHIQDTLFQQWYANYTTPYWYTTELMDK-LQELANYV-
   ..|  ||. .|  ..   |||  |.|.  |  .                      . |. .. | |.     |.. |   | .|. . |.||     
seyntqflksdtwlnhlkgitkelllevskalGsnkslgsggcshtlylpiavtrkldidnledlvdclithqchnaaipdkltedlakrgldellyrsy

LSLLFDSTMKKQLTG-GLWANEVIENMEDKSSKESnlTQRMILYSAHDTTVAAMLSVFNLFDKKQPLFSAAFVIELYSNDDNGH------YVKFLYHNET
 ||.. |  |.  .| |.   .. ... .  . |.   ....||| ||||.  .|| .|. . | | ... ...||..     .       |. ||  . 
sslkypsvekyarvGiGfllkdiwkevnesltGed..lrkfllysGhdttliqllsalnvdefkwppyasllllellevstapaastpqyavrvlynGkl

KS
| 
kk
subfamily_PXYLP1_pd Subfamily PXYLP1 54-349 2e-14 44.6 In-house 103-399 (419) alignment 
Range on Protein: 54-349
Range on HMM: 103-399/419.0
YGQLSIEGMKEEYNLGKLFQSRYLES-GFM--NATYNRTQIYVRSTQYDRTIMSAqcvLAAMYppteeevEFQPGLDWQPIPVHSTigPDYLLRgFASKL
 |||   |.    ..|.|..  |... ...  .  ... .... .|.. ||. ||   || .|        . |  ... | |. .  |. .   . .  
lgqLtqkGvvqhLevGdllrkvYakklklLlkpnelssDevvlettrkrrtlqsa...lally.......gllpkaklkairvres..psvafC.lgeCs

CPRYELLKNQTEKSSGYLATWnDNKELF---VELSNYTGEPVNLTNIWHIQDTLFQQWYANYTTPYWYT----TELMDKLQELANYvLSLLFDSTMKKQL
||  . .. . |.   .|    .. ..     |. . |  . .|. | .  |.|      | . |.        . .| |..||.  ||         .|
CPallrkrlekeadkqlLlrg.kvldvmksvgetlkgtilqttlngisnpvdalltvlChnvslPcrreGcvepshvdvlhklade.lsqrsakksyykl

TGGLWANEVIENMEDKSSKESNL--TQRMILYSAHDTTVAAMLSVFNLFDKKQPLFSAAFVIELYSND-DNGHYVKFLYHN--ETKSDQFHEL-THPNCE
.| | |. .....  .  |  .    ....|||.|| |.  ... ..| . . . ...  | ||| .. .. .|.. ||.    |.  .| |  .. . .
sGllraypllrdivsrmlkiieGvdkekfvlysghDvtlrplvaaLglseartiayasrlvfelyrreaskeyylrvlynGkDvtqkvdfCegdskrskk

TNCPLGKLKQIM
  |||  | . .
dlCPlenlvrfv
subfamily_MINPP1_pd Subfamily MINPP1 55-163 1.3e-08 26.1 In-house 90-190 (420) alignment 
Range on Protein: 55-163
Range on HMM: 90-190/420.0
GQLSIEGMKEEYNLGKLFQSRYLESgFMnATYNRTQIYVRSTQYDRTIMSAQCVLAAMyppTEEEVEFQPGLDWQPIPVHSTIGpDYLLRGFASklCPRY
..|  .| .| ..|.| ...|...  |  . ||.......||.  ||. |||  . ..   .|..  ..  ..   . .....  | ||| |.|  |..|
kslvaqgqeeleelakrlarrfpal.fe.evynpdsfsfastakkRtvksaqaFaeGL...setgevlgdefnivlqeiseqes.dklLrffds..Ckky

ELLKNQTEK
.   .. | 
knkvkknel
Mid2 Mid2 like cell wall stress sensor 375-412 2.6e-07 18.2 Pfam-A 47-82 (155) alignment 
Range on Protein: 375-412
Range on HMM: 47-82/155.0
GNKATVIGLGVALGVALVLLIttLAILIIFCIRVKRNN
 ||  |||  | .|| |.|.|  |... ||||. || .
knkniviGcvvGigvPlllvi..lvliyifCikekrtd
LTD Lamin Tail Domain 172-217 1.8e-06 14.5 Pfam-A 22-60 (116) alignment 
Range on Protein: 172-217
Range on HMM: 22-60/116.0
NDNKeLFVELSNYTGEPVNLTNiWHIQDTlfqqwYANYTTPYWYTT
..|.  ..|| |.....|.|.. | ..|       ..||... .. 
gsnn.kwielyNtgaaavdLsg.Wklkds.....gntytfasgvvl
MLANA Protein melan-A 373-422 4e-06 13.3 Pfam-A 13-61 (118) alignment 
Range on Protein: 373-422
Range on HMM: 13-61/118.0
TSGNKATVIGLGVALGVALVLLITTLaILIIFCIRVKRNNEYQMLQDSTS
  |.. . .    |||....... .| .|.. |  .|| . |..|.|.. 
fkgkgrsyvtaeealGigilivvlvl.llllgcWyykrrsGykrlrdksi