Gene pho-5 in Caenorhabditis elegans

Synonym: CELE_B0361.7, pho-5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily ACP2
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP145_AA protein Get Run
CeleP145_AA_22-381 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP2_pd Subfamily ACP2 26-367 7.4e-105 343.4 In-house 4-360 (361) alignment 
Range on Protein: 26-367
Range on HMM: 4-360/361.0
ANTDTLEYVHTVWRHGDRTPAElLFPDDITK---WPEGLGELTEQGAAQQYRLGQWLKRRYGS---WLGEKFNRNAIYIRSSDYNRTLMSAQANMAGLFP
.....|..|....|||||.| .  .|.|  |   ||.|||.|||.|..|||.||..|..||..   .| .|.|.. ||.||||.||||||||...|||||
seerkLkfvqvlfRHGdRsPln.typndkykedewpqglGqLTeeGmqqqyeLGkfLrkrYvedtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfp

P--KYPIAGGLMWQPIPVHTISKPTDKELYEEASCPTAEIEMNAQWKSTKANGIRKKFARELSFFSQKLNlPNMELKATWRIFDNLFCEKQ-NN-ITWPS
|  . .      |||.|||| |. .|. | ....||. .  ..   .| . . . .. .  |...|.. .  ...|.  ....|.|.||.. .| ...|.
petgvdypdeqeWqpvPvhtvseeedlllrakknCprydellqeakespevkklleenkelleklsestg.edidlenfyqlsdtlicerkyanelnlpe

WMNSSIFERVDQLYNEVSQLEFH-----TDTLRRLRGGTLLEEIFHRFSDKASGSLGKE-AKFYAYSAHDSTIAALLATLGVFYDIYPKYATCLLIEMHK
|.| ..||....|...|...||      |..|..||||.||.|.......|..... |.  |...|||||.|.||||..||.|.. .|.||.....|...
wandelfekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkceekkkklklflYSaHDttlaalLeaLgifekkappyasaiivElye

LANETRLIRVFHKNETDIDRLiEYSIPGC--DDPCTLQKLGDDLKKYFPEDWEAECGLKT
  ....|..|...|||. |.  | ..|||  .. |.|.|. . .|.. |.|.. .|  ||
eddgkplvkvlyrnetskdpp.eltlpgCkgeedCplskfkkivkpfipddvdelCeakt
0049226 Phosphoglycerate mutase-like 30-363 7e-82 268.3 In-house 2-340 (342) alignment 
Range on Protein: 30-363
Range on HMM: 2-340/342.0
TLEYVHTVWRHGDRTPAElLFPD---DITKWPEGLGELTEQGAAQQYRLGQWLKRRYGSWLGEKFNRNAIYIRSSDYNRTLMSAQANMAGLFPPKYP--I
.|..|. ..|||||||    .|      ..|. ||||||..|. |.| ||..|..||...|....|.. .|.||||..|||.|||| .|||||| ..  .
kLkqvqvliRHGdRtPla.kgpldflnewfwgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpil

AGGLMWQPIPVHTISKPTDKELY-EEASCPTAEIEMNAQWKSTKANGIRKKFARELSFFSQKLNLPNMELKATWR-IFDNLFCEKQNNITWPSWMNSSIF
   | |||||..|... .|  |.    |||... ...  .||. .. . ....  |. .|..|.|.   |. ..  ..|.| .|.......|.| .  ..
vplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllkklskllglnlstlsdvadtlydlllyelahglplppwcslftl

ERVDQLYNEVSQLE---FHTDTLRRLRGGTLLEEIFHRFSDKASGslGKEAKFYAYSAHDSTIAALLATLGVFYDIYPKYATCLLIEMHKLAnETRLIRV
| . .||... . .   .... ..||.||.|| ||..|.... .|  ....|.|.|.|||.||||||..||.|.| .| ||..| .|...   ..  .||
eelkalyaldllyyygigygeeiarlaggpllneilarleeaieg..psdlklylyfahdttiaallsalglfddqlPpyasnlvfElyecd.geyyVrv

FHKNETDiDRLIEYSIPGCDDPCTLQKLGDDLKKYFPEDWEAEC
.. ...  . .... .||||. |.|... . .||. |.|.| .|
lynggvl.slpvtlplpgcdglcpldefkelvkkflpgdfeelC
0046349 Phosphoglycerate mutase-like 30-371 2.4e-81 266.9 In-house 6-398 (409) alignment 
Range on Protein: 30-371
Range on HMM: 6-398/409.0
TLEYVHTVWRHGDRTP---AELLFPDDITK---WPEGLGELTEQGAAQQYRLGQWLKRRY--GSWLGEK--FNRNAIYIRSSDYNRTLMSAQANMAGLFP
.|..|. ..|||.|||    ..| ... ..   .| |.|.||..|. |.|.||..|..||  .. |...  .|.. ||.||||..|||.||||..|||||
eLkqvqvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfp

PKYP---------IAgGLMWQPIPVHTISKP-----TDKELYEEASCPTAEIEMNAQWKS-TKANG-----------IRKKFARELSFFSQKLNLPNMEL
| ..          .  ...||||..|.. .      |  |  . .||. .  ...  ||  . .            . ..... |. ....||. .. |
plggeivpllrqdll.dppfqpipidtvpiseddalddtllppdslcpaldkllkenlkslsevleflvdealldlelldetkdllkklaerlnselpgl

KAT-----WR-IFDNLFCEKQNNITWPSW---MNSSIFERVDQLYNEVSQLEFHTDTLRRLRGGTLLEEIFHRFSDKASGSLGK----EAKFYAYSAHDS
. |     .  ..|.|..|. .. ..|.|   .. ......  |..    ...... |..|.||.|| ||. |. |..||.       . |.|.|.|||.
nltdpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyylygsgelaklaggpllneilarledaisgknpvtfpldlklylyfaHdt

TIAALLATLGVFY-----DIYPKYATCLLIEMHKL-ANETRLIRVFHKNEtdidrliEYSIPGCDDPCTLQKLGDDLKKYFPE----DWEAECGLKTSFQ
||||||..||.|        .| ||..| .|...   .... .||.. ..       .. .|||...|.|... . |||. |.    |.. .|.|... .
tiaallsaLglfdrlfrssdippyasnlvfElyecpsdgeyyVrvlyngg.......plplpgcgegcplsefkellkkrlpgcgltdfdklCpledflr

F
|
f
0048946 Phosphoglycerate mutase-like 26-381 1.5e-80 264.2 In-house 36-427 (447) alignment 
Range on Protein: 26-381
Range on HMM: 36-427/447.0
ANTDTLEYVHTVWRHGDRTPA------------------------ELLFPDDIT-------KWPEGLGELTEQGAAQQYRLGQWLKRRYGSWLGekfNRN
 .  .|..|. ..|||.|||                         .| |..|..        || |||.||..|. |.| ||..|..||...|.   |..
pegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwpcglgqLTplGreqlyelGkrlrkrYlgllp...nps

AIYIRSSDYNRTLMSAQANMAGLFPPKYPIAgglmWQPIPVHTISKPTDKELYEeaSCPTAEiemnAQWKSTKANGIRKKFARELSFFSQKLNLPNMELK
 ||.||||..|||.||||..|||||| .|.     .||||.||  ...|  |.   ||| ..     ..|.. |  ... . . |..... |.  |. |.
eiyvrssdvdRtlqSaqaflaGlfppepplg....yqpipihtvpssndnlllp..sCpafk....ellkkelaeelkellkellerlkkllgglnltls

ATWRIFDNLFCEKQ-NNI-TWPSWMNSSIFERVDQLYNEVSQLEFH-TDTLRRLRGGTLLEEIFHRFSDKASGSLgkeaKFYAYSAHDSTIAALLATLGV
  . ..| |..|.. ..   ..|... . .|.. .|.. .  .|.  .| |.||.||.|| ||..|..|..||.     |.|.|.|||.||||||..||.
dvydlydlllyetaihglsplcslftpeelevleyladlefyyeygygdelarlaggpllneilarledaisgds....klylyfaHdttiaallsaLgl

FYDIYP------------------KYATCLLIEMHKLA-----NETRLIRVFHkNETDIDrlieysIPGCDDP----CTLQKLGDDLKKYFPeDWEAECG
| |. |                   ||..| .|...       .... .||.. |.....      .|||..     |.|... . |||. | ||| .||
fddelplpadnlpfnrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvly.ngeplp......lpgCgsgpgglCplddFkellkkflp.dweklCg

LKTSFQFIYLVIISILV
|..|. . . |.|..|.
ltlsvlallsvlidvll
0053031 Phosphoglycerate mutase-like 29-363 1.7e-80 263.8 In-house 1-340 (342) alignment 
Range on Protein: 29-363
Range on HMM: 1-340/342.0
DTLEYVHTVWRHGDRTPaELLFPD---DITKWPEGLGELTEQGAAQQYRLGQWLKRRYGSWLGEKFNRNAIYIRSSDYNRTLMSAQANMAGLFPPKYPIA
..|..|. ..|||.||| .  .|      . .| |.||||..| .|.| ||..|..||...|....|.. .|.||||..|||.|||| .|||||| ..  
eeLkqvivlvRHGaRtP.lskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpi

GG--LMWQPIPVHTISKPTDKELYE-EASCPTAEIEMNAQWKSTKANGIRKKFARELSFFSQKLNLPNMELKA-TWRIFDNLFCEKQNNITWPSWMNSSI
    | |||||.||... .|  |.    .||... .... ..|   . . ....  |. .|. |.|.   |    . ..|.|..|.... ..|.|..   
lnpllgwqpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqklskglgltlsdlldlvsdlydlllyelahglplppwctlft

FERVDQLYNEVSQLE---FHTDTLRRLRGGTLLEEIFHRFSDKASGslGKEAKFYAYSAHDSTIAALLATLGVFYDIYPKYATCLLIEMHKLAnETRLIR
.|.. .||... . .   .... |..|.||.|| ||..|. .| ||  ... |.|.|.|||.||||||..||.| | .| ||..| .|...   ..  .|
leelkalyaldllyyyglgpgnelaklaggpllneilarleekisg..pldlklylyfahdttiaallsaLglfddqlPpyasnlvfElyedp.geyyVr

VFHKNETDiDRLIEYSIPGCDDPCTLQKLGDDLKKYFPEDWEAEC
|.. ..|. . .... .||||. |.|... . .||. |.|.| .|
vlynggtl.seplvlplpgcdglcplsefkelvkkllpgdfeklC
0047369 Phosphoglycerate mutase-like 27-364 2.6e-76 250.5 In-house 40-437 (438) alignment 
Range on Protein: 27-364
Range on HMM: 40-437/438.0
NTDTLEYVHTVWRHGDRTP-----------------AELLFPDDITK-----WPEGLGELTEQGAAQQYRLGQWLKRRYgSWLgekfNRNAI-YIRSSDY
.  .|..|. ..|||.|||                 |  .....        .| |.|.||..|..|.| ||..| .|| ..|    |.. . |.||||.
egcelkqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrY.glL....npedvlyvrssdv

NRTLMSAQANMAGLFPPKY-PIAGGLMWQPIPVHTISKPTDKELY--EEASCPTAEIEMNAQWKSTKANGIRkkFARELSFFSQKLNLPNMELKATWRIF
.|||.||||..|||||| . ..   . |||||.|||.. .|  |      |||  .  ... . | . . .   ... |..... |.  |.. .  . ..
dRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnllpsdscpafdellkeflasdeflell..lkdilkrlkkllpglnltpsdvldly

DNLFCEKQNN-------ITWPSWMNSSIFERVDQLYNEVSQLEF-HTDTLRRLRGGTLLEEIFHRFSDKASGSLGK--------------EAKFYAYSAH
| .... ..|         ..|... ...| . .|....   .. ... |..|.||.|| ||. |. |...|.  .              . |.|.|.||
dlcaydtlangyaglplspfcslftpeelevleyladlefyylygygnelaklaggpllneilarledaingkstnlnltldsngvtfPldlklylyfaH

DSTIAALLATLGVFYDIYP---------------------KYATCLLIEMHKL-ANETRLIRVFHkNETDIDrlieysIPGCDDP----CTLQKLGDDLK
|.||||||..||.| | .|                      ||..| .|...   .... .||.. |. ..       .|||..     |.|... . .|
dttiaallsaLglfddtwplpglpldkialnrlfrsseivPyasnlvfElyecpsdgeyyVrvly.ngkvlp......lpgcgsgpgglCplddFkelvk

KYFPEDWEAECG
|. |.|.| .||
kllpgdfeelCg
0049059 Phosphoglycerate mutase-like 27-364 1.1e-75 248.2 In-house 39-435 (435) alignment 
Range on Protein: 27-364
Range on HMM: 39-435/435.0
NTDTLEYVHTVWRHGDRTPAE-----------------LLFPDD-----ITKWPEGLGELTEQGAAQQYRLGQWLKRRYgSWLgekFNRNAIYIRSSDYN
.  .|..|. ..|||.||| .                   . ..      ...| |.||||..|  |.|.||..| .|| . |   .|.. .|.||||..
egcelkqvqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrY.gfL...ynpdevyvrssdvd

RTLMSAQANMAGLFPPK----YPIAGGLMWQPIPVHTISKPTDKElyEEASCPTAEIEMNAQWKSTKANGI-RKKFARELSFFSQKLNLPNMELKATWRI
|||.||||..||||||       ...   .||.|..| .   |       |||  . .... ..| . . .  ....  |. ....|.|..  . . . .
RtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl..pydscpafdellkellasdeflelflerilkllqellpglgltpsdvldlydl

--FDNLFCEKQNNITWP--SWMNSSIFERVDQLYNEVSQLEFH-TDTLRRLRGGTLLEEIFHRFSDKASGSLGK--------------EAKFYAYSAHDS
  .|.|.... .....|  |... ...|.. .|.. .  .... .| ...|.||.|| ||..|. |...|.  .              . |.|.|.|||.
ckydtlllgyahglplpfcslfteeelevleyladlefyylygygdeiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaHdt

TIAALLATLGVFYDIY----------------------PkYATCLLIEMHKLANE-TRLIRVFHkNEtdidrlIEYSIPGCDDP----CTLQKLGDDLKK
|||.||..||.| |.                       | ||..| .|...  .. .. .||.. |.       .. .|||..     |.|... . .||
tiapllsaLglfddqlplpadntpfpeldrlfrtseivP.yasnlvfElyecpdgneyyVrvly.ng......kvlplpgcgsgpgglCplddFkelvkk

YFPEDWEAECG
. |.|.  |||
flpgddfdeCg
0048439 Phosphoglycerate mutase-like 23-355 3.5e-71 233.5 In-house 4-390 (391) alignment 
Range on Protein: 23-355
Range on HMM: 4-390/391.0
PiqaNTDTLEYVHTVWRHGDRTPA-------ELLFPDDITKWPEGLGELTEQGAAQQYRLGQWLKRRY--GSWLGEKF--NRNAIYIRSSDYNRTLMSAQ
|   .  .|..|. ..|||.|||        . | . . . .| ||||||..|. |.| ||..| .||  .. |..|.  |.. .|.||||..|||.|||
p...agcelkqvqvlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAq

ANMAGLFPP--------KYPIAGGLMWQPIPVHTISKPTDKELYEEASCPTAE------IEMNAQWK--------STKANGIRKKFARELSFFSQKLNLP
|..||||||         . .  .....|.|..|.... |. |..  |.. .        .... ..         ..  ...  .| |.  . ..|.| 
aflaGlfpplgltvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevlnrvlglnltaedvlslfdlcaketaalgsllkls

nMELKATWRIFDNLFCEKQNNITWPSWMNSSI-----FERVDQLYNEVSQLEFHTDTLRRLRGGTLLEEIFHRFsdKASGSlgKEAKFYAYSAHDSTIAA
 . |.  . ..|.|..|. .... |.|.....     .. .  |.||.  . .... ...|.||.|| ||. ..  .|.|.  .. |.|.|.|||.||||
.splcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsgeiaklaggpllneilddl..vangp..sdpklylyfaHdttiaa

LLATLGVFYD------IYPKYATCLLIEMHKLA-NETRLIRVFHkNETDIDRLI--------------EYSIPGCDDP----CTLQKLGDDLKKYF
||..||.| |       .| ||..| .|...   .... .||.. |. ..| .                . .|||..     |.|... . .||. 
llsaLglfndtlplpadlppyasnlvfElyecpsdgeyyVrvly.nggtldlprdltlldldefllrlvlplpgcgsgpgglCplddFvelvkkri
His_Phos_2 Histidine phosphatase superfamily (branch 2) 30-320 2.4e-53 174.2 Pfam-A 1-345 (347) alignment 
Range on Protein: 30-320
Range on HMM: 1-345/347.0
TLEYVHTVWRHGDRTP-------------AELL-------FPDDIT--------KWPEGLGELTEQGAAQQYRLGQWLKRRYGSWLGEKFNRNAIYIRSS
.|. |..|.|||||||              .||        ... .        ... ..|.|| .| .|.. ||..|..||.. | ...... ..||||
eLkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYpgllrdhltyedvkirss

DYNRTLMSAQANMAGLFPPKY-----PIAGGLMWQPIPVHTISK--PTDKELYEEAS--CPTAEI--EMNAQWKSTKANGIRKKFARELS-FFSQKLNLP
...|.|.||||..|||..|..          | .......|...   ..|||  | .  ||. .     ... .. . |  .|...  |.   |. .. .
serRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenlakrlsalctge

-NMELKATWRIFDNLFCEKQ--NNITWPSWMNS--SIFERVDQLYNE--VSQLEFHTDTLRRLRGGTLLEEIFHRFSDKASGSL-GKEAKFYAYSAHDST
 |.. |..|. ... |.|..  .. ..|.....    .. ..|| .     .|   .| ... .|. ||.... .. ......   ..||...|..|||.
dnllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDsh

IAALLATLGVFY------DIYPKYATCLLIEMHKLaNET-RLIRVF
|..||..||..         ...||... .|...  .|. . .|..
iytllnaLgleekiareaspelpyasqivfelyed.sekkfyvrll
His_Phos_2 Histidine phosphatase superfamily (branch 2) 30-320 2.4e-53 174.2 In-house 1-345 (347) alignment 
Range on Protein: 30-320
Range on HMM: 1-345/347.0
TLEYVHTVWRHGDRTP-------------AELL-------FPDDIT--------KWPEGLGELTEQGAAQQYRLGQWLKRRYGSWLGEKFNRNAIYIRSS
.|. |..|.|||||||              .||        ... .        ... ..|.|| .| .|.. ||..|..||.. | ...... ..||||
eLkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYpgllrdhltyedvkirss

DYNRTLMSAQANMAGLFPPKY-----PIAGGLMWQPIPVHTISK--PTDKELYEEAS--CPTAEI--EMNAQWKSTKANGIRKKFARELS-FFSQKLNLP
...|.|.||||..|||..|..          | .......|...   ..|||  | .  ||. .     ... .. . |  .|...  |.   |. .. .
serRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenlakrlsalctge

-NMELKATWRIFDNLFCEKQ--NNITWPSWMNS--SIFERVDQLYNE--VSQLEFHTDTLRRLRGGTLLEEIFHRFSDKASGSL-GKEAKFYAYSAHDST
 |.. |..|. ... |.|..  .. ..|.....    .. ..|| .     .|   .| ... .|. ||.... .. ......   ..||...|..|||.
dnllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDsh

IAALLATLGVFY------DIYPKYATCLLIEMHKLaNET-RLIRVF
|..||..||..         ...||... .|...  .|. . .|..
iytllnaLgleekiareaspelpyasqivfelyed.sekkfyvrll
subfamily_ACP6_pd Subfamily ACP6 61-366 8.4e-29 92.4 In-house 75-374 (376) alignment 
Range on Protein: 61-366
Range on HMM: 75-374/376.0
LGELTEQGAAQQYRLGQWLKRRYG---SWLGEKFNRNAIYIRSSDYNRTLMSAQANMAGLFPPKYpIAgglMWQPIPVHTISKPTDKELYEEASCPTAEI
.|.||. |  | . ||. |..||    ..| ..|| . .|||| . .||| ||.  .|||.  .  |       || ..|. .  .  . .  .||. . 
kGqLtkvGmqqvfdLGrkLrkrYvedikfLsqefnpqevyiRstnieRtlesarclvaGLygkii.iq...kelpiilytdeedeevlyPnrqrcpllsr

EMNAQWKST-KANGIrkkfARELSFFSQKLNLPNMELKATWRIFDNLFCEKQNNITWPSwMNSSIFERVDQLYNEVSQLEFH-TDT----LRRLRGGTLL
 ...  ||. . .||    .....   ..|.. . .      . ||.  ... |.. |  .  ........   | . . ..  |       .|  | .|
ayrsvrksaislpGi....sedtkqiadvldiseekkldfvslrDniaArlaHnlkvpp.ilkdvidliekhAveelvvlleggdrpekeilklsvGkvl

EEIFHRFSDKASGSLGKeAKFYAYSAHDSTIAALLATLGVFYDIYPKYATCLLIEMHKLANETRLIRVFHKNEtdidrliEYSIPGC-DDPCTLQKLGDD
.|| ... ..  . .    |.. ||||| |. .|| .|||| | .| .|. . .|...  ..   .||.....       |  ..|. .| . |.|  . 
keilenlekakekeipa.rklrLysaHDttlmtLLlalgvFDdkWPpfaadvileLyedkageyfvrvlYqek.......elrlrgseedlvPlekFkal

LKKYF-PEDWEAECGLK
|...  |.|..||| |.
lavlvlpkdyaaeCkle
subfamily_PXYLP1_pd Subfamily PXYLP1 61-320 6.6e-18 56.1 In-house 103-365 (419) alignment 
Range on Protein: 61-320
Range on HMM: 103-365/419.0
LGELTEQGAAQQYRLGQWLKRRYGSW---L--GEKFNRNAIYIRSSDYNRTLMSAQANMAGLFPPKypiagglMWQPIPVHTisKPTDKELYEEASCPtA
||.||..|  |  ..|. |.. |.     |   ...... ... .  ..||| || | . ||.| .        .. | |..  .|. .  ..| ||| |
lgqLtqkGvvqhLevGdllrkvYakklklLlkpnelssDevvlettrkrrtlqsalallygllpka.......klkairvre..spsvafClgeCsCP.a

EIEMNAQWKSTKANGIRKKFARELSFFSQ---KLNLPNMELKATwRIFDNLFCEKQNNITWPSWMNSSI----FERVDQLYNEVSQLEFHTDTLR---RL
  .   . .. |.  .| |.      ...     .|.. ..... .  | | .    |...|   . ..    .. . .| .|.|| .    . .   .|
llrkrlekeadkqlLlrgkvldvmksvgetlkgtilqttlngis.npvdalltvlChnvslPcrreGcvepshvdvlhkladelsqrsakksyyklsGll

RGGTLLEEIFHRFSDKASGSlgKEAKFYAYSAHDSTIAALLATLGVFYDIYPKYATCLLIEMHKLANET-RLIRVF
|   ||..|  |     .|   .. ||  ||.|| |.  |.|.||.    ...||. |. |... ....   .|| 
raypllrdivsrmlkiieGv..dkekfvlysghDvtlrplvaaLglseartiayasrlvfelyrreaskeyylrvl
subfamily_HP2-Group1_pd Subfamily HP2-Group1 199-315 2.6e-11 34.5 In-house 251-368 (422) alignment 
Range on Protein: 199-315
Range on HMM: 251-368/422.0
IFDNLFCEKQNNITWPSWMNSSIFER-VDQ-LYNEVSQLEFHT-DTLRRLRGGTLLEEIFHRFSDKASGSlgKEAKFYAYSAHDSTIAALLATLGVFYDI
. | |.  .  |...|  .   .. | .|. ||   | | . . .   |   | || .|.. . .  .|   .  ||  || ||.|.  ||..|.|   .
lvdclithqchnaaipdkltedlakrgldellyrsysslkypsvekyarvGiGfllkdiwkevnesltGe..dlrkfllysGhdttliqllsalnvdefk

YPKYATCLLIEMHKLANETR
.| ||. ||.|. . .   .
wppyasllllellevstapa
subfamily_MINPP1_pd Subfamily MINPP1 62-296 5.7e-11 33.9 In-house 90-330 (420) alignment 
Range on Protein: 62-296
Range on HMM: 90-330/420.0
GELTEQGAAQQYRLGQWLKRRYGSWLGEKFNRNAIYIRSSDYNRTLMSAQANMAGLFPPKYpiAGGLMWQPIPVHTISKPTDKELYEEASCPTAEIEMNA
..|..|| .. . |.. |.||.   ..|. |.. ....|.. .||. |||| . ||.. .     |   ... . . .. .|| |   .||.  . ... 
kslvaqgqeeleelakrlarrfpalfeevynpdsfsfastakkRtvksaqaFaeGLsetge..vlgdefnivlqeiseqesdklLrffdsCkkyknkvkk

QWKSTKAN---GIRKKFARELSFFSQKLNLPNMELKATWRIFDNLFCEKQNNITWPSWMNS--SIFERVDQlynevSQLEFH-----------TDTLRRL
.  ..| .      |.. . |.  ...||  .  |. |     ..|     .... .  |.  |.||. .       .||.              .. . 
nelnlkeeeefleskelqkaleeiakrlneekklleltekdiedmfeiCayelaikgisnvWcslfekdel.....leleYledLknyykegyGyeinys

RGGTLLEEIFHRFSDKASGSLGKEAkfyAYSAHDSTIAALLATLGVFYDIY
 . .||..|.. ..   .    ..     . ||..|.  ||..||.. | .
iscpLlndivkllksseeqkqksss...lrFaHaetllpllsllGlykDee
subfamily_HP2-Group1_pd Subfamily HP2-Group1 61-153 8.4e-11 32.8 In-house 92-184 (422) alignment 
Range on Protein: 61-153
Range on HMM: 92-184/422.0
LGELTEQGAAQQYRLGQWLKRRYG--SWLGEKFNRNAIYIRSSDYNRTLMSAQANMAGLFPPKYPIAGGlmWQPIPVHTISKPTDKELYEEASCP
...|| .|  ||   || |.. |    .|  ...   .|.|| | .||..|||| . |..|..         | ....|  |  |.   .   ||
vaqltleGykqqelnGqilrkvyvdtGflkssldssevylrsddesrtilsaqalilGmypqdtkaedr..aqvvdlytrdklfdsieanadlcp
His_Phos_1 Histidine phosphatase superfamily (branch 1) 37-168 3.4e-07 23.3 Pfam-A 4-72 (158) alignment 
Range on Protein: 37-168
Range on HMM: 4-72/158.0
VWRHGDRTpaeLLFPDDITKWPEglGELTEQGAAQQYRLGQWLKRrygswlgekFNRNAIYIRSSDYNRTLMSAQAnMAGlfppkypiagglmwqpipvh
. ||| .    .  .. ...| .   .|||.| .|  .||..|||          . .   . .|.. |..  |.. ..                     
lvRHGese...wnkegrlqgwsd..vpLtekGreqarelgkkLkr.........adlpidavytSplkRaiqTaei.lle....................

tiskP-TdkelyeeascptaeiemnaqwkstkA
      .                          
....eld.........................i
His_Phos_1 Histidine phosphatase superfamily (branch 1) 37-168 3.4e-07 23.3 In-house 4-72 (158) alignment 
Range on Protein: 37-168
Range on HMM: 4-72/158.0
VWRHGDRTpaeLLFPDDITKWPEglGELTEQGAAQQYRLGQWLKRrygswlgekFNRNAIYIRSSDYNRTLMSAQAnMAGlfppkypiagglmwqpipvh
. ||| .    .  .. ...| .   .|||.| .|  .||..|||          . .   . .|.. |..  |.. ..                     
lvRHGese...wnkegrlqgwsd..vpLtekGreqarelgkkLkr.........adlpidavytSplkRaiqTaei.lle....................

tiskP-TdkelyeeascptaeiemnaqwkstkA
      .                          
....eld.........................i
0048955 Phosphoglycerate mutase-like 38-187 1.3e-06 21.0 In-house 6-72 (240) alignment 
Range on Protein: 38-187
Range on HMM: 6-72/240.0
WRHGDRTPAellFPDDITKWPEglGELTEQGAAQQYRLGQWLKRRygswlgekfNRNAIYIRSSDYNRTLMSAQANMAGLfppkypiagglmwqpipvht
.||| ..      ..... |.    .|||.| .|  .||..|...         . .  .. ||.. |.. .|..  ..|                    
vRHGesewn...aegrlqgwtD..vpLtelGreqaralgerLadl.........gikfdlvysSpllRaiqTaeiiaeal....................

iskptdkelyeeascptaeiemnaqwkstkangirkkfarelsffsqklN
                                                 .
.................................................g
0051064 Phosphoglycerate mutase-like 38-191 1.5e-06 20.8 In-house 9-79 (241) alignment 
Range on Protein: 38-191
Range on HMM: 9-79/241.0
WRHGDRTPAellFPDDITKWPEglGELTEQGAAQQYRLGQWLKRRygswlGEKFNrnaiYIRSSDYNRTLMSAQANMAGLFPPKypiagglmwqpipvht
.||| ..      .. .. |..   .|||.| .|  .||..|...     | ||.    .. ||.. |.. .|..  ..|  |.                
vRHGesewn...aegrlqgwtD..vpLtelGreqaralgerladl.....gikfd....avysSpllRaiqTaeiiaealglpl................

iskptdkelyeeascptaeiemnaqwkstkangirkkfarelsffsqklnlpnM
                                                     .
.....................................................l