Gene EYA4 in Homo sapiens

Synonym: CMD1J, DFNA10, RP11-704J17.4, EYA4

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family EYA
Subfamily EYA
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP117_AA protein Get Run
HsapP117_AA_374-644 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_EYA_pd Subfamily EYA 376-645 2.5e-156 508.6 In-house 1-270 (270) alignment 
Range on Protein: 376-645
Range on HMM: 1-270/270.0
RVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLCLPT
|||.||||||||.|.||||||||.||.||....|.|||||||.|||||||.||||||||.||||.|||||||||||||||.||||||||||.||||||..
rvfiWdldetiiifrslltgsyatkyakdansvvalglrmeelifnladtklffndleeidqvhvddvssddngqdlstynfatdgfhaaatsanlclai

GVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCINVLVTTTQLIPALAKVLLYSLGGAFP
|||||||.|||||||||.||||||.||||||||||||||.|||||||||| |||||||.||||||.||.||||.|||||||||.|||||||||.||..||
gvrgGvdvmrklafryrkvkelynsyknnvggllgpakreawlqlraeiealtdsWltlalkslslissrsncvnvlvtttqlvpalakvllyglgsvfp

IENIYSATKIGKESCFERIVSRFGTNITYVVIGDGRDEEHAANQHNMPFWRISSHSDLLALHQALELEYL
||||||||||||||.|||||||||...||||||||.|||.||...|.||||||||||| ||..||.||||
ieniysatkiGkesvferivsrfGkkvtyvvigdgkdeetaakklnlPfWrisshsdlaalysaldleyl
EYA 375-644 1.7e-114 371.5 In-house 2-273 (274) alignment 
Range on Protein: 375-644
Range on HMM: 2-273/274.0
ERVFVWDLDETIIVFHSLLTGSYAQKYG--KDPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLc
|||.|||||||.|...|||.||||.|..  ||.  .|. |.|.|..|..|||.|.|....||||.|..|||..||.|.|||.|.|.||||..|. . |  
ervyvWdldetlillkslldGsyaekfdglkdhkksveigkrleklileladehffyeeieecdevflddvkedddGkdlsayefetdgfstasddlnk.

lptgvrggvdwmRKLAFRYRRVKELYNTYknnVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKS---------------LSIISTRSNCINVLVTTTQ
            ||||.|||.||| |. .   ...||.. |..|. .||.||. ||||||. |||.               |. ||.|.|..|||||..|
............rklayryrkvkekyekg...leklldsekkealdelrseidkltdsWlssalklrlkkvcvreeadgkslleissrensvnvlvtsgq

LIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIVSRFGT-NITYVVIGDGRDEEHAANQHNMPFWRISSHSDLLALHQALELEY
||||||||||| |.. ..|||.|||.|.||..||.||..||.  ....|||||||.|| ||.....||..|. |.|| |...||||..
liPalakvllyrldeilaienvysaikvGklqcfkrikerfdkpkvrfvviGdGreeetaakalklPfvkielhpdlsarfpalelkt