Gene AqueHP2-Un-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily HP2-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP195_AA protein Get Run
AqueP195_AA_29-426 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_HP2-Group1_pd Subfamily HP2-Group1 28-426 9e-223 731.1 In-house 3-422 (422) alignment 
Range on Protein: 28-426
Range on HMM: 3-422/422.0
QCGLTTAGWSIPPPpEDVNLKQVIAVIRHGD--RTAWNGsSCWPGDDYIWSCDLVHGQMPVdTKVEKERGTAGRIFEKIFLPTNEEMHGNCSVAQLTTIG
 ||.||...|...| |||.|||||.||||||  |.|.|| |||.|||.||.||||....|| .||||||....||..||.|.|.||..|.|.|||||..|
ycGktteakslglp.edvklkqvivvirhGdrvraaynG.scwdGddaiwdcdlvsaslpv.ikvekerivvdriyrkiylntreedaGdcavaqltleG

YKQHLANGGSLNSAYVKNGFLTPSLDPSQVFIRSDDIPRTILSAQSLMDGMFPQDGKCEDNgddgcTQFVPLYTRDTMYDNMEANADLCPKVTEYQTQFY
|||...||..|...||..|||..|||.|.|..||||..|||||||.|..||.|||.|.||.     .|.|.|||||...|..|||||||||..||.|||.
ykqqelnGqilrkvyvdtGflkssldssevylrsddesrtilsaqalilGmypqdtkaedr.....aqvvdlytrdklfdsieanadlcpklseyntqfl

ESTTWLNHLK-TTIEVVNNISNTIGFNIS----------------------DNFEHFCDCLITHYCHNASWPDKLTEDLALSGLDEMVWMSYNSLKYPSV
.|.||||||| .|.|.....|...|.|.|                      ||.|...||||||.||||..|||||||||..||||....||.|||||||
ksdtwlnhlkgitkelllevskalGsnkslgsggcshtlylpiavtrkldidnledlvdclithqchnaaipdkltedlakrgldellyrsysslkypsv

QENARAGIGFLLKDIWKNFNRSVNGEDYEKFSLYSGHDTTLIQLLVALGIDEGIWPPYSSMMLFELYSTSTAPA------AVRVLYNGKIKTLPFCNGQE
...||.|||||||||||..|.|..|||..||.|||||||||||||.||..||..||||.|..|.||...|||||      |||||||||.|.||||...|
ekyarvGiGfllkdiwkevnesltGedlrkfllysGhdttliqllsalnvdefkwppyasllllellevstapaastpqyavrvlynGklkklpfcdane

lCSYETFSNYLSTVTPPDDYQKfCQNYTNA
 ||||.|..|||||.|.||... |....|.
.csyeqfeaylstviphddaed.ckvsdne
0046349 Phosphoglycerate mutase-like 41-422 9e-77 251.8 In-house 2-392 (409) alignment 
Range on Protein: 41-422
Range on HMM: 2-392/409.0
PPeDVNLKQVIAVIRHGDRTAWNGSSCWPGDDYIWSCdlvhgqmpvdtkvekergtagrifekiflptneemHGNCSVAQLTTIGYKQHLANGGSLNSAY
.| . .||||....|||.|| . . |  |....|. .                                    |.|   |||  |..|. . |  | . |
vP.gceLkqvqvlfRHGaRtPtkklsflpnwpginwt...................................ngpcgagqLTplGreqayelGkrlrkrY

VKNGFLTPS--LDPSQVFIRSDDIPRTILSAQSLMDGMFPQDgkcEDNGD-------------DGCTQFVPLYTRDTMYDNMEANADLCPKVTEYQTQFY
|. |.| ..   .|.....||.|..||. |||... |.||..   ...               .  ...||....|.. |.. .. .|||.  ..  ...
vdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfppl...ggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkllkenl

ES-TTWLN-----------HLKTTIEVVNNISNTI-----GFNIS---DNFEHFCDCLITHYCHNASWPDK---LTEDLALSGLDeMVWMSYNSLKYPSv
.|   .|.           .|..| .... ... .     |.|..   | .....|.|. ...|. ..|.    .|....    .    ..|. | ... 
kslsevleflvdealldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplppwcdlftpeelkvlay.ladleyyylygsg.

qENARAGIGFLLKDIWKNFNRSVNGED------YEKFSLYSGHDTTLIQLLVALGIDE-----GIWPPYSSMMLFELYST-STAPAAVRVLYNGKikTLP
 | |..  | ||..| ..... ..|..        |..||..||||.. || |||...       .|||.|.. ||||.. |.    |||||||.  .||
.elaklaggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLglfdrlfrssdippyasnlvfElyecpsdgeyyVrvlyngg..plp

FCNGQELCSYETFSNYLSTVTPPD---DYQKFCQN
.....|.|....| ..|. . |.    |..|.|. 
lpgcgegcplsefkellkkrlpgcgltdfdklCpl
0049059 Phosphoglycerate mutase-like 30-421 5.5e-74 242.6 In-house 27-435 (435) alignment 
Range on Protein: 30-421
Range on HMM: 27-435/435.0
GLTTAGWSIpPPPEDVNLKQVIAVIRHGDRTAWNgsSCWPGDDYIWSCDLVHGQMPVdtkvekergtagrifekiflpTN----EEMHGNCSVAQLTTIG
     | |. ..||. .||||....|||.|| ..  ... . ...| ..| .   |                       .     ......   .||  |
apgvfgisl.dvpegcelkqvqvlfRHGaRtPts..klikklealwekllslltypn.....................gplsflndwnyplgageLTplG

YKQHLANGGSLNSAYvknGFLtpsLDPSQVFIRSDDIPRTILSAQSLMDGMFPQD-GKCEDNGDDGCTQFVPLYTRDTMYDNMeaNADLCPKVTEYQTQF
..|.   |  | . |   |||   ..|..|..||.|..||. |||... |.||..  .   . ..   |.||  |.| ..| .  . | ||.  |.. ..
reqayelGkrlrkrY...gfL...ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl..pydscpafdellkel

YESTTWLNH-LKTTIEVVNNISNTIGFNISDNFEHF----CDCLITHYCHNASWP--DKLTEDLALSGLDEMVWMSYNSLKYPSvqENARAGIGFLLKDI
..|  .|.. |. . .. ..... .|...|| . ..    .|.|...|.|. ..|  . .||...      . .. |.   | .  | |..  | ||..|
lasdeflelflerilkllqellpglgltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygd..eiaklaggpllnei

WKNFNRSVNGED----------------YEKFSLYSGHDTTLIQLLVALGIDEGIWP---------------------PYSSMMLFELYSTSTA-PAAVR
 ..... .||..                  |..||..||||.. || |||. ....|                     ||.|.. ||||....     ||
larledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvfElyecpdgneyyVr

VLYNGKIKTLPFCNGQE--LCSYETFSNYLSTVTPPDDYQKfCQ
||||||  .||.|....  ||....| .......|.||... |.
vlyngkvlplpgcgsgpgglCplddFkelvkkflpgddfde.Cg
0048946 Phosphoglycerate mutase-like 36-426 3.4e-73 240.0 In-house 31-415 (447) alignment 
Range on Protein: 36-426
Range on HMM: 31-415/447.0
WSiPPPPEDVNLKQVIAVIRHGDRTAWN-----------------------GSSCWPGDDYIWSCDLVHGqmpvdtkvekergtagrifekiflptneem
 . .|.||. .||||....|||.||  .                       . | .. ..| ....   .                              
ip.epvpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwp..............................

hgnCSVAQLTTIGYKQHLANGGSLNSAYvkNGFLTpslDPSQVFIRSDDIPRTILSAQSLMDGMFPQDgkcedngDDGCTQFVPLYTRDTMYDNMEANad
   |   |||  |..|.   |  | . |  .|.|    .||....||.|..||. |||... |.||..        ..  |..| .| . ..||  ..  
...cglgqLTplGreqlyelGkrlrkrY..lgllp...npseiyvrssdvdRtlqSaqaflaGlfppe.......pplgyqpipihtvpssndnlllp..

LCPKVTEYQTQFYEsTTWLNHLKTTIEVVNNISNTIGFNISDNFEHFCDCLITHYCHNAS-WPDKLTEDLALSGLDEMVWMSYNSLKYPSvqENARAGIG
 ||.  |......    . . || ..| .... ..  ...|| . ..  .|  ...|. | ... .|.....     . .. |    | .  | ||.  |
sCpafkellkkela.eelkellkellerlkkllgglnltlsdvydlydlllyetaihglsplcslftpeelevleyladlefyyeygygd..elarlagg

FLLKDIWKNFNRSVNGEDyeKFSLYSGHDTTLIQLLVALGIDEGIWP------------------PYSSMMLFELYSTS-----TAPAAVRVLYNGKIKT
 ||..| ..... ..|.   |..||..||||.. || |||. . ..|                  ||.|.. ||||...     .    |||||||.  .
pllneilarledaisgds..klylyfaHdttiaallsaLglfddelplpadnlpfnrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlyngeplp

LPFCNGQE--LCSYETFSNYLSTVTPpdDYQKFCQNYTNA
||.|....  ||....| ..|... |  |..|.|.. .. 
lpgCgsgpgglCplddFkellkkflp..dweklCgltlsv
0049226 Phosphoglycerate mutase-like 47-421 3.2e-72 236.5 In-house 3-341 (342) alignment 
Range on Protein: 47-421
Range on HMM: 3-341/342.0
LKQVIAVIRHGDRTAWNGSSCWPGDDYIwscdlvhgqmpvdtkvekergtagrifekiflptneemhGNCSVAQLTTIGYKQHLANGGSLNSAYvkNGFL
||||...||||||| ..   ...  ..                                        ..|.  .||  |..|. . |  | . |  .|.|
LkqvqvliRHGdRtPlakgpldflnewf.......................................wgcglgeLTplGreqayelGrrlrkrY..lgll

TPSLDPSQVFIRSDDIPRTILSAQSLMDGMFPQDGKCEDNgDDGCTQFVPLYTRDTMYDNMEA-NADLCPKVTEYQTQFYESTTWLNHLKTTIEVVNNIS
 . ..|..|..||.|..||. |||... |.||...  ... ..   |..|..| .  .|.. . . | ||.. ... ... |... ..|. . ......|
pstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilv.plldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllkkls

NTIGF---NISDNFEHFCDCLITHYCHNASWPDK---LTEDLALSGLDEMVWMSYNSLKYPsvqENARAGIGFLLKDIWKNFNRSVNGEDYEKFSLYSGH
. .|.   ..|| .....|.|. ...|. ..|.     | . ..   ...... |.    .   | ||. .| ||..| ..... ..| .  |..||..|
kllglnlstlsdvadtlydlllyelahglplppwcslftleelkalyaldllyyygigyge...eiarlaggpllneilarleeaiegpsdlklylyfah

DTTLIQLLVALGIDEGIWPPYSSMMLFELYSTStAPAAVRVLYNGKI------KTLPFCngQELCSYETFSNYLSTVTPPdDYQKFCQ
|||.. || |||. .. .|||.|.. ||||...     |||||||..       .||.|  ..||....| .......|. |....| 
dttiaallsalglfddqlPpyasnlvfElyecd.geyyVrvlynggvlslpvtlplpgc..dglcpldefkelvkkflpg.dfeelCf
0047369 Phosphoglycerate mutase-like 36-421 2.7e-71 233.9 In-house 34-437 (438) alignment 
Range on Protein: 36-421
Range on HMM: 34-437/438.0
WSiPPPPEDVNLKQVIAVIRHGDRTAwnGSSCWPGDDYIWSCDLVHGQMPVdtkvekergtagrifekiflPTNEEMH---GNCSVAQLTTIGYKQHLAN
.| ...||. .||||....|||.||    .|....   .|.... ..  |                     . .. ..   |.|   |||. |..|. . 
is.ldvpegcelkqvqvlfRHGaRtP..tksklkkleplwellenattyps....................gplsflndwlgpcgagqLTplGreqayel

GGSLNSAYvknGFLtpslDPSQV-FIRSDDIPRTILSAQSLMDGMFPQDGKCEDNGDDgcTQFVPLYTRDTMYDNMEA--NADLCPKVTEYQTQFYESTT
|  | . |   |.|    .|..| ..||.|..||. |||... |.||..|  | . .    |..|..|.   .| .    . | ||.. |.. .|. | .
GkrlrkrY...glL....npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapil..wqpipihtipesddfllnllpsdscpafdellkeflasde

WLNH-LKTTIEVVNNISNTIGFNISDnFEHFCDCL---ITHYCH----NASWPDKLTEDLAlSGLDEMVWMSYNSLKYPSVqENARAGIGFLLKDIWKNF
.|.. ||  ....... .......|| .  ..|..   . ....    . ....  |....   |  . .. .  |....  | |.. .| ||..| ...
flelllkdilkrlkkllpglnltpsd.vldlydlcaydtlangyaglplspfcslftpeel.evleyladlefyylygygn.elaklaggpllneilarl

NRSVNGED----------------YEKFSLYSGHDTTLIQLLVALGIDEGIWP---------------------PYSSMMLFELYST-STAPAAVRVLYN
.. .||..                  |..||..||||.. || |||. .  ||                     ||.|.. ||||.. |.    ||||||
edaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivPyasnlvfElyecpsdgeyyVrvlyn

GKIKTLPFCNGQE--LCSYETFSNYLSTVTPPdDYQKFCQ
||  .||.|....  ||....| .......|. |....|.
gkvlplpgcgsgpgglCplddFkelvkkllpg.dfeelCg
0053031 Phosphoglycerate mutase-like 46-420 2.6e-70 230.4 In-house 2-340 (342) alignment 
Range on Protein: 46-420
Range on HMM: 2-340/342.0
NLKQVIAVIRHGDRTAWNGSSCWPGDDYIWscdlvhgqmpvdtkvekergtagrifekiflptneemhgNCSVAQLTTIGYKQHLANGGSLNSAYvkNGF
.|||||...|||.|| ..   ..|  ....                                       .|.  .||  |..|... |  | . |   |.
eLkqvivlvRHGaRtPlskgpldplnewfy.......................................pcgageLTplGreqayelGrrlrkrY..lgl

LTPSLDPSQVFIRSDDIPRTILSAQSLMDGMFPQDGKCEDNGDDGcTQFVPLYTRDTMYDN-MEANADLCPKVTEYQTQFYESTTWLNHLKTTIEVVNNI
| . ..|..|..||.|..||. |||... |.||..|  ..| . |  |..|..| . ..|  .  | | ||.. ... ... | .. ..|. ..|... .
lpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllg.wqpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqkl

SNTIGFNISD---NFEHFCDCLITHYCHNASWPDKLTEDLALSGLDEMVWMSYNSLKYPSVQENARAGIGFLLKDIWKNFNRSVNGEDYEKFSLYSGHDT
|.. |...||   .. ...|.|. ...|. ..|. .|...    .  . .. ..  .. . .| |.. .| ||..| ..... ..|..  |. ||..|||
skglgltlsdlldlvsdlydlllyelahglplppwctlftleelkalyaldllyyyglgpgnelaklaggpllneilarleekisgpldlklylyfahdt

TLIQLLVALGIDEGIWPPYSSMMLFELYSTStAPAAVRVLYNGK------IKTLPFCNGqeLCSYETFSNYLSTVTPPdDYQKFC
|.. || |||. .. .|||.|.. ||||...     |||||||.        .||.|.|  ||....| ...... |. |..|.|
tiaallsaLglfddqlPpyasnlvfElyedp.geyyVrvlynggtlseplvlplpgcdg..lcplsefkelvkkllpg.dfeklC
0048439 Phosphoglycerate mutase-like 40-411 5.6e-64 209.8 In-house 2-390 (391) alignment 
Range on Protein: 40-411
Range on HMM: 2-390/391.0
PPPEDVNLKQVIAVIRHGDRTAWNGssCWPGDDYIWSCdlvhgqmpvdtkvekergtagrifekiflptnEEMHGNCSVAQLTTIGYKQHLANGGSLNSA
..|.. .||||....|||.||. ..   .   | .. .                                   .|.|   .||  |..|. . |  | . 
dvpagcelkqvqvlfRHGaRtPtss..ypnkldpllnk................................llpngpcglgeLTplGreqlyelGrrlrkr

YVKNGFLTPSL--DPSQVFIRSDDIPRTILSAQSLMDGMFPQ--------------DGKCEDNgddgCTQFVPLYTRDTMYDNMEA-----NADLCPKVT
||. |.| ...  .||.|..||.|..||. |||... |.||.              |    ..     ....||.  .. .|.. |       . .... 
YvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgltvilvivvesedpllnpl....pintcplledlllldalsalprfylseilerla

EYQTQFYESTTWLNHLKTTIEVVNNISNTIGFNISD-----NFEHFCDCLITHYCHNASWPDKLTEDL-----ALSGLDEMVWMSYNSLKYPsvqENARA
|.. ......  .. ......  .....  |....      .. . .|.|...|.|. . |. ||..|     .  . | . .. |    ..   | |. 
evlnrvlglnltaedvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsg...eiakl

GIGFLLKDIWKNFnrSVNGEDYEKFSLYSGHDTTLIQLLVALGIDEG------IWPPYSSMMLFELYST-STAPAAVRVLYNGK----------------
 .| ||..| ...   .||..  |..||..||||.. || |||. .        .|||.|.. ||||.. |.    |||||||.                
aggpllneilddl..vangpsdpklylyfaHdttiaallsaLglfndtlplpadlppyasnlvfElyecpsdgeyyVrvlynggtldlprdltlldldef

----IKTLPFCNGQE--LCSYETFSNYLSTVT
      .||.|....  ||....| .......
llrlvlplpgcgsgpgglCplddFvelvkkri
subfamily_ACP2_pd Subfamily ACP2 43-423 1.3e-62 204.5 In-house 5-359 (361) alignment 
Range on Protein: 43-423
Range on HMM: 5-359/361.0
EDVNLKQVIAVIRHGDRTAWNGSSCWPgddyiwscdlvhgqmpvdtkvekergtagrifekiflpTNEEMHGNcSVAQLTTIGYKQHLANGGSLNSAYV-
|. .|| | ...|||||.. |     .                                       .|.. ..    |||  |..|..  |  | . || 
eerkLkfvqvlfRHGdRsPlntypndk......................................ykedewpq.glGqLTeeGmqqqyeLGkfLrkrYve

KNGFLTPSLDPSQVFIRSDDIPRTILSAQSLMDGMFPQDGKCEDNGDDgCTQFVPLYTRDTMYDNMEANADLCPKVTEYQTQFYESTTWLNHLKTTIEVV
. .||... .|.|...|| |. ||. ||||.. |.||.... . . .    | ||  |..  .|..  .   ||.. | . ...||  . ..|.   |..
dtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfppetgvdypdeq.eWqpvPvhtvseeedlllrakknCprydellqeakespevkklleenkell

NNISNTIG--FNISDNFEhFCDCLIT-HYCHN-ASWPDKLTEDLaLSGLDEMVWMSYNSLKY---PSVQENARAGIGFLLKDIWKNFNRSVN---GEDYE
...|.  |  .. .. ..   | ||    ..|  ..|. ....| .. |.|.  ....   .      .| ..  .|.||... .|... ..    .. .
eklsestgedidlenfyq.lsdtlicerkyanelnlpewandel.fekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkceekkkkl

KFSLYSGHDTTLIQLLVALGIDEGIWPPYSSMMLFELYSTSTAPAAVRVLYNGKIKTLPF------CNGQELCSYETFSNYLSTVTPPDdYQKFCQNY
|. |||.|||||  ||.|||| |. .|||.|....|||....    |.|||. . .. |.      |.|.|.|. ..| .......| | ... |.. 
klflYSaHDttlaalLeaLgifekkappyasaiivElyeeddgkplvkvlyrnetskdppeltlpgCkgeedCplskfkkivkpfipdd.vdelCeak
subfamily_ACP6_pd Subfamily ACP6 45-422 6.4e-50 161.9 In-house 2-373 (376) alignment 
Range on Protein: 45-422
Range on HMM: 2-373/376.0
VNLKQVIAVIRHGDRTAWNGSScwPGDDYIWSCDLVHG--QMPVDTKVEKERGTAGRIFEKIFLPTNEEMHGNCSVAQLTTIGYKQHLANGGSLNSAYVK
..||||  | ||| ||  .       ..  |  ||...  .. .| .| .  |      .      .| ..| . . ||| .| .|  . |  |   || 
leLkqvqvvfrhGartPikslP..qeeeveWdkdlleslpdleidyrvtnlnGepkPeskieekykkeilkGGafkGqLtkvGmqqvfdLGrkLrkrYve

N-GFLTPSLDPSQVFIRSDDIPRTILSAQSLMDGMFPQDgKCEDNGDdgctqfVPLYTRDTMYDNMEANADLCPKVTEYQTQFYESTtwlNHLKTTIEVV
. .||...  | .|.||| .|.||. ||. |. |.. .  ... ..       . |||..   . .  |   ||.....  .  .|.    .|.   |  
dikfLsqefnpqevyiRstnieRtlesarclvaGLygki.iiqkelp......iilytdeedeevlyPnrqrcpllsrayrsvrksa...islpGisedt

NNISNTIGFNISDNFEHFC--DCLITHYCHNASWPDKLTEDLAL---SGLDEMVWMSYNSLKypSVQENARAGIGFLLKDIWKNFNRSVNGEDY-EKFSL
..| .... . ........  | .  .  || . |. | . . |      .|.| .  .  .  . .|  .. .| .||.| .|...  ..|   .|. |
kqiadvldiseekkldfvslrDniaArlaHnlkvppilkdvidliekhAveelvvlleggdr..pekeilklsvGkvlkeilenlekakekeiparklrL

YSGHDTTLIQLLVALGIDEGIWPPYSSMMLFELYSTSTAPAAVRVLYNGKIKTLPFCNgQELCSYETFSNYLSTVTPPDDYQKFCQN
|| |||||. ||.|||. .. |||... . .|||        |||||..|.. |. .. ..|. .| | . |.... |.||.. |. 
ysaHDttlmtLLlalgvFDdkWPpfaadvileLyedkageyfvrvlYqekelrlrgse.edlvPlekFkallavlvlpkdyaaeCkl
His_Phos_2 Histidine phosphatase superfamily (branch 2) 47-383 2.9e-37 121.3 Pfam-A 2-347 (347) alignment 
Range on Protein: 47-383
Range on HMM: 2-347/347.0
LKQVIAVIRHGDRTAWNGSSCW---------------PGDDYIWSCDLVHgqmpvdtkvekergtagrifekiflptnEEMHGNCSVAQLTTIGYKQHLA
||.|..||||||||  .                    .  .. .. . .                             |...  .   .||. | ||. .
LkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk............................eklqlilkwgglThsGrkqaee

NGGSLNSAYVknGFLTPSLDPSQVFIRSDDIPRTILSAQSLMDGMFPQDG--KCEDNGDDGCTQFVPLYTRDT----MYDNMEANADLCPKVTE-----Y
 | .| . |.  |.| . |....|.|||..  |.. |||... |.....|   .... |    . ..  | |       ... ..|. ||. ..      
lGeqlrqrYp..gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikve

QTQFYESTTWLNHLKTTIE-VVNNISNT-IGFNISDNFEHFCDCLITHY-CHNASWPDKLTE----DLALSGLDEMVWmSYNSlkYPSVQENARAGIGFL
...  .   . ..... ..  .... .    ..  .. | .  .....   ..  .|.  ..     | .. |...    |.   |   .|....  . |
krvvelvnklkkvmdenlakrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledlee.lykl..ygigdeeklkiglll

LKDIWKNFNRSVNGED---YEKFSLYSGHDTTLIQLLVALGIDE------GIWPPYSSMMLFELYSTSTAPAAVRVLYN
|... |.........    ..|. ||..||.....|| |||..|        ..||.| . ||||. |..   ||.|..
lnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyedsekkfyvrllfs
His_Phos_2 Histidine phosphatase superfamily (branch 2) 47-383 2.9e-37 121.3 In-house 2-347 (347) alignment 
Range on Protein: 47-383
Range on HMM: 2-347/347.0
LKQVIAVIRHGDRTAWNGSSCW---------------PGDDYIWSCDLVHgqmpvdtkvekergtagrifekiflptnEEMHGNCSVAQLTTIGYKQHLA
||.|..||||||||  .                    .  .. .. . .                             |...  .   .||. | ||. .
LkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk............................eklqlilkwgglThsGrkqaee

NGGSLNSAYVknGFLTPSLDPSQVFIRSDDIPRTILSAQSLMDGMFPQDG--KCEDNGDDGCTQFVPLYTRDT----MYDNMEANADLCPKVTE-----Y
 | .| . |.  |.| . |....|.|||..  |.. |||... |.....|   .... |    . ..  | |       ... ..|. ||. ..      
lGeqlrqrYp..gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikve

QTQFYESTTWLNHLKTTIE-VVNNISNT-IGFNISDNFEHFCDCLITHY-CHNASWPDKLTE----DLALSGLDEMVWmSYNSlkYPSVQENARAGIGFL
...  .   . ..... ..  .... .    ..  .. | .  .....   ..  .|.  ..     | .. |...    |.   |   .|....  . |
krvvelvnklkkvmdenlakrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledlee.lykl..ygigdeeklkiglll

LKDIWKNFNRSVNGED---YEKFSLYSGHDTTLIQLLVALGIDE------GIWPPYSSMMLFELYSTSTAPAAVRVLYN
|... |.........    ..|. ||..||.....|| |||..|        ..||.| . ||||. |..   ||.|..
lnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyedsekkfyvrllfs
subfamily_PXYLP1_pd Subfamily PXYLP1 43-400 3e-35 113.2 In-house 20-392 (419) alignment 
Range on Protein: 43-400
Range on HMM: 20-392/419.0
EDVNLKQVIAVIRHGDRTAWngSSCWPGDDYIWSCDLVHGQMPVDTKVEKER------GTAGRIFEKI----FLPTNEEMHGNCSVAQLTTIGYKQHLAN
|. .|| |  ||||||||    |     .   . |||. .. ..  |...        .. . . .|.     ||   . .. | ..||| .|  ||| .
egfkLkavlvvirhGDrtPl..sdipkskraeinCdlsaasknlvdklksfldnssseasgsdfenkvgplkslPllpnheriCelgqLtqkGvvqhLev

GGSLNSAYVKN-GFL--TPSLDPSQVFIRSDDIPRTILSAQSLMDGMFPQDgkcedngddgctQFVPLYTRDTMYDNMEANADLCPKVTEYQTQFYESTT
|  |  .| |. ..|     |   .| . .    ||. || .|. |..|..            ..  .. |..   ..  .   || ... . .  .   
GdllrkvYakklklLlkpnelssDevvlettrkrrtlqsalallygllpka............klkairvrespsvafClgeCsCPallrkrlekeadkq

WLNHLkTTIEVVNNIS----NTIGFNISDNFEHFCDCLITHYCHNASWPDKLTEDLALSGLDEMVWM----SYNSLKYPSVQENARAGIGFLLKDIWKNF
 |  .  ...| . ..     ||  .      .  | |.|. |||.|.| .    .  |  | .  .    | .| |    .   . ..  ||.|| .. 
lLlrg.kvldvmksvgetlkgtilqttlngisnpvdalltvlChnvslPcrreGcvepshvdvlhkladelsqrsakksyyklsGllraypllrdivsrm

NRSVNGEDYEKFSLYSGHDTTLIQLLVALGIDEGIWPPYSSMMLFELYSTSTA-PAAVRVLYNGKIKT--LPFCNG------QELCSY
 . ..| | ||| |||||| ||  |. |||..|. .. |.| ..||||   .     .||||||| .|  . ||.|      ..||  
lkiieGvdkekfvlysghDvtlrplvaaLglseartiayasrlvfelyrreaskeyylrvlynGkDvtqkvdfCegdskrskkdlCPl
subfamily_MINPP1_pd Subfamily MINPP1 357-421 6.1e-08 23.9 In-house 350-415 (420) alignment 
Range on Protein: 357-421
Range on HMM: 350-415/420.0
WPPYSSMMLFELYSTSTAPAAVRVLYNGKIKTLPFC-NGQELCSYETFSNYLSTVTPPDDYQKFCQ
  ||.. . |.||  |.    |.|| | |.  |. | .|...| ...| ......    | .| |.
ivpyaanlafvlydCskdqykvlvllnekvvkletcsegeifCelqdfkeiykkivdncdleklCe