Gene cf60 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily HP2-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP092_AA protein Get Run
DdisP092_AA_10-413 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0046349 Phosphoglycerate mutase-like 41-412 3.8e-74 243.2 In-house 4-393 (409) alignment 
Range on Protein: 41-412
Range on HMM: 4-393/409.0
GLTLKMVQILTRHGDRTPLYStlkptmntwdcnlgwlmV-----------SslnnvpgaatdvdrlfrkvympnreyfPGNCSDGQLTSLGFQQHLQLGQ
|..||.||.|.|||.|||...                                                         .|.| .|||| ||..|. .||.
gceLkqvqvlfRHGaRtPtkk.................lsflpnwpginwt...........................ngpcgagqLTplGreqayelGk

SLRQLYVDkYELLPSELSvDAASTIWVRSTDVPRTIQSVQGHLTALFPPTTVTS--------------GSGIPIININTMDNYYENMTPNPTLCPELAVL
 ||..|||   ||||.      ..|.|||.||.||.|| |  | .|||| ....              .  |... |...| . ... |...||| |  |
rlrkrYvd.lgLlpsnsl.ynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkl

IANTTTT-PEWGE-----------FITNTTQLKEDVMETL-----GIS---VFPGWSSLMDLFFATQCHDFPLPEG---VTQDMVTQVYEAAYWQYQYQL
.... .. .|. |           .   | .| . ..| |     |..   ..  .| |.|.... ..|..|||.    .|.... .....| ..| |. 
lkenlkslsevleflvdealldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyyly

SFPMIARLGMSTFLEEVVDNIRAFVNGTS------SVKYIVFSGHDDSVGPFTNLFGLMK------EWPPYASHVELELWSD-EKDNYFLQFKFNGQSYT
... .|.| ....| |....... ..|..      ..|......||  . .. ...|| .      ..|||||.. .||... ....|. .. .||. ..
gsgelaklaggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLglfdrlfrssdippyasnlvfElyecpsdgeyyVrvlynggplp

LNGCEDVmCPIDSFFETAYSILVP----NYADACSNS
| || .  || . | |   ..|..    .... |. .
lpgcgeg.cplsefkellkkrlpgcgltdfdklCple
0048946 Phosphoglycerate mutase-like 24-413 1.2e-73 241.5 In-house 21-413 (447) alignment 
Range on Protein: 24-413
Range on HMM: 21-413/447.0
KPFYCQAPEPTPSLNTDGLTLKMVQILTRHGDRTPLYSTLKPTMNTWDCNLGWlmvsslnnvpgaatdvdrlfrK-------VYM-PNREYFPG-----N
 |.... . ..|.   .|..||.||.|.|||.|||... || .....|.  ..                     .       . . .. .|...     .
spyfsvpgygipepvpegcelkqvqvlfRHGaRtPtkkylkgleplldllkna.....................nvlelggdlsflndwkyqlkneplwp

CSDGQLTSLGFQQHLQLGQSLRQLYvdkYELLPselsvdAASTIWVRSTDVPRTIQSVQGHLTALFPPTtvTSGSGIPIININTMDNYYENMTPnptLCP
|  |||| ||..|. .||. ||..|   . |||        |.|.|||.||.||.|| |  | .||||.  .... .||. . ... ... ..|    ||
cglgqLTplGreqlyelGkrlrkrY...lgllp......npseiyvrssdvdRtlqSaqaflaGlfppe..pplgyqpipihtvpssndnlllp...sCp

ELAVLIANTTTtPEWGEFITNTTQLKEDVMETLGISvFPGWSSLMDLFFA-TQCHDFPLPEGV-TQDMVTQVYEAAYWQYQYQLS-FPMIARLGMSTFLE
 .  |. .. . .|. |.. ..... ... ..| .. .  ...|.|| .. |..|. ... .. |....... ..| ... |  .  . .||| ....| 
afkellkkela.eelkellkellerlkkllgglnlt.lsdvydlydlllyetaihglsplcslftpeelevleyladlefyyeygygdelarlaggplln

EVVDNIRAFVNGTSsvKYIVFSGHDDSVGPFTNLFGLMKEWP-------------------PYASHVELELWSDE-----KDNYFLQFKFNGQSYTLNGC
|....... ..|.|  |......||  . .. ...||.. ..                   ||||.. .||....     ...|. .. .||. ..| ||
eilarledaisgds..klylyfaHdttiaallsaLglfddelplpadnlpfnrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlyngeplplpgC

ED---VMCPIDSFFETAYSIlVPNYADACSNST
..    .|| | | |   .. .|.....| ...
gsgpgglCplddFkellkkf.lpdweklCgltl
0047369 Phosphoglycerate mutase-like 11-410 2.6e-72 237.3 In-house 9-437 (438) alignment 
Range on Protein: 11-410
Range on HMM: 9-437/438.0
FLVSLILGVSLSQKPFYCQAPEPT---PSlNTDGLTLKMVQILTRHGDRTPLYSTLKPTMNTWDCNLGWLMVSSlnnvpgaatdvdrlfrkvymPNREYF
. |.. .   |... .|..|| ..   ..   .|..||.||.|.|||.|||..|.||  ...|.. . .  . |                    .. ...
lsvdfnillhlgtlspyfsapgvglisld.vpegcelkqvqvlfRHGaRtPtksklkkleplwellenattyps....................gplsfl

P---GNCSDGQLTSLGFQQHLQLGQSLRQLYvdkyELLpselsvdAASTI-WVRSTDVPRTIQSVQGHLTALFPPTTVTSGSGIP--IININTMDNYYEN
.   |.|  |||| ||..|. .||. ||..|     ||       . ... .|||.||.||.|| |  |  ||||.. ..   |    |.|.|.   .. 
ndwlgpcgagqLTplGreqayelGkrlrkrY....glL.......npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddf

MTP--NPTLCPELAVLIANTTTTPEWGEF-ITNTTQLKEDVMETLGISvFPGWSSLMDLF-FATQC-H-----DFPLPEGVTQDMVtQVYEAAYWQYQYQ
. .  .   || .. |. .. ...|. |.   . ... ......|... .  ...|.||. ..|.. .     . |... .|.... .|.|.... ..|.
llnllpsdscpafdellkeflasdeflelllkdilkrlkkllpglnlt.psdvldlydlcaydtlangyaglplspfcslftpeel.evleyladlefyy

LS--FPMIARLGMSTFLEEVVDNIRAFVNGTS----------------SVKYIVFSGHDDSVGPFTNLFGLMK-EWP---------------------PY
|    . .|.| ....| |....... .||.|                ..|......||  . .. ...|| . .||                     ||
lygygnelaklaggpllneilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivPy

ASHVELELWSD-EKDNYFLQFKFNGQSYTLNGCED---VMCPIDSFFETAYSILVPNYADACS
||.. .||... ....|. .. .||. ..|.||..    .|| | | |   ..|.......| 
asnlvfElyecpsdgeyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkllpgdfeelCg
0049059 Phosphoglycerate mutase-like 22-409 6.2e-72 235.8 In-house 19-434 (435) alignment 
Range on Protein: 22-409
Range on HMM: 19-434/435.0
SQKPFYCQAPEPT------PslntDGLTLKMVQILTRHGDRTPLYSTLKPTMNTWDCNLGWLMVSSlnnvpgaatdvdrlfrkvymPNREYFPG---NCS
 .. .|..|| ..      |    .|..||.||.|.|||.|||... .|    .|.. |  |   .                    .. ....    .. 
gtlspyfsapgvfgisldvp....egcelkqvqvlfRHGaRtPtsklikklealwekllslltypn....................gplsflndwnyplg

DGQLTSLGFQQHLQLGQSLRQLYvdkyellpSELsvDAASTIWVRSTDVPRTIQSVQGHLTALFPPT-----TVTSGSGIPIININTMDNYYENMtpNPT
.|.|| ||..|. .||. ||..|        . |     ....|||.||.||.|| |  | .||||      .. . ...  ..|.|.| ..  .  .. 
ageLTplGreqayelGkrlrkrY........gfL..ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl..pyd

LCPELAVLIANTTTTPEWGEF-ITNTTQLKEDVMETLGISVFpGWSSL-----MDLFFATQCHDFPLP--EGVTQDMVTQVYEAAYWQYQYQLS-FPMIA
 || .  |. .  ...|. |.   ....| ..... ||...   ...|     .|.......|..|||  . .|.... .....| ... |. .  . ||
scpafdellkellasdeflelflerilkllqellpglgltps.dvldlydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygdeia

RLGMSTFLEEVVDNIRAFVNGTS----------------SVKYIVFSGHDDSVGPFTNLFGLMKEWP----------------------PYASHVELELW
.| ....| |....... .||.|                ..|......||  . |. ...|| . ..                      ||||.. .||.
klaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvfEly

SDEKD-NYFLQFKFNGQSYTLNGCED---VMCPIDSFFETAYSILVPNYADAC
..... .|. .. .||. ..|.||..    .|| | | |   ..| ... | |
ecpdgneyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkflpgddfdeC
0048439 Phosphoglycerate mutase-like 40-396 2e-69 227.7 In-house 5-385 (391) alignment 
Range on Protein: 40-396
Range on HMM: 5-385/391.0
DGLTLKMVQILTRHGDRTPLYSTLKPTMNTWDCnlgwlmvsslnnvpgaatdvdrlfrkvympnrEYFPGNCSDGQLTSLGFQQHLQLGQSLRQLYVDkY
.|..||.||.|.|||.|||..|  ..  .....                                 .. |.| .|.|| ||..|. .||. ||..||| .
agcelkqvqvlfRHGaRtPtssypnkldpllnk................................llpngpcglgeLTplGreqlyelGrrlrkrYvd.l

ELLPSELSvDAASTIWVRSTDVPRTIQSVQGHLTALFPPTtvtSGSGIPIININTMDNYYENMTPNPTLCPELAVLIANTTTTPEW---------GEFI-
 |||| .     |...|||.||.||.|| |  | .||||.   ... | .| ....|... ..  |   ..|   | .. .  | .          |.. 
gllpskyt.lnpsevyvrssdvdRtlqSAqaflaGlfppl...gltvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevln

--TNTTQLKEDVMETLGI---------------SVFPGWSSLMDLFFATQCHDFPLPEGVTQDM-----VTQVYEAAYWQYQYQLSFPMIARLGMSTFLE
   . ..  ||| ... .               | .  ...|.| ... ..|..|||| .|...     ..|... ....| |. . . ||.| ....| 
rvlglnltaedvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsgeiaklaggplln

EVVDNIraFVNGTSSVKYIVFSGHDDSVGPFTNLFGLMK-------EWPPYASHVELELWSDE-KDNYFLQFKFNGQ--------------------SYT
|..|..   .|| |..|......||  . .. ...|| .        .|||||.. .||.... ...|. .. .||.                     ..
eilddl..vangpsdpklylyfaHdttiaallsaLglfndtlplpadlppyasnlvfElyecpsdgeyyVrvlynggtldlprdltlldldefllrlvlp

LNGCEDV---MCPIDSFFET
|.||..    .||.| | | 
lpgcgsgpgglCplddFvel
0053031 Phosphoglycerate mutase-like 43-409 5e-69 226.2 In-house 2-340 (342) alignment 
Range on Protein: 43-409
Range on HMM: 2-340/342.0
TLKMVQILTRHGDRTPLYSTLKPTMNTWDCnlgwlmvsslnnvpgaatdvdrlfrkvympnreyfpgNCSDGQLTSLGFQQHLQLGQSLRQLYvdkYELL
.||.|..|.|||.||||..  .   |.| .                                     .|..|.|| ||..|...||. ||..|   ..||
eLkqvivlvRHGaRtPlskgpldplnewfy.....................................pcgageLTplGreqayelGrrlrkrY...lgll

PSELSVDaasTIWVRSTDVPRTIQSVQGHLTALFPPTTVTSGSG------IPIININTMDNYyeNMTPNPTLCPELAVLIANTTTTPEWGEFITNTTQLK
|| .. |   ...|||.||.||.|| |  | .|||| . .. .       |||. .. . ..  ...||.. || .  |.... ...|. |.. ....| 
pstynpd...evyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessda..lllpnydpcpafdkllkealaseevkellerylell

EDVMETLGISVFpG----WSSLMDLFFATQCHDFPLPEGVTQDMVTQVYEA---AYWQYQYQLSFPMIARLGMSTFLEEVVDNIRAFVNGTSSVKYIVFS
. ....||...  .    .|.|.||... ..|..|||. .|...  ..       ...|    . . .|.| ....| |..........|....|.....
qklskglgltls.dlldlvsdlydlllyelahglplppwctlftleelkalyaldllyyyglgpgnelaklaggpllneilarleekisgpldlklylyf

GHDDSVGPFTNLFGL-MKEWPPYASHVELELWSDEkDNYFLQFKFNGQ------SYTLNGCEDvMCPIDSFFETAYSILVPNYADAC
.||  . .. ...||    .|||||.. .||..|. ..|.... .||.       ..| ||.. .||.. | |   ..|.......|
ahdttiaallsaLglfddqlPpyasnlvfElyedp.geyyVrvlynggtlseplvlplpgcdg.lcplsefkelvkkllpgdfeklC
0049226 Phosphoglycerate mutase-like 43-409 5.7e-69 225.9 In-house 2-340 (342) alignment 
Range on Protein: 43-409
Range on HMM: 2-340/342.0
TLKMVQILTRHGDRTPLYsTLKPTMNTWDCnlgwlmvsslnnvpgaatdvdrlfrkvympnreyfpGNCSDGQLTSLGFQQHLQLGQSLRQLYvdkYELL
.||.||.|.||||||||. ... .   . .                                    ..|..|.|| ||..|. .||. ||..|   ..||
kLkqvqvliRHGdRtPla.kgpldflnewf....................................wgcglgeLTplGreqayelGrrlrkrY...lgll

PSELsvdAASTIWVRSTDVPRTIQSVQGHLTALFPPTTVTSGSG------IPIININTMDNYyeNMTPNPTLCPELAVLIANTTTTPEWGEFITNTTQLK
|| .     ....|||.||.||.|| |  | .||||.. ..         |||| ..   ..  ..... . ||..  |. .. ...|. .|. ....| 
psty...npdevyvrssdvdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndt..llllpydscpnfdkllkellkseevqlfleeildll

EDVMETLGI---SVFPGWSSLMDLFFATQCHDFPLPE---GVTQDMVTQVYEAAYWQYQYQLSFPMIARLGMSTFLEEVVDNIRAFVNGTSSVKYIVFSG
... . ||.   .  . .. |.||. . ..|..|||.    .|.... ..|.   ..| .. . . |||| ....| |..........|.|..|......
kklskllglnlstlsdvadtlydlllyelahglplppwcslftleelkalyaldllyyygigygeeiarlaggpllneilarleeaiegpsdlklylyfa

HDDSVGPFTNLFGLMK-EWPPYASHVELELWSDEkDNYFLQFKFNGQS------YTLNGCEDVmCPIDSFFETAYSILVPNYADAC
||  . .. ...|| .  .|||||.. .||.... ..|.... .||..      ..| ||..  ||.| | |   ..|.......|
hdttiaallsalglfddqlPpyasnlvfElyecd.geyyVrvlynggvlslpvtlplpgcdgl.cpldefkelvkkflpgdfeelC
subfamily_ACP2_pd Subfamily ACP2 40-413 4.7e-62 202.6 In-house 5-360 (361) alignment 
Range on Protein: 40-413
Range on HMM: 5-360/361.0
DGLTLKMVQILTRHGDRTPLYsTLKPTMntwdcnlgwlmvsslnnvpgaatdvdrlfrkvYMpNREYfPGNCsdGQLTSLGFQQHLQLGQSLRQLYVDKY
.  .||.||.|.|||||.||  |.. ..                                |. ..|. |..   ||||..|.||...||. ||. ||...
eerkLkfvqvlfRHGdRsPln.typndk................................yk.edew.pqgl..GqLTeeGmqqqyeLGkfLrkrYvedt

ELLPSElsvDAASTIWVRSTDVPRTIQSVQGHLTALFPPTTVT---SGSGIPIININTMDNYYENMTPNPTLCPELAVLIANTTTTPEWGEFITNTTQLK
..|...     .. | |||.|| ||..| |  |..||||.| .   .    . . . | .. ..... . . ||    |.... ..||. ..... ..| 
kfldak...ynpkqiyvrSsdvnRTlmSaqsvlaglfppetgvdypdeqeWqpvPvhtvseeedlllrakknCprydellqeakespevkklleenkell

EDVMETLG--ISVFPGWSsLMDLFFA-TQCHD-FPLPEGVTQDMVTQVYEAAYWQYQYQLS-----FPMIARLGMSTFLEEVVDNIRAFVN---GTSSVK
| . |  |  |. .  .  | | ..   ...  ..||| ..... ... | | ...... .      . ...|   ..|.|...|... ..     .. |
eklsestgedidlenfyq.lsdtlicerkyanelnlpewandelfekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkceekkkklk

YIVFSGHDDSVGPFTNLFGL-MKEWPPYASHVELELWSDEKDNYFLQFKFNGQSYTLNG------CE-DVMCPIDSFFETAYSILVPNYADACSNST
....|.||. .... ...|.  |..|||||..  ||............ .. .. . .       |. . .||.. |.... .... .. . | ..|
lflYSaHDttlaalLeaLgifekkappyasaiivElyeeddgkplvkvlyrnetskdppeltlpgCkgeedCplskfkkivkpfipddvdelCeakt
subfamily_HP2-Group1_pd Subfamily HP2-Group1 27-413 4.5e-59 191.8 In-house 3-420 (422) alignment 
Range on Protein: 27-413
Range on HMM: 3-420/422.0
YCQAPEPTPSLN-TDGLTLKMVQILTRHGD--RTPLYSTLKP-TMNTWDCNLGWLMVSSlNNVPGAATDVDRLFRKVYMPNREYFPGNCSDGQLTSLGFQ
||  .  . ||   ... || |... ||||  |.    .  .     |||.|    .     |    . |||..||.|.. ||   |.|. .|||  |..
ycGktteakslglpedvklkqvivvirhGdrvraaynGscwdGddaiwdcdlvsaslpv.ikvekerivvdriyrkiylntreedaGdcavaqltleGyk

QHLQLGQSLRQLYVDKYeLLPSELSvdaASTIWVRSTDVPRTIQSVQGHLTALFPPTTVTSGSgIPIININTMDNYYENMTPNPTLCPELAVLIANTTTT
|..  ||.||. |||.  .| |.|.   .| ...|| |..|||.| |  .  ..|. |...     .....|.|. .... .|  ||| |.    .   .
qqelnGqilrkvyvdtG.flkssld...ssevylrsddesrtilsaqalilGmypqdtkaedr.aqvvdlytrdklfdsieanadlcpklseyntqflks

PEWGEFIT-NTTQLKEDVMETLGISVF----------------------PGWSSLMDLFFATQCHDFPLPEGVTQDMVTQVYEAAYWQYQYQLSFPM---
  | . .   | .|  .| ..||  .                        .   |.| ... |||.. .|...|.|.. .. .   ....  | .|    
dtwlnhlkgitkelllevskalGsnkslgsggcshtlylpiavtrkldidnledlvdclithqchnaaipdkltedlakrgldellyrsysslkypsvek

IARLGMSTFLEEVVDNIRAFVNGTSSVKYIVFSGHDDSVGPFTNLFGLMK-EWPPYASHVELELWSDE------KDNYFLQFKFNGQSYTLNGCEDVMCP
 || |.  .| ..  ..   ..| .  |....|||| .. ..   ... .  |||||| . |||..          .| ..  .||.  .|  |.   |.
yarvGiGfllkdiwkevnesltGedlrkfllysGhdttliqllsalnvdefkwppyasllllellevstapaastpqyavrvlynGklkklpfcdanecs

IDSFFETAYSILVPNYADACSNST
...| .   ... .. |. | .|.
yeqfeaylstviphddaedckvsd
subfamily_ACP6_pd Subfamily ACP6 42-411 3.5e-46 149.6 In-house 2-373 (376) alignment 
Range on Protein: 42-411
Range on HMM: 2-373/376.0
LTLKMVQILTRHGDRTPLYSTLKPTMNTWDCNLGWLMV-----SSLNNVPGAATDVdRLFRKVYmpNREYFPGNCSDGQLTSLGFQQHLQLGQSLRQLYV
| ||.||.. ||| |||..|  .    .|| .|   .        . |. |.       . . |  ..|  .| .  ||||  | ||  .||. ||. ||
leLkqvqvvfrhGartPikslPqeeeveWdkdlleslpdleidyrvtnlnGepkPe.skieeky..kkeilkGGafkGqLtkvGmqqvfdLGrkLrkrYv

DKYELLPSELSvdaASTIWVRSTDVPRTIQSVQGHLTALFPPTTVTSgsGIPIInINTMDNYYENMTPNPTLCPELAVLIANTTTTPewgEFITNTTQLK
.. ..|. | .   .  ...|||...||..|..  .. |.    .      ||| . | ..  | . ||   || |.  . .   .      .   .. .
edikfLsqefn...pqevyiRstnieRtlesarclvaGLygkiiiqk..elpii.lytdeedeevlyPnrqrcpllsrayrsvrksa...islpGisedt

EDVMETLGISV--FPGWSSLMDLFFATQCHDFPLPEgVTQDMVTQVYEAAYWQYQYQLS---FPM--IARLGMSTFLEEVVDNIRAFVNGTSS-VKYIVF
. . ..|.||      . || | . | . |. . |. ...|..  . . |  .  . |.    |   | .| .  .|.|...|...  .....  |  ..
kqiadvldiseekkldfvslrDniaArlaHnlkvpp.ilkdvidliekhAveelvvlleggdrpekeilklsvGkvlkeilenlekakekeiparklrLy

SGHDDSVGPFTNLFGLM-KEWPPYASHVELELWSDEKDNYFLQFKFNGQSYTLNGCEDVMCPIDSFFETAYSIL-VPNYADACSN
| || .. .    .|   ..|||.|..| |||. |....|| .  ....   | |.|. ..|.. | .    .    .||..|. 
saHDttlmtLLlalgvFDdkWPpfaadvileLyedkageyfvrvlYqekelrlrgseedlvPlekFkallavlvlpkdyaaeCkl
His_Phos_2 Histidine phosphatase superfamily (branch 2) 43-374 2.3e-33 108.5 Pfam-A 1-347 (347) alignment 
Range on Protein: 43-374
Range on HMM: 1-347/347.0
TLKMVQILTRHGDRTPLYSTLKPTMNTWDCNLGWlmvsslnnvpgaatdvdrlFRKVYMPNREYF--------PGNCSDGQLTSLGFQQHLQLGQSLRQL
.||.|... |||||||. .. |   ......|                      . |. .. ..            .  |.||. | .|. .||..||| 
eLkgvvvviRHGdRtPkqkfkksvtsekfisllk...................lknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqr

YVdkyELLPSELSVdaaSTIWVRSTDVPRTIQSVQGHLTALFPPTT---------VTSGSGIPIININT-MDNYYENMTPNPTLCPELAV--LIANTTTT
|.   .||...|     ... .||..  |...| |  . .|..|             ..| .... .    ..  |.....   ||..|   .   ....
Yp...gllrdhlty...edvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvv

PEWGEFITN----TT-QLKEDVMETLGISVFPGWSSLMDLFFATQ-CHDFPLPEGVTQ--DMVTQV--YEAAYWQYQYQLSFPMIARLGMSTFLEEVVDN
..  ..  .     . .|.. . .   .. .  |. |   || ..  . ...|| ...  . . ..  .|.    |..    . ...   . .|.... .
elvnklkkvmdenlakrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkk

IRAFVNGTS---SVKYIVFSGHDDSVGPFTNLFGLMK-------EWPPYASHVELELWSDEKDNYFLQFKFN
|.  ...|     .|... ..||  . .. |..|| .       ...||||.. .||..|...... .  |.
ilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyedsekkfyvrllfs
His_Phos_2 Histidine phosphatase superfamily (branch 2) 43-374 2.3e-33 108.5 In-house 1-347 (347) alignment 
Range on Protein: 43-374
Range on HMM: 1-347/347.0
TLKMVQILTRHGDRTPLYSTLKPTMNTWDCNLGWlmvsslnnvpgaatdvdrlFRKVYMPNREYF--------PGNCSDGQLTSLGFQQHLQLGQSLRQL
.||.|... |||||||. .. |   ......|                      . |. .. ..            .  |.||. | .|. .||..||| 
eLkgvvvviRHGdRtPkqkfkksvtsekfisllk...................lknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqr

YVdkyELLPSELSVdaaSTIWVRSTDVPRTIQSVQGHLTALFPPTT---------VTSGSGIPIININT-MDNYYENMTPNPTLCPELAV--LIANTTTT
|.   .||...|     ... .||..  |...| |  . .|..|             ..| .... .    ..  |.....   ||..|   .   ....
Yp...gllrdhlty...edvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvv

PEWGEFITN----TT-QLKEDVMETLGISVFPGWSSLMDLFFATQ-CHDFPLPEGVTQ--DMVTQV--YEAAYWQYQYQLSFPMIARLGMSTFLEEVVDN
..  ..  .     . .|.. . .   .. .  |. |   || ..  . ...|| ...  . . ..  .|.    |..    . ...   . .|.... .
elvnklkkvmdenlakrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkk

IRAFVNGTS---SVKYIVFSGHDDSVGPFTNLFGLMK-------EWPPYASHVELELWSDEKDNYFLQFKFN
|.  ...|     .|... ..||  . .. |..|| .       ...||||.. .||..|...... .  |.
ilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyedsekkfyvrllfs
subfamily_PXYLP1_pd Subfamily PXYLP1 40-410 1.4e-31 101.2 In-house 20-417 (419) alignment 
Range on Protein: 40-410
Range on HMM: 20-417/419.0
DGLTLKMVQILTRHGDRTPLYSTLKPTMNTWDCNLGWLM---VS----SLNNVPGAATDVDRL-----FRKVYM-PNReyfPGNCSDGQLTSLGFQQHLQ
.|  || | .. ||||||||.   |     ..|.|       |      |.|    |.. |       .. . . ||    .. |  ||||  |. |||.
egfkLkavlvvirhGDrtPlsdipkskraeinCdlsaasknlvdklksfldnssseasgsdfenkvgplkslPllpnh...eriCelgqLtqkGvvqhLe

LGQSLRQLYVDKYELL--PSELSVDAastIWVRSTDVPRTIQSVQGHLTALFPPTTVTSgsgipiININTMDNYyeNMTPNPTLCPELAVLIANTTTTPE
.|. ||..|  |..||  | ||| |    . . .|   ||.||    | .|.| ..  .      |.. .  .   ..  .   || |  .. .  .  .
vGdllrkvYakklklLlkpnelssDe...vvlettrkrrtlqsalallygllpkaklka......irvrespsv..afClgeCsCPallrkrlekeadkq

W---GEFITNTTQLKEDVMETLGISVFPGWSSLMDLFFATQCHDFPLPE---GVTQ----DMVTQVYEAAYWQYQYQLSFPMIARLGMSTFLEEVVDNIR
    |...    .. | .  |  .   .| |  .| . .  ||. .||    |. .    |.. .. .    . . .. . .  .|..  .|...| .. 
lLlrgkvldvmksvgetlkgtilqttlngisnpvdalltvlChnvslPcrreGcvepshvdvlhkladelsqrsakksyyklsGllraypllrdivsrml

AFVNGTSSVKYIVFSGHDDSVGPFTNLFGLMK-EWPPYASHVELELWS-DEKDNYFLQFKFNGQSYT--LNGCED-------VMCPIDS---FFETAY--
  ..| .  |....||||  . | .. .|| . ... ||| .  ||.  ... .|.|.  .||.  |  .. ||.        .||...   | .  |  
kiieGvdkekfvlysghDvtlrplvaaLglseartiayasrlvfelyrreaskeyylrvlynGkDvtqkvdfCegdskrskkdlCPlenlvrfvkkdyfs

SILVPNYADACS
 .   || |||.
alsatnykdaCt
subfamily_MINPP1_pd Subfamily MINPP1 39-194 1e-08 26.4 In-house 26-165 (420) alignment 
Range on Protein: 39-194
Range on HMM: 26-165/420.0
TDGLTLKMVQILTRHGDRTPLYSTLKPTMNTWDCNLGWLMVSSlNNVPGAATDVDrlfrkvympnREYFPGNCSDGQLTSLGFQQHLQLGQSLRQLYVDK
 .| .|. .||. ||| | |  |. |  ..|..         . .      .|.            .    .  ...|.  | ... .|.. | . . . 
eegCklvklqiiaRHGtRypskskikkiqetlekiknyseqld.gklsilnedle..........snleyetelekslvaqgqeeleelakrlarrfpal

YElLpselsVDAASTIWVRSTDVPRTIQSVQGHLTALFPPTTVT-SGSGIPIININT
.|       |.   .. ..||.  ||..| |  ...|.. ..|. .   |. ..|..
fe.e.....vynpdsfsfastakkRtvksaqaFaeGLsetgevlgdefnivlqeise