Gene pef-1 in Caenorhabditis elegans

Synonym: CELE_F23H11.8, pef-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP7C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP136_AA protein Get Run
CeleP136_AA_185-532 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP7C_pd Subfamily PPP7C 186-564 1.9e-196 645.2 In-house 1-382 (383) alignment 
Range on Protein: 186-564
Range on HMM: 1-382/383.0
DIDRNYKGPTLSLPLDKPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLCIILYKNGYPSVDNPYIFNGD
.....|.||.|||||.| .|.|.|||||..|.||.||||.||.||.|..|..|..||.||.||..||.|||||||.|||..||||||.|| .|||.||||
evedsytgprlslpltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIP
||||| .|.|.|..|.||..| |...|||||||||||.|||||||||...|||. .. |.|||||||.|||.||.||..|..|||||||.|....|||| 
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktdlelldkie

RHRFQSVLRPPVNKGM--ESEKENSAVNVD--EWKQMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCL
|....||||||...|.  |.|||.|.|.||  ||.|.|||.|||||...||.||..||||||||.|.|...|.|....||.||||||.|||||.|....|
rsklvsvlrpplkegeeaekekeessvkvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvl

TVFSASNYYETGSNRGAYVKFiGKSKQPHFVQYMASKTHRKSTLRERLGVVEESAVKELKEKLSSFHTDLQKEFEIMDIEKSG
|.||||||||.|||||||||. ||...|..|||.|||...|.|||.|...|||||..||.||| . ..||..||.  | .|||
tifsasnyyeeGsnrGayvkl.gkdltprivqyqaskatkkltlrqrvsiveesalrelrekllakksdlleefkkkdekksg
PPP_1 228-501 3.9e-93 304.5 In-house 7-263 (264) alignment 
Range on Protein: 228-501
Range on HMM: 7-263/264.0
HEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLcIILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRY
 |  |  | ... .......|...|.|||.||.|||| ..|.|.| || .. |.|.||.|||| .|.|.|..|.|| .. | ...|.|||||.. .. .|
aelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvy

GFIKELStkYKDLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIPRHRFQSVLRPPVNKGMESEkensavnvdewkqmLDIMWSDPK
|| ||.   .|  |. | ..|.||| .||.|..|| .|..||||.|..... . ... |.. ... . .... .|..               ||..||.|
gFkkEvl..kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekd..............vdillsddk

QNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVK
.......|  ||.| .||.|.|..||.|....|..|.||.| ||||| ......|.||||||||.|||||||||
eqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
0045823 Metallo-dependent phosphatases 186-532 1.4e-92 303.8 In-house 11-339 (473) alignment 
Range on Protein: 186-532
Range on HMM: 11-339/473.0
DIDRNYKGPTLSLPLDKPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTsisnQVTICGDLHGKFDDLCIILYKNGYPSVdNPYIFNGD
 . | . .| |. .|..... ..|| .| ...|.....| .|.||..|.| .|.. ..|      ....||.|| .|||. .| |.|.|.. . ..|.||
pvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drlvflGD

FVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYkdlSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTevSKLDKIP
.|||| .|.|||. |.||.|  | ...| |||||....|  ||| .|.  ||   . .... . .....||.| .|.  |..||||.|..   . || |.
lvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetleky...gedlyeeflewlrslPlaaviggkilfvHGGlspdl..plldqir

R-HRFQSVLRppvnkgmesekensavnvdeWKQMLDIMWSDPKQNKGC-------WPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHN
. .|......                    ....||..||||   .|.       ..| .|| | .||.|..  ||.|.|..|.||.|..  ||||. ..
eierpleipd....................dgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfd

NT------CLTVFSASNYYETGSNRGAYVKFIGKSkqPHFVQYMASKTHRKSTLRERLGVV
.       ..|||||.||. .| |..|.... ..   ..|.|...|..  . .|  . ...
gkvigiDtgiTvfSApnYcgrggnlaAvlvidedl..isfiqfdpsphplilplfldvfll
PPP_3 226-514 1.7e-90 295.7 In-house 6-269 (271) alignment 
Range on Protein: 226-514
Range on HMM: 6-269/271.0
ILHEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLcIILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNL
 |.|  |  | ... ......||..||.|||.||..||| ..|.||| || .. |.|.||.|||| .|.|||..|.|| |. | ...|.|||||.. .| 
elkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqink

RYGFIKELSTKYKdlSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIPRHRFQSVLRPPVNKGMesekensavnvdewkqmldimWSD
.||| ||. .|..  .. . . |..||..||.|..||....|||||.|....  . .|  ... ... . .. . .                     .|.
vYgFkkevlkkkg..gkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll.....................lss

PKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKfIGKSKQPHFVQY
........ |  || | .||.|.|..||||. ..|..|.||.| ||||. |.. ..|||||.||.|..||.||..| ........|.|.
dpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailk.leealtsefkql
subfamily_PPP5C_pd Subfamily PPP5C 187-517 4.1e-87 285.2 In-house 2-309 (322) alignment 
Range on Protein: 187-517
Range on HMM: 2-309/322.0
IDRNYKGPTLSL-PLDKPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLCIILYKNGYPSVDNPYIFNGD
.. .|.|| |    . |  | ...| || .| || ||.|.|| ||....|..||.  |... ....|.|||.||.| ||. |. .||.|| .|||.||||
vedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGd

FVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDlstPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVsKLDKIp
|||||  |.||. .|... .. | ...|.||||| . ||  |||  |  .||..    .. |. .||.|||.|..|. ...|||||. .. .| .||.. 
fvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakyte...kvadlftevfnwlPlahvinekvlvvhGGlfsedgv.tlddl.

rHRFQSVLRPPvnkgmeseKENsavnvdewkQMLDIMWSDPKQNKGCWPNvFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFS
 .. .   .||        .|.         ......||||....| .|   || | .|| |.|  ||.. ...|..|||| | ||||..|.  ..||||
.rkidrnaqpp........eeg.........llvellwsdpqeanGrsps.krGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfs

ASNYYETGSNRGAYVKFIGKSKQPHFVQYMAS
| || .. .|.||.... |. ....| .. | 
apnycdqmgnkgafitlrgddlklkfktfeav
PP2Ac_SM00156 219-515 3e-86 281.8 In-house 2-268 (271) alignment 
Range on Protein: 219-515
Range on HMM: 2-268/271.0
HPKYVLMILHEARKIFKAMPSVSRIStsisNQVTICGDLHGKFDDLCIILYKNGyPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNH
....|| .|.|...|.|..... ..|    ..||..||.||..|||  .| ..| .. ...|.|.||.|||| |||||...|||| |. |  ..|.||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

EDHIMNLRYGFIKELSTKYkdlSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISD-QTEVSKLDKIPRhrfqsvlrppvnkgmesekensAVNVDEWKQ
|.  .|  ||| .|.. ||   .. |   .|..||.||.|...|..|...|||.|   .......|. |                      . .  |...
Esssvnkiygfeeevkrky...gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr......................vkekpeegl

MLDIMWSDP-KQNKGCWPNVfRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFiGKSKQPHFVQYM
..|..|||| ...||. |.  || . .||.|..  ||.|. ..|..|.||.. ||||| ... ..|.|||.||..  || .|..|.  |. .....|. 
lidllwsdpeqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkv.eknlklsieqlk
0049330 Metallo-dependent phosphatases 193-519 4.1e-76 249.1 In-house 5-301 (309) alignment 
Range on Protein: 193-519
Range on HMM: 5-301/309.0
GPTLSLPLDKPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRIStsisNQVTICGDLHGKFDDLCIILYKNGYPSVdNPYIFNGDFVDRGGQ
.|.| |.| .. . ..|| ..  |.|. ...|..|..|..|.| .|.. ..|      ....||.|| .|||  .| |.|.|.. . ..|.||.|||| .
dpllllelilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpd

SIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYkdlSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQT-EVSKLDKIPRHRFQS
|.|||. |.||..  | ...| |||||....|  ||| .|.  ||   . .... . |....||.| .|. .|..||||.|..   .. .... |..   
slevlllllalkllypdnvfllrGNHElrllnglygfgdetlrky...gaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleip

VLRppvnkgmesekensavnvdewkQMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYE
  .                       . |..||||      ...  || | .||.... .||.|.|..|..|.|.. |.||.. ... ..|||||.||..
ldg......................llcdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycg

TGSNRGAYVKFiGKSKQPHFVQYMASKT
. .|.||.... .... ..|... ....
rlgnlgavlei.dedlvisfllfepvpl
0053225 Metallo-dependent phosphatases 204-516 1e-72 238.1 In-house 8-290 (293) alignment 
Range on Protein: 204-516
Range on HMM: 8-290/293.0
QVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRIStsisNQVTICGDLHGKFDDLCIILYKNGYPSVdNPYIFNGDFVDRGGQSIEVLCVLFAL
 . ..|| .. .|.|. ...|..|.||..|.| .|.. ..|      ....||.|| .|||  .| | |.|.. . ..|.||.|||| .|.|||. |.||
lldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlelllal

VIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYkdLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEvsKLDKIPRhrFQSVLRPPvnkgmes
 .. | ...| |||||....|  ||| .|   ||  .. .... | |....||.| .|. .|..||||.|..     || |..   . .||.|       
kllypdnvvllrGNHElmllnglygfgdetlrky..gaaelwdelldwlrslplaaliggkilfvHgGlspdls..lldqire..inrplrip.......

ekensavnvdEWKQMLDIMWSDPKQNKGCWPNvFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFi
          ... .||..||||   .|..|. .|| | .||....  ||.|.|..|..|.|.. ..||.. ... ..|||||.||... .|.||.... 
..........legllldllwsdpdlwsgwlps.yrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlal.

GKSKQPHFVQYMA
...  ..|.....
deglvwgfklfap
PPP_2 251-468 1e-69 227.2 In-house 1-198 (198) alignment 
Range on Protein: 251-468
Range on HMM: 1-198/198.0
VTICGDLHGKFDDLcIILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELStkYKDLSTPITRLLED
||.||||||..||| .||.||| || .. |.|.||.|||| .|.|||..|.|| .| | ...|.|||||.. .| .||| ||.   .|  .. . . |..
vtvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl..kkkggkkvykklqe

VFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIPRHRFQSVLRPPVNKGMESEKensavnvdewkqmldimWSDPKQNKGCWPNVFRGGGSYFGADITA
||..||.|..||....|||||.|....  . .|  ... .|. . .... .|.||                 .||||...... |  ||.| .||.|.|.
vfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeek.................lsdpkekeellansarGagllfgpdvte

SFLEKHGFRLLVRSHECK
..|||. ..|..|.||.|
elleknklkliiRaHevk
PPP_5_Dcr2 251-468 6.5e-67 218.4 In-house 1-199 (199) alignment 
Range on Protein: 251-468
Range on HMM: 1-199/199.0
VTICGDLHGKFDDLCIILYKNG-YPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYkDlSTPITRLLE
||.||||||..||| .||.|.|  || .. |.|.||.|||| .|.|||..|.|| .| |  ..|.||||||. .|..||| ||  .|| . .  | . |.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky.h.gkkiykils

DVFSWLPIATIIDRDIFVVHGGISDQTEV-SKLDKIPRhRFQSvlrppvnkgmeS-------EKEnsavnvdewkqmldiMWSDPK-QNKGCWPNVFRGG
|||.|||.|..||....|||||.|....  ..|.|| |  ...           .       ..                .||||. . .||. |  ||.
dvfdwlPlaalidekvlvvhgglspeiksiellekier.kiei...........peekgekadll...............lwsdprdaqegcklnseRGa

GSYFGADITASFLEKHGFRLLVRSHECK
| .|| |.|  ||||... |..||||.|
gllfgpdvtekfleknnlkliirshelk
PPP_4 251-468 7.1e-66 215.0 In-house 1-197 (197) alignment 
Range on Protein: 251-468
Range on HMM: 1-197/197.0
VTICGDLHGKFDDLCIILYKNG-YPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKykdLSTPITRLLE
||..||.||..||| ..|.|||  || .. |.|.||.|||| .|.|||..|.|| .| |  ..|.|||||.. .||.||| ||. .|    .  | . |.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek...hgkeilkklq

DVFSWLPIATIIDRDIFVVHGGISDQTEvSkLDKIPRH-RFQSVlrppvnkgmesE--------KEnsavnvdewkqmldiMWSDPK-QNKGcWPNVFRG
|||..||.|..||....|||||.||..| | |||| |. |.. .           .         .               .||||. ...| . |  ||
dvfdllplaalidekvlvvhgglsdele.s.ldkierierkies...........pleeekrkdll...............lwsdpreaqeg.lansvrG

GGSYFGADITASFLEKHGFRLLVRSHECK
.| .||.|.| .||||....|..||||.|
agllFgpdvtekfleknnlkliirshelk
subfamily_PPP1C_pd Subfamily PPP1C 218-501 3.9e-63 206.3 In-house 10-264 (282) alignment 
Range on Protein: 218-501
Range on HMM: 10-264/282.0
LHPKYVLMILHEARKIFKAMPSVSRIStsisNQVTICGDLHGKFDDLCIILYKNGYPSVDNpYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGN
|. . . ..|..||.|... | . ...    . |.|.||.||.. ||  .. ..|.|.  | |.| ||.|||| ||.|....|.|. |  | ...| |||
lkeaeieallkkareillsqpillele....aPvkivgdihGqyadllrlfetsgaPpesn.ylflGdyvdrGkqsletivlllaykikypenlfllrGn

HEDHIMNLRYGFIKELSTKYKDLstpITRLLEDVFSWLPIATIIDRDIFVVHGGisdqtevskldkiprhrfqsvLRPPVNKGMESEKENSAVNVDEWKQ
||.  .|  |||  |  ..|.     . . . |||..||.|...|  |..||||                     | | ...  . .| .  ..|.|   
hesasinriyGfydeckrrysik...lWktftdvfnclPlaalvdekilcvhGG.....................lspelksleqirkiqrPlevpekgl

MLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVK
. |..||||....  | .  ||    ||.|. ..||.|. . |.||.|..  .||||  ..  .|||||.|| ..  | || ..
lcdllWsdpdkevlgwsendrGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavls
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 212-515 1.2e-55 181.5 In-house 4-280 (287) alignment 
Range on Protein: 212-515
Range on HMM: 4-280/287.0
FKVNKVLHPKYVLMILHEARKIFKAMPSVSRIstsiSNQVTICGDLHGKFDDLCIILYKNGYPSvDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSI
. | . .  | .| .|.....|.. .|.. ..     . .||.||.||..|||  |. . |... .  |.| ||.||||..|.||  .||.| |  | ..
ygvldafsdkdilevlekieeileplpallev....eapitivGdihGqlddllrifnavGaap.kvqylflGdyvdrGakslevslllfslkiaypkkv

YLNRGNHEDHIMNLRYGFIKELSTKYKdlsTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEvsKLDKIprhrfQSVLRPpvnkgmesekeNSAVN
.| ||||| . .|  ||| .||  |..     . .  .|||| ||. ..... |. .|||||.. .   ||..     ... .|           .  ..
hllrGnhevkkinklyGfkeelkrkrq...erlykqfndvfselplcarvskrilcmhGGispklk..sldsl.....kalkkp...........ttpla

VDEWKQmLDIMWSDPKQN-KGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVkFIGKSKQPH
 ||  | .|..|.||... |.  .|  |.  . ||     ..|.| .  |.||.|| . |||.|  .. ..|||||. |    .| || |  . || .  
cdeglq.vdllwadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavv.vvskslels

FVQYM
||.  
fvvlk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 208-501 8.8e-55 178.8 In-house 14-279 (298) alignment 
Range on Protein: 208-501
Range on HMM: 14-279/298.0
MIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTsisnQVTICGDLHGKFDDLCIILYKNGYPSVDNpYIFNGDFVDRGGQSIEVLCVLFALVIVD
 ... |. ||.. . |  ....|.||||. .|.  . .     ...|||.||.. ||  .. |.|.|   | |.| ||.|||| |..||...|.|  .  
slsekkltkvikeedveklielakkifkkqkslvevda....pikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnlevivlllaykvky

PMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDLStpITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEvsKLDKIprhrfQSVLRPpvnkgMESEKEn
|  ..| ||||| ...|  ||| .| . .||.|.  .   ..|||..||....|   |. .|||.|.. .  .||..     ... ||     ..|..| 
pnnffllrGnheceainrvyGfyeeckrrykslr..lyaefqdvfnalpltaliggrilcmhGGlskklk..sldql.....relkrp.....fdskee.

sAVNvdewkqmLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVK
 ...        |..|.||....  | .  || .  ||.|  . .|||    |.||.|    .||||  ..  .|.||| .| .   |  | .|
.sla.......idllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmk
subfamily_PPP4C_pd Subfamily PPP4C 206-513 2.9e-51 167.4 In-house 4-281 (288) alignment 
Range on Protein: 206-513
Range on HMM: 4-281/288.0
AKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTsisnQVTICGDLHGKFDDLCIiLYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVI
 ..||  .  .... . |  . ..||.|.     | |. .     ||.|||.||.| ||   |.| |    .. |.| |||||||  |.| . .| || .
drqieklrrcelikeeevkalcakareilveesnvqrvds....pvtvcgdihgqfydlle.lfkvggdvpetnylflgdfvdrgfysvetfllllalkv

VDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKdlSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDqtEVSKLDKIprhrfQSvlrppVNKGMEsek
  |  |.| |||||   .   ||| .|   ||   |. . |.  .|| .|..|.||| .||.||||.|   ..|.||.|     .|     ...  |   
rypdritlirgnhesrqitqvygfydeclrkyg..sanvwryctevfdylslaaiidgkifcvhgglsp..sistldei.....rs.....idrkqe...

ensavnVDEWKQMLDIMWSDPKQNKgCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFiGK
      | .  .. |..||||.. . .|    || |  ||.|....| |. .. |..|.|.   ||| .  |.. |||.|| ||     |  | ...  .
......vphegplcdllwsdpedae.gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaailel.de

SKQPHFVQ
. . .|  
eldkdfki
subfamily_PPP2C_pd Subfamily PPP2C 204-517 4.1e-51 166.9 In-house 3-286 (290) alignment 
Range on Protein: 204-517
Range on HMM: 3-286/290.0
QVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTsisnQVTICGDLHGKFDDLcIILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFAL
.. |.|| .|  | |. . |  . ..|..|..    |  ...     ||.|||.||.| || . |.| |  | |  |.| ||.||||  |.| ...| ||
dldklieklkeckqleesevkelcekakeilskesnvqevkc....pvtvcgdvhgqfhdl.lelfkiggkspdtnylflgdyvdrgyysvetvtllval

VIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDlsTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQteVSKLDKIPR-HRFQSVlrpPvnkgme
 .  .  | . |||||   .   |||  |   || .  . . ... |.| .||.....|..||..|||.| .  .. ||||   .|.| |   |      
kvrykeritilrgnhesrqitqvygfydeclrkygn..anvwkyftdlfdylpltalvdeqifclhgglsps..idtldkiraldrlqev...p......

seKENsavnvdewkQMLDIMWSDPKqNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKF
  .|           . |..||||  ..| |    || |  || ||. .| .. |..|..|.|.  .|||..||..   |.||| ||     |..| ...
..heg.........plcdllwsdpd.drggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailel

iGKSKQPHFVQYMAS
  .. . .|.|. ..
.ddklkysflqfdpa
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 209-508 2.5e-48 157.6 In-house 7-280 (290) alignment 
Range on Protein: 209-508
Range on HMM: 7-280/290.0
IEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRIstsiSNQVTICGDLHGKFDDLCIILYKNGYPSvDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDP
.. . | . .  | .| ||.....|.. .|.. ..     . ..| ||.||..|.|   . . |||  .  ..| ||.|||| .|.||  .|| . |  .
llkygvldafsdkdileilekieeileplpallev....eapivivgdihgqldallryfdavgypp.kvkflflgdyvdrgakslevslllfcykirys

MSIYLNRGNHEDHIMNLRYGFIKELSTKYKdlsTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVskldkipRHRFQSVLRPpvnkgmesekeNS
 ...| |||||   .|  ||| .||  | .   . . .  .|||. |.. . ..| |. .|||||.. |         . .... .|           . 
kkvhllrgnhevrkvnrlygfkeelarkrg...srlwkqyqdvfaelslcarvgrkilcmhggisqkies.......weslkalkkp...........rv

AVNVDEWKQmLDIMWSDPKQNK--GCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVkFIGKS
 .. ||  | .|..|.||...|      |  |.    || .   ..|.| .. |.||.|| | ||..|  .. ..|||||  |    .| || .  . .|
pltcdeglq.vdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaia.tvses

KQ
 .
le
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 223-500 8e-46 149.4 In-house 11-259 (280) alignment 
Range on Protein: 223-500
Range on HMM: 11-259/280.0
VLMILHEARKIFKAMPSVSRIstsiSNQVTICGDLHGKFDDLCIILYKNGYPSvDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHI
.  .... .||..|  ..  .       |..||||||.. ||  .. . ..|  |. |.| ||.|||| | .||...|.|  .  | .... |||||   
idrviekckkiltaqatmvev....dapvavcgdlhgqytdllrlfarvsfpp.dqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

MNLRYGFIKELSTKYKDLstpITRLLEDVFSWLPIATIIDRDIFVVHGGISDQteVSKLDKIprhrfQSVLRPpvnkgMESEkeNSAVNVdewkqmlDIM
.| .|||  |   .|..    .   .....  ||.....   |...|||.|..  .  ||..     . . ||     ..||  .....        |..
inrkygfkdevkrrysla...lynefqelldslplvalvsgrilcmhgglsqk..lvslddl.....aelrrp.....fdse..declam.......dll

WSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYV
|.||....  | .  ||    |||..   . ||    |..| |.   .||||  ..  .||||| .| .  .|  | .
wadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavl
subfamily_PPP6C_pd Subfamily PPP6C 245-506 9e-46 149.3 In-house 38-274 (290) alignment 
Range on Protein: 245-506
Range on HMM: 38-274/290.0
TSISNQVTICGDLHGKFDDLCIiLYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDlsTPI
 ..|  ||.|||.||.| ||.  |...|    |. |.| |||||||  |.| .  |..| .  |  | | ||||| . .   ||| .|  .|| .  .  
qpvsspvtvcgdihgqfydlee.lfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygn..ana

TRLLEDVFSWLPIATIIDRDIFVVHGGISdqTEVSKLDKIprhrfqSVlrppVNKGMEsekensavnVDEWKQMLDIMWSDPkQNKGCWPNVFRGGGSYF
 . . .||  |.||.||| ... ||||.|  ..|  ||.|      .|    ... .|         . .   . |..|||| ..   |    || |  |
wkyctkvfdlltiaaiideqvlcvhGgls..pdvktldqi......rv....ieraqe.........iphkgafcdlvwsdp.edvetwavsprgagylf

GADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFIGKS
|. .| .|..   ..|..|.|.   ||...  ..   ||.|| ||     |  . ...  ..
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae
subfamily_PPP3C_pd Subfamily PPP3C 202-503 1.8e-44 145.3 In-house 25-310 (452) alignment 
Range on Protein: 202-503
Range on HMM: 25-310/452.0
KPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTsisnQVTICGDLHGKFDDLCIILYKNGYPSvDNPYIFNGDFVDRGGQSIEVLCVLF
||..  . | |. .  |. . .| |..|| |..|  ... ....     .|..||.||.| ||  ..  .| |. .  |.| ||.||||  |||..  |.
kpklevlkehflkegrleeeaalkiieeaakllkkektllevea....PitviGdihGqfydllklfevgGdPa.stkylflGdyvdrGyfsiecvlyly

ALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYkdlSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISdqTEVSKLDKIPR-HRFQsvlRPPVnKG
|| |  | ...| ||||| . .   . | .|. .||   |  .   . . |  ||.|.....  . ||||.|  .|...||.| . .||.    ||  .|
alkiaypstlfllrGnhecrhlteyftfkeeckiky...seevydacmesfdslPlaallnqqflcvhGGls..peikslddikkldrfk...eppa.sG

mesekensavnvdewkQMLDIMWSDPKQ-------NKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNN------TCLTVFSAS
                 . |..|||| .       ..   ||  ||   ...   ...||.|  .  ..|.||.. .||.  ...      . .|.|||.
................plcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsap

NYYETGSNRGAYVKFI
|| .. .|..| .|. 
nyldvynnkaavlkye
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 218-515 2e-43 141.8 In-house 3-272 (284) alignment 
Range on Protein: 218-515
Range on HMM: 3-272/284.0
LHPKYVLMILHEARKIFKAMPSVSRIStsisNQVTICGDLHGKFDDLCIILYKNGYPSVDNpYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGN
. |. |  .| .| .||.  | .  .       . ||||.||.| ||  .. |||.|   | |.| ||.|||| . .| . .|||  .. |  ... |||
ippedvetllfhafsifnkqpmlievn....spinicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgn

HEDHIMNLRYGFIKELSTKYKDLStpITRLLEDVFSWLPIATIIDRDIFVVHGGISDQT-EVSKLDKIPRhrfqsvlrPPVNKgmesekENSAVnvdewk
||  ..|  ||| .|   .|.  |  .   .| ||| .|..... . |...|||.|    .||.|  | |        |  |       |  ..      
hecslinkiygfyeecqrrynkps..vyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikr........pfdnp......epntl......

qMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNrGAYVKFIGKSKQPHFVQYM
  .||.|||| . .  |    ||    ||.|    .|..    |.||.|.   .||||  |   .|.|||  |     |  | | .. |     ||   
.aidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdn.aaavmyvnknlvcsfvvlr
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 227-501 3e-42 137.9 In-house 33-279 (299) alignment 
Range on Protein: 227-501
Range on HMM: 33-279/299.0
LHEARKIFKAMPSVSRIStsisNQVTICGDLHGKFDDLCIILYKNGYPSvDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLR
 . |...|   .|.  .     . . .|||.||.. ||  |. |.|.|  |  ..| ||.|||| | .|....|..  |  |  ... |||||   .|  
cavaksvfasqaslleve....apiivcgdihgqysdllrifdkagfpp.dvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrv

YGFIKELSTKYKdlSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQteVSKLDKIprhrfQSVLRPpvnkgmeSEKENSAVNvdewkqmLDIMWSDP
||| .|   .||  || .  ...| |...|.. .|   |...|||.| .  ...||..     . . ||        .  | ...       .|..|.||
ygfyeecnkryk..strlwsifqdafaampltgligsrilcmhgglspk..lqtldql.....rdltrp.......qdppnpslg.......idllwadp

KQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVK
 |    | .  ||    || |. |  ... .  |. |.|.   .||||  ..  .|.|||  |     |  | .|
dqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimk
subfamily_PPZ_pd Subfamily PPZ 215-500 1.7e-41 135.7 In-house 22-278 (300) alignment 
Range on Protein: 215-500
Range on HMM: 22-278/300.0
NKVLHPKYVLMILHEARKIFKAMPSVSRISTSisnqVTICGDLHGKFDDLCIILYKNGYPSVDNpYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLN
| .|. . .| | ..||..| | |..  .| |    | | ||.||.. ||  .. | |.| . | |.| ||.|||| ||.| . .|..  |  |  ..| 
nvclknseilqicikarelflaqpallelsps....vkivgdvhgqyadllrlftkcgfppsan.ylflgdyvdrgkqsletillllcykikypenffll

RGNHEDHIMNLRYGFIKELSTKykdLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQteVSKLDKIpRHrfqsVLRPpvnkgmesekensaVNVDE
|||||   .   |||  |   .       | . . | |  ||.|.|.   ||.||||.|    .  .|.| ||    | ||               .| .
rgnhecanvtrvygfydeckrr...cnikiwktfvdtfntlplaaivagkifcvhgglspv..lnsmdei.rh....vvrp..............tdvpd

WKQMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYV
.  . |..|||| ..   | .  ||    .       ||.| || |..|.|    .||||  . . .||||| ||     | || .
fglindllwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavm
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 244-504 2.5e-41 134.8 In-house 28-288 (302) alignment 
Range on Protein: 244-504
Range on HMM: 28-288/302.0
STSISNQVTICGDLHGKFDDLCIILY----------KNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKEL
 . ||  ||| ||.||.|.||  ||           |  |  . . ..| ||.|||| .||| .|..||| .. |    | ||||| . .|  ||| .||
laeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreel

STKYKDLS-TPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEvsKLDKIprhrfQSVLRPPVNKGMESEKENSAVNVDEWKQMLDIMWSDPKQNKgc
 ...       | . ...|||..|.|... . |. ||||||.. |   |..|     ... ||  . . .|  ..         |.| .. . || .|  
enrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispkle..sledi.....kkikrplkevtedslaqdllfadpldvqllaavsekPkyak..

wpNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFIG
  |. ||    |       . .. ...|.||.|    ||. |  ..  ||.|||..| .   |.|| .|  .
..nivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdt
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 229-504 3.1e-41 134.5 In-house 18-289 (302) alignment 
Range on Protein: 229-504
Range on HMM: 18-289/302.0
EARKIFKAMPSVsrisTSISNQVTICGDLHGKFDDLCIILY----------KNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNH
.  . .|   ..    . ||  ||| ||.||.|.||  ||           |  |  . . ..| ||.|||| .||| .|..||| .. |    | ||||
aviellkkektl....aeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnh

EDHIMNLRYGFIKELSTKYKDLS-TPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEvsKLDKIprhrfQSVLRPPVNKGMESEKENSAVNVDEWKQ
| . .|  ||| .|| ...       | . ...|||..|.|... . |. ||||||.. |   |..|     ... ||  . . .|  ..         |
etkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispkle..sledi.....kkikrplkevtedslaqdllfadpldvq

MLDIMWSDPKQNKgcwpNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFIG
.| .. . || .|    |. ||    |       . .. ...|.||.|    ||. |  ..  ||.|||..| .   |.|| .|  .
llaavsekPkyak....nivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdt
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 214-500 1.1e-40 132.7 In-house 19-279 (297) alignment 
Range on Protein: 214-500
Range on HMM: 19-279/297.0
VNKVLHPKYVLMILHEARKIFKAMPSVSRISTSIsnqvTICGDLHGKFDDLCIILYKNGYPSVDNpYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYL
. ||.  . || .|  | ..|||  |.  . . |     .|||.||.| ||  .... |.|   | |.| ||.||||  ||| . .|.|  .  |  ..|
lskviteervlklldlaldvfkaqksmvevnapi....kvcgdihgqfpdllrlfhrggwpptan.ylflgdyvdrgrfsietivlllaykvkfpgnlfl

NRGNHEDHIMNLRYGFIKELSTKYKdlSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISD-QTEVSKLDKIprhrfQSVLRPpvnkgMESeKEnsavnv
 |||||  ..|  ||| .|   .|.  |  .   ..||| |||.. .|   |...|||.|   |.   || .     . . |.      |  ||      
lrgnhecefvnkvygfyeecqkryq..svrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtl.....rkiers.....teg.ke......

dewKQMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYV
   . . |..|.||      . .  || |  || |       .  . |..|.|.   .||||      .|.|||  |     |  |..
...rlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafm
subfamily_PPG1_pd Subfamily PPG1 245-514 1.7e-40 132.2 In-house 37-293 (300) alignment 
Range on Protein: 245-514
Range on HMM: 37-293/300.0
TSISNQVTICGDLHGKFDDLCIIlYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDLSTpI
  |   ||. ||.||.| |.  | .| | .  |  |.| ||.||||  |.| . .| .| .  |  | | |||||   .   |||  |   ||   |. .
ieirspvtvvgdvhgqfydvlei.fkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggnsr.v

TRLLEDVFSWLPIATIIDRDIFVVHGGISDQteVSKLDKIP-RHRFQSVlrpPvNKGMESEKENSAVNVDEwKQMLDimwsDPKQNKGCWPNVFRGGGSY
 . | ..| .| .|.||| .|..||||.| .  |  .|.|    ||. |   | |.|  ..   |  . .. .  ||     | ..   . .  || |  
wkylteifdylvlaaiideeiycvhgglsps..vlsidqikvldrfrev...p.negaladllwsdpeenn.nptld....hpdregqhfvvsqrgagys

FGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFIGKSkQPHFVQY
.| |..  ||..  .. ..|.|.   |||.   .|   ||.|| || .   |. . ..   |  . .|  |
ygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekd.eryfnvy
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 223-502 2.5e-38 124.9 In-house 13-263 (281) alignment 
Range on Protein: 223-502
Range on HMM: 13-263/281.0
VLMILHEARKIFKAMPSVSristSISNQVTICGDLHGKFDDLCIILYKNGYPSvDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHI
.  ...|.. ||    ...     | . ... ||||..|.||  ..   | .. .. ..| ||.|||| ||.||| .||.| |  .  |.| |||||   
ienvireveaifseekaLv....eidkPivvvGdlhaqfndlkrlfellgrvp.eevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

MNLRYGFIKELSTKYkdlSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISdqTEVSKLDKIPRHrFQsVLRPPvNKGMesekensavnvdewkqMLDIM
.| .||| .|  |||    . .  |..  |  |||.. |.. . ..|||.|   |.  ||..  .  .  .|.. ..|.                . |..
vnkiygfyvecvtky...GeelwalfqrcfnrlpisaliakrvlcmhGGls..Peltaldelrnr.pk.pirnl.drGl................viDll

WSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKF
|.||...   | .  || .  || ..      . .  |..|.|   ..|||       .||||. || .   | .| .| 
wadpdnkveewkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkv
subfamily_PPPLV_pd Subfamily PPPLV 248-500 2.5e-38 125.0 In-house 23-273 (290) alignment 
Range on Protein: 248-500
Range on HMM: 23-273/290.0
SNQVTICGDLHGKFDDLCI---ILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDLSTPI
   . . ||||| . || .    |.. |   .   ..| ||.||||  |.|... |.|| .. |  ..| ||||| . .   . .  | | |. |    .
ksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleev

TRLLEDVFSWLPIATIIDRDIFVVHGGIS----DQTEVSKLDKIPRHRFqsvlrppvnkgmesekensaVNVDEWKQMLDIMWSDPK------------Q
   . .|| .||.|..||| .| ||.||      |. .| ...|. .                       ..|     |||.||||.             
weafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlk....................ddidgaplaldilwsdpaedrdlslrgelvl

NKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYeTGSNRGAYV
|.|  .|  || |  |..|   .||.. .   ..|.|| | .|... ..   |||||.|.|   .||  | .
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssryc.Gssneaali
Metallophos Calcineurin-like phosphoesterase 251-468 2.2e-36 119.0 Pfam-A 3-199 (200) alignment 
Range on Protein: 251-468
Range on HMM: 3-199/200.0
VTICGDLHGKFDDL---CIILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVL--FALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELST----------
....|||||..|||     ||.|.. ..  ....|.||.||||  |.|.|. |  ..| .  |  ..|.|||||.. .| .||| .| .           
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

---------------------KYKDLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDkiprhrfqsvlrppvnkgmesekensavnvde
                     .|..| ... .  ...| .||.....| .|...||..|. .. .                                   
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

wkqmldimwsdpkqnkgcwpnvfrgGGSYFGADITASFLEKHGFRLLVRSHECK
                         |. .|| | .  .|||.|  |..|.|..|
.........................gselfgpdalekllekygvdlvlrGHtHk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 249-514 9.1e-36 116.8 In-house 7-253 (263) alignment 
Range on Protein: 249-514
Range on HMM: 7-253/263.0
NQVTICGDLHGKFDDLCIILYKNGYpSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYK--DLSTPITR
  . |||| ||...||  |.   |  .    |.| ||.|||||.|.||. .||.| .  |  ..| ||||| . .|  |||  ||  ...  ..   .  
apinicgdthgqyndllrifnacga.atktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvyn

LLEDVFSWLPIATIIDRDIFVVHGGISDQteVSKLDKIprhrfQSVlRPPvnkgMESEKENSavnvdewkQMLDIMWSDP-KQNKGCWPNVFRGGGSYFG
 ...|||..|...|. . |...||||| .  .  || |     ...   |    .|. |              |..|.|| |. ||  ||  |     ||
hfnqvfsymplcaivskrilcmhggisph..lkslddi.....rai.plp....letakthp........lacdllwadpekdakgfepnkiraisnvfg

ADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVkFIGKSKQPHFVQY
      . ..    |.||.|.    || |  .   .|||||| |     |  | |  . |  .  ||| 
kkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavv.vvnkmlelsfvql
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 215-386 8e-34 110.4 In-house 5-175 (284) alignment 
Range on Protein: 215-386
Range on HMM: 5-175/284.0
NKVLHPKYVLMILHEARKIFKAmpsvSRISTSISNQVTICGDLHGKFDDLCIILYKNGYP-----SVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPM
.|.|. | .. . . ||..|       ..   |   |.|.||.||.|.||  .|  ||.|     . .. |.| ||.||||  ||||. .|||. .. | 
qkllkekelielcyrarelfwk....eklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpd

SIYLNRGNHEDHIMNLRYGFIKELSTKYkdlSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQ-TEVSKLDKIPR
 ..| |||||   .| .||| .|   .|   |. .   ..  |  .|....... |. .|||||..  .. .|||. |
kvfllrgnhesrpvnmqygfyleckkry...sealyeafqlafnamplcavvskkiicmhggisedlldlkqldkler
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 226-501 7.1e-33 107.1 In-house 28-277 (307) alignment 
Range on Protein: 226-501
Range on HMM: 28-277/307.0
ILHEARKIFKAMpsvsRISTSISNQVTICGDLHGKFDDLCIILYKNGYPSvDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNL
...||. || .     .    |   . . |||||.|.||  ..   | |  .  |.| ||.||||  |.|.. .||.  |. | .| | |||||   .| 
viyeaqtifsse....kalvdidppcvvvgdlhgqfndlinmfillgrpp.etvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk

RYGFIKELSTKYKDLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQteVSKLDKIPRHRfqSVLRPPVnKGMesekensaVNvdewkqmlDIMWSD
.||| .|  |        |  |.. .|  |||...|   |...|||.|    .. ||..  |     .| |. .|.        ||        |..|.|
kygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspa..ltcldelrnhp..kpirnpf.rgi........vn........dmlwad

PKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVK
|      |    || |  ||...      . |  |..|.|.  |.||        .|.|||  | .   | |. .|
pdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 279-499 3.3e-29 95.1 In-house 121-317 (339) alignment 
Range on Protein: 279-499
Range on HMM: 121-317/339.0
PYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKdlsTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQteV
 |.| ||.||||  |.||. .| || .  |  ||| ||||| . .|  ||| .|.  .|    . .   ....|  .|....|.  |...|||||..  .
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryd...aqlyecfqnmfnvfpfcavinntimcmhggiseh..l

SKLDKiprhrFqSVLRPPVnkgmesekENSAVNVdewkqMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNN
. ...     | ||.. |.        |   | |     . |. |.||   .  .    ||    ||     .||.|  .....| |.   .||||    
tsfnq.....f.svfkrpl........eipdvgv.....ltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgr

TCLTVFSASNYYETGSNRGAY
  .|.||| ||     |  | 
rlvtifsapnycgqndntaav
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 248-501 1.2e-28 93.3 In-house 32-260 (280) alignment 
Range on Protein: 248-501
Range on HMM: 32-260/280.0
SNQVTICGDLHGKFDDLCIILYKNGYpSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYkdlSTPITRL
   . . ||.| ...|.  ..   |    ..  .| ||.|||| | |||| .||.| |     ||| |||||   .|  |||  |   ||      .   
eapikvigdihaqyqdmnrlfdligr.vpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqyky...gvglwwd

LEDVFSWLPIATIIDRDIFVVHGGISDqtEVSKLDKIprhrfQSVLRP--PVNKGMesekensavnvdewkqMLDIMWSDPKQNKGCWPNVFRGGGSYFG
.. .|  .|.. .| . ....|||.|   |. .|| |     . . ||  |...|.                ..|..|||| ..   |    ||    ||
fqscfnrmpmsgliskrvlcmhgglsp..elinldti.....rniprpcepldrgl................lidllwsdptnkgegwfhsirgisymfg

ADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVK
  .     .     |..|.|.   .|||.      .||||  ||    .|  | | 
kgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvc
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 279-386 1.4e-24 79.9 In-house 102-207 (317) alignment 
Range on Protein: 279-386
Range on HMM: 102-207/317.0
PYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYkdlSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQ-TE
 |.| ||.||||  ||||. .|||| .. |  ..| |||||   .| .||| .|   .|   |. .   .. .|  ||......  |. .|||||.. ..
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry...saalyeafqlafnvlplcavvnkkilcmhGGiseelld

VSKLDKIPR
...|||. |
lkqldklkr
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 417-500 4.9e-15 48.5 In-house 216-299 (317) alignment 
Range on Protein: 417-500
Range on HMM: 216-299/317.0
QMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYV
 . |. |.||...   . .  || |  |||.    ||.|. . |.||.|.   .||||  .   .|.||| .|     | .| .
vladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 414-500 6.3e-14 45.1 In-house 181-267 (284) alignment 
Range on Protein: 414-500
Range on HMM: 181-267/284.0
EWKQMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYV
.   . |. |.||...   . .  || |  |||.    ||.|. . |.||.|.   .||||  ..  .|.|||  |     | .| .
digviadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavl
EF-hand_7 EF-hand domain pair 634-698 2.7e-10 30.2 Pfam-A 2-66 (66) alignment 
Range on Protein: 634-698
Range on HMM: 2-66/66.0
LETLFRFMDKDNSGQVSMKEFIDACEVLGKYTKRPLQTDYISQIAESIDFNKDGFIDLNELLEAF
|...|. .|||..|.... |.  ..  || . ..    . . .| . || |.|| ....|.|.|.
lkeaFkllDkdgdgyldkeeLlrllkhlgsplideevrevldyifkeiDkngdGvlsfeEflqai
PPP5 PPP5 TPR repeat region 178-240 7.4e-10 29.2 Pfam-A 29-92 (95) alignment 
Range on Protein: 178-240
Range on HMM: 29-92/95.0
EDTSPTNVDIDRNYKGPTLS-LPLDKPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSV
|     ...|. .|.|| |    . .  | ...| || .| || |.|  || . ....|..||.
esidiesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpsl
subfamily_YNL217W_pd Subfamily YNL217W 247-378 2e-08 27.0 In-house 8-142 (235) alignment 
Range on Protein: 247-378
Range on HMM: 8-142/235.0
ISNQVTICGDLHGKFDDLCIILY-KNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLfalvivDPMSIYLNRGNHEDHIMNlRYGFIK------EL--STKY
 . .. . || || .|.|  .|  |.|    .   .. ||....| .|.||.  .           .  .||||  ..  .| ..|      .|  |.|.
lgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll.aykwvkkpkgaeplefsskf

KDLSTPITRLLEDVFSWLPIA-TIIDRDIFVVHGGISDQTEV
. |   . .   .    |. .  |  ....|||.|.. .  .
sflesklskadmeyarelgfsldipsdellvvhaGlvpgkfl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 216-277 3.6e-08 25.9 In-house 7-64 (317) alignment 
Range on Protein: 216-277
Range on HMM: 7-64/317.0
KVLHPKYVLMILHEARKIFKAMPsvsrISTSISNQVTICGDLHGKFDDLCIILYKNGYPSVD
.... | .. . . ||..|   |    .  ..   |||.||.||.|.||  .|  ||.| ..
dlfkekelielcyrarelfwkep....lkleleapvtivGdihGqfedllalldlnGwplss
EF-hand_1 EF hand 634-659 5.8e-08 21.5 Pfam-A 2-27 (29) alignment 
Range on Protein: 634-659
Range on HMM: 2-27/29.0
LETLFRFMDKDNSGQVSMKEFIDACE
|. .|. .|||..|..| .||..|. 
lkeaFkefDkDgdGkIsfeEfkealk
EF-hand_6 EF-hand domain 634-659 2.3e-07 20.2 Pfam-A 2-27 (31) alignment 
Range on Protein: 634-659
Range on HMM: 2-27/31.0
LETLFRFMDKDNSGQVSMKEFIDACE
|. .|. .|||..|... .|...|. 
lreaFklfDkdgdGkidaeELrkaLr
EF-hand_8 EF-hand domain pair 632-657 3.3e-07 19.1 Pfam-A 25-50 (54) alignment 
Range on Protein: 632-657
Range on HMM: 25-50/54.0
STLETLFRFMDKDNSGQVSMKEFIDA
.....||| .| |..| .| .||...
eevdilfrefDtdgdGkisfeEFcvl
EF-hand_1 EF hand 676-699 7.2e-07 18.1 Pfam-A 4-27 (29) alignment 
Range on Protein: 676-699
Range on HMM: 4-27/29.0
QIAESIDFNKDGFIDLNELLEAFR
.. . .| ..||.|...|..||..
eaFkefDkDgdGkIsfeEfkealk
EF-hand_5 EF hand 635-654 2.1e-06 16.2 Pfam-A 2-21 (25) alignment 
Range on Protein: 635-654
Range on HMM: 2-21/25.0
ETLFRFMDKDNSGQVSMKEF
. .|| .||...|..|..|.
kdtFrafDkNgDGkIsreEL
EF-hand_5 EF hand 681-695 4.8e-06 15.1 Pfam-A 8-22 (25) alignment 
Range on Protein: 681-695
Range on HMM: 8-22/25.0
IDFNKDGFIDLNELL
.|.|.||.|.  || 
fDkNgDGkIsreELk