Gene PPEF2 in Homo sapiens

Synonym: PPP7CB, PPEF2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP7C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP145_AA protein Get Run
HsapP145_AA_99-586 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP7C_pd Subfamily PPP7C 109-586 2.6e-213 700.8 In-house 1-382 (383) alignment 
Range on Protein: 109-586
Range on HMM: 1-382/383.0
EVPDSYTGPRLSFPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGD
||.|||||||||.|| .|....|.|||..|..|||.|||..|.|.||.|.|||||.||||..|.|.||||||||.||||..|.|||||||.|..||||||
evedsytgprlslpltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIE
||||||.|||||.||.|..||||||..|||||||||..||||||.|||..|||||||.|||.|.|||.|||||||||||.||.|||.||.||||||||||
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktdlelldkie

RSKIVSTMRcktrqksekqmeekrranqkssaqgpipwflpesrslpsSPLRLGSyKAQKTSRSSSIPCSgsldgrelsrqvrssvelelercrqqagll
|||.||..|                                       .||. |. .|.|....||....                              
rsklvsvlr.......................................pplkege.eaekekeessvkvd..............................

vtgekeepsrsaseadseagelrkptQEEWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFS
                          .||||||.|||||||.|.||||.||.||||.|||||||..||||||...||||||||||||||.|..|||||||
..........................keewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifs

ASNYYEVGSNRGAYVKLGPALTPHIVQYQANKVTHTLTMRQRISRVEESALRALREKLFAHSSDLLSEFKKHDADKVG
||||||.|||||||||||..|||.||||||.|.|..||.|||.|.|||||||.|||||.|..||||.||||.|..|.|
asnyyeeGsnrGayvklgkdltprivqyqaskatkkltlrqrvsiveesalrelrekllakksdlleefkkkdekksg
PPP_1 146-525 2.7e-125 410.0 In-house 2-264 (264) alignment 
Range on Protein: 146-525
Range on HMM: 2-264/264.0
VLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLiFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHM
... |.|.||.|..|.|........|||||||||.|||.||| ....|.|.||||..|.|.||.|||||||||||..|.|..|.||||..|.|||||...
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrq

VNLRYGFTKEVMnkYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSEKQmeekrranqkssaqgpip
|. .|||.|||.  .|...|||..||.|||..||||.|||||.||.|||.|...||.. ...||.|.......|.....||.                  
vtkvygFkkEvl..kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekd..................

wflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqeewrqvVDIL
                                                                                                ||||
................................................................................................vdil

WSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
.||...||...||.|||.|..||.|||...|||.|....||.||.|.|||||...|||.||||||||||.||||||||||
lsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PPP_3 145-537 5.5e-115 376.0 In-house 2-270 (271) alignment 
Range on Protein: 145-537
Range on HMM: 2-270/271.0
YVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLiFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDH
.. | |.|..|.| .... .......|...|||||.||||||| ....|||.||||..|.|.||.|||||.|.|.|..|.|....||||.||.|||||..
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsr

MVNLRYGFTKEVMnkYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSekqmeekrranqkssaqgpi
..| .|||.|||.  .|..||.....||.||..||||.|||||||..|||.|. ....  .| ...||......|.....                    
qinkvYgFkkevl..kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll....................

pwflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqeewrqvvdi
                                                                                                    
....................................................................................................

lWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQ
 .|.....|....|. || |..||||||...|.|......||.||.|.||||..|..||.|.|||.||.| .||.||..||..|||....|..
.lssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
0045823 Metallo-dependent phosphatases 100-586 8.2e-97 317.7 In-house 2-368 (473) alignment 
Range on Protein: 100-586
Range on HMM: 2-368/473.0
KKCSDYESIEVPDSYTGPRLSFPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTcyseEITVCGDLHGQLDDLIFIFYKNGLPSP
... ..  | |....|.|.|...| . . ..|.| ..  ..|.....|.||.|.|..| . ||. ..|      |.|.||.|||||||. .. |.|.|..
drvlklvlipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe

eRSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYkvhGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDI-
 . .||.||.|||| ||.|.| .|.|... ||. ..| |||||....|  ||| .|.. ||   | .. . .......|||| .|..|.|. |||.|.  
.drlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetleky...gedlyeeflewlrslPlaaviggkilfvHGGlspdl

TDLELLDKIERSKIVSTmrcktrqksekqmeekrranqkssaqgpipwflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelel
. |. ...|||   ...                                                                                   
plldqireierpleipd...................................................................................

ercrqqagllvtgekeepsrsaseadseagelrkptqeeWRQVVDILWSDPMAQEGC-------KANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECK
                                       .....|.|||||. ..|.         |. || |..||||.....|.|.......|.|.. 
.......................................dgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthv

PEGYEFCHNRK------VLTIFSASNYYEVGSNRGAYVKLGPALtPHIVQYQANKVTHTLTMRQRISRVeesALRALREKLFAHSSDLLSEFKKHDADKV
|||||.....|      ..|.|||.||. .| |..|...... | ....|... .... |.. ...  .   .|..|.|||. . . ||. ..... .. 
peGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphplilplfldvfll...slpfllekltellllllnivsddelled

G
.
e
PPP_5_Dcr2 174-491 9.3e-90 292.9 In-house 1-199 (199) alignment 
Range on Protein: 174-491
Range on HMM: 1-199/199.0
ITVCGDLHGQLDDLIFIFYKNG-LPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYkvHGKEILRTLQ
.|||||||||||||..|..|.| .||.||.|||.||.|||||||.|.|..|.|..||||||.||.||||||...|..|||||||..||  |||.|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky..hgkkiykils

DVFCWLPLATLIDEKVLILHGGVSDITDL-ELLDKIERsKIVStmrcktrQKsekqmEEKRRANQKssaqgpipwflpesrslpssplrlgsykaqktsr
|||.|||||.|||||||..|||.|..... |||.|||| ||..       ..     |....|...                                  
dvfdwlPlaalidekvlvvhgglspeiksiellekier.kiei.......pe.....ekgekadll..................................

sssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqeewrqvvdiLWSDPM-AQEGCKANTIRGGGCYFGPD
                                                                         |||||. ||||||.|..||.|..||||
.........................................................................lwsdprdaqegcklnseRGagllfgpd

VTQQLLQKYNMQFLIRSHECK
||...|.|.|....|||||.|
vtekfleknnlkliirshelk
PPP_2 174-491 2.6e-88 287.9 In-house 1-198 (198) alignment 
Range on Protein: 174-491
Range on HMM: 1-198/198.0
ITVCGDLHGQLDDLiFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMnkYKVHGKEILRTLQD
.||||||||||||| .|..|||||||||.|.|.||.|||||.|.|.|..|.|..||||||.||.|||||...|| .|||.|||.  .|..||.....||.
vtvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl..kkkggkkvykklqe

VFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSekQ--Meekrranqkssaqgpipwflpesrslpssplrlgsykaqktsr
||..||||.|||||||..|||.|. ..|.  .| |..||.|....|.....  .                                              
vfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll..eeek...........................................

sssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqeewrqvvdilWSDPMAQEGCKANTIRGGGCYFGPDV
                                                                          .|||...|...||. ||.|..|||||
..........................................................................lsdpkekeellansarGagllfgpdv

TQQLLQKYNMQFLIRSHECK
|..||.|......||.||.|
teelleknklkliiRaHevk
PPP_4 174-491 1.2e-86 282.8 In-house 1-197 (197) alignment 
Range on Protein: 174-491
Range on HMM: 1-197/197.0
ITVCGDLHGQLDDLIFIFYKNG-LPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKykvHGKEILRTLQ
.||.||.|||||||.....||| |||.||||||.||.|||||||.|.|..|.|..||||||..|.|||||....||.|||.|||..|   ||||||..||
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek...hgkeilkklq

DVFCWLPLATLIDEKVLILHGGVSDITDLelLDKIERS--KIVStmrcktrqkseKQMEEKRRANQkssaqgpipwflpesrslpssplrlgsykaqkts
|||..||||.|||||||..|||.||...   ||||||.  ||.|           ...||||....                                  
dvfdllplaalidekvlvvhgglsdeles..ldkierierkies...........pleeekrkdll..................................

rsssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqeewrqvvdiLWSDPM-AQEGcKANTIRGGGCYFGP
                                                                          |||||. |||| .||..||.|..|||
..........................................................................lwsdpreaqeg.lansvrGagllFgp

DVTQQLLQKYNMQFLIRSHECK
|||...|.|.|....|||||.|
dvtekfleknnlkliirshelk
0049330 Metallo-dependent phosphatases 114-542 1.4e-77 253.9 In-house 3-302 (309) alignment 
Range on Protein: 114-542
Range on HMM: 3-302/309.0
YTGPRLSFPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGLPSPeRSYVFNGDFVDRG
...|.| ..|. .. ..|.| ..  ..|. ...|.||...|..| . ||. ..|      |.|.||.|||||||. .. |.|.|.. . .||.||.||||
lldpllllelilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrG

KDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYkvhGKEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSKI
 ||.|.| .|.|..| ||. ..| |||||....|  ||| .|.. ||   | |. . ..|....|||| .|..|.|. |||.| |.. |. ....||   
pdslevlllllalkllypdnvfllrGNHElrllnglygfgdetlrky...gaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerple

VSTMRcktrqksekqmeekrranqkssaqgpipwflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelelercrqqagllvtge
.   .                                                                                               
ipldg...............................................................................................

keepsrsaseadseagelrkptqeewrQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNY
                            ..|.|||||.      |. .|| |..||.......|.|......||.|.. ..||......|..|.|||.||
...........................llcdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapny

YEVGSNRGAYVKLGPALTPHIVQYQANKVT
... .|.||...... |......... ...
cgrlgnlgavleidedlvisfllfepvpll
0053225 Metallo-dependent phosphatases 127-538 2e-72 237.1 In-house 8-290 (293) alignment 
Range on Protein: 127-538
Range on HMM: 8-290/293.0
HATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGLPSPeRSYVFNGDFVDRGKDSVEILMILFAF
. ..|.| ..| ..|.. ..| ||.|.|..|.. ||. ..|      |.|.||.||.||||. .. | |.|.. . .||.||.|||| ||.|.| .|.|.
lldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlelllal

MLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYkvHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSKIVStmrcktrqkse
 |.||. ..| |||||....|  ||| .|.. ||  ...|. . |.|....|||| ||..|.|. |||.| |.. |. ...|.|   .            
kllypdnvvllrGNHElmllnglygfgdetlrky..gaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplrip...........

kqmeekrranqkssaqgpipwflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseads
                                                                                                    
....................................................................................................

eagelrkptqeEWRQVVDILWSDPMAQEGCKANtIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
           ... . |.|||||.  .|.  . .|| |..||.......|.|......||.|.. |.||......|..|.|||.||... .|.||...|
...........legllldllwsdpdlwsgwlps.yrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlal

GPALTPHIVQYQA
.. |....... .
deglvwgfklfap
subfamily_PPP5C_pd Subfamily PPP5C 110-310 5.7e-60 196.0 In-house 2-202 (322) alignment 
Range on Protein: 110-310
Range on HMM: 2-202/322.0
VPDSYTGPRLSF-PLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGD
| |||.||.|    .  .  . |.| |. ...|| .|.|..| |.|. | .|| .  ...  ....|||||.|||  ||. || .|||||.|..|.||||
vedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGd

FVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKvhgKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITD--LELLDK
|||||  |||....|..| |.||..|.|.||||| . .|  |||. || .||.   ....  ...||.|||||..|.||||..|||. .  .  |. | |
fvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakyt...ekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrk

IERS
|.| 
idrn
PP2Ac_SM00156 142-318 1.3e-57 187.9 In-house 2-163 (271) alignment 
Range on Protein: 142-318
Range on HMM: 2-163/271.0
HARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGlPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNH
.. .||.|| |.|. | | .|. .||    ...||.||.|||||||. .. ..| ..||  |||.||.||||. |.|....|||. ..||....|.||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

EDHMVNLRYGFTKEVMNKYkvhGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIERskivstmrC
|. .||  |||..||..||   ||||.  ....| .||||.|.|.|.|..|||.|  .. |. ..|..|         
Esssvnkiygfeeevkrky...gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr........v
subfamily_PPP1C_pd Subfamily PPP1C 139-313 2.1e-46 151.4 In-house 8-175 (282) alignment 
Range on Protein: 139-313
Range on HMM: 8-175/282.0
QQLHARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNR
 .|. . . .|| .... |.. | . ...    . ....||.|||. ||. .| ..| | ||..|.| ||.||||| |.|....|.|. . ||....| |
vklkeaeieallkkareillsqpillele....aPvkivgdihGqyadllrlfetsgaP.pesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHEDHMVNLRYGFTKEVMNKYKVHgkeILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSKIV
||||.  .|  |||  |. ..|...   . .|..||| .||||.|.|||.| .|||.| ....|| ..||.|   |
GnhesasinriyGfydeckrrysik...lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlev
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 134-311 8.6e-43 139.5 In-house 17-188 (298) alignment 
Range on Protein: 134-311
Range on HMM: 17-188/298.0
AFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTcyseEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKE
. .| .... . | .|. ..|| . . . .  | .     |.||||.|||  ||. .| |.| | |.  |.| ||.||||. ..|....|.|. . ||..
ekkltkvikeedveklielakkifkkqkslvevda....pikvcGdihGqysdllrlfdkagfp.pdanylflGdyvdrGrqnlevivlllaykvkypnn

FHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGkeILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIERSK
| | ||||| ...|  ||| .|. ..||     .  ..|||| .|||..|| ...| .|||.|. .. |. | ...|..
ffllrGnheceainrvyGfyeeckrrykslr..lyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpf
Metallophos Calcineurin-like phosphoesterase 174-492 8.3e-42 136.7 Pfam-A 3-200 (200) alignment 
Range on Protein: 174-492
Range on HMM: 3-200/200.0
ITVCGDLHGQLDDL---IFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMIL--FAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMN----------
|.|.|||||.||||     |..|.. ...   ..|.||.||||..| |.|..|  .. .| .|. ..|.|||||....| .|||..|. .          
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

---------------------KYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDkierskivstmrcktrqksekqmeekrranqk
                     .|. .|... .  ...|..|||..|.| |.|. ||..|. .....                                  
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ssaqgpipwflpesrslpssplrlgsykaqktsrsssipcsgsldgrelsrqvrssvelelercrqqagllvtgekeepsrsaseadseagelrkptqee
                                                                                                    
....................................................................................................

wrqvvdilwsdpmaqegckantirgGGCYFGPDVTQQLLQKYNMQFLIRSHECKP
                         |...||||..  ||.||... ..|.|..||
.........................gselfgpdalekllekygvdlvlrGHtHkp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 142-306 6.2e-39 126.6 In-house 11-168 (287) alignment 
Range on Protein: 142-306
Range on HMM: 11-168/287.0
HARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNH
  . .|..| .... |  || . .|     . ||..||.|||||||. || . | . |.  |.| ||.|||| .|.|. ..||.. . |||. || ||||
sdkdilevlekieeileplpalleve....apitivGdihGqlddllrifnavGaa.pkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnh

EDHMVNLRYGFTKEVMNKYKvhgKEILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDK
| . .|  ||| .|...|..   ... .. .|||  ||| . .....| .|||.|. .  |. |  
evkkinklyGfkeelkrkrq...erlykqfndvfselplcarvskrilcmhGGispklksldslka
subfamily_PPP4C_pd Subfamily PPP4C 132-312 5.5e-37 120.5 In-house 7-181 (288) alignment 
Range on Protein: 132-312
Range on HMM: 7-181/288.0
VEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCyseeITVCGDLHGQLDDLIFIFYKNGlPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYP
.|  |  . .. . | .|  .... ||.  |..|| .     .|||||.|||. ||. .|  .|   ||..|.| |||||||. ||| ...| |. . ||
ieklrrcelikeeevkalcakareilveesnvqrvdsp....vtvcgdihgqfydllelfkvgg.dvpetnylflgdfvdrgfysvetfllllalkvryp

KEFHLNRGNHEDHMVNLRYGFTKEVMNKYKvhGKEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSKI
.  .| |||||   .   ||| .|...||     .. |   .|| .|.||..||.|....|||.| .|. |. .  |.| . 
dritlirgnhesrqitqvygfydeclrkyg..sanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqe
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 173-310 3.4e-36 118.1 In-house 51-189 (297) alignment 
Range on Protein: 173-310
Range on HMM: 51-189/297.0
EITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgKEILRTLQ
 | ||||.|||. ||. .|.. | | |   |.| ||.||||. |.| ...|.|. . .| .. | |||||  .||  ||| .|. ..|.     .  ..|
pikvcgdihgqfpdllrlfhrggwp.ptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqkryqs..vrmyaafq

DVFCWLPLATLIDEKVLILHGGVSDIT----DLELLDKIERS
||| ||||. || .|.| .|||.| .      |. | |||||
dvfnwlpltgliatkilcmhgglsplltkeftldtlrkiers
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 170-311 1.3e-35 116.2 In-house 33-177 (284) alignment 
Range on Protein: 170-311
Range on HMM: 33-177/284.0
YSEEITVCGDLHGQLDDLIFIFYKNGLP-----SPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhg
    ....||.||| .||. ..  || |     . |. |.| ||.||||  |.|....|||. |..|.   | |||||   || .||| .|  ..| .  
ieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkryse..

kEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSK
  .  ..|  |  .||......|.. .|||.| |. ||. |||.||  
.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpi
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 172-309 2.9e-35 115.0 In-house 51-186 (299) alignment 
Range on Protein: 172-309
Range on HMM: 51-186/299.0
EEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgKEILRTL
  | ||||.|||  ||. || |.|.| |.  ..| ||.||||.. .|....|..| . ||..|.. |||||   .|  ||| .|. ..||     .   .
apiivcgdihgqysdllrifdkagfp.pdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkryks..trlwsif

QDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIER
|| | ..||. ||  ..| .|||.|  ...|. | .. |
qdafaampltgligsrilcmhgglspklqtldqlrdltr
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 141-302 4.7e-35 114.0 In-house 16-170 (290) alignment 
Range on Protein: 141-302
Range on HMM: 16-170/290.0
LHARYVLNLLYETKKHLVQLPNINRVStcysEEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGN
.  . .|..| . .. |  || . .|     . |.. ||.|||||.|.  | . | | |.  ..| ||.|||| .|.|. ..|| . . |.|. || |||
fsdkdileilekieeileplpalleve....apivivgdihgqldallryfdavgyp.pkvkflflgdyvdrgakslevslllfcykiryskkvhllrgn

HEDHMVNLRYGFTKEVMNKykvHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLE
||   ||  ||| .|.. |    | .. .  ||||  |.| . ...|.| .|||.|. |   |
hevrkvnrlygfkeelark...rgsrlwkqyqdvfaelslcarvgrkilcmhggisqkieswe
subfamily_PPP3C_pd Subfamily PPP3C 130-311 9.2e-35 113.3 In-house 30-204 (452) alignment 
Range on Protein: 130-311
Range on HMM: 30-204/452.0
ALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCyseeITVCGDLHGQLDDLIFIFYKNGLPSpERSYVFNGDFVDRGKDSVEILMILFAFMLV
.| | |  . .|... .|... |. | | . ... .|..     |||.||.|||  ||. .|  .| |. . .|.| ||.||||  |.|... |.|  . 
vlkehflkegrleeeaalkiieeaakllkkektlleveaP....itviGdihGqfydllklfevgGdPa.stkylflGdyvdrGyfsiecvlylyalkia

YPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKvhgKEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSK
||....| ||||| . .   . | .|.  ||.   .|.  .. . |  ||||.|.... | .|||.| .|..|. ..|..| |
ypstlfllrGnhecrhlteyftfkeeckikys...eevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 172-309 1.3e-34 112.6 In-house 33-167 (280) alignment 
Range on Protein: 172-309
Range on HMM: 33-167/280.0
EEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKvhgKEILRTL
  ..||||||||  ||. .| . ..| |.. |.| ||.||||.  .|....|.|. . ||..| . |||||   .| .|||  ||...|.   ...   .
apvavcgdlhgqytdllrlfarvsfp.pdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrrys...lalynef

QDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIER
|...  |||..|.  ..| .|||.|. .  |. | .. |
qelldslplvalvsgrilcmhgglsqklvslddlaelrr
subfamily_PPP6C_pd Subfamily PPP6C 154-313 1.6e-34 112.3 In-house 28-181 (290) alignment 
Range on Protein: 154-313
Range on HMM: 28-181/290.0
KKHLVQLPNINRVSTcyseEITVCGDLHGQLDDLIFIFYKNGlPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFT
.. |..  |.. ||.     .|||||.|||. ||  .| . |   |. |||| |||||||  |.| .  |... . ||..  | ||||| . .   ||| 
ldllleesnvqpvss....pvtvcgdihgqfydleelfrtgg.qvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfy

KEVMNKYKVhgKEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DITDLELLDKIERSKIV
.| .|||     .  . . .||  |..|..|||.|| .|||.| |.. |. .  |||.. .
declnkygn..anawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqei
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 172-298 6.8e-34 110.6 In-house 30-153 (284) alignment 
Range on Protein: 172-298
Range on HMM: 30-153/284.0
EEITVCGDLHGQLDDLIFIFYKNGLPSpERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgKEILRTL
  | .|||.|||. ||. .| |||.|     |.| ||.|||||  .| ...|||. ...|. | . |||||  ..|  ||| .|.  .|.     .  ..
spinicgdihgqfsdllrlfdkngfph.ranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrrynk..psvyvsf

QDVFCWLPLATLIDEKVLILHGGVSDI
. ||  .||..|. ...| .||||| .
egvfsvmpltalvgqrilcmhggvskm
subfamily_PPP2C_pd Subfamily PPP2C 132-309 1.4e-33 109.3 In-house 8-179 (290) alignment 
Range on Protein: 132-309
Range on HMM: 8-179/290.0
VEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTcyseEITVCGDLHGQLDDLIFIFyKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYP
.| ..  .||.   | .|  ..|. | .  |.. |..     .|||||.|||. ||. .| | |  ||.  |.| ||.||||  ||| . .| |. . |.
ieklkeckqleesevkelcekakeilskesnvqevkc....pvtvcgdvhgqfhdllelf.kiggkspdtnylflgdyvdrgyysvetvtllvalkvryk

KEFHLNRGNHEDHMVNLRYGFTKEVMNKYKvhGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDI-TDLELLDKIER
.   . |||||   .   |||  |.. ||     .. . . |.| .|||..|.||... ||||.|   . |. . ...|
eritilrgnhesrqitqvygfydeclrkyg..nanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldr
subfamily_PPG1_pd Subfamily PPG1 143-298 2.1e-33 108.9 In-house 16-165 (300) alignment 
Range on Protein: 143-298
Range on HMM: 16-165/300.0
ARYVLNLLYETKKHLVQLPNINRVSTCyseeITVCGDLHGQLDDLIFIFyKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHE
   | .| .  |. ||.  |. .. .     .|| ||.|||. |.. || | | . |.  |.| ||.||||  ||| ...| .. | ||   .| |||||
evtvkeltdklkellvkesnvieirsp....vtvvgdvhgqfydvleif.kiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhe

DHMVNLRYGFTKEVMNKYKVHgKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDI
   .   |||  |...||      . . | ..| .| ||..|||..  .|||.|  
srqitqvygfyteclrkyggn.srvwkylteifdylvlaaiideeiycvhgglsps
PP2Ac_SM00156 433-540 1.6e-32 105.6 In-house 164-271 (271) alignment 
Range on Protein: 433-540
Range on HMM: 164-271/271.0
PTQEEWRQVVDILWSDP-MAQEGCKANTiRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTP
 ...|. ...|.|||||   ..|..... || ...||.|.....|.|.|.. .||.||...|||||....|..|||||.||..  || .|..|.  .|..
kekpeegllidllwsdpeqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlkl

HIVQYQANK
.|.|....|
sieqlkeqk
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 170-309 2.3e-32 105.4 In-house 31-182 (302) alignment 
Range on Protein: 170-309
Range on HMM: 31-182/302.0
YSEEITVCGDLHGQLDDLIFIFYKN----------GLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNK
 |  .|. ||.||| .||. |. ..               .  .|| ||.||||. |.| . ..||. ..||... | ||||| . .|  ||| .|. |.
ispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreelenr

Y-KVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIER
. | .|||| . ...||...|||.|. ||.| .|||.|. .. || ..||.|
lgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikr
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 170-309 2.7e-32 105.2 In-house 32-183 (302) alignment 
Range on Protein: 170-309
Range on HMM: 32-183/302.0
YSEEITVCGDLHGQLDDLIFIFYKN----------GLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNK
 |  .|. ||.||| .||. |. ..               .  .|| ||.||||. |.| . ..||. ..||... | ||||| . .|  ||| .|. |.
ispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreelenr

Y-KVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKIER
. | .|||| . ...||...|||.|. ||.| .|||.|. .. || ..||.|
lgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikr
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 173-307 2.9e-31 101.7 In-house 36-164 (281) alignment 
Range on Protein: 173-307
Range on HMM: 36-164/281.0
EITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYkvhGKEILRTLQ
 |.| ||||.| .||. .|   | . ||. .|| ||.||||. |.|.|..||.. . |...  | |||||   || .||| .| . ||   |.|.   .|
PivvvGdlhaqfndlkrlfellgrv.peevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvtky...Geelwalfq

DVFCWLPLATLIDEKVLILHGGVSDitDLELLDKI
  |  ||...||...||..|||.|   .|  ||..
rcfnrlpisaliakrvlcmhGGlsP..eltaldel
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 174-298 1.6e-30 99.3 In-house 49-172 (307) alignment 
Range on Protein: 174-298
Range on HMM: 49-172/307.0
ITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQD
  | ||||||..||| .|   | | ||  ||| ||.||||  |.|....||.. ..||..  | |||||   || .||| .|..      |.||   .| 
cvvvgdlhgqfndlinmfillgrp.petvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfqr

VFCWLPLATLIDEKVLILHGGVSDI
.|  ||...||  |.| .|||.|  
cfnnlpisaliatkilcmhgglspa
subfamily_PPZ_pd Subfamily PPZ 170-307 1.3e-29 96.7 In-house 50-181 (300) alignment 
Range on Protein: 170-307
Range on HMM: 50-181/300.0
YSEEITVCGDLHGQLDDLIFIFYKNGLPsPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgkEILR
 |  . . ||.|||  ||. .| | |.| |   |.| ||.|||||.|.| ...|... . ||..| | |||||   |   |||  |.  . ..   .| .
lspsvkivgdvhgqyadllrlftkcgfp.psanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfydeckrrcni...kiwk

TLQDVFCWLPLATLIDEKVLILHGGVSDItdLELLDKI
|. | |  ||||...  |.. .|||.| .  |. .|.|
tfvdtfntlplaaivagkifcvhgglspv..lnsmdei
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 173-307 2.6e-29 95.7 In-house 8-141 (263) alignment 
Range on Protein: 173-307
Range on HMM: 8-141/263.0
EITVCGDLHGQLDDLIFIFYKNGLPSpERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHG--KEILRT
 | .||| ||| .||. ||   |  . .  |.| ||.||||  |.|..|.||.. |  |...|| ||||| . .|  |||  |. ....     . .   
pinicgdthgqyndllrifnacgaat.ktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynh

LQDVFCWLPLATLIDEKVLILHGGVSDitDLELLDKI
...|| ..||.... ...| .|||.|    |. || |
fnqvfsymplcaivskrilcmhggisp..hlkslddi
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 201-310 9.8e-29 93.5 In-house 101-208 (317) alignment 
Range on Protein: 201-310
Range on HMM: 101-208/317.0
RSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgkEILRTLQDVFCWLPLATLIDEKVLILHGGVS-DIT
. |.| ||.||||  |.|....|||. |.||.  .| |||||   || .||| .|| ..|..   ..  ..| .|  |||......|.| .|||.| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa...alyeafqlafnvlplcavvnkkilcmhGGiseell

DLELLDKIERS
||. |||..| 
dlkqldklkrp
subfamily_PPP5C_pd Subfamily PPP5C 439-540 3.1e-28 91.7 In-house 209-310 (322) alignment 
Range on Protein: 439-540
Range on HMM: 209-310/322.0
RQVVDILWSDPMAQEGCKaNTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL-GPALTPHIVQYQ
 ..|..|||||  ..| . .. || |..||||||...|.. |.. .||||| | ||||. |. |..|.||| || .  .|.||...| |  |.... ...
gllvellwsdpqeanGrs.pskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfe

ANK
| .
ave
subfamily_PPPLV_pd Subfamily PPPLV 164-296 1.3e-24 80.0 In-house 17-151 (290) alignment 
Range on Protein: 164-296
Range on HMM: 17-151/290.0
NRVSTCYSEeITVCGDLHGQLDDLIF---IFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKY
.|..   |  . | |||||.  |||.    ... |      |..| ||.||||. |||..  |.|  ..||  ..| ||||| . |   . .  | . |.
erllelksp.tyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkf

KVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVS
  . .|.  ....|| .||||. ||.||.  |.|. 
gdsleevweafnnvfdalplaavidrkvfcvhagip
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 169-307 7.8e-24 77.6 In-house 29-165 (280) alignment 
Range on Protein: 169-307
Range on HMM: 29-165/280.0
CYSE-EITVCGDLHGQLDDLIFIFYKNGLpSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVhgkEI
| .|  | | ||.| | .|.  .|   |   ||   .| ||.|||| . .|.|..||.. . |    .| |||||   ||  |||  |.  || |    .
ceaeapikvigdihaqyqdmnrlfdligr.vpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygv...gl

LRTLQDVFCWLPLATLIDEKVLILHGGVSD-ITDLELLDKI
   .| .|  .|.. || ..||..|||.|  . .|. . .|
wwdfqscfnrmpmsgliskrvlcmhgglspelinldtirni
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 201-297 5.6e-21 68.0 In-house 120-213 (339) alignment 
Range on Protein: 201-297
Range on HMM: 120-213/339.0
RSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEilrTLQDVFCWLPLATLIDEKVLILHGGVSD
. |.| ||.||||  |.|....| |. | ||   .| ||||| . ||  ||| .||  .|  .  |    .|..|  .|....|.. .. .|||.|.
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlye...cfqnmfnvfpfcavinntimcmhggise
subfamily_PPP1C_pd Subfamily PPP1C 430-529 7.5e-21 67.5 In-house 169-269 (282) alignment 
Range on Protein: 430-529
Range on HMM: 169-269/282.0
LRKPTQEEW-RQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPA
...|.. .    ..|.|||||  .    ..  ||    ||.|| ...|||.......|.|..  .||||  .|...|.|||.|| .   | || ...   
iqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdee

L
|
l
subfamily_PPP2C_pd Subfamily PPP2C 441-539 6.8e-20 64.4 In-house 189-286 (290) alignment 
Range on Protein: 441-539
Range on HMM: 189-286/290.0
VVDILWSDPMAQEGCKAnTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQAN
..|.|||||  ..|    . || |  || |..... .. ......|.|.   |||...|.|.| ||||| ||     |..| ..|  .|. ...|... 
lcdllwsdpddrggwgi.sprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 438-541 6.2e-19 61.0 In-house 180-284 (287) alignment 
Range on Protein: 438-541
Range on HMM: 180-284/287.0
WRQVVDILWSDPMA-QEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQY
   .||.||.||   ... . | ||.    ||  . ..||.| ......|.|| . |||.|  .....|.|||. |    .| || |..  .|   .|. 
eglqvdllwadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvl

QANKV
. ...
kpedf
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 429-527 8.1e-19 60.8 In-house 183-282 (298) alignment 
Range on Protein: 429-527
Range on HMM: 183-282/298.0
ELRKPTQEEW-RQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGP
||..|....  . ..|.||.||  .    |.  || .. || || ..||.| .. ...|.|    .||||  ..|..||||| .| .   |  | .|.  
elkrpfdskeeslaidllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvde
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 441-526 3.6e-17 55.5 In-house 217-302 (317) alignment 
Range on Protein: 441-526
Range on HMM: 217-302/317.0
VVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLG
. |. |.|| |..   ... || |  ||..  ...|.|.......|.|.   .||||  .||..||||| .|     | .| ... 
ladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavlsvd
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 431-534 6e-17 54.8 In-house 168-272 (281) alignment 
Range on Protein: 431-534
Range on HMM: 168-272/281.0
RKPTQEEWRQV-VDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPAL
 || ..  | . .|.||.||  .     ...|| .  || .| ..  .. .....||.|    .|||    ||..|.||. || .   | .| .|.  .|
pkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetl

TPHIV
  ..|
gislv
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 439-534 2.2e-16 52.7 In-house 187-284 (290) alignment 
Range on Protein: 439-534
Range on HMM: 187-284/290.0
RQVVDILWSDPMA--QEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIV
  .||.||.||    ..  . |  |.    || .. ..||.|  .....|.|| | ||..|  ..|..|.|||  |    .| || ...  .|  .||
glqvdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsiv
subfamily_PPP4C_pd Subfamily PPP4C 440-532 2.8e-16 52.6 In-house 187-278 (288) alignment 
Range on Protein: 440-532
Range on HMM: 187-278/288.0
QVVDILWSDPMAQEGCkANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPH
...|.|||||  .||  | . || |  || ||..|. .. ......|.|.   ||| .  |.||||..|| ||     |  | ..|  .|  .
plcdllwsdpedaegw.avsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkd
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 430-522 8.9e-16 51.0 In-house 186-278 (297) alignment 
Range on Protein: 430-522
Range on HMM: 186-278/297.0
LRKPTQEEWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAY
. ..|. . | | |.||.||..      .  || || || |   .|  ....... |.|.   .||||   ||..|||||  |     |  |.
ierstegkerlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaaf
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 430-525 2e-15 49.7 In-house 165-261 (280) alignment 
Range on Protein: 430-525
Range on HMM: 165-261/280.0
LRKPTQEE-WRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
||.| . |      |.||.||  .    |.. ||    || .| ..| .| ......| |.   .||||  ..|..|.||| .| .  .|  | ...
lrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavliv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 441-522 1.4e-14 46.9 In-house 236-317 (339) alignment 
Range on Protein: 441-522
Range on HMM: 236-317/339.0
VVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAY
. |. |.||   |     . ||    |||   . .|.| ..|..|| |.   .||||   |...||||| ||     |  | 
ltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaav
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 441-525 1.6e-14 47.1 In-house 185-269 (284) alignment 
Range on Protein: 441-525
Range on HMM: 185-269/284.0
VVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
. |. |.|| |.    ... || |  ||..  ...|.|.......|.|.   .||||  .||..|||||  |     | .| ...
iadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 440-523 1.7e-14 47.0 In-house 175-258 (284) alignment 
Range on Protein: 440-523
Range on HMM: 175-258/284.0
QVVDILWSDPMA-QEGCKANtIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYV
  .|||||||   |.| . |  ||    || |  ..||.. ......|.|.   .||||  ||...|||||  |     |  | .
laidilwsdptnfqkgwnpn.srgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavm
subfamily_PPP3C_pd Subfamily PPP3C 440-527 3.6e-14 45.4 In-house 211-311 (452) alignment 
Range on Protein: 440-527
Range on HMM: 211-311/452.0
QVVDILWSDPMAQ-------EGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHN------RKVLTIFSASNYYEVGSNRGAYVKLG
 . |.|||||. .       |  . |..||  ....   . ..||| ..  .||.||.. .||.  ..        ..|.|||.|| .| .|..| .|. 
plcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkye

P
 
n
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 441-525 5.9e-14 44.9 In-house 193-286 (302) alignment 
Range on Protein: 441-525
Range on HMM: 193-286/302.0
VVDILWSDPMAQEGC---------KANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
  |.|..||.  ..          . |..||    |     ... ...|.....|.|   |||. |  ..|.||||||..| .   |.|| .|.
aqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 441-525 7.3e-14 44.6 In-house 194-287 (302) alignment 
Range on Protein: 441-525
Range on HMM: 194-287/302.0
VVDILWSDPMAQEGC---------KANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
  |.|..||.  ..          . |..||    |     ... ...|.....|.|   |||. |  ..|.||||||..| .   |.|| .|.
aqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_PPP6C_pd Subfamily PPP6C 441-525 1.3e-13 43.8 In-house 187-270 (290) alignment 
Range on Protein: 441-525
Range on HMM: 187-270/290.0
VVDILWSDPMAQEGCkANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
..|..||||   |   | . || |  ||  ||.....  |.....|.|.   ||...  . |. |..|| ||     |  . ..|
fcdlvwsdpedvetw.avsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilal
subfamily_PPPLV_pd Subfamily PPPLV 444-523 1.9e-13 43.4 In-house 183-273 (290) alignment 
Range on Protein: 444-523
Range on HMM: 183-273/290.0
ILWSDP------------MAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEvGSNRGAYV
||||||              .||   |  || |. |. |  ...|.. |..|..|.|| | .|... .. ..||.||.|.|   .||  | .
ilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycG.ssneaali
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 441-536 2.3e-13 43.1 In-house 196-291 (299) alignment 
Range on Protein: 441-536
Range on HMM: 196-291/299.0
VVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQY
 .|.||.||        . .||    ||.|| .. ... ..... |.|.   .||||  ..|..|||||  |     |  | .|.   |   .| .
gidllwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 441-528 8.2e-13 41.4 In-house 177-264 (280) alignment 
Range on Protein: 441-528
Range on HMM: 177-264/280.0
VVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPA
..|.|||||  .      .|||    ||  | .|  .  .....||.|.   .|||.   |...|.||  ||    .|  | | |   
lidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnan
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 431-536 3.1e-12 39.3 In-house 183-289 (307) alignment 
Range on Protein: 431-536
Range on HMM: 183-289/307.0
RKPTQEEWRQVV-DILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPAL
 || .. .| .| |.||.||         . || |  || .| ... ..  ....||.|.   .||     ||..|||||  | ..  | |. .|.  .|
pkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetl

TPHIVQY
  ..| .
giqlvaf
EF-hand_7 EF-hand domain pair 657-721 3.6e-12 36.2 Pfam-A 2-66 (66) alignment 
Range on Protein: 657-721
Range on HMM: 2-66/66.0
LETIFRIIDSDHSGFISLDEFRQTWKLFSSHMNIDITDDCICDLARSIDFNKDGHIDINEFLEAF
|...|. .|.|..|... .|...  | ..|..  . ... . .. . || |.|| .. .|||.|.
lkeaFkllDkdgdgyldkeeLlrllkhlgsplideevrevldyifkeiDkngdGvlsfeEflqai
subfamily_PPG1_pd Subfamily PPG1 441-525 1.3e-11 37.3 In-house 187-282 (300) alignment 
Range on Protein: 441-525
Range on HMM: 187-282/300.0
VVDILWSDPM----------AQEG-CKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKL
. |.|||||            .||    .. || |  .| ||....|.. .|. .||.|.   |||.   . |. |..|| || .   |. . ..|
ladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilel
subfamily_PPZ_pd Subfamily PPZ 437-524 1.5e-10 34.1 In-house 192-279 (300) alignment 
Range on Protein: 437-524
Range on HMM: 192-279/300.0
EWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVK
..  . |.|||||        .  ||    .     ...|.|. .... |.|    .||||  .| ..|.||| ||     | || . 
dfglindllwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavms
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 437-536 1.7e-10 34.0 In-house 153-253 (263) alignment 
Range on Protein: 437-536
Range on HMM: 153-253/263.0
EWRQVVDILWSDPMA-QEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQ
     .|.||.||    .| . | ||     ||    ..| .. ......|.|.    || |  .|...|.|||| |     |  | | .   |   .||
thplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvq

Y
 
l
PPP5 PPP5 TPR repeat region 95-163 2.8e-10 30.5 Pfam-A 24-92 (95) alignment 
Range on Protein: 95-163
Range on HMM: 24-92/95.0
QDSEMKKCsDYESIEVPDSYTGPRLS-FPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNI
. | .... |.||||. |.|.||||    .  .   .|.| |. ...|| ..| ..| ..|. | .||..
krsvaesi.diesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpsl
EF-hand_1 EF hand 657-682 3.6e-09 25.3 Pfam-A 2-27 (29) alignment 
Range on Protein: 657-682
Range on HMM: 2-27/29.0
LETIFRIIDSDHSGFISLDEFRQTWK
|. .|...| |..|.||..||.. .|
lkeaFkefDkDgdGkIsfeEfkealk
EF-hand_5 EF hand 658-679 1.2e-07 20.2 Pfam-A 2-23 (25) alignment 
Range on Protein: 658-679
Range on HMM: 2-23/25.0
ETIFRIIDSDHSGFISLDEFRQ
. .|| .| . .|.|| .|...
kdtFrafDkNgDGkIsreELkr
EF-hand_6 EF-hand domain 657-680 2.8e-07 19.9 Pfam-A 2-25 (31) alignment 
Range on Protein: 657-680
Range on HMM: 2-25/31.0
LETIFRIIDSDHSGFISLDEFRQT
|. .|...| |..|.|...|.|. 
lreaFklfDkdgdGkidaeELrka
subfamily_YNL217W_pd Subfamily YNL217W 170-301 3.7e-07 22.9 In-house 8-142 (235) alignment 
Range on Protein: 170-301
Range on HMM: 8-142/235.0
YSEEITVCGDLHGQLDDLIFIFY-KNGLPSPERSYVFNGDFVDRGKDSVEILMILfafmlvYPKEFHLNRGNHEDHMVN-LRY-----GFTKE-VMNKYK
 . .. | || ||  |.|| ..  |.|   ..   |. ||....| .|||..  .        .. .  .||||  ..  ...     |...    .|..
lgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfs

VHGKEILRTLQDVFCWLPLA-TLIDEKVLILHGGVSDITDL
.  ... .   .    |. .  .  ...|..|.|..    |
flesklskadmeyarelgfsldipsdellvvhaGlvpgkfl
EF-hand_8 EF-hand domain pair 654-682 4.8e-07 18.6 Pfam-A 24-52 (54) alignment 
Range on Protein: 654-682
Range on HMM: 24-52/54.0
RSNLETIFRIIDSDHSGFISLDEFRQTWK
 . ....|| .| |..| ||..|| . ..
eeevdilfrefDtdgdGkisfeEFcvlle
EF-hand_1 EF hand 702-722 9.4e-07 17.7 Pfam-A 7-27 (29) alignment 
Range on Protein: 702-722
Range on HMM: 7-27/29.0
RSIDFNKDGHIDINEFLEAFR
. .| ..||.|. .||.||..
kefDkDgdGkIsfeEfkealk
IQ IQ calmodulin-binding motif 21-39 3.4e-06 16.0 Pfam-A 2-20 (21) alignment 
Range on Protein: 21-39
Range on HMM: 2-20/21.0
KAAALIQRWYRRYVARLEM
||| .||...|.|.|| . 
kaaikIQaawRgylaRkry
EF-hand_5 EF hand 703-718 4.6e-06 15.2 Pfam-A 7-22 (25) alignment 
Range on Protein: 703-718
Range on HMM: 7-22/25.0
SIDFNKDGHIDINEFL
 .|.|.|| |.. |. 
afDkNgDGkIsreELk