Gene ACP5 in Homo sapiens

Synonym: PAPL

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily ACP5
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP132_AA protein Get Run
HsapP132_AA_27-243 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PAPL_pd Subfamily PAPL 30-244 1.8e-99 323.2 In-house 2-212 (212) alignment 
Range on Protein: 30-244
Range on HMM: 2-212/212.0
AVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLrKVPWYVLAGNHDHLGNVSAQIAYSKISKR
..|||||...||..||...| |||...... | |.|.|.||||||..||.|..|.||.|||||||...|| .|||||.|||||. |||||||||||.|||
vlgDwGgleeapyttaaqeavakelgkvaeeleaqfvlalGDnfYekGvkdvddarfketfedvftaesl.qvpwyvvagnHDykGnvsaqiaYsklskr

WNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDflSQqPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLA
|.||| .|. .||||..|..|.....||| |||.|||  .. .|.|.||.||..|..||...|.|...||..|||||||||.||||||..|||.|.|||.
Wkfpslyytksfkipdsnatvqlvlidtvllcgksdd..lk.legpvdvslaeeqwawleeeLkaseadylivaGhypvwsvaehGptkiLvkrLkPlLe

TYGVTAYLCGHDHNL
.| |||||.||||||
kynvtaylsGhDhnl
ACP5 28-243 1.1e-75 245.6 In-house 1-198 (198) alignment 
Range on Protein: 28-243
Range on HMM: 1-198/198.0
FVAVGDWGGVPNAPFhtareMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLrKVPWYVLAGNHDHLGNVSAQIAYSKIS
|..|||||. .....     .|.||....... |..||.||||||||..||....|.||.|.||......|| .|||||..||||..|||||||.|.|.|
flvvGDwGrkgeynq.....savakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytaksl.qvpWyvvlGNHDyrgnvsaqieyakrs

KRWNFPSPFYRLHFKIpqtnvsvaifmlDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPL
|...|||..|.|..|.            ....|. ...|. |.|.|.... | |..||.||.|.||. ..|...|.||.||.||.|||.|..||..|.||
kdsrfpslryslskke............vvtelftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdtkelverllpl

LATYGVTAYLCGHDHN
| .|.|.|||.||||.
lkkykvdaYlnGHdHc
Metallophos Calcineurin-like phosphoesterase 26-243 5.4e-22 72.0 Pfam-A 1-199 (200) alignment 
Range on Protein: 26-243
Range on HMM: 1-199/200.0
LRFVAVGDWGGVPNAPFhtareMaNAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQetfedVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSK
||....||..| .. .         . .. .  .  ..|..| |||...     .   ....      ..   |...|...| |||.  .  ||  .. .
lrilvigDlHgglddle.....d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalld.....ylvlklllpipvfllrGNHesdpgnsaygflle

ISKRWNFPSPFYRLHFKIpqtnvsvaifmLdTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTH----CLV
..|... . . .   .             . .  | .. . . .  ..  .. . .. || ..   ...| .|.... .| |..|  ..| ..    .  
qlkdlrglangeeeyenl...........k.itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgp

KQLRPLLATYGVTAYLCGHDHN
. |..||  |||...|.||.| 
dalekllekygvdlvlrGHtHk
subfamily_ACP5_pd Subfamily ACP5 49-243 2.9e-15 48.7 In-house 11-187 (189) alignment 
Range on Protein: 49-243
Range on HMM: 11-187/189.0
ANAKEIARTVQILGADFILSLGDNFYFTGVqdiNDKRFQETFEDVFSDrSLRKVPWYVLAGNHDHLGnvsaqiAYSKISKRWNFPspfyrL---HFKIPQ
|..... .. .   .|.|. .||  | ..    ....  ..| .....    |||. |..|||..         .|...||.. |          ...  
aslatllkeeeaneldliihvGDlaYalka...kneavwdefmnliep.laskvPymvsiGnhesds......nfsaykkrfsmp.....sknewYsfdy

TNVSvaIFMLDTVTLC--GnsddflsqqperprdvklaRTQLSWLKKQLAAA----REDYVLVAGHYPVWSIAEHGPTH----CLVK-----QLRPLLAT
..|   . .|.| .    |                   ..|..||.|.|..|     .....|.|| |..   ...  .     ||.     .| .||  
gpvh..fislstevdfslg...................seqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllyk

YGVTAYLCGHDHN
|.|  .|.||.|.
ykvdlalsgHeHs
PAPL 51-243 6e-13 41.4 In-house 14-193 (194) alignment 
Range on Protein: 51-243
Range on HMM: 14-193/194.0
AKEIARTVQILGADFILSLGDNFYFTGVQDINDKRF-QETFEDVFSdrslrKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKipqtNVS
.|......|    |.|| .||  | .. |. .|.    .  | ...     .||. |..|||..  | |.. |... ..... .|. ...  .    ..|
lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaa.....svpymvapGNHEeeynfsnykarfsmpgseegesnssesgsn....sys

VAIFMLDTVTLCGNSDdFLSQQperprdvklarTQLSWL---KKQLAAAREDYVLVAGHYPVWSIAEHGP----THCLVKQLRPLLATYGVTAYLCGHDH
..  .  ...|. ..| . ...           .|. ||   ...   .. ... |.|| |...  ..      .   ...| .||  |||  .|.|| |
fetesvhfivlsseed.vkeks...........eqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvlaGHeH

N
.
s
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 50-257 5.2e-09 28.3 Pfam-A 15-133 (156) alignment 
Range on Protein: 50-257
Range on HMM: 15-133/156.0
NAKEIARTVQilGADFILSLGDnfyftgvqdiN--DkrfqetfEDVfsDRSLRKVPWYVLAGNHDhlgnvsaqiaY---------SKiskrwnfpspfyr
..... . ..  ..|.|| .||                     | |   . |...| ... ||||          .          .             
aleavledik..evdlilhaGD..........lvep.......eev..velledipvlavrGnhD..........eaelpkelavel.............

lhfkipqtnvsvaifmldtvtlcgnsddflsqqperprdvklartqlswlkkQ---LA--AAREDYVLVAG---HypvwsiaehgPTHCLVkQLRPLLAT
                                                        .|  . ... .|| |   .          ...    .|. || .
....................................................llaaaaleiegdrvllvhgtpls..........vqssee.elaellke

YGVTAYLCGHDHNLQYLQdENGVGYVL
.|. ....|| |. .. . ..|. .| 
agadlvflGHtHkpkvek.rggtlvvn