Gene EYA3 in Homo sapiens

Synonym: RP11-460I13.4, EYA3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family EYA
Subfamily EYA
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP116_AA protein Get Run
HsapP116_AA_304-575 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_EYA_pd Subfamily EYA 306-575 8.9e-148 480.5 In-house 1-270 (270) alignment 
Range on Protein: 306-575
Range on HMM: 1-270/270.0
RVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSV
|||.||||||||||.||||||||.||.||...|.  ||.|||.||..|||.||||||||.|||||.||.|||||||||.|.|.||||.....|.......
rvfiWdldetiiifrslltgsyatkyakdansvvalglrmeelifnladtklffndleeidqvhvddvssddngqdlstynfatdgfhaaatsanlclai

GVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFP
||.||||.|||||||||||.|.|...|.||||||.|...||...||||||.||||||..||||| ||.||.||||||.||||||||||||||||||..||
gvrgGvdvmrklafryrkvkelynsyknnvggllgpakreawlqlraeiealtdsWltlalkslslissrsncvnvlvtttqlvpalakvllyglgsvfp

IENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
||||||||||||||.||||||||||||||||||||.||| |||..|.|||||..|.|| .|..||.|..|
ieniysatkiGkesvferivsrfGkkvtyvvigdgkdeetaakklnlPfWrisshsdlaalysaldleyl
EYA 305-575 3e-122 396.9 In-house 2-274 (274) alignment 
Range on Protein: 305-575
Range on HMM: 2-274/274.0
ERVFLWDLDETIIIFHSLLTGSYAQKYG--KDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGsgGSGSHG
|||..||||||.|...|||.||||.|..  ||.......|...|..|.|.||.|.|....||||.|...||..||.|.|||.|.|.|||||.  .|....
ervyvWdldetlillkslldGsyaekfdglkdhkksveigkrleklileladehffyeeieecdevflddvkedddGkdlsayefetdgfst..asddln

SsvgvqggvdwmRKLAFRYRKVREIYDKHksnVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKS---------------LLLIQSRKNCVNVLITTTQ
.           ||||.|||||.|.|.|.   ...||....||||..||.||..||||||..|||.               ||.|.||.|.||||.|..|
k...........rklayryrkvkekyekg...leklldsekkealdelrseidkltdsWlssalklrlkkvcvreeadgkslleissrensvnvlvtsgq

LVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGK-KVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
|.|||||||||.|.||..|||.|||.|.||..||.||..||.| ||..|||||||.||.|||....||..|..|.||.....||||..|
liPalakvllyrldeilaienvysaikvGklqcfkrikerfdkpkvrfvviGdGreeetaakalklPfvkielhpdlsarfpalelktl
Proho_convert Prohormone convertase enzyme 67-81 4.3e-06 12.8 Pfam-A 11-25 (41) alignment 
Range on Protein: 67-81
Range on HMM: 11-25/41.0
NDYTSQMYSAKPYAH
|||. . |.|||| |
nDYvDrFYnakPYKH