Gene CDC25C in Homo sapiens

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC3
Superfamily CC3
Family CDC25
Subfamily CDC25
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP199_AA protein Get Run
HsapP199_AA_390-502 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Subfamily.CDC25.PD 391-502 1e-48 155.6 In-house 3-116 (117) alignment 
Range on Protein: 391-502
Range on HMM: 3-116/117.0
LLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLN--QYPALYYPELY
||.|... ||||...||||||||| ||||.||.||||.||| ..|||.| |. ...|| |..|||||||||||...|.||| ||.||  .||.|.|||||
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYRDFFPEYM
.|.|||..|| |. 
lLegGykeffeeve
Family.CDC25.PD 391-502 1e-48 155.6 In-house 3-116 (117) alignment 
Range on Protein: 391-502
Range on HMM: 3-116/117.0
LLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLN--QYPALYYPELY
||.|... ||||...||||||||| ||||.||.||||.||| ..|||.| |. ...|| |..|||||||||||...|.||| ||.||  .||.|.|||||
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYRDFFPEYM
.|.|||..|| |. 
lLegGykeffeeve
Group.Cx5R-II.PD 391-502 1e-48 155.6 In-house 3-116 (117) alignment 
Range on Protein: 391-502
Range on HMM: 3-116/117.0
LLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLN--QYPALYYPELY
||.|... ||||...||||||||| ||||.||.||||.||| ..|||.| |. ...|| |..|||||||||||...|.||| ||.||  .||.|.|||||
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYRDFFPEYM
.|.|||..|| |. 
lLegGykeffeeve
subfamily_CDC25_pd Subfamily CDC25 392-502 8.1e-48 152.4 In-house 2-113 (114) alignment 
Range on Protein: 392-502
Range on HMM: 2-113/114.0
LSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPlDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLN--QYPALYYPELYI
|.|.|.  |.....||||||||| ||||.|| ||||.||. ...|||| |. ...|| ||.|||||||||||...|.||| ||.||  .||.|.|||||.
lkgefeekiaevliiDcRypyEyegGHikgavnlysreeveeellkkpkvk.seekrkiiifhCefsseRgPklarllrevdrelnkeeypkleypelyl

LKGGYRDFFPEYM
|..||..|| |..
lekGYkeffeeve
M-inducer_phosp M-phase inducer phosphatase 233-350 1.4e-32 101.3 Pfam-A 115-259 (259) alignment 
Range on Protein: 233-350
Range on HMM: 115-259/259.0
NGNLVDSEMKYLGSPITTVPKLDKnpnlGED-------QAEEISDELMEFS-------------LKDQEAK----VSRSGLYRSPSMPENLNRPRLKQVE
. .....|||.|||||.|| | ||    .||       .|||..|||.|.|             |...|.|    .||..||||||.||.|.||.||.||
kveveegemkalgspistvsktdk....eeDDGFvDlldaeelkdeleepsgmasLlsaPLvkkleeeeekdlillsrcrLyrspslpesltrpvLKrve

KFKDNTIPDKVKKKYFSGQ---GKlRKGLCLKKTV-----SLCDITITQM
..||...|.|||.......    | ......||.|     |||...|...
rpkdeetPvkvKrrksvsspveek.eeaeepkkrvslrskSlckveieti
M-inducer_phosp M-phase inducer phosphatase 171-233 4.6e-19 57.1 Pfam-A 1-74 (259) alignment 
Range on Protein: 171-233
Range on HMM: 1-74/259.0
LDETGHLDSSGLQE-----------VHLAG-MNHDQHLMKCSPAQLLcSTPNGLDRGHRKRDAMCSSSANKENDN
||..|.|||.. .|           ..|.. ....|.|...|||..  |....||...||.||..|||.||||..
LdspgpldskeaeeaipdaarvkkkiplrrinslpqkllgssPalkr.sasdaldsekrkadalisssenKENeg
Rhodanese Rhodanese-like domain 398-497 2e-14 46.1 Pfam-A 7-110 (113) alignment 
Range on Protein: 398-497
Range on HMM: 7-110/113.0
GLI--EKFYVIDCRYPYEYLGGHIQGALNLYS----------QEELFNFFLKKPIVPLDTQKRIiiVFHCeFSSERGPRMCRCLREEDRSLNQYPalyyp
 |.  ||. ..|.| |.|| .|||.||.|.            ... .   |..    ||  |..  |..| .|..|. .....|..   . . |.     
ellekekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktv..vvyc.rsgnrsggaaalllalilkelgyk.....

ELYILKGGYRDF
. |.|.||. ..
nvyvLdGGfeaw
subfamily_Acr2_pd Subfamily Acr2 394-497 4.6e-08 23.5 In-house 4-108 (113) alignment 
Range on Protein: 394-497
Range on HMM: 4-108/113.0
GKFQGLIEKFYVIDCRYpYEYLGGHIQGALNL-YS---QEELFNFFLKKPIVPLDTQKR--IIIVFHCEFSSERGPRMCRCLReedRSLNQyPALYYPEL
|. . | |.| |.| |   .|...||. |  . .|   |.. .   ||| ..   .. |  . ..|||  | .|||..   |    |||.    |    |
Glietlredfqvvdvrr.edyardhikdawhvavsrlkqdkeylrelkkrllekqadsrgalkvifhctlskqrGPkvamlll...rsldt.aelsrcrl

YILKGGYRDF
..|.||.  |
wvlrggfskf