Gene PPEF1 in Homo sapiens

Synonym: PP7, PPEF, PPP7C, PPP7CA, RP3-499B10.1, PPEF1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP7C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP144_AA protein Get Run
HsapP144_AA_94-503 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP7C_pd Subfamily PPP7C 102-501 1.2e-206 678.8 In-house 1-382 (383) alignment 
Range on Protein: 102-501
Range on HMM: 1-382/383.0
DVPDSYNGPRLQFPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNGD
.|.|||.||||..|||..... |.|||||...|||.|||..|.|.||||||.||.....|. |||||.|||||||||||.||.||||||||.||||||||
evedsytgprlslpltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVE
||||||.|.|||.||....||||....||||||||...||||||.||. .||| |||.||..||...||||..|..|..||..|||||..|||.||...|
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktdlelldkie

RNKMKSVLIPPTETNRDHDTDSKHNKVGVTfnahgriktngsptehltEHEWEQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIR
|.|..||| ||...............| |.                  ..||.|..|||||||. |.||.|||.||||.|||||||.|.|.||.||.|||
rsklvsvlrpplkegeeaekekeessvkvd..................keewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllir

SHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQPLRQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSG
||||||||||..|| ||.||||||||||||||||||.||.. .|||..|||..|||. ..|||||...|.||.. |||.....||||...|. .|..|||
sheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqaskatkkltlrqrvsiveesalrelrekllakksdlleefkkkdekksg
PPP_1 139-440 3.9e-111 363.5 In-house 2-264 (264) alignment 
Range on Protein: 139-440
Range on HMM: 2-264/264.0
VLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLfLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFM
..|.|.|.|| ||...|....... |.|.|.|||.||..||| |...|.|.||... |.|.||.|||||.|.|||..|.. .|.||..|.|.|||||. .
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrq

MNLRYGFTKEILhkYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHDtdskhnkvgvtfnahgri
.. .|||.||.|  .| ..|.|...|......||.....|..||..|||.|...||.. .| ||.|....   ........|                  
vtkvygFkkEvl..kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekd..................

ktngsptehlteheweqiIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYI
                  .|||.||.. ......|..||.|..||.|||.|.|.|..||..||.||.|.||||.....|||||||||||||||||||||.
..................vdillsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv

KL
||
kl
PPP_3 138-452 1.3e-101 332.2 In-house 2-270 (271) alignment 
Range on Protein: 138-452
Range on HMM: 2-270/271.0
YVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLfLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDF
.. ..| |..| ||.... ... .. |..||.|||.||.|||| |...|||.||... |.|.||.|||||.|.|.|..|..  ..||...||.|||||. 
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsr

MMNLRYGFTKEILhkYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRdhdtdskhnkvgvtfnahgr
..| .|||.||.|  .| .||.... |.|....||.....|...||.|||.|.....   .. ...|....   .. ..                     
qinkvYgFkkevl..kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll....................

iktngsptehlteheweqiidilWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAY
                       .|... |.... |. || |..||||||...|.|..||..||.||.|.|||||.|||||||.|||.||.|..||.||.
.......................lssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagai

IKLCSGTTPRFFQYQ
.|| . .|..| |..
lkleealtsefkqle
PP2Ac_SM00156 134-453 3.8e-94 307.7 In-house 1-269 (271) alignment 
Range on Protein: 134-453
Range on HMM: 1-269/271.0
LHAHYVLEVLFETKKVLKQMPNFTHIQtspsKEVTICGDLHGKLDDLFLIFYKNGlPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGN
|....|||.| |.|..|||..|.....    ..||..||.||.||||. .. ..| ......|||.||.||||..|||....|.   ..||....|.|||
lskeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGn

HEDFMMNLRYGFTKEILHKYklhGKRILQILEEFYAWLPIGTIVDNEILVIHGGISEttDLNLLHRVERNKMksvlipptetnrdhdtdskhnkvgvtfn
||. ..|  |||..|. .||   ||.|....||....||....||..||..|||.|.  .|. |..... |.                            
HEsssvnkiygfeeevkrky...gkeiyekfeeafsllPlaalvdskilcmhGGlsp..eleslddirklkr............................

ahgriktngspteHLTEHEWEQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSN
             . ...|....||.|||||. |. .| ...|| ...||.|.....|.|..||..||.||...||||...|.|.||||||.||..| ||
.............vkekpeegllidllwsdpeqkekgfqpskrglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsn

RGAYIKLCSGTTPRFFQYQV
 .|..|..........|.. 
kaavlkveknlklsieqlke
0045823 Metallo-dependent phosphatases 95-503 3.3e-92 302.6 In-house 4-370 (473) alignment 
Range on Protein: 95-503
Range on HMM: 4-370/473.0
WDYVDSIDVPDSYNGPRLQFPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTspskEVTICGDLHGKLDDLFLIFYKNGLPSErN
. ..  | |......|.| ..|.  |.|||.| .|....|.....|..| |.|..||..||. ...      ....||.|| ||||  .. |.|.|.| .
vlklvlipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.d

PYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYklhGKRILQILEEFYAWLPIGTIVDNEILVIHGGISET-TD
 .||.||.|||| .|.|.| .|   .. ||.. .| |||||. ..|  ||| .|.|.||   | .. . . |. ..||.  .... ||..|||.|   . 
rlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetleky...gedlyeeflewlrslPlaaviggkilfvHGGlspdlpl

LNLLHRVERnkmksVLIPPTetnrdhdtdskhnkvgvtfnahgriktngsptehlteheWEQIIDILWSDPRGKNGC-------FPNTCRGGGCYFGPDV
|. ....||     .| .|.                                       . .. |.|||||  ..|.       |.|. || |..||||.
ldqireier.....pleipd.......................................dgllldllwsdPweddgdgllrlrffgnsprgagylFgpda

TSKILNKYQLKMLIRSHECKPEGYEICHDGK------VVTIFSASNYYEEGSNRGAYIKLCSGTtPRFFQYQVTKATCFQPLRQRVDTMensAIKILRER
. ..|.|..|....|.|.. |||||...|||      ..|.|||.||. .| |..|.... ... . |.|.. .. . ..|| ..| ..   ....|.| 
veeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphplilplfldvfll...slpfllek

VISRKSDLTRAFQLQDHRKSGKL
...  . |..... ... . ...
ltellllllnivsddellededi
PPP_5_Dcr2 167-406 1e-78 256.9 In-house 1-199 (199) alignment 
Range on Protein: 167-406
Range on HMM: 1-199/199.0
VTICGDLHGKLDDLFLIFYKNG-LPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYklHGKRILQILE
||.||||||.||||.||..|.| .|||.. |||.||.|||||.|.|.|..|.   ||||...||.|||||| ..|..||||||.|.||  |||.|..||.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky..hgkkiykils

EFYAWLPIGTIVDNEILVIHGGISETTDL-NLLHRVERnKMKSvlipPTETNRDHDTDskhnkvgvtfnahgriktngsptehlteheweqiidiLWSDP
... |||. ...|...||.|||.|..... .||...|| |...    |.|.....|..                                     |||||
dvfdwlPlaalidekvlvvhgglspeiksiellekier.kiei....peekgekadll.....................................lwsdp

R-GKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECK
|  ..||. |..||.|..||||||.|.|.|..||..|||||.|
rdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
PPP_2 167-406 1.2e-76 249.9 In-house 1-198 (198) alignment 
Range on Protein: 167-406
Range on HMM: 1-198/198.0
VTICGDLHGKLDDLfLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILhkYKLHGKRILQILEE
||.||||||.|||| ||..||||||... |.|.||.|||||.|.|.|..|..  ||||...||.|||||. ..| .|||.||.|  .| .||.... |.|
vtvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl..kkkggkkvykklqe

FYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHDTdskhnkvgvtfnahgriktngsptehlteheweqiidilWSDPRG
....||.....|...||.|||.||...|   .. |..|..|.   .....  ..                                        .|||. 
vfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeek.......................................lsdpke

KNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECK
|.... |. ||.|..||||||...|.|..||..||.||.|
keellansarGagllfgpdvteelleknklkliiRaHevk
0049330 Metallo-dependent phosphatases 108-457 7.9e-76 248.1 In-house 4-302 (309) alignment 
Range on Protein: 108-457
Range on HMM: 4-302/309.0
NGPRLQFPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQtspsKEVTICGDLHGKLDDLFLIFYKNGLPSErNPYVFNGDFVDRGK
 .|.| ..|.....|||.| .. ...|. ...|..|...|..||..||. ...      ....||.|| ||||  .. |.|.|.| . .||.||.|||| 
ldpllllelilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGp

NSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYklhGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETT----DLNLLHRVERN
.|.|.| .|    | ||.. .| |||||. ..|  ||| .|.|.||   | .. . . .....||.  .....||..|||.|       ... |.|. . 
dslevlllllalkllypdnvfllrGNHElrllnglygfgdetlrky...gaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerplei

KMKSvlipptetnrdhdtdskhnkvgvtfnahgriktngsptehlteheweQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSH
 . .                                                . |.|||||      |..  || |..||.... ..|.|..|...||.|
pldg...............................................llcdllwsdplpiregfapnprglgvvfghtaverflkkngldliirgh

ECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKAT
.. ..||....|||..|.|||.||... .|.||.... ......|....... .
gavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
PPP_4 167-406 1.5e-75 246.6 In-house 1-197 (197) alignment 
Range on Protein: 167-406
Range on HMM: 1-197/197.0
VTICGDLHGKLDDLFLIFYKNG-LPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKyklHGKRILQILE
||..||.||.||||.|...||| ||||.. |||.||.|||||.|.|.|..|.   ||||....|.|||||. ..||.|||.||.|.|   |||.||..|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek...hgkeilkklq

EFYAWLPIGTIVDNEILVIHGGISETTDLnlLHRVERNKMK--SvlipptetnRDHDT-----Dskhnkvgvtfnahgriktngsptehlteheweqiid
.....||. ...|...||.|||.|....   |...||.. |  |         . ...     .                                    
dvfdllplaalidekvlvvhgglsdeles..ldkierierkies.........pleeekrkdll....................................

iLWSDPR-GKNGcFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECK
 ||||||  ..| . |..||.|..||||||.|.|.|..||..|||||.|
.lwsdpreaqeg.lansvrGagllFgpdvtekfleknnlkliirshelk
0053225 Metallo-dependent phosphatases 115-453 1.3e-71 234.4 In-house 3-290 (293) alignment 
Range on Protein: 115-453
Range on HMM: 3-290/293.0
PLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQtspsKEVTICGDLHGKLDDLFLIFYKNGLPSErNPYVFNGDFVDRGKNSIEILM
.|.....|||.| .. ...|.....|..|.|.|..||..||. ...      ....||.|| ||||  .. | |.|.| . .||.||.|||| .|.|.| 
slilllldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevle

ILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYklHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTD-LNLLHRVERNKMKSvlippt
.|    |.||.. .| |||||. ..|  ||| .|.|.||  ..... . | .....||.  .....||..|||.|   . |. .....|  .        
lllalkllypdnvvllrGNHElmllnglygfgdetlrky..gaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplrip......

etnrdhdtdskhnkvgvtfnahgriktngsptehltehEWEQIIDILWSDPRGKNGCFPNtCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEIC
                                      ... . |.|||||.  .|. |.  || |..||.... ..|.|..|...||.|.. |.||...
......................................legllldllwsdpdlwsgwlps.yrglgvvfghtavlrflkkngldliirghqvvpdgylpw

HDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQV
.|||.||.|||.||... .|.||...| .|....|... .
fdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_PPP5C_pd Subfamily PPP5C 103-304 4.3e-61 199.7 In-house 2-203 (322) alignment 
Range on Protein: 103-304
Range on HMM: 2-203/322.0
VPDSYNGPRLQF-PLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNGD
| |||.||.|.   .|   .. ||| ||.|. ||  |.|..| |.|..||..| ...|... .|..|.|||.||.  ||. || .||||||.|||.||||
vedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGd

FVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKlhgKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNL--LHR
|||||  |.|....|    |.|||...|.|||||   ||  |||. |. .||.   ....... | . |||.........||.|||. .. ...|  |..
fvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakyt...ekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrk

VERNK
..||.
idrna
subfamily_PPP1C_pd Subfamily PPP1C 132-443 2.5e-59 193.8 In-house 8-268 (282) alignment 
Range on Protein: 132-443
Range on HMM: 8-268/282.0
QILHAHYVLEVLFETKKVLKQMPNFTHIQtSPskeVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNR
  |. . . ..| .....|.. | . ...  |   |.|.||.||.. ||  .| ..| |.|.| |.| ||.|||||.|.|....| .  . ||..|.| |
vklkeaeieallkkareillsqpillele.aP...vkivgdihGqyadllrlfetsgaPpesn.ylflGdyvdrGkqsletivlllaykikypenlfllr

GNHEDFMMNLRYGFTKEILHKYKLHgkrILQILEEFYAWLPIGTIVDNEILVIHGGisettdlnllhrvernkmksvlipptetnrdhdtdskhnkVGVT
||||.  .|  |||  |. ..|. .   . ... . ...||. ..||..||..|||                                        .  .
GnhesasinriyGfydeckrrysik...lWktftdvfnclPlaalvdekilcvhGG........................................lspe

FNAHGRIKTNGSPTEHLTEhewEQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEG
..    |..   |.|  ..     ..|.|||||  ..  . .  ||    ||.|| .|.|.|..|....|.|..  .|||   . ..||.|||.|| .| 
lksleqirkiqrPlevpek...gllcdllWsdpdkevlgwsendrGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgef

SNRGAYIKLCSG
 | || ... . 
dnagavlsvdee
Metallophos Calcineurin-like phosphoesterase 167-407 2.7e-50 164.4 Pfam-A 3-200 (200) alignment 
Range on Protein: 167-407
Range on HMM: 3-200/200.0
VTICGDLHGKLDDL---FLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMIL--CVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILH----------
....|||||.||||   .||..|.. ... ....|.||.||||..|.|.|..|  .| .| .|....|.|||||....| .|||..|.|.          
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

---------------------KYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHrvernkmksvlipptetnrdhdtdskhnkvgv
                     .|.|.|... .  .|....||. ..||. ||..||..|....... .                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

tfnahgriktngsptehlteheweqiidilwsdprgkngcfpntcrgGGCYFGPDVTSKILNKYQLKMLIRSHECKP
                                               |...||||...|.|.||......|.|..||
...............................................gselfgpdalekllekygvdlvlrGHtHkp
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 130-303 1.2e-36 119.2 In-house 20-187 (298) alignment 
Range on Protein: 130-303
Range on HMM: 20-187/298.0
EQQILHAHYVLEVLFETKKVLKQMPNFTHIQTsPskeVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHL
  .... . | ... ..||..|. . .  ... |   ...|||.||.  ||. .| |.| | . | |.| ||.||||....|....| .  . |||.. |
ltkvikeedveklielakkifkkqkslvevda.p...ikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnlevivlllaykvkypnnffl

NRGNHEDFMMNLRYGFTKEILHKYKlhGKRILQILEEFYAWLPIGTIVDNEILVIHGGISE-TTDLNLLHRVERN
 |||||  ..|  ||| .|. ..||    |. . ... ...||. ... . || .|||.|.  . |. |....| 
lrGnheceainrvyGfyeeckrryk..slrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 136-292 3.8e-35 114.2 In-house 12-160 (287) alignment 
Range on Protein: 136-292
Range on HMM: 12-160/287.0
AHYVLEVLFETKKVLKQMPNFTHIQTsPskeVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHE
 . .|||| .....|. .| . .... |   .||.||.||.||||. || . | ... . |.| ||.|||| .|.|. ..|    . ||. .|| |||||
dkdilevlekieeileplpallevea.p...itivGdihGqlddllrifnavGaapkvq.ylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

DFMMNLRYGFTKEILHKYKlhgKRILQILEEFYAWLPIGTIVDNEILVIHGGISETT
   .|  ||| .|. .|..   .|. .  .. .. ||. ..|.. || .|||||.  
vkkinklyGfkeelkrkrq...erlykqfndvfselplcarvskrilcmhGGispkl
subfamily_PPP4C_pd Subfamily PPP4C 120-301 1.8e-33 109.0 In-house 2-177 (288) alignment 
Range on Protein: 120-301
Range on HMM: 2-177/288.0
DIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTsPskeVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVS
|.|  .|  .. .... . | ..  .....| .  | ..... |   ||.|||.||.. ||  .|  .|   |.| |.| |||||||..|.| ...| . 
dldrqieklrrcelikeeevkalcakareilveesnvqrvds.p...vtvcgdihgqfydllelfkvggdvpetn.ylflgdfvdrgfysvetfllllal

FLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKlhGKRILQILEEFYAWLPIGTIVDNEILVIHGGISET-TDLNLLHRVE
 . ||. ..| |||||   .   ||| .|.|.||     .. .   | . .|....|.|..|...|||.|   . |. .  ..
kvrypdritlirgnhesrqitqvygfydeclrkyg..sanvwryctevfdylslaaiidgkifcvhgglspsistldeirsid
subfamily_PPG1_pd Subfamily PPG1 122-291 1.3e-32 106.3 In-house 2-165 (300) alignment 
Range on Protein: 122-291
Range on HMM: 2-165/300.0
DLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSpskeVTICGDLHGKLDDLFLIFYKNGlPSERNPYVFNGDFVDRGKNSIEILMILCVSFL
|  || ..  ..|    | |. .  |..| .  |  .|..     ||. ||.||.. |.. ||   | .     |.| ||.||||  |.| ...| |  |
decleklqkaellpevtvkeltdklkellvkesnvieirsp....vtvvgdvhgqfydvleifkigg.qvpdtnylflgdyvdrglysvetisllivlkl

VYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKlHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISET
 ||  ..| |||||   .   |||  | |.||     |. . | |.. .| . .|.|.|| ..|||.| .
rypsritllrgnhesrqitqvygfyteclrkyg.gnsrvwkylteifdylvlaaiideeiycvhgglsps
subfamily_PPP3C_pd Subfamily PPP3C 120-304 8.9e-32 103.4 In-house 27-204 (452) alignment 
Range on Protein: 120-304
Range on HMM: 27-204/452.0
DIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTsPskeVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVS
 ...| | |...  |... .|... |. |.||. ... .... |   .|..||.||.  ||. .|  .| |.. . |.| ||.||||  |||... |   
klevlkehflkegrleeeaalkiieeaakllkkektllevea.P...itviGdihGqfydllklfevgGdPastk.ylflGdyvdrGyfsiecvlylyal

FLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKlhgKRILQILEEFYAWLPIGTIVDNEILVIHGGIS-ETTDLNLLHRVERNK
 . ||. |.| |||||   .   . | .|. .||.   ... . . | .  ||. ...... | .|||.| | ..|. .....| |
kiaypstlfllrGnhecrhlteyftfkeeckikys...eevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfk
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 126-292 2e-31 102.1 In-house 14-166 (290) alignment 
Range on Protein: 126-292
Range on HMM: 14-166/290.0
EAFKEQQIlhahyvLEVLFETKKVLKQMPNFTHIQTsPskeVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVSFLVYPN
.||....|      ||.| . ...|. .| . .... |   ..| ||.||.||.|.  | . | | . . ..| ||.|||| .|.|. ..|    . |..
dafsdkdi......leilekieeileplpallevea.p...ivivgdihgqldallryfdavgyppkvk.flflgdyvdrgakslevslllfcykirysk

DLHLNRGNHEDFMMNLRYGFTKEILHKyklHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETT
 .|| |||||   .|  ||| .|.  |    | |. .  .. .| |.. . |.. || .|||||.  
kvhllrgnhevrkvnrlygfkeelark...rgsrlwkqyqdvfaelslcarvgrkilcmhggisqki
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 131-303 4.2e-31 101.4 In-house 5-176 (284) alignment 
Range on Protein: 131-303
Range on HMM: 5-176/284.0
QQILHAHYVLEVLFETKKVLKQMPNFTHIQTSpskeVTICGDLHGKLDDLFLIFYKNGLP-----SERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPN
|..|. . ..|. . ..... . .   .|..     |.|.||.||. .||  ..  || |     .. . |.| ||.||||  |||....|    |..|.
qkllkekelielcyrarelfwkeklkleieap....vkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpd

DLHLNRGNHEDFMMNLRYGFTKEILHKYKlhgKRILQILEEFYAWLPIGTIVDNEILVIHGGISET-TDLNLLHRVERN
 . | |||||   .| .||| .|  ..|    ... ....  .  .|. ..|.. |. .||||||   ||. |...|| 
kvfllrgnhesrpvnmqygfyleckkrys...ealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerp
subfamily_PPP5C_pd Subfamily PPP5C 354-461 2.2e-30 98.8 In-house 209-316 (322) alignment 
Range on Protein: 354-461
Range on HMM: 209-316/322.0
EQIIDILWSDPRGKNGCFPnTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKL-CSGTTPRFFQYQ
......|||||. .||  | . || |..||||||.| |.. .|...||||| | ||||. ||||..|.||| || .. .|.||.|.|  . ....| ...
gllvellwsdpqeanGrsp.skrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfe

VTKATCFQP
  .    .|
avehpdvkp
subfamily_PPPLV_pd Subfamily PPPLV 168-438 2.9e-30 98.6 In-house 27-273 (290) alignment 
Range on Protein: 168-438
Range on HMM: 27-273/290.0
TICGDLHGKLDDLFL---IFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQIL
 . |||||   ||      ... |       ..| ||.||||. |.|..  |    ..||  ..| |||||   .   . .  |  .|.  . . . . .
yvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweaf

EEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLipptetnrdhdtdskhnkvgvtfnahgrIKTNGSPT--EHLTEHEWEQIIDILWS
 . . .||. ...|.... .|.|| ...  .      .. .. .                              . .|.|   . | .   |.  . | .
nnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlk............................ddidgaplaldilwsdpaedrdlslrg

DPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYeEGSNRGAYI
.  ...|  .|  || |. |. |   . |.. .|. ..|.|| | .|... ..|...|.||.|.|   .||  | |
elvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssryc.Gssneaali
subfamily_PPP2C_pd Subfamily PPP2C 119-293 3.4e-30 98.2 In-house 2-169 (290) alignment 
Range on Protein: 119-293
Range on HMM: 2-169/290.0
TDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTsPskeVTICGDLHGKLDDLFLIFYKNGlPSERNPYVFNGDFVDRGKNSIEILMILCV
.|.| |.| .|| . |. . | |.  ..|..|..  |  .... |   ||.|||.||.. ||. .|   |  |    |.| ||.||||  |.| . .| .
kdldklieklkeckqleesevkelcekakeilskesnvqevkc.p...vtvcgdvhgqfhdllelfkigg.kspdtnylflgdyvdrgyysvetvtllva

SFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKlhGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTD
  . |.. . . |||||   .   |||  | | ||      . ... ... .||. ..||..|...|||.| . |
lkvrykeritilrgnhesrqitqvygfydeclrkyg..nanvwkyftdlfdylpltalvdeqifclhgglspsid
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 141-292 1.6e-29 95.9 In-house 13-156 (280) alignment 
Range on Protein: 141-292
Range on HMM: 13-156/280.0
EVLFETKKVLKQMPNFTHIQTSpskeVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMN
.|. . ||.|.    .  ...     |..||||||.  ||. .| . ..| ..| |.| ||.||||.  .|....|    . |||.. . |||||   .|
rviekckkiltaqatmvevdap....vavcgdlhgqytdllrlfarvsfppdqn.ylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisin

LRYGFTKEILHKYKLHgkrILQILEEFYAWLPIGTIVDNEILVIHGGISETT
 .|||  |. ..|.|.   . . ..|..  ||. ..|   ||..|||.|.  
rkygfkdevkrrysla...lynefqelldslplvalvsgrilcmhgglsqkl
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 165-302 2.9e-29 95.3 In-house 51-186 (299) alignment 
Range on Protein: 165-302
Range on HMM: 51-186/299.0
KEVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKlhGKRILQIL
  . .|||.||.  ||. || |.|.| . | ..| ||.||||.. .|....| .  . ||..... |||||   .|  ||| .|  ..||    |.  |.
apiivcgdihgqysdllrifdkagfppdvn.flflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkryk..strlwsif

EEFYAWLPIGTIVDNEILVIHGGISET-TDLNLLHRVER
.. .|..|.  .. . ||..|||.|   ..|. |  . |
qdafaampltgligsrilcmhgglspklqtldqlrdltr
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 138-302 4e-29 94.9 In-house 27-188 (297) alignment 
Range on Protein: 138-302
Range on HMM: 27-188/297.0
YVLEVLFETKKVLKQMPNFTHIQTsPskeVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDF
 ||..|  . .|.|.  ..  ... |   . .|||.||.. ||. .|.. | |   | |.| ||.||||. ||| ...|    . .| .| | |||||  
rvlklldlaldvfkaqksmvevna.p...ikvcgdihgqfpdllrlfhrggwpptan.ylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhece

MMNLRYGFTKEILHKYKlhGKRILQILEEFYAWLPIGTIVDNEILVIHGGISE--T--TDLNLLHRVER
..|  ||| .|  ..|.    |.   ... . |||.  .. ..||..|||.|   |    |. |...||
fvnkvygfyeecqkryq..svrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkier
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 139-291 5.3e-29 94.5 In-house 8-153 (284) alignment 
Range on Protein: 139-291
Range on HMM: 8-153/284.0
VLEVLFETKKVLKQMPNFTHIQtSPskeVTICGDLHGKLDDLFLIFYKNGLPSeRNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFM
|  .||.. ..... | .  .. ||   . ||||.||.. ||. .| |||.|  |  |.| ||.|||||  .| ...|    ...|| . . |||||  .
vetllfhafsifnkqpmlievn.sp...inicgdihgqfsdllrlfdkngfph.ranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

MNLRYGFTKEILHKYKLhgKRILQILEEFYAWLPIGTIVDNEILVIHGGISET
.|  ||| .|  ..|.     . . .|  .. .|. ..| . ||..|||.|. 
inkiygfyeecqrrynk..psvyvsfegvfsvmpltalvgqrilcmhggvskm
subfamily_PPP6C_pd Subfamily PPP6C 153-303 2.9e-28 91.8 In-house 31-178 (290) alignment 
Range on Protein: 153-303
Range on HMM: 31-178/290.0
MPNFTHIQTSpSKEVTICGDLHGKLDDLFLIFYKNGLPSERnPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHK
. . . .|.  |  ||.|||.||.. ||  .| . |   .   ||| |||||||  |.| .  | .  . ||. . | |||||   .   ||| .| |.|
lleesnvqpv.sspvtvcgdihgqfydleelfrtggqvpdt.syvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnk

YKLhgKRILQILEEFYAWLPIGTIVDNEILVIHGGISET-TDLNLLHRVERN
|        . . . .  |.|..|.|...| .|||.|   . |. .. .||.
ygn..anawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirviera
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 139-292 2.4e-25 82.3 In-house 11-171 (302) alignment 
Range on Protein: 139-292
Range on HMM: 11-171/302.0
VLEVLFETKKVLKQMPNFTHIqtspSKEVTICGDLHGKLDDLFLIFYKN----------GLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLH
.| .. .  . ||.  ....|    |  ||| ||.||. .||. |. ..               .. .|| ||.||||..||| . ..    ..||..  
llllieaviellkkektlaei....spPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LNRGNHEDFMMNLRYGFTKEILHKY-KLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETT
| |||||   .|  ||| .|.  .. | .||.| . ..| ....|. ..| . || .|||||.  
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispkl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 139-292 3e-25 82.0 In-house 12-172 (302) alignment 
Range on Protein: 139-292
Range on HMM: 12-172/302.0
VLEVLFETKKVLKQMPNFTHIqtspSKEVTICGDLHGKLDDLFLIFYKN----------GLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLH
.| .. .  . ||.  ....|    |  ||| ||.||. .||. |. ..               .. .|| ||.||||..||| . ..    ..||..  
llllieaviellkkektlaei....spPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LNRGNHEDFMMNLRYGFTKEILHKY-KLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETT
| |||||   .|  ||| .|.  .. | .||.| . ..| ....|. ..| . || .|||||.  
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispkl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 167-291 5.9e-25 81.4 In-house 9-134 (263) alignment 
Range on Protein: 167-291
Range on HMM: 9-134/263.0
VTICGDLHGKLDDLFLIFYKNGLpSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHG--KRILQIL
. |||| ||. .||. ||   |  . .  |.| ||.||||  |.|..|.|    |  |  .|| |||||   .|  |||  |. ....     . . . .
inicgdthgqyndllrifnacga.atktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhf

EEFYAWLPIGTIVDNEILVIHGGISET
.. ....|. .|| . ||..|||||  
nqvfsymplcaivskrilcmhggisph
subfamily_PPZ_pd Subfamily PPZ 135-291 1.4e-24 80.2 In-house 26-174 (300) alignment 
Range on Protein: 135-291
Range on HMM: 26-174/300.0
HAHYVLEVLFETKKVLKQMPNFthIQTSPSkeVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNH
.   .|.. .......   |..  .. |||  | | ||.||.  ||. .| | |.|   | |.| ||.|||||.|.| ...| .  . ||... | ||||
knseilqicikarelflaqpal..lelsps..vkivgdvhgqyadllrlftkcgfppsan.ylflgdyvdrgkqsletillllcykikypenffllrgnh

EDFMMNLRYGFTKEILHKYKLhgkRILQILEEFYAWLPIGTIVDNEILVIHGGISET
|   .   |||  |  .. ..   .| . . . .  ||. .||  .|...|||.|  
ecanvtrvygfydeckrrcni...kiwktfvdtfntlplaaivagkifcvhgglspv
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 137-295 1.4e-24 79.8 In-house 11-162 (281) alignment 
Range on Protein: 137-295
Range on HMM: 11-162/281.0
HYVLEVLFETKKVLKQMPNFTHIQTsPskeVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHED
. . .|..|.. .. .  ... |.. |   ... ||||.. .||  .|   | ..|.  .|| ||.||||..|.|.|..| .  . |.. . | ||||| 
eeienvireveaifseekaLveidk.P...ivvvGdlhaqfndlkrlfellgrvpeev.lvflgdyvdrgpqslevlillftlkiryrdrivllrgnhei

FMMNLRYGFTKEILHKYklhGKRILQILEEFYAWLPIGTIVDNEILVIHGGISE-TTDLN
  .| .||| .|   ||   |. .   ... .  ||| . ... .|..|||.|   | |.
asvnkiygfyvecvtky...GeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltald
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 194-303 3e-24 78.8 In-house 101-208 (317) alignment 
Range on Protein: 194-303
Range on HMM: 101-208/317.0
NPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKlhgKRILQILEEFYAWLPIGTIVDNEILVIHGGISET-T
. |.| ||.||||  |||....|    |.||. ..| |||||   .| .||| .|. ..|.   ... ....  .  ||. ..|...|| .||||||  .
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrys...aalyeafqlafnvlplcavvnkkilcmhGGiseell

DLNLLHRVERN
||. |....| 
dlkqldklkrp
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 167-291 4.4e-24 78.2 In-house 49-172 (307) alignment 
Range on Protein: 167-291
Range on HMM: 49-172/307.0
VTICGDLHGKLDDLFLIFYKNGLPSERnPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEE
. . |||||...||  .|   | | |   ||| ||.||||  |.|....| .  ..||... | |||||   .| .||| .| .      |. |  ... 
cvvvgdlhgqfndlinmfillgrppet.vyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfqr

FYAWLPIGTIVDNEILVIHGGISET
 .  ||| ...   ||..|||.| .
cfnnlpisaliatkilcmhgglspa
subfamily_PPP2C_pd Subfamily PPP2C 355-453 3.6e-20 65.3 In-house 188-285 (290) alignment 
Range on Protein: 355-453
Range on HMM: 188-285/290.0
QIIDILWSDPRGKNGcFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQV
 . |.|||||  ..| .  . || |  || |.. |. .. .|....|.|.   |||. .|| .||||||| ||     |..| ..|    . .| |.. 
plcdllwsdpddrgg.wgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 195-292 1.6e-19 63.2 In-house 121-216 (339) alignment 
Range on Protein: 195-292
Range on HMM: 121-216/339.0
PYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLhgkRILQILEEFYAWLPIGTIVDNEILVIHGGISET-T
 |.| ||.||||  |.|....|    | ||. ..| |||||   .|  ||| .|. ..|     .. . .....  .|. ....| |...||||||  |
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda...qlyecfqnmfnvfpfcavinntimcmhggisehlt
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 355-440 7.2e-18 57.6 In-house 195-280 (298) alignment 
Range on Protein: 355-440
Range on HMM: 195-280/298.0
QIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKL
  ||.||.||  .   . .  || .. || ||  ..|.| .. ...|.|    .|||   . |.|||||| .| ..  |  | .|.
laidllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkv
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 331-442 1.7e-17 56.3 In-house 159-270 (287) alignment 
Range on Protein: 331-442
Range on HMM: 159-270/287.0
TFNAHGRIKTNGSPTEHLTEHEwEQIIDILWSDPRGK-NGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYE
  ..   .|.   || .|. .|   ..|.||.||  . ..  .|  |.    ||  .  ..|.| ......|.|| . |||.   | ..||.|||. |  
klksldslkalkkpttplacde.glqvdllwadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysg

EGSNRGAYIKLCS
| .| || ...  
edtnlgavvvvsk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 356-439 2.5e-17 56.0 In-house 217-300 (317) alignment 
Range on Protein: 356-439
Range on HMM: 217-300/317.0
IIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIK
. |. |.||  .   . .. || |  ||..   . |.|..|....|.|.   .|||   | |.|||||| .|  .  | .| ..
ladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 166-295 6.8e-17 54.8 In-house 34-160 (280) alignment 
Range on Protein: 166-295
Range on HMM: 34-160/280.0
EVTICGDLHGKLDDLFLIFYKNGLPSERNpYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHgkrILQILE
 . . ||.| . .|.  .|   |   | .  .| ||.|||| . ||.|..| .  . | . ..| |||||   .|  |||  |. .|| .    .   ..
pikvigdihaqyqdmnrlfdligrvpeek.lmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvg...lwwdfq

EFYAWLPIGTIVDNEILVIHGGISE-TTDLN
  .  .|.  .. . .|..|||.|    .|.
scfnrmpmsgliskrvlcmhgglspelinld
subfamily_PPP4C_pd Subfamily PPP4C 355-448 1.1e-15 50.6 In-house 187-279 (288) alignment 
Range on Protein: 355-448
Range on HMM: 187-279/288.0
QIIDILWSDPRGKNgCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRF
...|.|||||. .. ..  . || |  || ||...  .. ......|.|.   |||    . ||.|..|| ||     |  | ..| . .  .|
plcdllwsdpedae.gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdf
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 356-440 2.3e-15 49.8 In-house 185-269 (284) alignment 
Range on Protein: 356-440
Range on HMM: 185-269/284.0
IIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKL
| |. |.||  .   . .. || |  ||..   ..|.|..|....|.|.   .|||.  | |.||||||  |  .  | .| ...
iadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnv
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 350-438 4.2e-15 48.8 In-house 191-279 (297) alignment 
Range on Protein: 350-438
Range on HMM: 191-279/297.0
EHEWEQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYI
| . . . |.||.||      | .  || || || |   |.  ...| .. |.|.   .|||.    |.||||||  |  .  |  |..
egkerlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafm
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 332-441 4.7e-15 48.4 In-house 166-276 (290) alignment 
Range on Protein: 332-441
Range on HMM: 166-276/290.0
FNAHGRIKTNGSPTEHLTEHEwEQIIDILWSDPRG-KN-GCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYE
 ..   .|.   |  .|| .|   ..|.||.||   |.     |  |.    || ..  ..|.|  |....|.|| | ||...  | |.||.|||  |  
iesweslkalkkprvpltcde.glqvdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysg

EGSNRGAYIKLC
. .| || ... 
ndtnlgaiatvs
EF-hand_7 EF-hand domain pair 574-635 7e-15 44.8 Pfam-A 5-66 (66) alignment 
Range on Protein: 574-635
Range on HMM: 5-66/66.0
IFNAIDTDHSGLISVEEFRAMWKLFSSHYNvhidDSQVNKL----ANIMDLNKDGSIDFNEFLKAF
.|...|.|..| ...||.... | ..|.      |..| .      . .|.|.|| ..|.|||.|.
aFkllDkdgdgyldkeeLlrllkhlgspli....deevrevldyifkeiDkngdGvlsfeEflqai
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 357-440 7.3e-15 47.8 In-house 178-261 (280) alignment 
Range on Protein: 357-440
Range on HMM: 178-261/280.0
IDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKL
 |.||.||  |   . .. ||    || .|  .. .| .. ...| |.   .|||.  | |.||.||| .| .| .|  | ...
mdllwadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavliv
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 354-440 2e-14 46.5 In-house 177-263 (281) alignment 
Range on Protein: 354-440
Range on HMM: 177-263/281.0
EQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKL
  .||.||.||  |   . .. || .  || .|  ..  . .. ..||.|    .|||.    |..|.||. || .   | .| .|.
GlviDllwadpdnkveewkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkv
subfamily_PPG1_pd Subfamily PPG1 356-450 7e-14 44.8 In-house 187-292 (300) alignment 
Range on Protein: 356-450
Range on HMM: 187-292/300.0
IIDILWSDPR----------GKNG-CFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGT
. |.|||||            ..|  | .. || |  .| ||. |.|.. ... .||.|.   |||.|  |.|. |..|| || .   |. . ..| .  
ladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekd

TPRFFQ
   |  
eryfnv
subfamily_PPP6C_pd Subfamily PPP6C 355-440 1e-13 44.1 In-house 186-270 (290) alignment 
Range on Protein: 355-440
Range on HMM: 186-270/290.0
QIIDILWSDPRGKNgCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKL
 . |..||||   .  .  . || |  ||  ||.....  .||...|.|.   ||..   | |.||..|| ||     |  . ..|
afcdlvwsdpedve.twavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilal
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 356-436 1.2e-13 44.1 In-house 176-256 (284) alignment 
Range on Protein: 356-436
Range on HMM: 176-256/284.0
IIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGA
 ||||||||   .  .    ||    || |   |.|.. |. ...|.|.   .|||.  . ..||||||  |  .  |  |
aidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaa
subfamily_PPP3C_pd Subfamily PPP3C 355-442 1.5e-13 43.4 In-house 211-311 (452) alignment 
Range on Protein: 355-442
Range on HMM: 211-311/452.0
QIIDILWSDPRG-------KNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHD------GKVVTIFSASNYYEEGSNRGAYIKLC
 . |.|||||         ..   ||. ||  ....   ... |.| .|  .||.||.. .||.  ..        ..|.|||.|| .  .|..| .|. 
plcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkye

S
.
n
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 356-436 1.9e-13 43.2 In-house 236-316 (339) alignment 
Range on Protein: 356-436
Range on HMM: 236-316/339.0
IIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGA
. |. |.||   .  .  ..||    |||     .|.| .|.|.|| |.   .|||.    ..|||||| ||  .  |  |
ltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaa
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 357-453 3.2e-13 42.6 In-house 197-293 (299) alignment 
Range on Protein: 357-453
Range on HMM: 197-293/299.0
IDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQV
||.||.||      . .  ||    ||.|| ...... .. .. |.|.   .|||.  . |.||||||  |  .  |  | .|.       |  .. 
idllwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkp
subfamily_PPZ_pd Subfamily PPZ 351-444 3.5e-13 42.7 In-house 191-284 (300) alignment 
Range on Protein: 351-444
Range on HMM: 191-284/300.0
HEWEQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGT
 ..  | |.|||||   .  . .  ||    .      |.|||. . .. |.|    .|||.  |  .||.||| ||  |  | || . .. | 
pdfglindllwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegl
PPP5 PPP5 TPR repeat region 92-158 1.2e-12 38.1 Pfam-A 28-94 (95) alignment 
Range on Protein: 92-158
Range on HMM: 28-94/95.0
RDRWDyVDSIDVPDSYNGPRLQ-FPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTH
 .  | ..||.. |.|.||||.   .| . .. ||| ||.|. || ..| ..| ..|..||..|.. .
aesid.iesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslve
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 370-440 3.3e-12 39.2 In-house 216-286 (302) alignment 
Range on Protein: 370-440
Range on HMM: 216-286/302.0
CFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKL
   |. ||    |      .. ....||...|.|   |||.    | |..|||||..| .|  |.|| .|.
yaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 370-440 3.7e-12 39.1 In-house 217-287 (302) alignment 
Range on Protein: 370-440
Range on HMM: 217-287/302.0
CFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKL
   |. ||    |      .. ....||...|.|   |||.    | |..|||||..| .|  |.|| .|.
yaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 354-441 8.6e-12 38.1 In-house 175-262 (280) alignment 
Range on Protein: 354-441
Range on HMM: 175-262/280.0
EQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLC
  .||.|||||  |   .  . ||    ||  |  .  .  .. ..||.|.   .|||.    ...|.||  ||  . .|  | . | 
gllidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvcln
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 357-440 7.6e-10 31.4 In-house 195-278 (307) alignment 
Range on Protein: 357-440
Range on HMM: 195-278/307.0
IDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKL
 |.||.||      .  . || |  || .|   . ..  ....||.|.   .|| .    |..|||||  | .   | |. .|.
ndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkv
EF-hand_1 EF hand 571-597 1.6e-09 26.4 Pfam-A 2-28 (29) alignment 
Range on Protein: 571-597
Range on HMM: 2-28/29.0
LEIIFNAIDTDHSGLISVEEFRAMWKL
|. .|. .|.|..| ||.|||....| 
lkeaFkefDkDgdGkIsfeEfkealkk
EF-hand_8 EF-hand domain pair 570-596 4.5e-09 25.1 Pfam-A 26-52 (54) alignment 
Range on Protein: 570-596
Range on HMM: 26-52/54.0
DLEIIFNAIDTDHSGLISVEEFRAMWK
...|.|...|||..| || ||| ....
evdilfrefDtdgdGkisfeEFcvlle
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 354-438 9e-09 28.3 In-house 155-240 (263) alignment 
Range on Protein: 354-438
Range on HMM: 155-240/263.0
EQIIDILWSDPRGK-NGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYI
    |.||.||    .|  ||  |     ||      . .. .. ...|.|.    || .  | ...|.|||| |  |  |  | .
placdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavv
EF-hand_5 EF hand 572-594 2.5e-08 22.3 Pfam-A 2-24 (25) alignment 
Range on Protein: 572-594
Range on HMM: 2-24/25.0
EIIFNAIDTDHSGLISVEEFRAM
. .|.|.|.. .| || ||....
kdtFrafDkNgDGkIsreELkrl
EF-hand_8 EF-hand domain pair 606-635 1.1e-07 20.7 Pfam-A 22-51 (54) alignment 
Range on Protein: 606-635
Range on HMM: 22-51/54.0
IDDSQVNKLANIMDLNKDGSIDFNEFLKAF
. ...|  | . .|...|| |.|.||....
lseeevdilfrefDtdgdGkisfeEFcvll
EF-hand_1 EF hand 612-635 1.2e-07 20.5 Pfam-A 3-26 (29) alignment 
Range on Protein: 612-635
Range on HMM: 3-26/29.0
NKLANIMDLNKDGSIDFNEFLKAF
... ...| ..|| |.|.||..|.
keaFkefDkDgdGkIsfeEfkeal
IQ IQ calmodulin-binding motif 18-35 2.3e-07 19.7 Pfam-A 2-19 (21) alignment 
Range on Protein: 18-35
Range on HMM: 2-19/21.0
RAALIIQNWYRGYKARLK
.||..|| ..|||.|| .
kaaikIQaawRgylaRkr
subfamily_YNL217W_pd Subfamily YNL217W 162-311 3.9e-07 22.8 In-house 7-159 (235) alignment 
Range on Protein: 162-311
Range on HMM: 7-159/235.0
SPSKEVTICGDLHGKLDDLFLIFY-KNGLPSERNPYVFNGDFVDRGKNSIEILMILcvsflvYPNDLHLNRGNHEDFMMN-LRY-----GFTKE-ILHKY
  .|.. . || ||  |.|  ..  |.|   |    |. ||....| .|.|..  .        .. .  .||||  ..  ...     |...     |.
vlgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskf

KLHGKRILQILEEFYAWLPIG-TIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIP
.   ... .   |..  |.    |  .|.||.|.|..    |.  .. |  ... .|. 
sflesklskadmeyarelgfsldipsdellvvhaGlvpgkfleensidevlslrnllvd
EF-hand_6 EF-hand domain 574-596 9.6e-07 18.3 Pfam-A 5-27 (31) alignment 
Range on Protein: 574-596
Range on HMM: 5-27/31.0
IFNAIDTDHSGLISVEEFRAMWK
.|...|.|..| |. ||.|.. .
aFklfDkdgdGkidaeELrkaLr
EF-hand_5 EF hand 617-633 1.7e-06 16.5 Pfam-A 7-23 (25) alignment 
Range on Protein: 617-633
Range on HMM: 7-23/25.0
IMDLNKDGSIDFNEFLK
 .|.|.|| |.. |. .
afDkNgDGkIsreELkr
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 131-191 5.7e-06 18.7 In-house 6-62 (317) alignment 
Range on Protein: 131-191
Range on HMM: 6-62/317.0
QQILHAHYVLEVLFETKKVLKQMPNFTHIQTsPskeVTICGDLHGKLDDLFLIFYKNGLPS
|...... ..|. . ..... . | . .... |   |||.||.||. .||  ..  || | 
qdlfkekelielcyrarelfwkeplklelea.p...vtivGdihGqfedllalldlnGwpl