Gene PAPL-4 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP085_AA protein Get Run
MbreP085_AA_90-292 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP5_pd Subfamily ACP5 164-378 6.6e-49 158.4 In-house 10-188 (189) alignment 
Range on Protein: 164-378
Range on HMM: 10-188/189.0
AVPVRTLLESLkDTKAIDFIWHLGDIGYADDAfshaplkfGYESAYNGYMNWIQNLTATMPYMVSVGNHESEChspacvadtkignalrNFSAYNTRWHM
| ...|||..  .....|.|.|.||..||..|          |.... .||.|..|....|||||.|||||.                 |||||..|..|
aaslatllkee.eaneldliihvGDlaYalka........kneavwdefmnlieplaskvPymvsiGnhesds................nfsaykkrfsm

PsE-DSkgvlnmWYSWNYGPVHFISLNTETDFPGAgeentgdshdpfmpaghfapdGTYLAWLEQELAAAHaNRAQRPWIIAGGHRPF-------PDI--
| . ..      |||..|||||||||.||.||                         . ..|||..|..|. ||...||||. ||||.        |.  
p.skne......wYsfdygpvhfislstevdfslg.....................seqykWLekdLkean.nrkktpwiivmgHrPmYcsnkdeddctk

--------AANGVQELFERYEVDVYVAGHTHSY
          .....|...|.||....||.|||
eetlvrkglresledllykykvdlalsgHeHsY
PAPL 163-292 4.7e-16 51.5 In-house 12-119 (194) alignment 
Range on Protein: 163-292
Range on HMM: 12-119/194.0
SAvpvRTLLESLKDTKAIDFIWHLGDIGYADDAFShaplkfgyESAYNGYMNWIQNLTATMPYMVSVGNHESECHSPACVAdtkignalRNFSAYNTRWH
|.    . |.. .... .|.|.|.||. ||||  .        |    ..|. |..|.|..||||..||||.|... ...|        |.. ...... 
ss...lkrlqketqkgkydailhvGDlaYaddeqn........ewdgdefmrqieplaasvpymvapGNHEeeynfsnyka........rfsmpgseege

MPSEDSKgvlNMWYSWNYGPVHFISLNTET
..|..|.   .  || ....|||| |..|.
snssesg...snsysfetesvhfivlssee
Metallophos Calcineurin-like phosphoesterase 136-378 5.1e-15 49.3 Pfam-A 4-200 (200) alignment 
Range on Protein: 136-378
Range on HMM: 4-200/200.0
ALFGDMGYLGSAERpmvvatgglqknwsaVpVRTLLESLKDTKAIDFIWHLGDIGYADDAFSHAPLKFGyesayngymNWIQNLTATMPYMVSVGNHESE
...||...                       .. .|. .     .|....|||. ...| .|.    .          .. ..|..  |...  ||||| 
lvigDlHgglddle...............d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalld.........ylvlklllpipvfllrGNHesd

CHSPA-----CVADTKIGNALRNFSAYNTrwhmpsedskgvlnmwyswnygpvhfislntetdfPgagEENTGDSHDPFMPAGHFAPDGTYLAWLEQELA
..  |      ...   |.| .  .  |.                                   .   .  . .| . .   |    .|.. ..  .|  
pgnsaygflleqlkdlrglangeeeyenl...................................k...itllttsgelyglsglypllgdsaqeeqleef

AAHANRAQRPWIIAGGHRPFPDIAANGVQ------------ELFERYEVDVYVAGHTHSY
.|  .||. ...|. .|.|. .   .|..            .|.|.| ||... |||| .
lalplralvdgkilltHgplsssggsgddigselfgpdalekllekygvdlvlrGHtHkp
PAPL 322-378 3.7e-13 42.0 In-house 126-194 (194) alignment 
Range on Protein: 322-378
Range on HMM: 126-194/194.0
LAWLEQELAAAHANRAQRPWIIAGGHRPFPDIA------------ANGVQELFERYEVDVYVAGHTHSY
  . ..|.. |..||...||||. ||||.                 .....|. .|.||...||| |||
eqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvlaGHeHsY
PhoD PhoD-like phosphatase 80-194 8.2e-10 29.2 Pfam-A 65-147 (453) alignment 
Range on Protein: 80-194
Range on HMM: 65-147/453.0
ApqsyldghgfhhvVRVLNLQPATEYMYQVGD-QTDGWSDTFVFRSAPATSDVPVSFALFGDMGY-LGSaerpmvvatgglqknwsavpvRTLLESLKDT
              |.| .|.|..|| |..   ...  | .  .| .|...   ...|..... |  |                       . .. | ..
k.............vevtgLepgqeyfYrfraeegesespvGrtrTlpeaaveslrlavvSCsnyeqGy.....................fnayrelaek

KAIDFIWHLGDIGYADD
. .||. ||||. |.. 
edlDfvlhlGDyiYeyg
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 169-406 1.4e-09 30.2 Pfam-A 15-138 (156) alignment 
Range on Protein: 169-406
Range on HMM: 15-138/156.0
TLLESLKDTKAIDFIWHLGDigyaddafS--HaplkfgyesayngymNWIQNLTATMPYMVSVGNHEsechspacvadtkignalrnF----------Sa
.| . |.| | .|.|.|.||        .  .               . . .| ...|  .  |||.                                 
aleavledikevdlilhaGD........lvep...............eevvelledipvlavrGnhD....................eaelpkelavel.

yntrwhmpsedskgvlnmwyswnygpvhfislntetdfpgageentgdshdpfmpaghfapdgtylawleqELAAAHANRAQRPWIIAGGHRPFPDIAAN
                                                                        ||||. .  .. ...  |..  ..  ..
.......................................................................llaaaaleiegdrvllvhgtplsvqssee

GVQELFERYEVDVYVAGHTHSYSRsmpgnlngssyHNLNGTVLVVAGGTG
 ..||.. ...|... |||| ..               .||..|. |  |
elaellkeagadlvflGHtHkpkv...........ekrggtlvvnpGsvg
subfamily_PAPL_pd Subfamily PAPL 166-377 1.7e-08 25.9 In-house 21-211 (212) alignment 
Range on Protein: 166-377
Range on HMM: 21-211/212.0
PVRTLLESLKDTKAIDFIWHLGDIGYADDAFSHAPLKFgyESAYNGYMNWiQNLtaTMPYMVSVGNHESECHSPACVADTKIgnalrnfsayNTRWHMPS
 | . | .. ..   .|. .|||. | .   . .  .|  .. ..   .. . |  ..|..|  |||. .    | .| .|.           .||..||
avakelgkvaeeleaqfvlalGDnfYekGvkdvddarf..ketfedvfta.esl..qvpwyvvagnHDykGnvsaqiaYskl..........skrWkfps

EDSKGVLNMWYSwnYGPVHFISLNTETdFPGAGEENTgdshdPFMPAGHFAPDgTYLAWLEQELAAAHANraqrpWIIAGGHRPFPDIAANGV-------
   .  ...  |     |... ..|   . |  ....     .  |.   . . . .||||.||.|..|.     ..| .|| |   .| .|        
lyytksfkipds..natvqlvlidtvl.lcgksddlk.....legpvdvslae.eqwawleeeLkasead.....ylivaGhypvwsvaehGptkiLvkr

-QELFERYEVDVYVAGHTHS
 . | |.|.|..|..|| |.
LkPlLekynvtaylsGhDhn
ACP5 314-376 4.6e-07 21.7 In-house 128-197 (198) alignment 
Range on Protein: 314-376
Range on HMM: 128-197/198.0
HFAPDGTYLAWLEQELAAAhANRAQRPWIIAGGHRPFPDIAANGV--------QELFERYEVDVYVAGHTH
  |.. .| ... ..| .|  .. .  |.|  || |   |. .|         . |...|.||.|..|| |
evaerekyaeeqlkwleka.lakstadwkiVvGHhpvySigehgdtkelverllpllkkykvdaYlnGHdH