Gene CDC25B in Homo sapiens

Synonym: RP5-1009E24.3, CDC25B

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC3
Superfamily CC3
Family CDC25
Subfamily CDC25
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP189_AA protein Get Run
HsapP189_AA_422-534 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
M-inducer_phosp M-phase inducer phosphatase 113-384 2.2e-111 359.6 Pfam-A 1-259 (259) alignment 
Range on Protein: 113-384
Range on HMM: 1-259/259.0
MDSPSPMDPHMAEQtfeqAIQAASRIirNEQFAIRRFQSMPVRLLGHSPVLRNiTNSQAPDGrRKSEAGsgAASSSGEDKENDGFVFKMPWKPThpssTH
.|||.|.|...||.    ||..|.|.  ......||..|.| .|||.||.|.. ..|.| |  .|..|.  |..||.|.|||.||.||.|.||.    ..
Ldspgpldskeaee....aipdaarv..kkkiplrrinslpqkllgssPalkr.sasdalds.ekrkad..alisssenKENegfefKkpvkpv....lr

ALAeWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESD-LKDDDAVPPGMESLISAPLVKTLEKEEEKDLVM
||. ||.|.|...||.||||.||..||..|.|||| .. |||....|... |.||||||||.|... |||....|.||.||.||||||.||.||||||..
all.waerkellvqrqssapalmlsspeekveveegemkalgspistvsktdkeeDDGFvDlldaeelkdeleepsgmasLlsaPLvkkleeeeekdlil

YSKCqRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQ-EAEEPKARV-LRSKSLCHDEIENL
.|.| ||.||||.|.|..||.|||.|||.|..|||..|||.||..|.|.. ||||||.|| |||||||..|||..
lsrc.rLyrspslpesltrpvLKrverpkdeetPvkvKrrksvsspveekeeaeepkkrvslrskSlckveieti
Subfamily.CDC25.PD 423-534 1.9e-46 148.3 In-house 3-116 (117) alignment 
Range on Protein: 423-534
Range on HMM: 3-116/117.0
LLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVN--DYPSLYYPEMY
||.|.... ..|..|.||||||||||||||.||||  ....|...||.| ...| .||.|.||||||||||||...|..||.|| .|  .||.|.|||.|
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYKEFFPQHP
.|.||||||| ...
lLegGykeffeeve
Family.CDC25.PD 423-534 1.9e-46 148.3 In-house 3-116 (117) alignment 
Range on Protein: 423-534
Range on HMM: 3-116/117.0
LLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVN--DYPSLYYPEMY
||.|.... ..|..|.||||||||||||||.||||  ....|...||.| ...| .||.|.||||||||||||...|..||.|| .|  .||.|.|||.|
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYKEFFPQHP
.|.||||||| ...
lLegGykeffeeve
Group.Cx5R-II.PD 423-534 1.9e-46 148.3 In-house 3-116 (117) alignment 
Range on Protein: 423-534
Range on HMM: 3-116/117.0
LLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVN--DYPSLYYPEMY
||.|.... ..|..|.||||||||||||||.||||  ....|...||.| ...| .||.|.||||||||||||...|..||.|| .|  .||.|.|||.|
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYKEFFPQHP
.|.||||||| ...
lLegGykeffeeve
subfamily_CDC25_pd Subfamily CDC25 423-534 4.7e-46 146.7 In-house 1-113 (114) alignment 
Range on Protein: 423-534
Range on HMM: 1-113/114.0
LLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPcSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVN--DYPSLYYPEMY
||.|.|.. .....|.||||||||||||||.||||  ....|..|||.| .. | .|| |.||||||||||||...|..||.||..|  .||.|.|||.|
llkgefeekiaevliiDcRypyEyegGHikgavnlysreeveeellkkpkvk.seekrkiiifhCefsseRgPklarllrevdrelnkeeypkleypely

ILKGGYKEFFPQHP
.|..|||||| ...
llekGYkeffeeve
Rhodanese Rhodanese-like domain 433-529 5.7e-17 54.3 Pfam-A 12-110 (113) alignment 
Range on Protein: 433-529
Range on HMM: 12-110/113.0
DKFVIVDCRYPYEYEGGHIKTAVNLPL--------ERDAESFLLKSPIAPCSLDKRVILIFHCeFSSERGPRMCRFIRERDRAVNDYPslyypEMYILKG
.|.|..|.| |.||..|||. |||.||        ... . .  . . .  .|||    ...| .|..|. ..... ..   . . |.     ..|.|.|
ekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktvvvyc.rsgnrsggaaalllalilkelgyk.....nvyvLdG

GYKEF
|....
Gfeaw
subfamily_Acr2_pd Subfamily Acr2 426-529 2e-08 24.7 In-house 4-108 (113) alignment 
Range on Protein: 426-529
Range on HMM: 4-108/113.0
GKFSNIVDKFVIVDCRYpYEYEGGHIKTAVNLPLERDAESFL----LKSPIAPCSLDKR--VILIFHCEFSSERGPRMC-RFIRERDRAvndypSLYYPE
|.  .  ..| .|| |   .| ..||| |  ... |  .       ||  .     | |  . .||||  | .|||..   ..|  | |      |    
Glietlredfqvvdvrr.edyardhikdawhvavsrlkqdkeylrelkkrllekqadsrgalkvifhctlskqrGPkvamlllrsldta.....elsrcr

MYILKGGYKEF
...|.||.  |
lwvlrggfskf