Gene acp-4 in Caenorhabditis elegans

Synonym: CELE_F14E5.6, acp-4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily ACP2
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP004_AA protein Get Run
CeleP004_AA_78-338 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP2_pd Subfamily ACP2 93-338 8.3e-56 182.0 In-house 5-269 (361) alignment 
Range on Protein: 93-338
Range on HMM: 5-269/361.0
PIRRLIFAHTIFRHGSRAPSK-----NANNTYYPRGRGQLTDRGYNHSFMLGRFLKKRY-VGTGFLSDFMKPSEMEWRFRAVERCLATASAVAAGMFKT-
  |.|.| ...||||.|.|..     . ... .|.| ||||..|......||.||.||| . |.||.. ..|.....|.  |.|.|..|..|.||.|.. 
eerkLkfvqvlfRHGdRsPlntypndkykedewpqglGqLTeeGmqqqyeLGkfLrkrYvedtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfppe

------EERKWLTVPITTNHANQDKLLNtPVHSCDIFESAMEKACPNLEADNHRDESAIMYECAGSNHP--IFQKISIDDSDKYIN--DYKNNVPVPDFI
      .|..| .||..|.....|.||. . ..|.........|. . | ... .|.....|.  ...   | .. ... ||..|   .|.|....|...
tgvdypdeqeWqpvPvhtvseeedlllr.akknCprydellqeakespevkklleenkelleklsestgedidlenfyqlsdtlicerkyanelnlpewa

C----ENIEVISEEYMKYRNLKNGIGKPVIIKFRFGVLIDTLLENLKTAWTNNLANKEsLKFKVYST
     |..| ..........  |   .. . |.|.|.|...||||.|....... .|. ||. .||.
ndelfekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkceekkkk.lklflYSa
0048946 Phosphoglycerate mutase-like 79-338 2.1e-36 118.8 In-house 16-304 (447) alignment 
Range on Protein: 79-338
Range on HMM: 16-304/447.0
VHTSSTPYPVTQTNPIR-------RLIFAHTIFRHGSRAPSKNA--------------------------NNT--------YYPRGRGQLTDRGYNHSFM
  . ..||.. .. .|        .|.... .||||.|.|.|.                           |..        ..| | ||||..|.   ..
hlgtlspyfsvpgygipepvpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwpcglgqLTplGreqlye

LGRFLKKRYvgTGFLSdfmKPSEMEWRFRAVERCLATASAVAAGMFKTE-ERKWLTVPITTNHANQDKLLNTpvhSCDIFESAMEKACPNLEADNHRDES
||..|.|||  .|.|.    |||. .|   |.|.|..| |..||.|  |   .. ..|| | .  .| ||..   ||. |.. . |..    .. ...  
lGkrlrkrY..lgllp...npseiyvrssdvdRtlqSaqaflaGlfppepplgyqpipihtvpssndnlllp...sCpafkellkkelaeelkellkell

AIMYECAG-SNHPIFQKISIDDSDKYINDYKNNVPVPDFI-CENIEVISEEYMKYRNLKNGIGKPvIIKFRFGVLIDTLLENLKTAWTNNLankeslKFK
. ... .| .|  . .  .. |  .|   . . .| ....  | .||. . .  .  ...|.| . . . ..|.|.. .|..|. |. ..       |. 
erlkkllgglnltlsdvydlydlllyetaihglsplcslftpeelevleyladlefyyeygygde.larlaggpllneilarledaisgds......kly

VYST
.|..
lyfa
0049059 Phosphoglycerate mutase-like 95-338 8.6e-36 116.8 In-house 41-329 (435) alignment 
Range on Protein: 95-338
Range on HMM: 41-329/435.0
RRLIFAHTIFRHGSRAPSKNA-------------------------NNTYYPRGRGQLTDRGYNHSFMLGRFLKKRYvgtGFLsdfMKPSEMEWRFRAVE
 .|.... .||||.|.| ..                          |...|| | |.||..|.   ..||..| |||   |||   ..|.|. .|   |.
celkqvqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrY...gfL...ynpdevyvrssdvd

RCLATASAVAAGMFKTE---------ERKWLTVPITTNHANQDKLlntPVHSCDIFESAMEKAC--PNLEADNHRDESAIMYECA----GSNHPIFQKIS
|.|..| |..||.|  |         .  .. ||| |... .| |   |  ||. |. ....    .      ... .... | .     ... ..   .
RtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl...pydscpafdellkellasdeflelflerilkllqellpglgltpsdvldlyd

IDDSDKYINDYKNNVPVP--D-FICENIEVISEEYMKYRNLKNGIGKpVIIKFRFGVLIDTLLENLKTAWTNNLANKE------------SLKFKVYST
.   | ... | ...|.|  . |  | .||... .  .  . .|.|   | | . |.|.. .|..|. |. ..  | .            .||. .|..
lckydtlllgyahglplpfcslfteeelevleyladlefyylygygd.eiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfa
0053031 Phosphoglycerate mutase-like 96-338 1.2e-35 116.5 In-house 2-256 (342) alignment 
Range on Protein: 96-338
Range on HMM: 2-256/342.0
RLIFAHTIFRHGSRAPSKNAN-----NTYYPRGRGQLTDRGYNHSFMLGRFLKKRYvgTGFLSDFMKPSEMEWRFRAVERCLATASAVAAGMFKTEERKW
.|.... ..|||.|.|  . .     ...|| |.|.||..|.  ...|||.|.|||  .|.|.. ..|.|. .|   |.|.|..| |..||.|  |  . 
eLkqvivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrY..lgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpi

LT-------VPITTNHANQDKLLNTPVHSCDIFESAMEKACPNLEADNHRDES----AIMYECAGSNHPIFQKISIDDSDKYINDYKNNVPVPD----FI
|        .|| | ....| ||... ..|. |......|. . | ... ..     . .... | ..  .... .|  | .. .. .. |.|.    | 
lnpllgwqpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqklskglgltlsdlldlvsdlydlllyelahglplppwctlft

CENIEVISEEYMKYRNlKNGIGKPvIIKFRFGVLIDTLLENLKTAWTNnlanKESLKFKVYST
 |...........| . ..| | . ..| ..|.|.. .|..|. .. .    . .||. .|..
leelkalyaldllyyy.glgpgne.laklaggpllneilarleekisg....pldlklylyfa
0048439 Phosphoglycerate mutase-like 96-338 1.2e-35 116.7 In-house 8-288 (391) alignment 
Range on Protein: 96-338
Range on HMM: 8-288/391.0
RLIFAHTIFRHGSRAPSKNANN----------TYYPRGRGQLTDRGYNHSFMLGRFLKKRYVGTGFLSDFM--KPSEMEWRFRAVERCLATASAVAAGMF
.|.... .||||.|.| ..  |          ...| | |.||..|.   . |||.| |||| .|.|.. .  .|||. .|   |.|.|..| |..||.|
elkqvqvlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlf

KtE--------------ERKWLTVPITTNHANQDKLLNTPVHSCDIF------ESAMEKACPNLEADNHRD-----------ESAIMYECAGSNHPIFQK
  .              .  .  .|| |  . .|.|| ... ... |      |...|     |.  .  .           |.|. . . . ..|... 
p.plgltvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevlnrvlglnltaedvlslfdlcaketaalgsllklssplcdl

ISIDDSdkYINDYKNNVPVPDFICEN------IEVISEEYMKYRNLKNGIGkpVIIKFRFGVLIDTLLENLktawtnNLANKESLKFKVYST
 .. |   .. .| .. |.|... ..      ...... .. . .. .| |  .| | ..|.|....|..|      . ... ..|. .|..
ftlydt..llyeyahglplpewltdellspellkqladlvnelyyyltgsg..eiaklaggpllneilddl......vangpsdpklylyfa
0046349 Phosphoglycerate mutase-like 96-338 1.7e-35 116.0 In-house 6-301 (409) alignment 
Range on Protein: 96-338
Range on HMM: 6-301/409.0
RLIFAHTIFRHGSRAPSKN----ANNTY-----YPRGRGQLTDRGYNHSFMLGRFLKKRYVGTGFLSDF--MKPSEMEWRFRAVERCLATASAVAAGMFK
.|.... .||||.|.| |.     | ..     .|.| ||||..|..  ..||..|.|||| .|.|..   ..|.|. .|   |.|.|..| |..||.| 
eLkqvqvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfp

TEERKWLTVPITTNH------ANQDKLLNTPVHSCDIFESAMEKACPNLEADNHRDES--AIMYE-----------CAGSNHPIFQKIS---------ID
 .. .. .......        . | .    ....| .  .....||.|... ..  .  . ..|           . . . ....|..         ..
plggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkllkenlkslsevleflvdealldlelldetkdllkklaerlnselpgln

----------DSDKYINDYKNNVPVPD----FICENIEVISEEYMKYRNLKNGIGkpVIIKFRFGVLIDTLLENLKTAWTNNLANKE--SLKFKVYST
            | .. .. .. | |.    |  | ..|... .  . .. .| |   . | . |.|.. .|..|. |....  ..   .||. .|..
ltdpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyylygsg..elaklaggpllneilarledaisgknpvtfpldlklylyfa
0049226 Phosphoglycerate mutase-like 96-338 3.7e-35 114.8 In-house 2-256 (342) alignment 
Range on Protein: 96-338
Range on HMM: 2-256/342.0
RLIFAHTIFRHGSRAPSKNAN-----NTYYPRGRGQLTDRGYNHSFMLGRFLKKRYvgTGFLSDFMKPSEMEWRFRAVERCLATASAVAAGMFKTEERKW
.|.... ..|||.|.| .. .     ..... | |.||..|.   ..|||.|.|||  .|.|.. ..|.|. .|   |.|.|..| |..||.|  | . .
kLkqvqvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrY..lgllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpi

LT-------VPITTNHANQDKLLNTPVHSCDIFESAMEKACPNLEADNHRDE----SAIMYECAGSNHPIFQKISIDDSDKYINDYKNNVPVPDF----I
|        .||.| .. .| ||..|  ||. |...... . . |.... .|       .... | |   .....    | .. .. ...|.|..    .
lvplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllkklskllglnlstlsdvadtlydlllyelahglplppwcslft

CENIEVISEEYMKYRNLKNGiGKpVIIKFRFGVLIDTLLENLKTAWTnnlaNKESLKFKVYST
 | ..........| .. .  |   | . . |.|.. .|..|. |.     .. .||. .|..
leelkalyaldllyyygigy.ge.eiarlaggpllneilarleeaie....gpsdlklylyfa
0047369 Phosphoglycerate mutase-like 95-338 6.6e-34 110.8 In-house 42-331 (438) alignment 
Range on Protein: 95-338
Range on HMM: 42-331/438.0
RRLIFAHTIFRHGSRAPSKNA-------------------------NNTYYPRGRGQLTDRGYNHSFMLGRFLKKRYvgtGFLsdfmKPSEM-EWRFRAV
 .|.... .||||.|.|.|..                         |....| | ||||..|.   ..||..| |||   |.|     |...  .|   |
celkqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrY...glL....npedvlyvrssdv

ERCLATASAVAAGMFKTEERKWL------TVPITTNHANQDKLLNT-PVHSCDIFESAMEKACP--NLEADNHRDESAIMYECAG-SNHPIFQKISIDDS
.|.|..| |..||.|  | ...|      ..|| | . ..| |||. |  ||. |. .... .         ..| .... . .. .| .. . ... | 
dRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnllpsdscpafdellkeflasdeflelllkdilkrlkkllpglnltpsdvldlydl

---DKYINDYKNN--VPVPD-FICENIEVISEEYMKYRNLKNGIGKpVIIKFRFGVLIDTLLENLKTAWTNNLANKE------------SLKFKVYST
   | ..|.| .   .| .. |  | .||..  .  .   ..|.|.  . | . |.|.. .|..|. |....  | .            .||. .|..
caydtlangyaglplspfcslftpeelevleyladlefyylygygn.elaklaggpllneilarledaingkstnlnltldsngvtfPldlklylyfa
His_Phos_2 Histidine phosphatase superfamily (branch 2) 97-325 1.8e-19 62.8 Pfam-A 2-284 (347) alignment 
Range on Protein: 97-325
Range on HMM: 2-284/347.0
LIFAHTIFRHGSRAPSKNAN-------------------------NT------YYPRGRGQLTDRGYNHSFMLGRFLKKRYVgtGFLSDFMKPSEMEWRF
| . ....||| |.| .. .                         .|       .. . |.|| .| .  . ||..|..||.  |.|.| ....... | 
LkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYp..gllrdhltyedvkirs

RAVERCLATASAVAAGMFKTEE----------RKWLTVPITTNHA---NQDKLLNTPVHSCDIFES----AMEKACPNLEADNHRDESAIM----YECAG
   .|.||.| |.|||... |.          ... .... | .    ... || .  .||  |..      ..... ..  .   .  ..      | |
sserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenlakrlsalctg

-SNHPIFQKISIDDSDKYINDYKNNVPVPDFiCENIEVISEEYMKYRNLKN-----GIGKPvIIKFRFGVLIDTLLENLKTAWTNNL
 .|   ..  .  . . .  ..... ..|.   ....   ... ....|..     |||.. . . . . |.  ||.... .  .. 
ednllfkerweklfreffeeekfdiskipel.ydtmkydalhnrqledleelyklygigde.eklkigllllnpllkkilsdleetq
His_Phos_2 Histidine phosphatase superfamily (branch 2) 97-325 1.8e-19 62.8 In-house 2-284 (347) alignment 
Range on Protein: 97-325
Range on HMM: 2-284/347.0
LIFAHTIFRHGSRAPSKNAN-------------------------NT------YYPRGRGQLTDRGYNHSFMLGRFLKKRYVgtGFLSDFMKPSEMEWRF
| . ....||| |.| .. .                         .|       .. . |.|| .| .  . ||..|..||.  |.|.| ....... | 
LkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYp..gllrdhltyedvkirs

RAVERCLATASAVAAGMFKTEE----------RKWLTVPITTNHA---NQDKLLNTPVHSCDIFES----AMEKACPNLEADNHRDESAIM----YECAG
   .|.||.| |.|||... |.          ... .... | .    ... || .  .||  |..      ..... ..  .   .  ..      | |
sserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenlakrlsalctg

-SNHPIFQKISIDDSDKYINDYKNNVPVPDFiCENIEVISEEYMKYRNLKN-----GIGKPvIIKFRFGVLIDTLLENLKTAWTNNL
 .|   ..  .  . . .  ..... ..|.   ....   ... ....|..     |||.. . . . . |.  ||.... .  .. 
ednllfkerweklfreffeeekfdiskipel.ydtmkydalhnrqledleelyklygigde.eklkigllllnpllkkilsdleetq
subfamily_ACP6_pd Subfamily ACP6 124-337 2.8e-14 44.6 In-house 75-289 (376) alignment 
Range on Protein: 124-337
Range on HMM: 75-289/376.0
RGQLTDRGYNHSFMLGRFLKKRYVG-TGFLSDFMKPSEMEWRFRAVERCLATASAVAAGMFK-TEERKWLTVPITTNHANQDKLLNTpVHSCDIFE---S
 ||||  | .  | ||| |.||||   .|||   .| |.  |   .|| |  |  . ||...    .| | . . |. .... |.    ..|   .   .
kGqLtkvGmqqvfdLGrkLrkrYvedikfLsqefnpqevyiRstnieRtlesarclvaGLygkiiiqkelpiilytdeedeevlyPn.rqrcpllsrayr

AMEKACPNLEADNHrDESAIMYECAGSNHPIFQKISIDdsDKYINDYKNNVPVPDFICENIEVISEEYM-KYRNLKNGIGKPV--IIKFRFGVLIDTLLE
...|   .|.   . | . |  .   |..  .. .|.   |.     . |..||. . . |..| .  . . . | .|  .|   |.|.  | .....||
svrksaislpGise.dtkqiadvldiseekkldfvslr..DniaArlaHnlkvppilkdvidliekhAveelvvlleggdrpekeilklsvGkvlkeile

NLKTAWTNNLANkesLKFKVYS
||. |  ....     |...||
nlekakekeipa...rklrLys
subfamily_HP2-Group1_pd Subfamily HP2-Group1 124-187 1.2e-09 29.0 In-house 92-155 (422) alignment 
Range on Protein: 124-187
Range on HMM: 92-155/422.0
RGQLTDRGYNHSFMLGRFLKKRYVGTGFLSDFMKPSEMEWRFRAVERCLATASAVAAGMFKTEE
 .|||  ||    . |. |.| || ||||   ...||.  |   . | . .| |.  ||.  . 
vaqltleGykqqelnGqilrkvyvdtGflkssldssevylrsddesrtilsaqalilGmypqdt
subfamily_MINPP1_pd Subfamily MINPP1 123-233 7.1e-06 17.1 In-house 88-198 (420) alignment 
Range on Protein: 123-233
Range on HMM: 88-198/420.0
GRGQLTDRGYNHSFMLGRFLKKRYVGtgFLSDFMKPSEMEWRFRAVERCLATASAVAAGMFKTEE---RKWLTVPITTNHANQDKLLNtPVHSCDIFESA
  ..|.  |..   .|.. |..|.    ...  ..| ... .  | .|.. .|.| | |...|.|    .   | ........||||  ...||. ....
lekslvaqgqeeleelakrlarrfpa..lfeevynpdsfsfastakkRtvksaqaFaeGLsetgevlgdefnivlqeiseqesdklLr.ffdsCkkyknk

MEKACPNLEADNHR
..|   ||.  .. 
vkknelnlkeeeef