Gene PAPL in Homo sapiens

Synonym: SPENCDI, TRAP, ACP5

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP131_AA protein Get Run
HsapP131_AA_136-337 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP5_pd Subfamily ACP5 138-338 1.3e-80 261.8 In-house 1-189 (189) alignment 
Range on Protein: 138-338
Range on HMM: 1-189/189.0
VFGDLGADNPKAVPRLRRDTQQGMYDAVLHVGDFAYNLDQDNARVGDRFMRLIEPVAASLPYMTCPGNHEERYNFSNYKARFSMPgdNEGLWYSWDLGPA
||||||....... .| ........|...||||.||.|...|..|.|.||.||||.|. .|||...||||...|||.||.|||||  ..  |||.|.||.
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp..sknewYsfdygpv

HIISFSTEVYFFLHygrhlvQRQFRWLESDLQKANkNRAARPWIITMGHRPMYCSNADLDDCTRHESKVRKGlqgKLYGLEDLFYKYGVDLQLWAHEHSY
|.||.||||.|.|.      ..|..|||.||..|| ||...||||.||||||||||.| ||||..|. ||||   . ..||||.|||.||| |..|||||
hfislstevdfslg......seqykWLekdLkean.nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkg...lresledllykykvdlalsgHeHsY

E
|
e
PAPL 137-337 1.1e-79 259.1 In-house 1-194 (194) alignment 
Range on Protein: 137-337
Range on HMM: 1-194/194.0
AVFGDLGADNPKAVPRLRRDTQQGMYDAVLHVGDFAYNLDQDNARVGDRFMRLIEPVAASLPYMTCPGNHEERYNFSNYKARFSMPGDNEGLWYSWDLGP
|||||||..|.....||...||.|.|||.|||||.||..|..|...||.|||.|||.|||.|||..||||||.||||||||||||||..|| ..|...|.
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgs

AH-IISFSTEVYFFLHYGRHLVQRQFRWLESDLQKANKNRAARPWIITMGHRPMYCSNADLDDCTRHESKvrkglqgkLYGLEDLFYKYGVDLQLWAHEH
.. ...........|.. ..  ...... . ....|..||...||||.||||||||||.| |||......        |..||||.|||||||.|..|||
nsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakm........laaledllykygVDlvlaGHeH

SY
||
sY
Metallophos Calcineurin-like phosphoesterase 135-337 4.1e-29 95.3 Pfam-A 2-200 (200) alignment 
Range on Protein: 135-337
Range on HMM: 2-200/200.0
RLAVFGDLGADNPKA---VPRLRRDTQQGMYDAVLHVGDFAYNLDQDNARVGDRFmRLIEPVAASLPYMTCPGNHEERYNFSNYKARFSMPGDNEGLWYS
| .|.|||. ..  .   . .| .  ...  |.||. ||. .  |  .   ...  .| ...... |.. ..|||| ..  | |...  ...|..||.. 
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang

WDLGPAH--IISFSTEVYFFLHYGRHLVQRQFRWLESDLQKANKNRAARPWIITMGHRPMYCSNADLDDCtrheskvrKGLQGKLYGLEDLFYKYGVDLQ
.. .  .  .. . . ... |.  ..|..  . .   .   |...||  ...| ..|.|...|    ||         ..     . ||.|..|||||| 
eeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi........gselfgpdalekllekygvdlv

LWAHEHSY
|..|.| .
lrGHtHkp
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 361-425 3.9e-22 69.8 Pfam-A 1-62 (62) alignment 
Range on Protein: 361-425
Range on HMM: 1-62/62.0
RGPVHIITGSAGCeeRLTPFAVFPRPWSAVRVKEYGYTRLHILNGTHIHIQQVSDDqDGKIVDDV
..||||..|.||.  .|..|   . .|||.| ..|||.||.. | ||.| ..|..| ||...|..
kApvhIvvGaAGn..glskfskpqpewsafresdyGysrltvvNrthLhwefvrsd.dgqvlDsf
ACP5 138-335 3.6e-10 31.8 In-house 3-197 (198) alignment 
Range on Protein: 138-335
Range on HMM: 3-197/198.0
VFGDLGADNPKA----VPRLRRDTQQGMYDAVLHVGDFAYNLDQ---DNARVGDRFMRLIEPVAASLPYMTCPGNHEERYNFSNYKARFSMPGDNEGLWY
|.|| | ..          . . ...  .|.|| .||  |.      |  |. ..| .  .  . ..|.... |||. | | |   .  .   |.. ...
vvGDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpsl

SWDLGPAHIISFSTEVYFFLHYGRHLVQRQFRWLES---DLQKANKNRAArPWIITMGHRPMYCSNADLDD-CTRHEskvrkglqgklygLEDLFYKYGV
 . |  ....          .. .. |... .  |.   .|.||...  |  |.| .|| |.|      |  .  ..             |. |. ||.|
ryslskkevvtelftekkdeksdqrevaerekyaeeqlkwlekalaksta.dwkiVvGHhpvySigehgdtkelver.............llpllkkykv

DLQLWAHEH
|. |  |.|
daYlnGHdH
PhoD PhoD-like phosphatase 91-179 3.7e-08 23.8 Pfam-A 61-150 (453) alignment 
Range on Protein: 91-179
Range on HMM: 61-150/453.0
LYIHRVTLRKLLPGVQYVYRCGSA--QGWSRRFRFRALKNGAHWSPRLAVFGDLGADNPKaVPRLRRDTQQGMYDAVLHVGDFAYNLDQDN
 |. .|....| || .| ||  ..  .  |.  |.| |...|  | ||||...    ..  .. .|. ...  .|.|||.||. |.  ...
dytvkvevtgLepgqeyfYrfraeegesespvGrtrTlpeaaveslrlavvSCsnyeqGy.fnayrelaekedlDfvlhlGDyiYeygegt