Gene PAPL-5 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP086_AA protein Get Run
MbreP086_AA_262-489 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP5_pd Subfamily ACP5 269-468 1.3e-69 225.9 In-house 1-189 (189) alignment
Range on Protein: 269-468
Range on HMM: 1-189/189.0
VWGDMGRHGgSQALDRLTLEAsdDHRNVTTLIHFGDFAYDLDDNGGINGDTFMTRIQQLASHKPYMTCVGNHEIEdGSFSNYLNRFTMPrydvN--Ngwd
|.||.| .  ...|..|  |.  ........||.||.||.|... .  .|.||. |..|||. |||...|||| .  .||.| .||.||    .  .   
vfgDlgvse.aaslatllkee..eaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesd.snfsaykkrfsmp....skne...

mlWHSWDVHLVHFISYSTEVYFSNKfdiQRQYDWLEADLQAANaNRTLRPWIIAFGHRPMYCSNLDGDDCTKNSSVVRAG----LEDLFHKYGVDIVFEA
  |.|.|.. |||||.||||.||..   ..||.|||.||..|| ||. .||||..||||||||| |.|||||....||.|    ||||..||.||.....
..wYsfdygpvhfislstevdfslg...seqykWLekdLkean.nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlalsg

HEHSYE
||||||
HeHsYe

PAPL 269-467 1.5e-56 183.6 In-house 2-194 (194) alignment
Range on Protein: 269-467
Range on HMM: 2-194/194.0
VWGDMGRHGGSQaldRLTLEASDDHRNVTTLIHFGDFAYDLDDNGGINGDTFMTRIQQLASHKPYMTCVGNHEIEDgSFSNYLNRFTMPR--YDVNNGWD
| ||.| .  |.     .|... ..... ...|.||.||..|.. . .|| ||  |..||...|||...|||| |   |||| .||.||   .  .| ..
vfGDlGqtnass...lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeey.nfsnykarfsmpgseegesnsse

MLW--HSWDVHLVHFISYSTEVYFSNKfdiQRQYDWLeaDLQAANANRTLRPWIIAFGHRPMYCSNLDGDDCTKNSSVvRAGLEDLFHKYGVDIVFEAHE
. .  .| ... |||| .|.|  ...|   . ||.||  ... |..||. .||||..||||||||| | |||...... .|.||||..|||||.|. .||
sgsnsysfetesvhfivlsseedvkek...seqyewl..eedlakvnRsktPWiivmgHrpmYcsnkdkddckekakm.laaledllykygVDlvlaGHe

HSY
|||
HsY

Metallophos Calcineurin-like phosphoesterase 276-467 3.8e-16 53.0 Pfam-A 10-200 (200) alignment
Range on Protein: 276-467
Range on HMM: 10-200/200.0
HGGSQAL--DRLTLEASDDHRNVTTLIHFGDFAYDLDDNGGINGDTFmTRIQQLASHKPYMTCVGNHEIEDGSFSNYLNRFTMP-RYDVNNGWDMLWHSW
|||   |  ..| |..   . ....... ||. .  |.  .. ..      ..|.  .|.. . ||||   | . .. .  . . ... .||..  .  .
HgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeeeyenlk

dvHLVHFISYSTEVYFSNKFDIQRQYDWLEADLQAANANRTLRPWIIAFGHRPMYCSNLDGDDCtKNSSVVRAGLEDLFHKYGVDIVFEAHEHSY
     .. |. . .  . . . .  . .   .  .|. .|.| ...|. .|.|...|   |||  ..    .  ||.|. |||||.|. .|.| .
..itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.gselfgpdalekllekygvdlvlrGHtHkp

Metallophos_C Iron/zinc purple acid phosphatase-like protein C 487-546 1.3e-11 36.1 Pfam-A 1-51 (62) alignment
Range on Protein: 487-546
Range on HMM: 1-51/62.0
KAAVHLVSGAAGCNEANgaclnpILTGRLPWSAFRSsaqGTYSFGHLNIHNSTHAYFDSY
|| ||.|.||||... .        . . .|||||.    .| .. |...|.||.... .
kApvhIvvGaAGnglsk......fskpqpewsafre...sdyGysrltvvNrthLhwefv

ACP5 267-466 3.4e-11 35.2 In-house 1-198 (198) alignment
Range on Protein: 267-466
Range on HMM: 1-198/198.0
FLVWGDMGRHGGSQAL-DRLTLEASDDHRNVTTLIHFGDFAYDLDDNGGIN---GDTFMTRIQQLASHKPYMTCVGNHEIEdGSFSNYLNRFTMPRYDVN
||| ||.||.| ..      ...   .. ..   .  ||  ||   ..       ..|    .. . ..|.....|||... |. |  ..     .    
flvvGDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyr.gnvsaqieyakrskdsrf

NGWDMLWHSWDVHLVHFISYSTEVYFSNKFDIQRQ-YDWLEADLQAANANRTlRPWIIAFGHRPMYCSNLDGDD-CTKNSsvvragLEDLFHKYGVDIVF
      .... |    | .  .| . ... . ...   .. ..|..|.|. |   |.| .|| |.|     ||  .  ..      |. |..||.||. .
pslryslskkevvtelftekkdeksdqrevaerekyaeeqlkwlekalakst.adwkiVvGHhpvySigehgdtkelver......llpllkkykvdaYl

EAHEHS
  |.|.
nGHdHc

subfamily_PAPL_pd Subfamily PAPL 390-466 8.9e-07 20.3 In-house 145-211 (212) alignment
Range on Protein: 390-466
Range on HMM: 145-211/212.0
NKFDIQRQYDWLEADLQAANANrtlrpWIIAFGHRPMYCSNLDGDdctknSSVVRAGLEDLFHKYGVDIVFEAHEHS
.    ..|. |||..|.|..|.     ..| .|| |..    .|       ....  |. | .|| |.  .  |.|.
dvslaeeqwawleeeLkasead.....ylivaGhypvwsvaehGp.....tkiLvkrLkPlLekynvtaylsGhDhn

Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 276-469 1.5e-06 20.3 Pfam-A 10-123 (156) alignment
Range on Protein: 276-469
Range on HMM: 10-123/156.0
HGGSQALDrltlEASDDHRNVTTLIHFGDFAYdldDnggingDTFMTRIQQLashkPYMTCVGNHEIEDgsFSNYLNRFTmprydvnngwdmlwhswdvh
||. .||.    .. .|...| ...| ||.            .... .....    |  .. |||. ..  . . |.. .                    
Hgnldale....avledikevdlilhaGDlve...p......eevvelledi....pvlavrGnhDeae..lpkelavel....................

lvhfisystevyfsnkfdiqrqydwleadlQAANANRTLRPWIIAFGHRPMYCsnldgddCTKNSSVvragLEDLFHKYGVDIVFEAHEHSYER
                                |.|..... . . . |.  .        .... .     |. |. ..|.|.|| .| | .. 
..............................llaaaaleiegdrvllvhgtpls.......vqsseee....laellkeagadlvflGHtHkpkv