Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| FCP1_C | FCP1, C-terminal | 716-961 | 3.5e-132 | 427.4 | Pfam-A | 1-263 (263) | alignment | ||
Range on Protein: 716-961
Range on HMM: 1-263/263.0
ERWDKVEEQLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGP-PAP-----SSSLPIRQEPSSFRAVP
|||.|||||||||.||.||.|||||||||||||.| .||||||.|. .|||||||||||||.||||||.||... ||| ||||....||||.|||.
erwekveeqlfPlkddytkkqrensPaafpdresvlqtalfhpapirlkaqPgPevriydsvtGklirkgaqasapaplqapsssslsdkgepsslravq
PPQPQMFGEELPDAQDGEQPGPSRRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSDDSDSEKRRP----EEQEEEPQPRK---PGTRRERTLGAP
|.|.|.||||....||.||||||||||||||||||||||||||||||||||||||||||||||||||... ||.||..|.|| |..|||....||
phqeqlfgeeagesqddeqpGPsrrkrqpsmsetmPlytlckedlesmdkevddilGegsddsdsekkkkedkeeeeeeaaqqrkqkaPeerresdvrap
ASSERSAAGGRGPRGHKRKLNEE---DAASESSRESSNEDE-GSSSEADEMAKALEAELNDLM
.||||||||||.||||||||.|| ||.||.|.||||||| ||||||||||.|||||||||.
sssersaaggrvPrGhkrkldeedeedaeseeskessnedeeGssseademaaaleaelndll
|
|||||||||
| subfamily_FCP1_pd | Subfamily FCP1 | 182-324 | 5.3e-64 | 206.7 | In-house | 1-146 (146) | alignment | ||
Range on Protein: 182-324
Range on HMM: 1-146/146.0
KLVLMVDLDQTLIHTTEQ---HCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDECI
||||.|||||||||||.. .......|.| .|.| . . . ...|||..|.||||..||||||..|.|.| ||..|| .|||||||||.|||||||..
klvLvvDlDqtlihttkdptievkeekkkdikkftlpeekevyyvklRpnlkefleklsklyelhiytmgtraYaeqiakilDpekklfserilsrdell
DPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQ
|..|||..|..|||..||||.|||||||||.||.|||.||.|..|.
dassktkklkklfptddsmvviiDDredvWnfaenlikvkpykffk
|
|||||||||
| CPDc_SM00577 | 181-324 | 4.4e-38 | 122.5 | In-house | 1-143 (146) | alignment | |||
Range on Protein: 181-324
Range on HMM: 1-143/146.0
RKLVLMVDLDQTLIHT----TEQHCQQMSNKGIFHFqlgrgePMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKkLFSHRILSRDE
.|.||..|||.||.|. ........|.. . ... .||....||.|.|||.||..|| .|. ||.||. .|||.. |...|.|.|..
kkkvLVlDLdetLvhsanmaepksfsevsptdslae......tlvlvlkRPyvdeFLkkaaklfelvifTsaskkyadtildllDpkr.llkyrvlyRqd
CIDPFSKTG-NLRNLFPCGDSMVCIIDDREDVWKFAP-NLITVKKYVYFQ
| .| .. .|... .|.|.|||..|..... | |.. .|.|....
crlvkgkllkddlsllkvdlskvviiDnseestlvnpenalkikpyisal
|
|||||||||
| NIF | NLI interacting factor-like phosphatase | 184-321 | 4.6e-25 | 80.4 | Pfam-A | 2-133 (159) | alignment | ||
Range on Protein: 184-321
Range on HMM: 2-133/159.0
VLMVDLDQTLIHTTEQHCQqmsnK----GIfhfqlgRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFsHRILSRDECID
.| .|||.||.|..|. . | . . . .. .||....||....| ||. .|| .|. ||. . |||.|||| ...|.|..|
tLVLDLDetLvhskekkdl....kedgkkv......eektkasvkkRPgldeFLkelskayevviftasskeyaepvldkldpkkklf.kkrlyresctl
PFS-KTGNLRNLfpcGD--SMVCIIDDREDVWKF-APNLITVKKYV
. .. .|. | |. | | |.||....... |.| .....
rngkyvKdLsll...grdlsrvvivDdsprsfelqpdngipiepfy
|
|||||||||
| subfamily_CTDSPL2_pd | Subfamily CTDSPL2 | 185-278 | 7e-19 | 60.2 | In-house | 2-92 (142) | alignment | ||
Range on Protein: 185-278
Range on HMM: 2-92/142.0
LMVDLDQTLIHTTEQHCQQMSNKGIFHFQlgRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRiLSRDECI
|..|||.||.|.. .. .. . . . .|. . .. ||||. ..|||...||.|. .|| ..||. . .|||||||. || | |..|.
lvldldetlvhcslekleeatltfpvlfe..nktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklikhr.lfrehcv
|
|||||||||
| subfamily_DULLARD_pd | Subfamily DULLARD | 184-321 | 1.4e-17 | 55.8 | In-house | 3-146 (153) | alignment | ||
Range on Protein: 184-321
Range on HMM: 3-146/153.0
VLMVDLDQTLIHTTEQHCQQMSNK------GIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILsRDEC
.|..|||.||||..... .. ..| . .... . . ... |||. ||....| |.| .|| . . ||.... .|| .. ....| |..|
tlvlDlDetlihsahdsvtkstvkpgtapdfvvkvlidkepvlfyvykrPhvDlfLdvvskWydlviftasmeeyaaavvdkLdsgrgilkrryy.rqhC
IDPFSKT-GNLRNLFPcGDSMVCIIDDREDVW-KFAPNLITVKKYV
. ..| .| . . | |.|.|. . |.. | |..| ..
vlesgkytkdlslvss.dlssviilDnspvayrknpdnaipikswl
|
|||||||||
| PTCB-BRCT | twin BRCT domain | 638-710 | 1.3e-15 | 46.8 | Pfam-A | 2-63 (63) | alignment | ||
Range on Protein: 638-710
Range on HMM: 2-63/63.0
AIIFSGLHPTNfpieKTREHYHATALGAKILTRLvLSpdapdRATHLIAARAGTEKVLQAQECGhLHVVNPDW
| .||..... ..| ....||||.| ..| . . ||||..||..||. .||..| ..||.|.|
vicvsgysgdd....rkrlqkliralGasiskdl.tk.....kvTHLickraegeKyekAqkwg.ipvVspeW
|
|||||||||
| subfamily_SCP_pd | Subfamily SCP | 184-313 | 5.3e-12 | 37.7 | In-house | 2-127 (142) | alignment | ||
Range on Protein: 184-313
Range on HMM: 2-127/142.0
VLMVDLDQTLIHTTEQHCQqmSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEkKLFSHRiLSRDECIdpFSK
.|..|||.||.|.. . . . . .. . .. ||| ..||.....|.|. .|| ||. .| .|| . |....| | |..|. | |
clvidldetlvhssfkpvk..nadfvvpveidgtvhqvyvlkrphvdeflkrvgelfevvlftaslakyadpvadlldkk.kvlrar.lfrescv..fhk
TGNLRNLFPCGDSM--VCIIDDREDVWKFAPN
. ...| | .. | |.|. . | |.
gnyvkdlsrlgrdlkkviivdnspasyifhpe
|
|||||||||
| subfamily_TIM50_pd | Subfamily TIM50 | 223-320 | 7.7e-07 | 21.3 | In-house | 23-119 (126) | alignment | ||
Range on Protein: 223-320
Range on HMM: 23-119/126.0
TRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPeKKLFSHRILSRDECIDPFSKTGNLRNLFpCGDSMVCIIDDREDVWKFAP-NLITVKKY
.. || . |||..|.|.|. ||| . |.|. . ||| |.| ..|.. ... .| .| | | ..| .. |. | | ...||.
fkkrPgvdafleqlaelfeivvftseqgltaaplidkldP.kqlimyrlfrdatkyvdGehvkdlskln.rdlskvivvdldkksvklqpenalalkkw
|
|||||||||
| BRCT | BRCA1 C Terminus (BRCT) domain | 661-715 | 1.7e-06 | 17.7 | Pfam-A | 29-78 (78) | alignment | ||
Range on Protein: 661-715
Range on HMM: 29-78/78.0
TALGAKIltrlvlSPDAPDRATHLIAARA--GTEKVLQAQECGhLHVVNPDWLWSCL
.||.|. |.. .. |||.. . .|.|.|.|.. . ..||..||. |.
kelGGkv......stevskktthlvvgepelrtlkylaaialn.ipivneeWlldci
|
|||||||||