Gene PPEF2 in Homo sapiens

Synonym: PPP7CB, PPEF2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP7C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP145_AA protein Get Run
HsapP145_AA_99-586 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP7C_pd Subfamily PPP7C 109-586 2.6e-213 700.8 In-house 1-382 (383) alignment
Range on Protein: 109-586
Range on HMM: 1-382/383.0
EVPDSYTGPRLSFPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGD
||.|||||||||.|| .|....|.|||..|..|||.|||..|.|.||.|.|||||.||||..|.|.||||||||.||||..|.|||||||.|..||||||
evedsytgprlslpltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIE
||||||.|||||.||.|..||||||..|||||||||..||||||.|||..|||||||.|||.|.|||.|||||||||||.||.|||.||.||||||||||
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktdlelldkie

RSKIVSTMRcktrqksekqmeekrranqkssaqgpipwflpesrslpsSPLRLGSyKAQKTSRSSSIPCSgsldgrelsrqvrssvelelercrqqagll
|||.||..|                                       .||. |. .|.|....||....                              
rsklvsvlr.......................................pplkege.eaekekeessvkvd..............................

vtgekeepsrsaseadseagelrkptQEEWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFS
                          .||||||.|||||||.|.||||.||.||||.|||||||..||||||...||||||||||||||.|..|||||||
..........................keewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifs

ASNYYEVGSNRGAYVKLGPALTPHIVQYQANKVTHTLTMRQRISRVEESALRALREKLFAHSSDLLSEFKKHDADKVG
||||||.|||||||||||..|||.||||||.|.|..||.|||.|.|||||||.|||||.|..||||.||||.|..|.|
asnyyeeGsnrGayvklgkdltprivqyqaskatkkltlrqrvsiveesalrelrekllakksdlleefkkkdekksg

PPP_1 146-525 2.7e-125 410.0 In-house 2-264 (264) alignment
Range on Protein: 146-525
Range on HMM: 2-264/264.0
VLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLiFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHM
... |.|.||.|..|.|........|||||||||.|||.||| ....|.|.||||..|.|.||.|||||||||||..|.|..|.||||..|.|||||...
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrq

VNLRYGFTKEVMnkYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSEKQmeekrranqkssaqgpip
|. .|||.|||.  .|...|||..||.|||..||||.|||||.||.|||.|...||.. ...||.|.......|.....||.                  
vtkvygFkkEvl..kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekd..................

wflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqeewrqvVDIL
                                                                                                ||||
................................................................................................vdil

WSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
.||...||...||.|||.|..||.|||...|||.|....||.||.|.|||||...|||.||||||||||.||||||||||
lsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl

PPP_3 145-537 5.5e-115 376.0 In-house 2-270 (271) alignment
Range on Protein: 145-537
Range on HMM: 2-270/271.0
YVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLiFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDH
.. | |.|..|.| .... .......|...|||||.||||||| ....|||.||||..|.|.||.|||||.|.|.|..|.|....||||.||.|||||..
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsr

MVNLRYGFTKEVMnkYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSekqmeekrranqkssaqgpi
..| .|||.|||.  .|..||.....||.||..||||.|||||||..|||.|. ....  .| ...||......|.....                    
qinkvYgFkkevl..kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll....................

pwflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqeewrqvvdi
                                                                                                    
....................................................................................................

lWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQ
 .|.....|....|. || |..||||||...|.|......||.||.|.||||..|..||.|.|||.||.| .||.||..||..|||....|..
.lssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle

0045823 Metallo-dependent phosphatases 100-586 8.2e-97 317.7 In-house 2-368 (473) alignment
Range on Protein: 100-586
Range on HMM: 2-368/473.0
KKCSDYESIEVPDSYTGPRLSFPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTcyseEITVCGDLHGQLDDLIFIFYKNGLPSP
... ..  | |....|.|.|...| . . ..|.| ..  ..|.....|.||.|.|..| . ||. ..|      |.|.||.|||||||. .. |.|.|..
drvlklvlipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe

eRSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYkvhGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDI-
 . .||.||.|||| ||.|.| .|.|... ||. ..| |||||....|  ||| .|.. ||   | .. . .......|||| .|..|.|. |||.|.  
.drlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetleky...gedlyeeflewlrslPlaaviggkilfvHGGlspdl

TDLELLDKIERSKIVSTmrcktrqksekqmeekrranqkssaqgpipwflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelel
. |. ...|||   ...                                                                                   
plldqireierpleipd...................................................................................

ercrqqagllvtgekeepsrsaseadseagelrkptqeeWRQVVDILWSDPMAQEGC-------KANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECK
                                       .....|.|||||. ..|.         |. || |..||||.....|.|.......|.|.. 
.......................................dgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthv

PEGYEFCHNRK------VLTIFSASNYYEVGSNRGAYVKLGPALtPHIVQYQANKVTHTLTMRQRISRVeesALRALREKLFAHSSDLLSEFKKHDADKV
|||||.....|      ..|.|||.||. .| |..|...... | ....|... .... |.. ...  .   .|..|.|||. . . ||. ..... .. 
peGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphplilplfldvfll...slpfllekltellllllnivsddelled

G
.
e

PPP_5_Dcr2 174-491 9.3e-90 292.9 In-house 1-199 (199) alignment
Range on Protein: 174-491
Range on HMM: 1-199/199.0
ITVCGDLHGQLDDLIFIFYKNG-LPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYkvHGKEILRTLQ
.|||||||||||||..|..|.| .||.||.|||.||.|||||||.|.|..|.|..||||||.||.||||||...|..|||||||..||  |||.|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky..hgkkiykils

DVFCWLPLATLIDEKVLILHGGVSDITDL-ELLDKIERsKIVStmrcktrQKsekqmEEKRRANQKssaqgpipwflpesrslpssplrlgsykaqktsr
|||.|||||.|||||||..|||.|..... |||.|||| ||..       ..     |....|...                                  
dvfdwlPlaalidekvlvvhgglspeiksiellekier.kiei.......pe.....ekgekadll..................................

sssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqeewrqvvdiLWSDPM-AQEGCKANTIRGGGCYFGPD
                                                                         |||||. ||||||.|..||.|..||||
.........................................................................lwsdprdaqegcklnseRGagllfgpd

VTQQLLQKYNMQFLIRSHECK
||...|.|.|....|||||.|
vtekfleknnlkliirshelk

PPP_2 174-491 2.6e-88 287.9 In-house 1-198 (198) alignment
Range on Protein: 174-491
Range on HMM: 1-198/198.0
ITVCGDLHGQLDDLiFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMnkYKVHGKEILRTLQD
.||||||||||||| .|..|||||||||.|.|.||.|||||.|.|.|..|.|..||||||.||.|||||...|| .|||.|||.  .|..||.....||.
vtvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl..kkkggkkvykklqe

VFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSekQ--Meekrranqkssaqgpipwflpesrslpssplrlgsykaqktsr
||..||||.|||||||..|||.|. ..|.  .| |..||.|....|.....  .                                              
vfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll..eeek...........................................

sssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqeewrqvvdilWSDPMAQEGCKANTIRGGGCYFGPDV
                                                                          .|||...|...||. ||.|..|||||
..........................................................................lsdpkekeellansarGagllfgpdv

TQQLLQKYNMQFLIRSHECK
|..||.|......||.||.|
teelleknklkliiRaHevk

PPP_4 174-491 1.2e-86 282.8 In-house 1-197 (197) alignment
Range on Protein: 174-491
Range on HMM: 1-197/197.0
ITVCGDLHGQLDDLIFIFYKNG-LPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKykvHGKEILRTLQ
.||.||.|||||||.....||| |||.||||||.||.|||||||.|.|..|.|..||||||..|.|||||....||.|||.|||..|   ||||||..||
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek...hgkeilkklq

DVFCWLPLATLIDEKVLILHGGVSDITDLelLDKIERS--KIVStmrcktrqkseKQMEEKRRANQkssaqgpipwflpesrslpssplrlgsykaqkts
|||..||||.|||||||..|||.||...   ||||||.  ||.|           ...||||....                                  
dvfdllplaalidekvlvvhgglsdeles..ldkierierkies...........pleeekrkdll..................................

rsssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqeewrqvvdiLWSDPM-AQEGcKANTIRGGGCYFGP
                                                                          |||||. |||| .||..||.|..|||
..........................................................................lwsdpreaqeg.lansvrGagllFgp

DVTQQLLQKYNMQFLIRSHECK
|||...|.|.|....|||||.|
dvtekfleknnlkliirshelk

0049330 Metallo-dependent phosphatases 114-542 1.4e-77 253.9 In-house 3-302 (309) alignment
Range on Protein: 114-542
Range on HMM: 3-302/309.0
YTGPRLSFPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGLPSPeRSYVFNGDFVDRG
...|.| ..|. .. ..|.| ..  ..|. ...|.||...|..| . ||. ..|      |.|.||.|||||||. .. |.|.|.. . .||.||.||||
lldpllllelilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrG

KDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYkvhGKEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSKI
 ||.|.| .|.|..| ||. ..| |||||....|  ||| .|.. ||   | |. . ..|....|||| .|..|.|. |||.| |.. |. ....||   
pdslevlllllalkllypdnvfllrGNHElrllnglygfgdetlrky...gaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerple

VSTMRcktrqksekqmeekrranqkssaqgpipwflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelelercrqqagllvtge
.   .                                                                                               
ipldg...............................................................................................

keepsrsaseadseagelrkptqeewrQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNY
                            ..|.|||||.      |. .|| |..||.......|.|......||.|.. ..||......|..|.|||.||
...........................llcdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapny

YEVGSNRGAYVKLGPALTPHIVQYQANKVT
... .|.||...... |......... ...
cgrlgnlgavleidedlvisfllfepvpll

0053225 Metallo-dependent phosphatases 127-538 2e-72 237.1 In-house 8-290 (293) alignment
Range on Protein: 127-538
Range on HMM: 8-290/293.0
HATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGLPSPeRSYVFNGDFVDRGKDSVEILMILFAF
. ..|.| ..| ..|.. ..| ||.|.|..|.. ||. ..|      |.|.||.||.||||. .. | |.|.. . .||.||.|||| ||.|.| .|.|.
lldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlelllal

MLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYkvHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSKIVStmrcktrqkse
 |.||. ..| |||||....|  ||| .|.. ||  ...|. . |.|....|||| ||..|.|. |||.| |.. |. ...|.|   .            
kllypdnvvllrGNHElmllnglygfgdetlrky..gaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplrip...........

kqmeekrranqkssaqgpipwflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseads
                                                                                                    
....................................................................................................

eagelrkptqeEWRQVVDILWSDPMAQEGCKANtIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
           ... . |.|||||.  .|.  . .|| |..||.......|.|......||.|.. |.||......|..|.|||.||... .|.||...|
...........legllldllwsdpdlwsgwlps.yrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlal

GPALTPHIVQYQA
.. |....... .
deglvwgfklfap

subfamily_PPP5C_pd Subfamily PPP5C 110-310 5.7e-60 196.0 In-house 2-202 (322) alignment
Range on Protein: 110-310
Range on HMM: 2-202/322.0
VPDSYTGPRLSF-PLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGD
| |||.||.|    .  .  . |.| |. ...|| .|.|..| |.|. | .|| .  ...  ....|||||.|||  ||. || .|||||.|..|.||||
vedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGd

FVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKvhgKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITD--LELLDK
|||||  |||....|..| |.||..|.|.||||| . .|  |||. || .||.   ....  ...||.|||||..|.||||..|||. .  .  |. | |
fvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakyt...ekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrk

IERS
|.| 
idrn

PP2Ac_SM00156 142-318 1.3e-57 187.9 In-house 2-163 (271) alignment
Range on Protein: 142-318
Range on HMM: 2-163/271.0
HARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGlPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNH
.. .||.|| |.|. | | .|. .||    ...||.||.|||||||. .. ..| ..||  |||.||.||||. |.|....|||. ..||....|.||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

EDHMVNLRYGFTKEVMNKYkvhGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIERskivstmrC
|. .||  |||..||..||   ||||.  ....| .||||.|.|.|.|..|||.|  .. |. ..|..|         
Esssvnkiygfeeevkrky...gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr........v

subfamily_PPP1C_pd Subfamily PPP1C 139-313 2.1e-46 151.4 In-house 8-175 (282) alignment
Range on Protein: 139-313
Range on HMM: 8-175/282.0
QQLHARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNR
 .|. . . .|| .... |.. | . ...    . ....||.|||. ||. .| ..| | ||..|.| ||.||||| |.|....|.|. . ||....| |
vklkeaeieallkkareillsqpillele....aPvkivgdihGqyadllrlfetsgaP.pesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHEDHMVNLRYGFTKEVMNKYKVHgkeILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSKIV
||||.  .|  |||  |. ..|...   . .|..||| .||||.|.|||.| .|||.| ....|| ..||.|   |
GnhesasinriyGfydeckrrysik...lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlev

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 134-311 8.6e-43 139.5 In-house 17-188 (298) alignment
Range on Protein: 134-311
Range on HMM: 17-188/298.0
AFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTcyseEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKE
. .| .... . | .|. ..|| . . . .  | .     |.||||.|||  ||. .| |.| | |.  |.| ||.||||. ..|....|.|. . ||..
ekkltkvikeedveklielakkifkkqkslvevda....pikvcGdihGqysdllrlfdkagfp.pdanylflGdyvdrGrqnlevivlllaykvkypnn

FHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGkeILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIERSK
| | ||||| ...|  ||| .|. ..||     .  ..|||| .|||..|| ...| .|||.|. .. |. | ...|..
ffllrGnheceainrvyGfyeeckrrykslr..lyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpf

Metallophos Calcineurin-like phosphoesterase 174-492 8.3e-42 136.7 Pfam-A 3-200 (200) alignment
Range on Protein: 174-492
Range on HMM: 3-200/200.0
ITVCGDLHGQLDDL---IFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMIL--FAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMN----------
|.|.|||||.||||     |..|.. ...   ..|.||.||||..| |.|..|  .. .| .|. ..|.|||||....| .|||..|. .          
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

---------------------KYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDkierskivstmrcktrqksekqmeekrranqk
                     .|. .|... .  ...|..|||..|.| |.|. ||..|. .....                                  
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ssaqgpipwflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqee
                                                                                                    
....................................................................................................

wrqvvdilwsdpmaqegckantirgGGCYFGPDVTQQLLQKYNMQFLIRSHECKP
                         |...||||..  ||.||... ..|.|..||
.........................gselfgpdalekllekygvdlvlrGHtHkp

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 142-306 6.2e-39 126.6 In-house 11-168 (287) alignment
Range on Protein: 142-306
Range on HMM: 11-168/287.0
HARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNH
  . .|..| .... |  || . .|     . ||..||.|||||||. || . | . |.  |.| ||.|||| .|.|. ..||.. . |||. || ||||
sdkdilevlekieeileplpalleve....apitivGdihGqlddllrifnavGaa.pkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnh

EDHMVNLRYGFTKEVMNKYKvhgKEILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDK
| . .|  ||| .|...|..   ... .. .|||  ||| . .....| .|||.|. .  |. |  
evkkinklyGfkeelkrkrq...erlykqfndvfselplcarvskrilcmhGGispklksldslka

subfamily_PPP4C_pd Subfamily PPP4C 132-312 5.5e-37 120.5 In-house 7-181 (288) alignment
Range on Protein: 132-312
Range on HMM: 7-181/288.0
VEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCyseeITVCGDLHGQLDDLIFIFYKNGlPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYP
.|  |  . .. . | .|  .... ||.  |..|| .     .|||||.|||. ||. .|  .|   ||..|.| |||||||. ||| ...| |. . ||
ieklrrcelikeeevkalcakareilveesnvqrvdsp....vtvcgdihgqfydllelfkvgg.dvpetnylflgdfvdrgfysvetfllllalkvryp

KEFHLNRGNHEDHMVNLRYGFTKEVMNKYKvhGKEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSKI
.  .| |||||   .   ||| .|...||     .. |   .|| .|.||..||.|....|||.| .|. |. .  |.| . 
dritlirgnhesrqitqvygfydeclrkyg..sanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqe

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 173-310 3.4e-36 118.1 In-house 51-189 (297) alignment
Range on Protein: 173-310
Range on HMM: 51-189/297.0
EITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgKEILRTLQ
 | ||||.|||. ||. .|.. | | |   |.| ||.||||. |.| ...|.|. . .| .. | |||||  .||  ||| .|. ..|.     .  ..|
pikvcgdihgqfpdllrlfhrggwp.ptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqkryqs..vrmyaafq

DVFCWLPLATLIDEKVLILHGGVSDIT----DLELLDKIERS
||| ||||. || .|.| .|||.| .      |. | |||||
dvfnwlpltgliatkilcmhgglsplltkeftldtlrkiers

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 170-311 1.3e-35 116.2 In-house 33-177 (284) alignment
Range on Protein: 170-311
Range on HMM: 33-177/284.0
YSEEITVCGDLHGQLDDLIFIFYKNGLP-----SPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhg
    ....||.||| .||. ..  || |     . |. |.| ||.||||  |.|....|||. |..|.   | |||||   || .||| .|  ..| .  
ieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkryse..

kEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSK
  .  ..|  |  .||......|.. .|||.| |. ||. |||.||  
.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpi

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 172-309 2.9e-35 115.0 In-house 51-186 (299) alignment
Range on Protein: 172-309
Range on HMM: 51-186/299.0
EEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgKEILRTL
  | ||||.|||  ||. || |.|.| |.  ..| ||.||||.. .|....|..| . ||..|.. |||||   .|  ||| .|. ..||     .   .
apiivcgdihgqysdllrifdkagfp.pdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkryks..trlwsif

QDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIER
|| | ..||. ||  ..| .|||.|  ...|. | .. |
qdafaampltgligsrilcmhgglspklqtldqlrdltr

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 141-302 4.7e-35 114.0 In-house 16-170 (290) alignment
Range on Protein: 141-302
Range on HMM: 16-170/290.0
LHARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGN
.  . .|..| . .. |  || . .|     . |.. ||.|||||.|.  | . | | |.  ..| ||.|||| .|.|. ..|| . . |.|. || |||
fsdkdileilekieeileplpalleve....apivivgdihgqldallryfdavgyp.pkvkflflgdyvdrgakslevslllfcykiryskkvhllrgn

HEDHMVNLRYGFTKEVMNKykvHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLE
||   ||  ||| .|.. |    | .. .  ||||  |.| . ...|.| .|||.|. |   |
hevrkvnrlygfkeelark...rgsrlwkqyqdvfaelslcarvgrkilcmhggisqkieswe

subfamily_PPP3C_pd Subfamily PPP3C 130-311 9.2e-35 113.3 In-house 30-204 (452) alignment
Range on Protein: 130-311
Range on HMM: 30-204/452.0
ALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCyseeITVCGDLHGQLDDLIFIFYKNGLPSpERSYVFNGDFVDRGKDSVEILMILFAFMLV
.| | |  . .|... .|... |. | | . ... .|..     |||.||.|||  ||. .|  .| |. . .|.| ||.||||  |.|... |.|  . 
vlkehflkegrleeeaalkiieeaakllkkektlleveaP....itviGdihGqfydllklfevgGdPa.stkylflGdyvdrGyfsiecvlylyalkia

YPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKvhgKEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSK
||....| ||||| . .   . | .|.  ||.   .|.  .. . |  ||||.|.... | .|||.| .|..|. ..|..| |
ypstlfllrGnhecrhlteyftfkeeckikys...eevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfk

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 172-309 1.3e-34 112.6 In-house 33-167 (280) alignment
Range on Protein: 172-309
Range on HMM: 33-167/280.0
EEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKvhgKEILRTL
  ..||||||||  ||. .| . ..| |.. |.| ||.||||.  .|....|.|. . ||..| . |||||   .| .|||  ||...|.   ...   .
apvavcgdlhgqytdllrlfarvsfp.pdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrrys...lalynef

QDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIER
|...  |||..|.  ..| .|||.|. .  |. | .. |
qelldslplvalvsgrilcmhgglsqklvslddlaelrr

subfamily_PPP6C_pd Subfamily PPP6C 154-313 1.6e-34 112.3 In-house 28-181 (290) alignment
Range on Protein: 154-313
Range on HMM: 28-181/290.0
KKHLVQLPNINRVSTcyseEITVCGDLHGQLDDLIFIFYKNGlPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFT
.. |..  |.. ||.     .|||||.|||. ||  .| . |   |. |||| |||||||  |.| .  |... . ||..  | ||||| . .   ||| 
ldllleesnvqpvss....pvtvcgdihgqfydleelfrtgg.qvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfy

KEVMNKYKVhgKEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSKIV
.| .|||     .  . . .||  |..|..|||.|| .|||.| |.. |. .  |||.. .
declnkygn..anawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqei

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 172-298 6.8e-34 110.6 In-house 30-153 (284) alignment
Range on Protein: 172-298
Range on HMM: 30-153/284.0
EEITVCGDLHGQLDDLIFIFYKNGLPSpERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgKEILRTL
  | .|||.|||. ||. .| |||.|     |.| ||.|||||  .| ...|||. ...|. | . |||||  ..|  ||| .|.  .|.     .  ..
spinicgdihgqfsdllrlfdkngfph.ranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrrynk..psvyvsf

QDVFCWLPLATLIDEKVLILHGGVSDI
. ||  .||..|. ...| .||||| .
egvfsvmpltalvgqrilcmhggvskm

subfamily_PPP2C_pd Subfamily PPP2C 132-309 1.4e-33 109.3 In-house 8-179 (290) alignment
Range on Protein: 132-309
Range on HMM: 8-179/290.0
VEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTcyseEITVCGDLHGQLDDLIFIFyKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYP
.| ..  .||.   | .|  ..|. | .  |.. |..     .|||||.|||. ||. .| | |  ||.  |.| ||.||||  ||| . .| |. . |.
ieklkeckqleesevkelcekakeilskesnvqevkc....pvtvcgdvhgqfhdllelf.kiggkspdtnylflgdyvdrgyysvetvtllvalkvryk

KEFHLNRGNHEDHMVNLRYGFTKEVMNKYKvhGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDI-TDLELLDKIER
.   . |||||   .   |||  |.. ||     .. . . |.| .|||..|.||... ||||.|   . |. . ...|
eritilrgnhesrqitqvygfydeclrkyg..nanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldr

subfamily_PPG1_pd Subfamily PPG1 143-298 2.1e-33 108.9 In-house 16-165 (300) alignment
Range on Protein: 143-298
Range on HMM: 16-165/300.0
ARYVLNLLYETKKHLVQLPNINRVSTCyseeITVCGDLHGQLDDLIFIFyKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHE
   | .| .  |. ||.  |. .. .     .|| ||.|||. |.. || | | . |.  |.| ||.||||  ||| ...| .. | ||   .| |||||
evtvkeltdklkellvkesnvieirsp....vtvvgdvhgqfydvleif.kiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhe

DHMVNLRYGFTKEVMNKYKVHgKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDI
   .   |||  |...||      . . | ..| .| ||..|||..  .|||.|  
srqitqvygfyteclrkyggn.srvwkylteifdylvlaaiideeiycvhgglsps

PP2Ac_SM00156 433-540 1.6e-32 105.6 In-house 164-271 (271) alignment
Range on Protein: 433-540
Range on HMM: 164-271/271.0
PTQEEWRQVVDILWSDP-MAQEGCKANTiRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTP
 ...|. ...|.|||||   ..|..... || ...||.|.....|.|.|.. .||.||...|||||....|..|||||.||..  || .|..|.  .|..
kekpeegllidllwsdpeqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlkl

HIVQYQANK
.|.|....|
sieqlkeqk

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 170-309 2.3e-32 105.4 In-house 31-182 (302) alignment
Range on Protein: 170-309
Range on HMM: 31-182/302.0
YSEEITVCGDLHGQLDDLIFIFYKN----------GLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNK
 |  .|. ||.||| .||. |. ..               .  .|| ||.||||. |.| . ..||. ..||... | ||||| . .|  ||| .|. |.
ispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreelenr

Y-KVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIER
. | .|||| . ...||...|||.|. ||.| .|||.|. .. || ..||.|
lgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikr

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 170-309 2.7e-32 105.2 In-house 32-183 (302) alignment
Range on Protein: 170-309
Range on HMM: 32-183/302.0
YSEEITVCGDLHGQLDDLIFIFYKN----------GLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNK
 |  .|. ||.||| .||. |. ..               .  .|| ||.||||. |.| . ..||. ..||... | ||||| . .|  ||| .|. |.
ispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreelenr

Y-KVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIER
. | .|||| . ...||...|||.|. ||.| .|||.|. .. || ..||.|
lgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikr

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 173-307 2.9e-31 101.7 In-house 36-164 (281) alignment
Range on Protein: 173-307
Range on HMM: 36-164/281.0
EITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYkvhGKEILRTLQ
 |.| ||||.| .||. .|   | . ||. .|| ||.||||. |.|.|..||.. . |...  | |||||   || .||| .| . ||   |.|.   .|
PivvvGdlhaqfndlkrlfellgrv.peevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvtky...Geelwalfq

DVFCWLPLATLIDEKVLILHGGVSDitDLELLDKI
  |  ||...||...||..|||.|   .|  ||..
rcfnrlpisaliakrvlcmhGGlsP..eltaldel

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 174-298 1.6e-30 99.3 In-house 49-172 (307) alignment
Range on Protein: 174-298
Range on HMM: 49-172/307.0
ITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQD
  | ||||||..||| .|   | | ||  ||| ||.||||  |.|....||.. ..||..  | |||||   || .||| .|..      |.||   .| 
cvvvgdlhgqfndlinmfillgrp.petvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfqr

VFCWLPLATLIDEKVLILHGGVSDI
.|  ||...||  |.| .|||.|  
cfnnlpisaliatkilcmhgglspa

subfamily_PPZ_pd Subfamily PPZ 170-307 1.3e-29 96.7 In-house 50-181 (300) alignment
Range on Protein: 170-307
Range on HMM: 50-181/300.0
YSEEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgkEILR
 |  . . ||.|||  ||. .| | |.| |   |.| ||.|||||.|.| ...|... . ||..| | |||||   |   |||  |.  . ..   .| .
lspsvkivgdvhgqyadllrlftkcgfp.psanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfydeckrrcni...kiwk

TLQDVFCWLPLATLIDEKVLILHGGVSDItdLELLDKI
|. | |  ||||...  |.. .|||.| .  |. .|.|
tfvdtfntlplaaivagkifcvhgglspv..lnsmdei

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 173-307 2.6e-29 95.7 In-house 8-141 (263) alignment
Range on Protein: 173-307
Range on HMM: 8-141/263.0
EITVCGDLHGQLDDLIFIFYKNGLPSpERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHG--KEILRT
 | .||| ||| .||. ||   |  . .  |.| ||.||||  |.|..|.||.. |  |...|| ||||| . .|  |||  |. ....     . .   
pinicgdthgqyndllrifnacgaat.ktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynh

LQDVFCWLPLATLIDEKVLILHGGVSDitDLELLDKI
...|| ..||.... ...| .|||.|    |. || |
fnqvfsymplcaivskrilcmhggisp..hlkslddi

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 201-310 9.8e-29 93.5 In-house 101-208 (317) alignment
Range on Protein: 201-310
Range on HMM: 101-208/317.0
RSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgkEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DIT
. |.| ||.||||  |.|....|||. |.||.  .| |||||   || .||| .|| ..|..   ..  ..| .|  |||......|.| .|||.| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa...alyeafqlafnvlplcavvnkkilcmhGGiseell

DLELLDKIERS
||. |||..| 
dlkqldklkrp

subfamily_PPP5C_pd Subfamily PPP5C 439-540 3.1e-28 91.7 In-house 209-310 (322) alignment
Range on Protein: 439-540
Range on HMM: 209-310/322.0
RQVVDILWSDPMAQEGCKaNTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL-GPALTPHIVQYQ
 ..|..|||||  ..| . .. || |..||||||...|.. |.. .||||| | ||||. |. |..|.||| || .  .|.||...| |  |.... ...
gllvellwsdpqeanGrs.pskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfe

ANK
| .
ave

subfamily_PPPLV_pd Subfamily PPPLV 164-296 1.3e-24 80.0 In-house 17-151 (290) alignment
Range on Protein: 164-296
Range on HMM: 17-151/290.0
NRVSTCYSEeITVCGDLHGQLDDLIF---IFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKY
.|..   |  . | |||||.  |||.    ... |      |..| ||.||||. |||..  |.|  ..||  ..| ||||| . |   . .  | . |.
erllelksp.tyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkf

KVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVS
  . .|.  ....|| .||||. ||.||.  |.|. 
gdsleevweafnnvfdalplaavidrkvfcvhagip

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 169-307 7.8e-24 77.6 In-house 29-165 (280) alignment
Range on Protein: 169-307
Range on HMM: 29-165/280.0
CYSE-EITVCGDLHGQLDDLIFIFYKNGLpSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgkEI
| .|  | | ||.| | .|.  .|   |   ||   .| ||.|||| . .|.|..||.. . |    .| |||||   ||  |||  |.  || |    .
ceaeapikvigdihaqyqdmnrlfdligr.vpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygv...gl

LRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKI
   .| .|  .|.. || ..||..|||.|  . .|. . .|
wwdfqscfnrmpmsgliskrvlcmhgglspelinldtirni

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 201-297 5.6e-21 68.0 In-house 120-213 (339) alignment
Range on Protein: 201-297
Range on HMM: 120-213/339.0
RSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEilrTLQDVFCWLPLATLIDEKVLILHGGVSD
. |.| ||.||||  |.|....| |. | ||   .| ||||| . ||  ||| .||  .|  .  |    .|..|  .|....|.. .. .|||.|.
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlye...cfqnmfnvfpfcavinntimcmhggise

subfamily_PPP1C_pd Subfamily PPP1C 430-529 7.5e-21 67.5 In-house 169-269 (282) alignment
Range on Protein: 430-529
Range on HMM: 169-269/282.0
LRKPTQEEW-RQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPA
...|.. .    ..|.|||||  .    ..  ||    ||.|| ...|||.......|.|..  .||||  .|...|.|||.|| .   | || ...   
iqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdee

L
|
l

subfamily_PPP2C_pd Subfamily PPP2C 441-539 6.8e-20 64.4 In-house 189-286 (290) alignment
Range on Protein: 441-539
Range on HMM: 189-286/290.0
VVDILWSDPMAQEGCKAnTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQAN
..|.|||||  ..|    . || |  || |..... .. ......|.|.   |||...|.|.| ||||| ||     |..| ..|  .|. ...|... 
lcdllwsdpddrggwgi.sprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 438-541 6.2e-19 61.0 In-house 180-284 (287) alignment
Range on Protein: 438-541
Range on HMM: 180-284/287.0
WRQVVDILWSDPMA-QEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQY
   .||.||.||   ... . | ||.    ||  . ..||.| ......|.|| . |||.|  .....|.|||. |    .| || |..  .|   .|. 
eglqvdllwadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvl

QANKV
. ...
kpedf

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 429-527 8.1e-19 60.8 In-house 183-282 (298) alignment
Range on Protein: 429-527
Range on HMM: 183-282/298.0
ELRKPTQEEW-RQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGP
||..|....  . ..|.||.||  .    |.  || .. || || ..||.| .. ...|.|    .||||  ..|..||||| .| .   |  | .|.  
elkrpfdskeeslaidllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvde





subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 441-526 3.6e-17 55.5 In-house 217-302 (317) alignment
Range on Protein: 441-526
Range on HMM: 217-302/317.0
VVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLG
. |. |.|| |..   ... || |  ||..  ...|.|.......|.|.   .||||  .||..||||| .|     | .| ... 
ladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavlsvd

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 431-534 6e-17 54.8 In-house 168-272 (281) alignment
Range on Protein: 431-534
Range on HMM: 168-272/281.0
RKPTQEEWRQV-VDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPAL
 || ..  | . .|.||.||  .     ...|| .  || .| ..  .. .....||.|    .|||    ||..|.||. || .   | .| .|.  .|
pkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetl

TPHIV
  ..|
gislv

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 439-534 2.2e-16 52.7 In-house 187-284 (290) alignment
Range on Protein: 439-534
Range on HMM: 187-284/290.0
RQVVDILWSDPMA--QEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIV
  .||.||.||    ..  . |  |.    || .. ..||.|  .....|.|| | ||..|  ..|..|.|||  |    .| || ...  .|  .||
glqvdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsiv

subfamily_PPP4C_pd Subfamily PPP4C 440-532 2.8e-16 52.6 In-house 187-278 (288) alignment
Range on Protein: 440-532
Range on HMM: 187-278/288.0
QVVDILWSDPMAQEGCkANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPH
...|.|||||  .||  | . || |  || ||..|. .. ......|.|.   ||| .  |.||||..|| ||     |  | ..|  .|  .
plcdllwsdpedaegw.avsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkd

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 430-522 8.9e-16 51.0 In-house 186-278 (297) alignment
Range on Protein: 430-522
Range on HMM: 186-278/297.0
LRKPTQEEWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAY
. ..|. . | | |.||.||..      .  || || || |   .|  ....... |.|.   .||||   ||..|||||  |     |  |.
ierstegkerlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaaf

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 430-525 2e-15 49.7 In-house 165-261 (280) alignment
Range on Protein: 430-525
Range on HMM: 165-261/280.0
LRKPTQEE-WRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
||.| . |      |.||.||  .    |.. ||    || .| ..| .| ......| |.   .||||  ..|..|.||| .| .  .|  | ...
lrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavliv

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 441-522 1.4e-14 46.9 In-house 236-317 (339) alignment
Range on Protein: 441-522
Range on HMM: 236-317/339.0
VVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAY
. |. |.||   |     . ||    |||   . .|.| ..|..|| |.   .||||   |...||||| ||     |  | 
ltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaav

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 441-525 1.6e-14 47.1 In-house 185-269 (284) alignment
Range on Protein: 441-525
Range on HMM: 185-269/284.0
VVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
. |. |.|| |.    ... || |  ||..  ...|.|.......|.|.   .||||  .||..|||||  |     | .| ...
iadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnv

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 440-523 1.7e-14 47.0 In-house 175-258 (284) alignment
Range on Protein: 440-523
Range on HMM: 175-258/284.0
QVVDILWSDPMA-QEGCKANtIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYV
  .|||||||   |.| . |  ||    || |  ..||.. ......|.|.   .||||  ||...|||||  |     |  | .
laidilwsdptnfqkgwnpn.srgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavm

subfamily_PPP3C_pd Subfamily PPP3C 440-527 3.6e-14 45.4 In-house 211-311 (452) alignment
Range on Protein: 440-527
Range on HMM: 211-311/452.0
QVVDILWSDPMAQ-------EGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHN------RKVLTIFSASNYYEVGSNRGAYVKLG
 . |.|||||. .       |  . |..||  ....   . ..||| ..  .||.||.. .||.  ..        ..|.|||.|| .| .|..| .|. 
plcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkye

P
 
n

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 441-525 5.9e-14 44.9 In-house 193-286 (302) alignment
Range on Protein: 441-525
Range on HMM: 193-286/302.0
VVDILWSDPMAQEGC---------KANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
  |.|..||.  ..          . |..||    |     ... ...|.....|.|   |||. |  ..|.||||||..| .   |.|| .|.
aqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 441-525 7.3e-14 44.6 In-house 194-287 (302) alignment
Range on Protein: 441-525
Range on HMM: 194-287/302.0
VVDILWSDPMAQEGC---------KANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
  |.|..||.  ..          . |..||    |     ... ...|.....|.|   |||. |  ..|.||||||..| .   |.|| .|.
aqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv

subfamily_PPP6C_pd Subfamily PPP6C 441-525 1.3e-13 43.8 In-house 187-270 (290) alignment
Range on Protein: 441-525
Range on HMM: 187-270/290.0
VVDILWSDPMAQEGCkANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
..|..||||   |   | . || |  ||  ||.....  |.....|.|.   ||...  . |. |..|| ||     |  . ..|
fcdlvwsdpedvetw.avsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilal

subfamily_PPPLV_pd Subfamily PPPLV 444-523 1.9e-13 43.4 In-house 183-273 (290) alignment
Range on Protein: 444-523
Range on HMM: 183-273/290.0
ILWSDP------------MAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEvGSNRGAYV
||||||              .||   |  || |. |. |  ...|.. |..|..|.|| | .|... .. ..||.||.|.|   .||  | .
ilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycG.ssneaali

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 441-536 2.3e-13 43.1 In-house 196-291 (299) alignment
Range on Protein: 441-536
Range on HMM: 196-291/299.0
VVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQY
 .|.||.||        . .||    ||.|| .. ... ..... |.|.   .||||  ..|..|||||  |     |  | .|.   |   .| .
gidllwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvl

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 441-528 8.2e-13 41.4 In-house 177-264 (280) alignment
Range on Protein: 441-528
Range on HMM: 177-264/280.0
VVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPA
..|.|||||  .      .|||    ||  | .|  .  .....||.|.   .|||.   |...|.||  ||    .|  | | |   
lidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnan

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 431-536 3.1e-12 39.3 In-house 183-289 (307) alignment
Range on Protein: 431-536
Range on HMM: 183-289/307.0
RKPTQEEWRQVV-DILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPAL
 || .. .| .| |.||.||         . || |  || .| ... ..  ....||.|.   .||     ||..|||||  | ..  | |. .|.  .|
pkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetl

TPHIVQY
  ..| .
giqlvaf

EF-hand_7 EF-hand domain pair 657-721 3.6e-12 36.2 Pfam-A 2-66 (66) alignment
Range on Protein: 657-721
Range on HMM: 2-66/66.0
LETIFRIIDSDHSGFISLDEFRQTWKLFSSHMNIDITDDCICDLARSIDFNKDGHIDINEFLEAF
|...|. .|.|..|... .|...  | ..|..  . ... . .. . || |.|| .. .|||.|.
lkeaFkllDkdgdgyldkeeLlrllkhlgsplideevrevldyifkeiDkngdGvlsfeEflqai

subfamily_PPG1_pd Subfamily PPG1 441-525 1.3e-11 37.3 In-house 187-282 (300) alignment
Range on Protein: 441-525
Range on HMM: 187-282/300.0
VVDILWSDPM----------AQEG-CKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
. |.|||||            .||    .. || |  .| ||....|.. .|. .||.|.   |||.   . |. |..|| || .   |. . ..|
ladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilel

subfamily_PPZ_pd Subfamily PPZ 437-524 1.5e-10 34.1 In-house 192-279 (300) alignment
Range on Protein: 437-524
Range on HMM: 192-279/300.0
EWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVK
..  . |.|||||        .  ||    .     ...|.|. .... |.|    .||||  .| ..|.||| ||     | || . 
dfglindllwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavms

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 437-536 1.7e-10 34.0 In-house 153-253 (263) alignment
Range on Protein: 437-536
Range on HMM: 153-253/263.0
EWRQVVDILWSDPMA-QEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQ
     .|.||.||    .| . | ||     ||    ..| .. ......|.|.    || |  .|...|.|||| |     |  | | .   |   .||
thplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvq

Y
 
l

PPP5 PPP5 TPR repeat region 95-163 2.8e-10 30.5 Pfam-A 24-92 (95) alignment
Range on Protein: 95-163
Range on HMM: 24-92/95.0
QDSEMKKCsDYESIEVPDSYTGPRLS-FPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNI
. | .... |.||||. |.|.||||    .  .   .|.| |. ...|| ..| ..| ..|. | .||..
krsvaesi.diesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpsl

EF-hand_1 EF hand 657-682 3.6e-09 25.3 Pfam-A 2-27 (29) alignment
Range on Protein: 657-682
Range on HMM: 2-27/29.0
LETIFRIIDSDHSGFISLDEFRQTWK
|. .|...| |..|.||..||.. .|
lkeaFkefDkDgdGkIsfeEfkealk

EF-hand_5 EF hand 658-679 1.2e-07 20.2 Pfam-A 2-23 (25) alignment
Range on Protein: 658-679
Range on HMM: 2-23/25.0
ETIFRIIDSDHSGFISLDEFRQ
. .|| .| . .|.|| .|...
kdtFrafDkNgDGkIsreELkr

EF-hand_6 EF-hand domain 657-680 2.8e-07 19.9 Pfam-A 2-25 (31) alignment
Range on Protein: 657-680
Range on HMM: 2-25/31.0
LETIFRIIDSDHSGFISLDEFRQT
|. .|...| |..|.|...|.|. 
lreaFklfDkdgdGkidaeELrka

subfamily_YNL217W_pd Subfamily YNL217W 170-301 3.7e-07 22.9 In-house 8-142 (235) alignment
Range on Protein: 170-301
Range on HMM: 8-142/235.0
YSEEITVCGDLHGQLDDLIFIFY-KNGLPSPERSYVFNGDFVDRGKDSVEILMILfafmlvYPKEFHLNRGNHEDHMVN-LRY-----GFTKE-VMNKYK
 . .. | || ||  |.|| ..  |.|   ..   |. ||....| .|||..  .        .. .  .||||  ..  ...     |...    .|..
lgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfs

VHGKEILRTLQDVFCWLPLA-TLIDEKVLILHGGVSDITDL
.  ... .   .    |. .  .  ...|..|.|..    |
flesklskadmeyarelgfsldipsdellvvhaGlvpgkfl

EF-hand_8 EF-hand domain pair 654-682 4.8e-07 18.6 Pfam-A 24-52 (54) alignment
Range on Protein: 654-682
Range on HMM: 24-52/54.0
RSNLETIFRIIDSDHSGFISLDEFRQTWK
 . ....|| .| |..| ||..|| . ..
eeevdilfrefDtdgdGkisfeEFcvlle

EF-hand_1 EF hand 702-722 9.4e-07 17.7 Pfam-A 7-27 (29) alignment
Range on Protein: 702-722
Range on HMM: 7-27/29.0
RSIDFNKDGHIDINEFLEAFR
. .| ..||.|. .||.||..
kefDkDgdGkIsfeEfkealk

IQ IQ calmodulin-binding motif 21-39 3.4e-06 16.0 Pfam-A 2-20 (21) alignment
Range on Protein: 21-39
Range on HMM: 2-20/21.0
KAAALIQRWYRRYVARLEM
||| .||...|.|.|| . 
kaaikIQaawRgylaRkry

EF-hand_5 EF hand 703-718 4.6e-06 15.2 Pfam-A 7-22 (25) alignment
Range on Protein: 703-718
Range on HMM: 7-22/25.0
SIDFNKDGHIDINEFL
 .|.|.|| |.. |. 
afDkNgDGkIsreELk