Synonym: CELE_H25K10.1, CELE_H25K10.1
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_ACP5_pd | Subfamily ACP5 | 125-321 | 4.5e-65 | 211.1 | In-house | 1-189 (189) | alignment | ||
Range on Protein: 125-321
Range on HMM: 1-189/189.0
IFGDLSVDIGQETIDYLTT-KRDQLDVIIHIGDLAYNLHDQNGTTGDEYMNVIEPFAAYVPYMVFAGNHESNSIFNHIIHRFTMPkngvyNDNLFWSFDF
.||||.|. .... ..|.. ....||.|||.|||||.|...|....||.||.|||.|..|||||..|||||.| |... .||.|| ..| ..|||.
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp.....sknewYsfdy
GNAHFIGLNSEYYPEKMskeaQAQYKWLREDL----EQNSRNWVIVMLHRPWYCSNETPEGCnDGWDTLPRQGlgkLFPGLEDLLNEYTVDMVLYGHRHT
|..|||.|..|.. . . |||||..|| ......|.||| |||.||||.. . | . .|| |.| |...|||||..|.||..|.||.|.
gpvhfislstevdfslg....seqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddc.tkeetlvrkg...lresledllykykvdlalsgHeHs
YE
||
Ye
|
|||||||||
| PAPL | 124-320 | 9.9e-52 | 167.9 | In-house | 1-194 (194) | alignment | |||
Range on Protein: 124-320
Range on HMM: 1-194/194.0
AIFGDLSVDIGQE-TIDYLTTKRDQLDVIIHIGDLAYNLHDQNGTTGDEYMNVIEPFAAYVPYMVFAGNHESNSIFNHIIHRFTMPKNGVYNDNL-----
|.|||| . .. . . .|.....|.|.|.|||||....||...|||.|. |||.||.||||| .||||... |.. .||.||.. . |
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgs
-FWSFDFGNAHFIGLNSeyypEKMSKEAQAQYKWLREDLEQNSR---NWVIVMLHRPWYCSNETPEGCNDGWdtlprqglgKLFPGLEDLLNEYTVDMVL
.||... .||| |.| |. || . ||.|| |||... | |.|||.|||.||||.. . |... | . .||||| .| ||.||
nsysfetesvhfivlss....eedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckeka.........kmlaaledllykygVDlvl
YGHRHTY
|| |.|
aGHeHsY
|
|||||||||
| Metallophos | Calcineurin-like phosphoesterase | 122-320 | 2.7e-20 | 66.5 | Pfam-A | 2-200 (200) | alignment | ||
Range on Protein: 122-320
Range on HMM: 2-200/200.0
RAAIFGDLSVDIGQE----TIDYLTTKRDQLDVIIHIGDLAYNLHDQNGTTGDEYmNVIEPFAAYVPYMVFAGNHESNSIFNHIIHRFTMPKNGVYNDNL
| ...||| . . | . .. . |.... ||| . . ..| .. . . .......|... ||||| .. .. ...| ....|
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang
FWSFD------FGNAHFIGLNSEYYPEKMSKEAQAQYKWLREDLEQNSRNWVIVMLHRPWYCSNETPEGCndgwdtlprQGLGKLFPGLEDLLNEYTVDM
..... ... .| ||.. .....| ... . .. . ...|.. |.|...| .. . .. . ||.||..| ||.
eeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.........gselfgpdalekllekygvdl
VLYGHRHTY
||.|| | .
vlrGHtHkp
|
|||||||||
| Metallophos_C | Iron/zinc purple acid phosphatase-like protein C | 345-409 | 7.5e-18 | 56.0 | Pfam-A | 2-62 (62) | alignment | ||
Range on Protein: 345-409
Range on HMM: 2-62/62.0
APVYILTGSAGChsHEDPSDHIMQDFSVKALGEYGYTYLTVHNSTHLFTDFVDTFSGNItsLDSF
|||.|..|.||. .... .. ....|. .|||. |||.|.||| .|| . .|.. ||||
ApvhIvvGaAGn..glskfskpqpewsafresdyGysrltvvNrthLhwefvrsddgqv..lDsf
|
|||||||||
| ACP5 | 143-318 | 2.8e-10 | 32.2 | In-house | 26-197 (198) | alignment | |||
Range on Protein: 143-318
Range on HMM: 26-197/198.0
TKRDQLDVIIHIGDLAYNLHDQNGTTG---DEYMNVIEPFAAYVPYMVFAGNHESNSIFNHIIHRFTMPKNGV-Y------NDNLFWSFDFGNAHFIGLN
... ..|... .|| |. .. . ... .. . . ||..| .|||. . . |. |. . ... . | . . .
aekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpslryslskkevvtelftekkdeksd
SEYyPEKMSKEAQAQYKWLREDLEQNSRNWVIVMLHRPWYCSNETPEGcndgwDTLPRQglgklfpgLEDLLNEYTVDMVLYGHRH
... .. .|.|. | |||.. |.... .|.||. | | | | . ..| .. |. ||..| ||. | || |
qre.vaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdt.....kelver........llpllkkykvdaYlnGHdH
|
|||||||||
| Metallophos_2 | Calcineurin-like phosphoesterase superfamily domain | 122-350 | 3.5e-10 | 32.1 | Pfam-A | 2-133 (156) | alignment | ||
Range on Protein: 122-350
Range on HMM: 2-133/156.0
RAAIFGDLSVDIGQ--ETIDYLttkrDQLDVIIHIGDLAYnlHdqngttgdeyMNVIEPFAAYvPYMVFAGNHESNSIFNHIIHRFtmpkngvyndnlfw
..||..|| . . . .... . |.|.| ||| . . |.| .... | . |||. . . ... ...
kiaiiSDlHgnldaleavledi....kevdlilhaGDlve..p..........eevvelledi.pvlavrGnhDeaelpkelavel..............
sfdfgnahfiglnseyypekmskeaqaqykwLREDLEQNSRNWVIVMLHRpwycsneTPEGCNDGWDTlprqglgklfpgLEDLLNEYTVDMVLYGHRHT
| . .. . ... ....|. || ..... . |. ||.|. .|.|..|| |
...............................llaaaaleiegdrvllvhg.......tplsvqsseee............laellkeagadlvflGHtHk
YERmwpiynknpyksenpghiKNAPAPVYIL
.. . . ...
pkv..................ekrggtlvvn
|
|||||||||
| PhoD | PhoD-like phosphatase | 78-165 | 9.1e-09 | 25.8 | Pfam-A | 59-150 (453) | alignment | ||
Range on Protein: 78-165
Range on HMM: 59-150/453.0
QMRYTHRATMQNLVQGKVYYYQVGS--SQAMSSIFNFRQPDQF--QPLRAAIFGDLSVDIGQETIDYLTTKRDQLDVIIHIGDLAYNLHDQN
.. || ......| .|. |.|.. . ... | . ..| . . || |.... . | .. ......||...|.|| |. ....
erdytvkvevtgLepgqeyfYrfraeegesespvGrtrTlpeaaveslrlavvSCsnyeqGyfnayrelaekedlDfvlhlGDyiYeygegt
|
|||||||||
| subfamily_PAPL_pd | Subfamily PAPL | 149-319 | 7e-07 | 20.6 | In-house | 36-211 (212) | alignment | ||
Range on Protein: 149-319
Range on HMM: 36-211/212.0
DVIIHIGDLAYN--LHDQN-GTTGDEYMNVIEPFAAYVPYMVFAGNHESNSI------FNHIIHRFTMPKNgVYNDNLFWSFDFGNAHFI-------GLN
......|| |. ..| . ... .| . . ||..|.||||. . . .. .|...|. |. .. .. . ... .
qfvlalGDnfYekGvkdvddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYsklskrWkfpsl.yytksfkipdsnatvqlvlidtvllcgk
SEY-YP--EKMSKEAQAQYKWLREDLEQNSRNWVIVMLHRPWYCSNEtpEGcndgwdtlPRQglgKLFPGLEDLLNEYTVDMVLYGHRHT
|. . . .. |..|..||.|.|.... ...|| | | . | .| | . | |. ||..| |. | || |.
sddlklegpvdvslaeeqwawleeeLkaseadylivaGhypvwsvae..hG........ptk...iLvkrLkPlLekynvtaylsGhDhn
|
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