Gene ACP2 in Homo sapiens

Synonym: LAP, ACP2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily ACP2
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP158_AA protein Get Run
HsapP158_AA_23-374 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP2_pd Subfamily ACP2 29-373 1.2e-126 415.0 In-house 5-359 (361) alignment 
Range on Protein: 29-373
Range on HMM: 5-359/361.0
RARSLRFVTLLYRHGDRSPVKTYPKDPYQEEEWPQGFGQLTKEGMLQHWELGQALRQRY---HGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPN
. |.|.||..|.|||||||..|||.|.|.|.|||||.||||.||| |. |||. ||.||   ..||...|.....||||.|..|||||| ..|||||||.
eerkLkfvqvlfRHGdRsPlntypndkykedewpqglGqLTeeGmqqqyeLGkfLrkrYvedtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfppe

GMQRFNPNISWQPIPVHTVPITEDRLLKfPLGPCPRYEQLQNETRQTPEYQNESSRNAQFLDMVANETGlTDLTLETVWNVYDTLFCEQT-HG-LRLPPW
. . ......|||.|||||. .|| ||. .  .||||..|..|....||.... ..|...|. . ..|| .|..||......|||.||.  .. | ||.|
tgvdypdeqeWqpvPvhtvseeedlllr.akknCprydellqeakespevkklleenkelleklsestg.edidlenfyqlsdtlicerkyanelnlpew

ASPQTMQRLSRLKDFSFRFLFGI--YQQAEKARLQGGVLLAQIRKNLTLMAT---TSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQE
|. .....|..|.| .... ||.  ... |...|.||.||... .|.   ..   ...  ||..||||||||.|| .||....... ||||. |.|||.|
andelfekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkceekkkklklflYSaHDttlaalLeaLgifekkappyasaiivElyee

DSGNFSVEMYFRNESDKAPWPLSLPGCP--HRCPLQDFLRLTEPVVPKDWQQECQLA
|.|.. |....|||..| |  |.||||.  ..|||..| ....|..|.|....|. .
ddgkplvkvlyrnetskdppeltlpgCkgeedCplskfkkivkpfipddvdelCeak
0053031 Phosphoglycerate mutase-like 33-370 5.2e-105 344.3 In-house 3-340 (342) alignment 
Range on Protein: 33-370
Range on HMM: 3-340/342.0
LRFVTLLYRHGDRSPVKTYPKDPYQEEEWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFNP
|..| .|.|||.|.|. ..|.||..| ..| |.|.|| .|..|..|||..||.||.|.|.  |...||||||.|.||||.||.| |||||||.|.. .||
LkqvivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnp

NISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNESSRNAQFLDMVANETGLTDLTLET-VWNVYDTLFCEQTHGLRLPPWASPQTMQR
...|||||.||.| ..| || ..  |||....|..|. ...|...  .| ...|. ... .|||  .|.  |...||.|..|..||| |||| .  |...
llgwqpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqklskglgltlsdlldlvsdlydlllyelahglplppwctlftlee

LSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDsGNFSVEMYFRN
| .| ........|.. . | |.|.||.|| .| ..|. .   .  .|| .|.|||||..|| .||.....   ||||. .||||. . |...|......
lkalyaldllyyyglgpgnelaklaggpllneilarleekisgpldlklylyfahdttiaallsaLglfddqlPpyasnlvfElyedp.geyyVrvlyng

ESDKAPWPLSLPGCPHRCPLQDFLRLTEPVVPKDWQQEC
...  |..| ||||.  |||..|..|.....|.|....|
gtlseplvlplpgcdglcplsefkelvkkllpgdfeklC
0049226 Phosphoglycerate mutase-like 33-370 1.6e-104 342.7 In-house 3-340 (342) alignment 
Range on Protein: 33-370
Range on HMM: 3-340/342.0
LRFVTLLYRHGDRSPVKTYPKDPYQEEEWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFNP
|..| .|.|||||.|....|.|...|  |. |.|.|| .|. |..|||..||.||.|.|.  |...||||||.|.||||.||.| |||||||.. ....|
LkqvqvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvp

NISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNESSRNAQFLDMVANETGLTDLTLETVWN-VYDTLFCEQTHGLRLPPWASPQTMQR
...|||||..|.| . | || .|  .||....|..|. ...|.|.  .. ...|..... .||.  ||. |.. .||.| .|. ||| |||| |  |.. 
lldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllkklskllglnlstlsdvadtlydlllyelahglplppwcslftlee

LSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDsGNFSVEMYFRN
|  | ........||.   | |||.||.|| .| ..|. .  ..  .|| .|.|||||..|| .||..... . ||||. .||||. | |...|......
lkalyaldllyyygigygeeiarlaggpllneilarleeaiegpsdlklylyfahdttiaallsalglfddqlPpyasnlvfElyecd.geyyVrvlyng

ESDKAPWPLSLPGCPHRCPLQDFLRLTEPVVPKDWQQEC
.. . |..| ||||. .|||..|..| ....|.|....|
gvlslpvtlplpgcdglcpldefkelvkkflpgdfeelC
0046349 Phosphoglycerate mutase-like 32-372 3.9e-97 318.8 In-house 6-392 (409) alignment 
Range on Protein: 32-372
Range on HMM: 6-392/409.0
SLRFVTLLYRHGDRSP---VKTYPKDPYQEEE-WPQGFGQLTKEGMLQHWELGQALRQRY--HGFLNTS--YHRQEVYVRSTDFDRTLMSAEANLAGLFP
 |..| .|.|||.|.|    ...|..|..    .| |.|||| .|. |..|||..||.||  .|.|...  |...|.||||.|.||||.||.|.||||||
eLkqvqvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfp

PNGMQRF------NPNISWQPIPVHTVPITE----DRLLKFPLGPCPRYEQLQNETRQT-PEYQN-----------ESSRNAQFLDMVANET-----GLT
|.| . .      .... .||||..|||| |    |  | .|  .||....| .|. .. .|...            .......|. .|...     ||.
plggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkllkenlkslsevleflvdealldlelldetkdllkklaerlnselpgln

DLTLETVWN-VYDTLFCEQTHGLRLPPW---ASPQTMQRLSRLKDFSFRFLFGIyqQaEKARLQGGVLLAQIRKNLTLMATTSQ------LPKLLVYSAH
  ... |.. .||||..|. ||| ||||    .|. ...|. | |... .|.|     | |.|.||.|| .| ..|. ......       .|| .|.||
ltdpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyylygs..g.elaklaggpllneilarledaisgknpvtfpldlklylyfaH

DTTLVALQMALDVYN-----GEQAPYASCHIFELYQE-DSGNFSVEMYFRNEsdkapwPLSLPGCPHRCPLQDFLRLTEPVVPK----DWQQECQL
|||..|| .||....      .  ||||. .||||.  ..|...|.......      || ||||.  |||..|..| ....|.    |....|.|
dttiaallsaLglfdrlfrssdippyasnlvfElyecpsdgeyyVrvlyngg......plplpgcgegcplsefkellkkrlpgcgltdfdklCpl
0049059 Phosphoglycerate mutase-like 30-371 3.4e-96 315.7 In-house 40-435 (435) alignment 
Range on Protein: 30-371
Range on HMM: 40-435/435.0
ARSLRFVTLLYRHGDRSPVK-----------------TYPKDPYQEEEW---PQGFGQLTKEGMLQHWELGQALRQRYhGFLntsYHRQEVYVRSTDFDR
   |..| .|.|||.|.|..                 |||..|...  .   |.|.|.|| .|. |..|||. ||.|| |||   |...||||||.|.||
gcelkqvqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrY.gfL...ynpdevyvrssdvdR

TLMSAEANLAGLFPPN--GMQRFNPNISWQPIPVHTVPITEDRLlkfPLGPCPRYEQLQNETRQTPEYQNE-SSRNAQFLDMVANETGLTDLTLETVWNV
||.||.|.|||||||.  | | .||.. .||.|..||. . | |   |  .||....|..|  ...|...   .|....|. .....|||  .. .....
tlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl...pydscpafdellkellasdeflelflerilkllqellpglgltpsdvldlydl

--YDTLFCEQTHGLRLP--PWASPQTMQRLSRLKDFSFRFLFGIYQqaEKARLQGGVLLAQIRKNLTLMATTSQ----------------LPKLLVYSAH
  ||||.....||| ||  .. ... ...|..| |. | .|.|...  | |.|.||.|| .| ..|. ..  ..                 .|| .|.||
ckydtlllgyahglplpfcslfteeelevleyladlefyylygygd..eiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaH

DTTLVALQMALDVYNGEQA---------------------PYASCHIFELYQEDSG-NFSVEMYFrNEsdkapWPLSLPGCPH----RCPLQDFLRLTEP
|||...| .||.......                      ||||. .||||. ..| ...|.... |.      .| ||||..    .|||.||..| ..
dttiapllsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvfElyecpdgneyyVrvly.ng.....kvlplpgcgsgpgglCplddFkelvkk

VVPKDWQQECQ
..|.|. .||.
flpgddfdeCg
0048946 Phosphoglycerate mutase-like 30-374 7.1e-96 314.7 In-house 38-413 (447) alignment 
Range on Protein: 30-374
Range on HMM: 38-413/447.0
ARSLRFVTLLYRHGDRSPV-----------------------------KTYPKDPYQEEEWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNtsyHRQEV
   |..| .|.|||.|.|.                             .........| .|| |.|||| .|. |..|||..||.||.|.|.   ...|.
gcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwpcglgqLTplGreqlyelGkrlrkrYlgllp...npsei

YVRSTDFDRTLMSAEANLAGLFPPNgmqrfnPNISWQPIPVHTVPITEDRLLKFplgPCPRYEQLQNETRQtPEYQNessRNAQFLDMVANETGLTDLTL
||||.|.||||.||.|.|||||||.      |....||||.|||| ..| ||..   .||....|.... . .|...    . ..|..... .|  .|||
yvrssdvdRtlqSaqaflaGlfppe......pplgyqpipihtvpssndnlllp...sCpafkellkkela.eelke...llkellerlkkllgglnltl

ETVWNVYDTLFCE-QTHGLR-LPPWASPQTMQRLSRLKDFSFRFLFGIYQqaEKARLQGGVLLAQIRKNLTLMATTSQlpKLLVYSAHDTTLVALQMALD
. |...||.|..| . |||  |... .|. ...| .| |..|....|...  | |||.||.|| .| ..|. ..  ..  || .|.|||||..|| .||.
sdvydlydlllyetaihglsplcslftpeelevleyladlefyyeygygd..elarlaggpllneilarledaisgds..klylyfaHdttiaallsaLg

VYNGEQA------------------PYASCHIFELYQED-----SGNFSVEMYFRNEsdkapwPLSLPGCPH----RCPLQDFLRLTEPVVPkDWQQECQ
... |.                   ||||. .||||. .     .|...|.... .|      || ||||..     |||.||..|.....| ||...|.
lfddelplpadnlpfnrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlynge......plplpgCgsgpgglCplddFkellkkflp.dweklCg

LAS
|  
ltl
0047369 Phosphoglycerate mutase-like 24-371 4.1e-94 309.1 In-house 35-437 (438) alignment 
Range on Protein: 24-371
Range on HMM: 35-437/438.0
VMPPTRARSLRFVTLLYRHGDRSP-----------------VKTYPKDPYQEEE---WPQGFGQLTKEGMLQHWELGQALRQRYhGFLntsyHRQEV-YV
 ...     |..| .|.|||.|.|                 ..|||..|..      .|.|.|||| .|. |..|||. ||.|| |.|     ...| ||
sldvpegcelkqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrY.glL....npedvlyv

RSTDFDRTLMSAEANLAGLFPPNGMQRFNPnISWQPIPVHTVPITEDRLLKF-PLGPCPRYEQLQNETRQTPEYQNESsrNAQFLDMVANETGLTDLTLE
||.|.||||.||.|.|||||||.| . ..| | |||||.||.| . | ||.. | ..||....|..|. ...|...    ....|..... .. ..|| .
rssdvdRtlqSAqaflaGlfppegtgelap.ilwqpipihtipesddfllnllpsdscpafdellkeflasdeflell..lkdilkrlkkllpglnltps

TVWNVYDT----LFCEQTHGLRLPPW---ASPQTMQRLSRLKDFSFRFLFGIYQqaEKARLQGGVLLAQIRKNLTLMATTSQ----------------LP
.|...||.    ... ...|| |.|.    .|. .. |. | |. | .|.|..   | |.|.||.|| .| ..|. ... ..                 .
dvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygn..elaklaggpllneilarledaingkstnlnltldsngvtfPldl

KLLVYSAHDTTLVALQMALDVYNGEQA---------------------PYASCHIFELYQE-DSGNFSVEMYFrnesdkAPWPLSLPGCPH----RCPLQ
|| .|.|||||..|| .||.... ..                      ||||. .||||.  ..|...|....       . .| ||||..     |||.
klylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivPyasnlvfElyecpsdgeyyVrvly......ngkvlplpgcgsgpgglCpld

DFLRLTEPVVPKDWQQECQ
||..|.....|.|....|.
dFkelvkkllpgdfeelCg
0048439 Phosphoglycerate mutase-like 31-363 1.4e-90 297.3 In-house 7-391 (391) alignment 
Range on Protein: 31-363
Range on HMM: 7-391/391.0
RSLRFVTLLYRHGDRSPVKTYPK--DPYQEEEW---PQGFGQLTKEGMLQHWELGQALRQRY--HGFLNTSY--HRQEVYVRSTDFDRTLMSAEANLAGL
  |..| .|.|||.|.|...||.  ||. .  .   | |.|.|| .|. |..|||..||.||  .|.|. .|  ...||||||.|.||||.||.|.||||
celkqvqvlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGl

FPPNGMQRFNP------NISWQPIPVHTVPITEDRLLKFPLGPCPRY------EQLQNETRQTPEYQNESSRNAQFLDMVANETGLTD------LTLETV
|||.| .  ..      .. ..|.|..|.| .|| ||...|  .||.      |.|.... .......  . .....|. |.||  .        .|  .
fpplgltvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevlnrvlglnltaedvlslfdlcaketaalgsllklssplcdl

WNVYDTLFCEQTHGLRLPPWASPQTMQR--LSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLtlMATTSQLPKLLVYSAHDTTLVALQMALDVYN
...||||..|. ||| ||.|.  ....   |  | |.  ....... . | |.|.||.|| .| ..|   |. .. ||| .|.|||||..|| .||...|
ftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsgeiaklaggpllneilddl..vangpsdpklylyfaHdttiaallsaLglfn

G------EQAPYASCHIFELYQED-SGNFSVEMYFRNESDKAPW--------------PLSLPGCPH----RCPLQDFLRLTEPVVP
        . ||||. .||||. . .|...|........ . |               .| ||||..     |||.||..|.....|
dtlplpadlppyasnlvfElyecpsdgeyyVrvlynggtldlprdltlldldefllrlvlplpgcgsgpgglCplddFvelvkkrip
His_Phos_2 Histidine phosphatase superfamily (branch 2) 33-329 6.1e-64 209.1 Pfam-A 2-346 (347) alignment 
Range on Protein: 33-329
Range on HMM: 2-346/347.0
LRFVTLLYRHGDRSPVKTYPKDPYQEE--------------------------EWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTD
|..| .. |||||.|.....|.  .|                           ... . |.||..|. |. |||. ||||| |.|.  .....|..||..
LkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYpgllrdhltyedvkirsss

FDRTLMSAEANLAGLFPPNG---MQRFNPNISWQPIPVHTVPI---TEDRLLKFPLGPCPRYEQ--LQNETRQTPEYQNESSRNAQFLD-MVANE-TGLT
 .|.|.||.|..|||..|.|   ... ..  ........|..    ... ||      ||....  ...|.|.... .. ..  .. |   . .  || .
erRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenlakrlsalctged

DLTLETVWNVYDTLFCEQT--HGLRLPPWASP--QTMQRLSRLKDFSFRFLF-GIYQQaeKARLQGGVLLAQIRKNLTLMATTSQ---LPKLLVYSAHDT
 |. . .|. ... |.|.   .....| ...   . .. .. |.|..  . . || ..   .. .|. || .. |...  .  .|     ||..|..||.
nllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigde..eklkigllllnpllkkilsdleetqpsrhaklrlyfthDs

TLVALQMALDVYN------GEQAPYASCHIFELYQEDSGNFSVEMYF
....| .||....       .. ||||. .||||...  .|.|...|
hiytllnaLgleekiareaspelpyasqivfelyedsekkfyvrllf
His_Phos_2 Histidine phosphatase superfamily (branch 2) 33-329 6.1e-64 209.1 In-house 2-346 (347) alignment 
Range on Protein: 33-329
Range on HMM: 2-346/347.0
LRFVTLLYRHGDRSPVKTYPKDPYQEE--------------------------EWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTD
|..| .. |||||.|.....|.  .|                           ... . |.||..|. |. |||. ||||| |.|.  .....|..||..
LkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYpgllrdhltyedvkirsss

FDRTLMSAEANLAGLFPPNG---MQRFNPNISWQPIPVHTVPI---TEDRLLKFPLGPCPRYEQ--LQNETRQTPEYQNESSRNAQFLD-MVANE-TGLT
 .|.|.||.|..|||..|.|   ... ..  ........|..    ... ||      ||....  ...|.|.... .. ..  .. |   . .  || .
erRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenlakrlsalctged

DLTLETVWNVYDTLFCEQT--HGLRLPPWASP--QTMQRLSRLKDFSFRFLF-GIYQQaeKARLQGGVLLAQIRKNLTLMATTSQ---LPKLLVYSAHDT
 |. . .|. ... |.|.   .....| ...   . .. .. |.|..  . . || ..   .. .|. || .. |...  .  .|     ||..|..||.
nllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigde..eklkigllllnpllkkilsdleetqpsrhaklrlyfthDs

TLVALQMALDVYN------GEQAPYASCHIFELYQEDSGNFSVEMYF
....| .||....       .. ||||. .||||...  .|.|...|
hiytllnaLgleekiareaspelpyasqivfelyedsekkfyvrllf
subfamily_ACP6_pd Subfamily ACP6 65-373 3.8e-42 136.3 In-house 75-374 (376) alignment 
Range on Protein: 65-373
Range on HMM: 75-374/376.0
FGQLTKEGMLQHWELGQALRQRYH---GFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFnpniswQPIPVHTVPITEDRLLkfPlgPCPR
 ||||| || | ..||. ||.||    .|| ...  ||||.|||. .||| ||.  .|||.    .|.        || ..|    |. |.  |     |
kGqLtkvGmqqvfdLGrkLrkrYvedikfLsqefnpqevyiRstnieRtlesarclvaGLygkiiiqke......lpiilytdeedeevly..P..nrqr

YEQLQNETRQTPEYQNESSRNAQFLDMVANETGLTD-LTLETVwNVYDTLFCEQTHGLRLPPwASPQTMQRLSRLKDFSFRFLFGIYQQAE--KARLQGG
 ..|.. .|.  .   .    ..... .|.. ....   |. |  . | .  .. |.|  ||    . .... .    . ..|.   ...|    .|  |
cpllsrayrsvrksaislpGisedtkqiadvldiseekkldfv.slrDniaArlaHnlkvpp.ilkdvidliekhAveelvvlleggdrpekeilklsvG

VLLAQIRKNLTLMATTSQL-PKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDSGNFSVEMYFRNESdkapwpLSLPGCPH-RCPLQDFLR
 .| .| .||  .       .|| .||||||||..| .||.|....  |.|.  |.|||....|.. | ......       | |.|...  .||. |  
kvlkeilenlekakekeiparklrLysaHDttlmtLLlalgvFDdkWPpfaadvileLyedkageyfvrvlYqeke......lrlrgseedlvPlekFka

LTEPVV-PKDWQQECQLA
| ...| |||...||.|.
llavlvlpkdyaaeCkle
subfamily_PXYLP1_pd Subfamily PXYLP1 65-321 4.3e-21 66.6 In-house 103-357 (419) alignment 
Range on Protein: 65-321
Range on HMM: 103-357/419.0
FGQLTKEGMLQHWELGQALRQRY---HGFL--NTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPpngmqrfnpNISWQPIPVHTVPITedrLLKFPLGPC
 ||||. |..|| |.|. ||. |   ...|  .  . . ||.. .|   ||| || | | ||.|         . ... | |...|     .  .    |
lgqLtqkGvvqhLevGdllrkvYakklklLlkpnelssDevvlettrkrrtlqsalallygllp.........kaklkairvrespsv...afClgeCsC

PRYEQLQNETRQTPEYQNESsRNAQFLDMVANETGLTDL--TLETVWNVYDTLFCEQTHGLRLPPWA----SPQTMQRLSRLKDF-SFRFL-FGIYQQAe
|  .... |  .  ..      . .   .|..    |.|  ||. . |. |.| .   | . ||        |. .. | .|.|  | |    . |... 
PallrkrlekeadkqlLlrg.kvldvmksvgetlkgtilqttlngisnpvdalltvlChnvslPcrreGcvepshvdvlhkladelsqrsakksyykls.

kARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDSG
  .|.   || .| ...  .    . .|  .||.|| ||  |  ||.. ...   |||  .||||. .. 
.GllraypllrdivsrmlkiieGvdkekfvlysghDvtlrplvaaLglseartiayasrlvfelyrreas
subfamily_HP2-Group1_pd Subfamily HP2-Group1 199-372 3.6e-16 50.5 In-house 244-418 (422) alignment 
Range on Protein: 199-372
Range on HMM: 244-418/422.0
TLETVWNVYDTLFCEQTHGLRLPPWASPQTMQRLsrLKDFSFRF--LFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMA
 .... .. | |.  | |.. .|.  . . ..|   | .. .|.   .    . ..||   | || .| |...   |  .| |.|.|| |||||. |  |
didnledlvdclithqchnaaipdkltedlakrg..ldellyrsysslkypsvekyarvGiGfllkdiwkevnesltGedlrkfllysGhdttliqllsa

LDVYNGEQAPYASCHIFELYQEDSG------NFSVEMYFRNESDKAPWplslpgCP-HRCPLQDFLRLTEPVVPKDWQQECQL
|.| ..   ||||  ..||..  .       ...| . .  .  | |.      |  . |... |    . |.|.|  ..|. 
lnvdefkwppyasllllellevstapaastpqyavrvlynGklkklpf......cdanecsyeqfeaylstviphddaedckv
subfamily_HP2-Group1_pd Subfamily HP2-Group1 65-131 1.7e-13 41.7 In-house 92-160 (422) alignment 
Range on Protein: 65-131
Range on HMM: 92-160/422.0
FGQLTKEGMLQHWELGQALRQRY--HGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFN
 .||| ||  |.   ||.||. |   |||..|..  |||.|| |  ||..||.| . |..|....   .
vaqltleGykqqelnGqilrkvyvdtGflkssldssevylrsddesrtilsaqalilGmypqdtkaedr
subfamily_MINPP1_pd Subfamily MINPP1 66-214 1.6e-11 35.7 In-house 90-240 (420) alignment 
Range on Protein: 66-214
Range on HMM: 90-240/420.0
GQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFNPNISWQPIPVHTVpiteDRLLKFpLGPCPRYEQL
..|...|  .. ||.. | .|.  ...  |........||.  ||. ||.| . ||.. . .   . ||. | |  .      |.||.|    |..|.. 
kslvaqgqeeleelakrlarrfpalfeevynpdsfsfastakkRtvksaqaFaeGLsetgevlgdefnivlqeiseqes....dklLrf.fdsCkkyknk

QNETRQTPEYQ---NESSRNAQFLDMVANET----GLTDLTLETVWNVYDTLFCEQ
 ..   . ...    ||.   . |. .|...     | .|| . . .....   |.
vkknelnlkeeeefleskelqkaleeiakrlneekklleltekdiedmfeiCayel