Gene DDB_G0268222 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP068_AA protein Get Run
DdisP068_AA_210-402 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP5_pd Subfamily ACP5 212-403 5.4e-63 204.3 In-house 1-189 (189) alignment 
Range on Protein: 212-403
Range on HMM: 1-189/189.0
VYADMGYGGGYNNTVKVIEENLSKYSLILHIGDIAYADYNkveqGNQTIWTNFLQALEPITSKVPYMTAPGNHDVFYSFNSYQNTFNMPgsSNQPWYSYD
|..|.|.  . . . .. ||. ....||.|.||.|||. .     |...| .|....||..||||||...|||.....|..|...|.||  |.. |||.|
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalka....kneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp..sknewYsfd

YNGVHFLSYSTESDLAPFTQQYQWIKNDLETYRKKNPSGWVIAYAHRPYYCSTQMDW-C--RKQTLRALIESTIGELFQNYNVDIYLAGHTHAYE
|..||| |.||| | .. ..||.|...||....... . |.|...|||.|||.. .. |  .....|.   ... .|...|.||..|.||.|.||
ygpvhfislstevdfslgseqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlalsgHeHsYe
PAPL 211-402 1e-47 154.8 In-house 1-194 (194) alignment 
Range on Protein: 211-402
Range on HMM: 1-194/194.0
AVYADMGYGGGYNNTVKVIEENLSKYSLILHIGDIAYADYNKVEQgnqtIWTNFLQALEPITSKVPYMTAPGNHDVFYSFNSYQNTFNMPGSSNQPWYSY
||..|.|.    ...    |.. .||..|||.||.||||... |.       .|.. .||....||||.|||||.  | |..|...|.||||......|.
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnew....dgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnss

---------DYNGVHFLSYSTESDLAPFTQQYQWIKNDLETYRKKNpSGWVIAYAHRPYYCSTQMD-WCRKqtlRALIESTIGELFQNYNVDIYLAGHTH
         ....|||. .|.|.|  .  .||.| ..||.   ...   |.|...||| |||.. . .|..    | . . . .|...|.||..|||| |
esgsnsysfetesvhfivlsseedvkekseqyewleedlakvnRsk.tPWiivmgHrpmYcsnkdkddcke...kakmlaaledllykygVDlvlaGHeH

AY
.|
sY
Metallophos Calcineurin-like phosphoesterase 210-402 3.8e-18 59.5 Pfam-A 3-200 (200) alignment 
Range on Protein: 210-402
Range on HMM: 3-200/200.0
AAVYADMGYGGGYN---NTVKVIEENLSKYSLILHIGDIAYADYNKVEQGNQTIwtnflQALEPITSKVPYMTAPGNHDVFYSFNSYQNTFNMPGSSNQP
 .| .|...|  ..             .|  |.|. ||. ... .  |.  .       . ..... ..|.. ..|||....    |  . ..... . .
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.....ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrgl

WYSYD-----------YNGVHFLSYSTESDLAPFTQQYQWIKNDLETYRKKNpsGWVIAYAHRPYYCSTQM-DWCrkqTLRALIESTIGELFQNYNVDIY
.. ..            .|. . . . . .| . .|..|... ...  |...  ...|. .|.| ..|..  |.          .    .|...|.||..
angeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralv..dgkilltHgplsssggsgddi...gselfgpdalekllekygvdlv

LAGHTHAY
| |||| .
lrGHtHkp
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 422-482 2.5e-16 51.1 Pfam-A 2-60 (62) alignment 
Range on Protein: 422-482
Range on HMM: 2-60/62.0
GTVHFTIGTPGNqeGLDHnWILPAPSWSASRFGELGYGQLNVVNNTHILWQFLTDQ-QVIFD
..|| ..|. ||  ||.. .  | |.||| |  . ||. |.|||.||. |.|  .. . ..|
ApvhIvvGaAGn..glsk.fskpqpewsafresdyGysrltvvNrthLhwefvrsddgqvlD
ACP5 220-400 2.5e-11 35.6 In-house 11-197 (198) alignment 
Range on Protein: 220-400
Range on HMM: 11-197/198.0
GGYNNT-----VKVIEENLsKYSLILHIGDIAYADynKVEQGNQT-IWTNFLQALEPITSKVPYMTAPGNHDVFYSFNSYQNTFNMPGSSNQPWYSYDYN
| || .     .. . |.| ... .| .||  | |   |.. ... . ..| .  .  . .||...  ||||.  . .. ..  .   .|. |.. | ..
geynqsavakqmgkvaekl.didfvlslGDnfydd..GvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpslrysls

GVH-FLSYSTESDLAPFT--------QQYQWIKNDLETYRKKNPSGWVIAYAHRPYYCSTQMDwcrkqTLRALIEStIGELFQNYNVDIYLAGHTH
  . . .. ||..             .. ..  ..||.  .|.   |.|   | | |   .         . |.|. .  |...|.||.||.|| |
kkevvtelftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehg.....dtkelver.llpllkkykvdaYlnGHdH
PhoD PhoD-like phosphatase 130-255 1e-09 28.9 Pfam-A 49-148 (453) alignment 
Range on Protein: 130-255
Range on HMM: 49-148/453.0
TVNGKStTFSNWKGYSNSVVLTGLSPKTTYYYQCGGsssnilsqTNYFTTSNFPTTTTAntSGKNVKStttdnfqvtpFTAAVYADMGYGGGYNNTVKVI
  .|.  . .. . |.  | .|||.|...|.|.           ..  ..|    |.|.   ...|.|          .. ||.... |  || |. . .
vrsgtv.latserdytvkvevtgLepgqeyfYrfra........eegesespvGrtrTl..peaaves..........lrlavvSCsnyeqGyfnayrel

EENlSKYSLILHIGDIAYADYnkveQ
 |. ... ..||.||. |..     .
aek.edlDfvlhlGDyiYeyg....e
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 224-439 7.6e-08 24.5 Pfam-A 15-146 (156) alignment 
Range on Protein: 224-439
Range on HMM: 15-146/156.0
NTVKVIEENlSKYSLILHIGDIAYAdynkveqgnqtiwtnfLQALEPItSKVPYMTAPGNHDVFYSFNSYQNTFnmpgssnqpwysydyngvhflsyste
.. .|.|.   .. |||| ||.                    . .| . ...|  . .||||     .... ..                          
aleavledi.kevdlilhaGDlvep................eevvell.edipvlavrGnhDeaelpkelavel..........................

sdlapftqqyqwikndLETYRKKNPSGWVIAYAHR---PyycstqmdwcRKqtlraLIESTIGELFQNYNVDIYLAGHTHAYERtvpvyqqspigtyEYP
                |... . .  |. .   |.   .           .       |. . ||......|... |||| ..              |  
................llaaaaleiegdrvllvhgtpls..........vq.....sseeelaellkeagadlvflGHtHkpkv.............ekr

GGTVHFTIGTPGNQ-EGLDH
|||.... |..|.. || ..
ggtlvvnpGsvgepregdea
subfamily_PAPL_pd Subfamily PAPL 238-401 1.8e-06 19.3 In-house 37-211 (212) alignment 
Range on Protein: 238-401
Range on HMM: 37-211/212.0
LILHIGDIAYADYNKvEQGNQTIWTNFLQALEPITSKVPYMTAPGNHD--------VFYSFNSyqNTFNMPGSSNQPWYSYDYNG--V-------HFLSY
..|..||. | .  | .  .. . ..| .  .  . .||... .||||        . ||  |  . ...|    .  .... .   |        .|..
fvlalGDnfYekGvk.dvddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYskls..krWkfpslyytksfkipdsnatvqlvlidtvllcg

S-------TESDLAPFTQQYQWIKNDLETyrkkNPSGWVIAYAHRPYYCSTQmdwcrKQTLRALIeSTIGELFQNYNVDIYLAGHTHA
        .  |.   ..|..|....|..    .   ..|   | | .  ..     . . . |  . .  | ..|||. ||.|| | 
ksddlklegpvdvslaeeqwawleeeLka....seadylivaGhypvwsvae.....hGptkiLv.krLkPlLekynvtaylsGhDhn
GRP Glycine rich protein family 11-76 8.5e-06 12.7 Pfam-A 11-77 (95) alignment 
Range on Protein: 11-76
Range on HMM: 11-77/95.0
LLFVFLVLISVCLAENKQqNHSPKINSSASPSKANKNN-GSN-NNNNNNKIDLTSNGGGSSSEGGDIN
||.....|||   |.... ... | ....   ....   |.. .  .. .     .||| .  ||  .
lllaavlLissevaaael.skeeksekeeevkdekyggggkhggGgygggggggngGGGykgggGgyg