Gene PPP4C-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP104_AA protein Get Run
MbreP104_AA_3-293 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP4C_pd Subfamily PPP4C 5-293 1.1e-168 552.8 In-house 1-286 (288) alignment 
Range on Protein: 5-293
Range on HMM: 1-286/288.0
SDLDAQLEKLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRY
|||| |.|||.|||||.||.| .||.|||||||||.||| |.||||.|||||||||||.|||..|||||...|.||||.|||||.|||||||||||||||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRVYLIRGNHESRQITQVYGFYDDCLRKYGSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPEDIE
|||..|||||||||||||||||||.||||||||.||..||.||||.||...||...|||||||||..|.|||||.||||.|||||||.||||||||||.|
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

AWAMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYNgSHSDPRysFRLFSEAP
.||.||||||.|||..|..||||.|....|.|||||||||||.||.|.||||||||||||||||.|||.|.. ...| .  |..|..|.
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileld.eeldkd..fkifeaaa
subfamily_PPP2C_pd Subfamily PPP2C 5-293 5.4e-143 468.4 In-house 2-287 (290) alignment 
Range on Protein: 5-293
Range on HMM: 2-287/290.0
SDLDAQLEKLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRY
.|||...||||.|. ..|..| ||| ||.||| .|.|||.|..|||.|||.||||.||.||| |||..|.  |.|||||||||..||||  || ||||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRVYLIRGNHESRQITQVYGFYDDCLRKYGSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPEDIE
..|. ..|||||||||||||||||.||||||.| ||.. ||.|||..|. |.|...||.||||||... ||.|| .||  |||||||.||||||||.| .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

AWAMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYNGSHsdpRYSFRLFSEAP
 |..||||||. ||  .. .||..|.|..||||||||||||.| . ..| |..||||||||||| |||.| . ..   .|||  |  ||
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddkl...kysflqfdpap
subfamily_PPP6C_pd Subfamily PPP6C 7-296 1.8e-140 460.1 In-house 2-288 (290) alignment 
Range on Protein: 7-296
Range on HMM: 2-288/290.0
LDAQLEKLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPD
||  .|  |.|. ..|.....|| .  ..|.||.|||||.||||.|||||||||||.|||  ||.||. |||||||.||||..|.||| .||.||..|||
ldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypd

RVYLIRGNHESRQITQVYGFYDDCLRKYGSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPEDIEAW
|. |.|||||||||||||||||.||.|||.| .|. ||.||| .... .||..|.||||||||..  ||.||.|.| .|.||.|..|||.||||||.|.|
ritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvetw

AMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYNGSHsdpRYSFRLFSEAPASK
|.||||||.|||..|...|.. |||..|.||||||.||.|..| |.. ||||||||||||||.|.|.. . ..     ...||.  | ..
avsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae...ereaklfkavpdee
subfamily_PPG1_pd Subfamily PPG1 7-296 3.9e-122 400.2 In-house 1-300 (300) alignment 
Range on Protein: 7-296
Range on HMM: 1-300/300.0
LDAQLEKLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPD
||  ||||...||. |  | ||. | .|.||.|.||. ..||||. ||.||||||..|.|.|||.||.  |.|||||||||..||||  ||..||.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RVYLIRGNHESRQITQVYGFYDDCLRKY-GSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPE----
|. |.|||||||||||||||| .||||| | ..||.  |..|||..|...||.|..||||||||.   .|.|...||  |||.|| ..||||||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DIEA--WAMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYNGShsDPRYsFRLFSEAP
      | |   . .|.||||. .| .|. .| . |... | |||||..|||. .| . . |||||||||||||| |.| | .    | || |  ..|||
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyek..dery.fnvyeeap

ASK
 ||
esk
PPP_3 20-278 2.7e-116 380.3 In-house 2-261 (271) alignment 
Range on Protein: 20-278
Range on HMM: 2-261/271.0
ISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQ
.||....||..|..||| .|.|.. ...|||.|||||||..||.|||..||..|...|.||||||||| .|.|..|||||||..||..|.|.||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDDCLRKYGSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDL-LWSDPEDIEAWAMSPRGAGFLFG
|..||||....|.|.|...|.. ...||....|. |||..|..|||||||....||.|. ..||||||.||...|| |.||||. | .. |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

ASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYNGS
..|...|.|.|.|..|.|||.|..|||. .. ..|.||.||||||.|..| .||.. . .
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleea
0045823 Metallo-dependent phosphatases 5-293 9.5e-114 373.5 In-house 28-325 (473) alignment 
Range on Protein: 5-293
Range on HMM: 28-325/473.0
SDLDAQLEKLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRY
.|||. .| ||...|..||....|...|.||| .| |..... .....||||||..||..|.|. |  | . .|||||.|||| .|.|...||||||..|
ldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkiky

PDRVYLIRGNHESRQITQVYGFYDDCLRKYgSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPEDIE
|..|.|.|||||.|.....|||.|..|.|| ...... . .....  |...|.. ...||||||| |. ||.||.|.| .|.|..|...|||||||....
pgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwedd

A--------WAMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEE------VLTVWSAPNYCYRCGNIAAIFEYNGshsDPrYSFRLFS
         .  ||||||.|||. .. .| ..|.| .| |.|. |.|||...|         ..||.||||||.|.|| ||. ....   |  .||..| 
gdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvide...dl.isfiqfd

EAP
 .|
psp
PPP_1 21-274 1.9e-110 361.3 In-house 2-263 (264) alignment 
Range on Protein: 21-274
Range on HMM: 2-263/264.0
SEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQI
.||...||..|..|.|..| |.. |....|.||||||||.||..||..||..|...|.||||||||| .|||..|||||||..||....|.||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDDCLRKYGSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDL--------LWSDPEDIEAWAMSPRG
|.||||....|.|..|.......|||||...|. |||.....|||||||.|..||.|| ..||.|||.||..|||        |..|.|. ||.| |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFE
||.|||..|...|...|||..|.|||....|||.... ..|.|..||.||.....| .|. .
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
0049330 Metallo-dependent phosphatases 4-279 8.9e-107 349.6 In-house 14-289 (309) alignment 
Range on Protein: 4-279
Range on HMM: 14-289/309.0
CSDLDAQLEKLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVR
.|.||...|.|... |.|||....|. ||.||| .| |..... .....||||||..||..|.|. | .| . .|||||.|||| .|.|..|||||||..
lslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkll

YPDRVYLIRGNHESRQITQVYGFYDDCLRKYGsAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPE-D
|||.|.|.|||||.|.....|||.|..||||| |..|. ..|....  | ..|.....|||||||| |  ||.||...| .|.|..|..||||||||  .
ypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpi

IEAWAMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYNGSH
.| .|..|||.|..||. .  .| ..|.|..| |.|..|..||...| ....||.||||||.|.|| .|. |.....
regfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedl
0053225 Metallo-dependent phosphatases 4-278 3.2e-104 341.3 In-house 6-280 (293) alignment 
Range on Protein: 4-278
Range on HMM: 6-280/293.0
CSDLDAQLEKLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVR
...||...| |... |.|||....|. .|.|||..| |..... .....|||||...||..|.|. | .| . .|||||.|||| .|.|...||||||..
lllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkll

YPDRVYLIRGNHESRQITQVYGFYDDCLRKYGSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPEDI
|||.|.|.|||||.......|||.|..|||||.|..|. ..|....  |..||......||||||| || ||.||.|.| ...|.||...||||||| ..
ypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlw

EAWAMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYNGS
. |..|.||.|..||. .  .| ..|.|..| |.||.|..||...| ....||.|||||..|.|| .|. .....
sgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeg
PP2Ac_SM00156 21-277 1.7e-102 335.1 In-house 2-258 (271) alignment 
Range on Protein: 21-277
Range on HMM: 2-258/271.0
SEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQI
|.|.|.||.....||| .|.|.  |..|||..||||||..||..|.| .| .|.  ||||||||||| .|.|. |||.|||..||..|.| ||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDDCLRKYgSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDP-EDIEAWAMSPRGAGFLFGA
...|||.... ||| ...... ....|....|..|.|....|.||||||.|..||.|| ..|  | |.||...||||||| .. . ...| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

SVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYNG
.....| ..|||. | |||..|.|||.. . ....|..||||||....| ||..... 
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkvek
subfamily_PPP1C_pd Subfamily PPP1C 18-275 6.9e-100 326.9 In-house 8-265 (282) alignment 
Range on Protein: 18-275
Range on HMM: 8-265/282.0
ELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHES
  ..|... .|..||||||.... .  .. ||.|.||||||..||. |||..|  |...|.||||||||| .|.|| .||||.|..||....|.||||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

RQITQVYGFYDDCLRKYGSAhVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPE-DIEAWAMSPRGAGFL
 .|...|||||.| |.|..  .|.  ||||... |. |.|....||||||||.|..|..|| | | .|||..| .||||||||. ... |. . ||  | 
asinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsft

FGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEY
||..| ..| ..|.|..| ||||.| .||...  ....||.|||||| . .| .|... 
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsv
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 5-276 1.3e-87 286.6 In-house 9-281 (298) alignment 
Range on Protein: 5-276
Range on HMM: 9-281/298.0
SDLDAQLEKLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRY
. | . |.. | .. |.||.| .|...|..|. . . .  |..|...|||||||. ||. ||. .|  |.  |.||||||||| ...|. .|||| ||.|
evlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvky

PDRVYLIRGNHESRQITQVYGFYDDCLRKYGSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPED-I
|....|.|||||  .| .|||||..| |.| | ....   |||. . |  || . ..|.|||||.||..||..| . | .. ..|    ||||.|||. .
pnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenav

EAWAMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYN
. || . ||... ||. |  .. |. .. ...||||.| .||..     ..|..|||.|| .  | ||. . .
kgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvd
subfamily_PPP3C_pd Subfamily PPP3C 12-277 1.3e-85 280.8 In-house 33-311 (452) alignment 
Range on Protein: 12-277
Range on HMM: 33-311/452.0
EKLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLI
|....   ..||..... ..| ..| .| ..  |..|.|..||||||||||..|||.|||  . .|.||||||||| ||.|. | |.|||. ||....|.
ehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfll

RGNHESRQITQVYGFYDDCLRKYgSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPE-DIEAW----
|||||.| .|. . | ..|  || | .|.. |.. || . |. |.... .||||||||....||.|. .||  |.|. ||.||||||||  | .      
rGnhecrhlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeektee

---AMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFT------EEVLTVWSAPNYCYRCGNIAAIFEYNG
     |.||  .... . ...| ..|.|  | |||.   .||. .          ..|..|||||.    | ||...|. 
kfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_PPP5C_pd Subfamily PPP5C 18-284 3.1e-81 265.9 In-house 32-303 (322) alignment 
Range on Protein: 18-284
Range on HMM: 32-303/322.0
ELISEEQVVELCRKAREILVEEANVQ----PVQSPVTICGDIHGQFYDLMELFEIGGDV-PQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIR
. . .  ....  .|.|.| ... .     . .. .|.|||||||||||...||. | . ....|.| ||.|||| ||||. |.||..|. ||....| |
kklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsr

GNHESRQITQVYGFYDDCLRKYgSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPK-LSQLDEIRMIDRKIEVPHEGPMCDLLWSDPEDIEAWAMSPR
||||| .. ..||| ...  || ...| .| |.||... |. .|...|. |||||  .   .||..| |||  . |.|| ...||||||.. .  ..| |
GnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrspskr

GAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYNGSHSDPRY
| |. ||  |...| . |||. | |.|.. .|||. .   ...||.|||||| . || .|. . .|.. ....
GvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkf
PPP_2 49-240 1e-80 263.1 In-house 1-197 (198) alignment 
Range on Protein: 49-240
Range on HMM: 1-197/198.0
VTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQITQVYGFYDDCLRKYGSAHVWQLCTDVFD
||.|||.|||..||..||. |...|.|.|.||||||||| .|.|..|||||||..||..|.|.||||||.....||||....|.|.|...|.. ...||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDL-----LWSDPEDIEAWAMSPRGAGFLFGASVASQFNERNNLHFIARAHQL
...|. |||..|..||||||.....||.|. ..||||.|.||...||     |....|. | .| | ||||.|||..|.... |.|.|..| |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 18-274 2.5e-79 259.7 In-house 6-268 (284) alignment 
Range on Protein: 18-274
Range on HMM: 6-268/284.0
ELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDV------PQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLI
.|..|....||| .|||.. .|   . ...||.|.||||||| ||. |... |         .. |.||||||||| ||.|  .||.|.|...||.|.|.
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQVYGFYDDCLRKYgSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPE-DIEAWAMSP
||||||| . . |||| .| ..| |  ...     |  . |. .... ..|.|||.| .| .|...  ..| |..|  | ..|| |.||| ..| .. ||
rgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFE
|||| .|||.   .|... .|... ||||.||.||..    ...|..||| || .  ||||...
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavln
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 19-275 2.1e-77 253.3 In-house 23-280 (299) alignment 
Range on Protein: 19-275
Range on HMM: 23-280/299.0
LISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESR
 . |.....||. |.......| .  |..|. .|||||||. ||. .|.. |  |.  ..|||||||||   .|.  |||. |..||.| ...|||||  
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecp

QITQVYGFYDDCLRKYGSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPED-IEAWAMSPRGAGFLF
 | .|||||..| ..| |. .| .  | |... |. ||   ..|.||||||||..|| .| . |  . |      ||||.||.. .  |    ||  ..|
ainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvf

GASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEY
|  | ..  .| .. ..|||||.| .||..     ..|..||| || .  | |||.. 
gqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkv
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 20-276 2.1e-77 253.1 In-house 8-264 (281) alignment 
Range on Protein: 20-276
Range on HMM: 8-264/281.0
ISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQ
...|..... |... |..|| ..  ...|... ||.|.|| || .|||. | ||.. .||||||||||  |.|...||..||.||.||..|.|||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

ITQVYGFYDDCLRKYGSaHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPED-IEAWAMSPRGAGFLFG
. ..|||| .|  |||   .| |    |. . .| ||.  | |.||||||.|  |||.| . . |. .. | . ||||.||..  | |  | ||..|.||
vnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

ASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYN
 .|  .   | .. .| ||||.|..||.   .  ..||.|.||||    | ||.   .
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvd
PPP_4 49-240 7.9e-77 250.7 In-house 1-196 (197) alignment 
Range on Protein: 49-240
Range on HMM: 1-196/197.0
VTICGDIHGQFYDL-MELFEIGGDVP-QRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQITQVYGFYDDCLRKyGSAHVWQLCTDV
||..||||||..|| ..|...||. . .||||||||||||| .|.|..|||||||..||..|.|.||||||......|||....|.|  ...... ..||
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVP-HEGPMCDL-LWSDPE-DIEAWAMSPRGAGFLFGASVASQFNERNNLHFIARAHQL
||...|. |||..|..||||||..|..||.|. |.||||.| .|. ..|| |||||. . | .| | ||||.|||..|...| |.|||..| |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 15-274 1e-75 247.5 In-house 3-260 (280) alignment 
Range on Protein: 15-274
Range on HMM: 3-260/280.0
KRCelISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGN
 .|  | | .. .. .| ..||. .| .  |..||..|||.|||. ||. ||.  .  |.. |.||||||||| . .|  ||||| |||||.. ...|||
lac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgn

HESRQITQVYGFYDDCLRKYGSaHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPE-DIEAWAMSPRGA
||  .| . |||.|.. |.|   ....   ...| . |  |.   ..|.|||||.||  ||... . | .. ..|    ||||.||| ..  || ..||.
hevisinrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgv

GFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFE
  .||| |  .. |. .. .||| ||.| .||..     ..||.|||.|.    | ||.  
svifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavli
PPP_5_Dcr2 49-240 1.5e-75 246.6 In-house 1-198 (199) alignment 
Range on Protein: 49-240
Range on HMM: 1-198/199.0
VTICGDIHGQFYDL-MELFEIGGDVP-QRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQITQVYGFYDDCLRKYGSAHVWQLCTDV
||.|||.|||..|| ..||. ||| . .|.||||||||||| .|.|..|||||||..||..|.|.|||||..|....|||....|.||....... ..||
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVP-HEGPMCDL-LWSDPE-DIEA-WAMSPRGAGFLFGASVASQFNERNNLHFIARAHQL
||...|. |||..|..|||||||.. ...... |.||||.| ..| ..|| |||||. . |  .. | ||||.||| .|...| |.|||..| |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_PPZ_pd Subfamily PPZ 20-273 2.4e-71 233.7 In-house 25-278 (300) alignment 
Range on Protein: 20-273
Range on HMM: 25-278/300.0
ISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQ
. .......| ||||... . ..  .  .| | ||.|||. ||. ||   |  |.  |.|||||||||  |.|| ||||. |..||. ..|.|||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDDCLRKYgSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPEDI-EAWAMSPRGAGFLFG
.|.||||||.| |.    ..|.   | |. . |. ..  ..||||||||| |  .|||| . |  .||  | . ||||||| |  . |    ||  . . 
vtrvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

ASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIF
     .| ..  . ...||| .| .||..     ..||.||||||    |  |..
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavm
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 11-273 5e-70 229.1 In-house 14-279 (297) alignment 
Range on Protein: 11-273
Range on HMM: 14-279/297.0
LEKLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYL
  .   ...|.||.|..|   | ...  . ..  |..|. .|||||||| ||. ||  ||  |   |.||||||||| ||.|| .|||| ||..|  ..|
thekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfl

IRGNHESRQITQVYGFYDDCLRKYGSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSP---KLSQLDEIRMIDRKIEVpHEGPMCDLLWSDPE-DIEAW
.|||||   . .|||||..| ..| | ...    |||... |. || ....|.||||||   |   || .| |.|  |  .|. ..||||.||   .  .
lrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgf

AMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIF
    ||||  ||     .     .| ...||||.| .||..    ...|..||| || .  | ||..
menqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafm
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 17-276 5.2e-70 229.1 In-house 3-262 (280) alignment 
Range on Protein: 17-276
Range on HMM: 3-262/280.0
CELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHE
|....  ... . |    |..||.|.   ..|. . |||| |. |.  ||.. | ||.   .|||||||||   .| ..||..||.|| ||.||.|||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDDCLRKYGSAHVWQLCTdVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPED-IEAWAMSPRGAGF
.  . ..|||| .|  ||| .  |.. . .|. . .| ||   |.|.||||||.| .|| || | | .|    | . ||||||| .  |.|  | ||  .
tpsvnkiygfyvecqykygvglwwdfqs.cfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYN
.||  |  |  .  .. .| ||||.| .||.      ..||.| |||| .  | ||.   |
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvcln
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 13-277 1.1e-69 227.5 In-house 3-270 (287) alignment 
Range on Protein: 13-277
Range on HMM: 3-270/287.0
KLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIR
|    . .|.....|. .|..|||     .  |..|.||.||||||. ||. .|.  |  |.  |.|||||||||  |.|  |||..||..|| .|.|.|
kygvldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllr

GNHESRQITQVYGFYDDCLRKYGsAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKI--EVPHEGPMCDLLWSDPE-DIEAWAMS
|||| ..| ..|||...  ||..  ....   |||....|   ..  ..|.|||.||||  ||... . .       .|| . ||||.||| | .. .. 
GnhevkkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfeln

-PRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYNG
  |.   .|| ..  .. .. .. .| |||... |||.. | . ..||.||| |. .  |..|.   . 
kiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 74-275 9.3e-67 218.4 In-house 100-301 (317) alignment 
Range on Protein: 74-275
Range on HMM: 100-301/317.0
QRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQITQVYGFYDDCLRKYgSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQ
.. |.||||||||| ||.|  .||.|||..|||.|.|.||||||| . . |||| .. ..| ||....    .|  . |. .......|.|||.| .| .
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDEIRMIDRKIEVPHEGPMCDLLWSDPE-DIEAWAMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAI
|...  ..| ...|  | ..|| |.||. ... .. |.||||..|||.   .|... .|... ||||.|..||..    ...|..|||.|| .  ||||.
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

FEY
.. 
lsv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 19-276 2.2e-64 210.6 In-house 2-261 (284) alignment 
Range on Protein: 19-276
Range on HMM: 2-261/284.0
LISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESR
||. |.|  |  .| .|. ..  .  |.||. ||||||||| ||. ||.  |   .  |.|||||||||   .|| |||.| || .|......|||||  
lippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecs

QITQVYGFYDDCLRKYGSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPM-CDLLWSDPEDIE-AWAMSPRGAGFL
 | ..||||..| |.|    |..    ||  . |. |. . ..|.|||.|  | .. ..| | | .. |    .  |.||||| ...  |    ||  ..
linkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyv

FGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEYN
||.    .. .| .. .. ||||.| .||..     ..|..||| || .  | ||..  |
fgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvn
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 10-275 1.8e-63 207.3 In-house 6-275 (290) alignment 
Range on Protein: 10-275
Range on HMM: 6-275/290.0
QLEKLKRCELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVY
.|.|    . .|.....|. .|..|||     .  |..|..| ||||||. .|.. |.  |  |.  ..|||||||||  |.|  |||. .|.||. .|.
hllkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvh

LIRGNHESRQITQVYGFYDDCLRKYGSaHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRK--IEVPHEGPMCDLLWSDPED--IEA
|.||||| |.. ..|||...  || || ..|.   |||. .||   ..  ..|.|||.|.|.   . .. . .       .|| . ||||.||.    ..
llrgnhevrkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddt

WAMS-PRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEY
 |.   |.   .|| ..  .. ..  |..| |||..  ||... | . ..||.||| |. .  |. || . 
ialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatv
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 23-272 6.2e-59 192.7 In-house 23-275 (307) alignment 
Range on Protein: 23-272
Range on HMM: 23-275/307.0
EQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQITQ
|.. ..  .|. |.  |  .  .. |. . ||.|||| ||...| . |  |.  ||| |||||||..|.|. |||.. |. ||. . |.|||||  .. .
eefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk

VYGFYDDCLRKYG--SAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPMCDLLWSDPED-IEAWAMSPRGAGFLFGA
 ||||..|.         .| |   .|. . .| ||   ..|.|||||| |. |||.|   . |  |  | . |.||.||.  .  |  | ||.|| ||.
kygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgt

SVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAI
 |  .   |  . .| ||||....||       ..|..||| ||    |  ..
nviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 75-275 1.4e-53 175.1 In-house 120-320 (339) alignment 
Range on Protein: 75-275
Range on HMM: 120-320/339.0
RSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQITQVYGFYDDCLRKYgSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQL
. |.||||||||| ||.|  .|| |||. ||||.||.||||||| .   |||| .   .|  |....   ..|. . .  .|.. ..|.|||.| .|. .
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsf

DEIRMIDRKIEVPHEGPMCDLLWSDPEDIE-AWAMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIF
... .. | .|.|  | . || |.||.  |  .  | ||| |.||      | .. .|... | ||.| .||..     ..|..|||||| .  | ||.|
nqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavf

EY
  
si
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 20-274 2e-53 174.5 In-house 6-285 (302) alignment 
Range on Protein: 20-274
Range on HMM: 6-285/302.0
ISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGG-----------DVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRV
 |..... |...  | | .| ..  . .|||| ||||||| ||. ..                  .  .||||||||||  |.|   |..|||| || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

YLIRGNHESRQITQVYGFYDDCLRKYGSAH---VWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIE-VPHEGPMCDLLWSDPEDIE
 |.|||||.. |   ||| .    ..| ..   .|.   .|| .. |..|. . ..|||||.||||. |..|. |.| .. | ..    |||..|| |..
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

AWAMS----------PRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFE
. |.            ||  ..|  .   .. .| ||..| |||| . ||.|..  . .||..|||.|     |  |...
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 20-274 2.8e-53 174.0 In-house 7-286 (302) alignment 
Range on Protein: 20-274
Range on HMM: 7-286/302.0
ISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGG-----------DVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRV
 |..... |...  | | .| ..  . .|||| ||||||| ||. ..                  .  .||||||||||  |.|   |..|||| || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

YLIRGNHESRQITQVYGFYDDCLRKYGSAH---VWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIE-VPHEGPMCDLLWSDPEDIE
 |.|||||.. |   ||| .    ..| ..   .|.   .|| .. |..|. . ..|||||.||||. |..|. |.| .. | ..    |||..|| |..
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

AWAMS----------PRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFE
. |.            ||  ..|  .   .. .| ||..| |||| . ||.|..  . .||..|||.|     |  |...
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlk
subfamily_PPPLV_pd Subfamily PPPLV 26-272 5.1e-52 170.0 In-house 3-273 (290) alignment 
Range on Protein: 26-272
Range on HMM: 3-273/290.0
VELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLM----ELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQIT
. || .| .||..| .. ...||. . ||.||.. ||.     |. .| |.   |..||||||||| ||||    |||||| || .|.|.||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDDCLRKYGSA--HVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKL---SQLDEIRMIDRKIEVPHEG-PM-CDLLWSDPEDIEAW--------
. . .. ..  |.|    .||.  ..|||.. |.  ||..|||||.|.       ...  |. |  ... . .| |.  |.|||||.. .          
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

----A-MSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAI
    .  . || | .|..    .| .|||| |. |||.   .|..      .|||.|. .||    . | |
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaali
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 45-273 2e-51 168.1 In-house 5-240 (263) alignment 
Range on Protein: 45-273
Range on HMM: 5-240/263.0
VQSPVTICGDIHGQFYDLMELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLLLALKVRYPDRVYLIRGNHESRQITQVYGFYDDCLRKYGSAHVW----
.|.|. |||| |||. ||. .|.  |   .  |.||||||||| .|.|  .||..||.  | ...|.||||| . | . |||. .  ...    |.    
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

QLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIRMIDRKIEVPHEGPM-CDLLWSDPEDiEAWAMSP---RGAGFLFGASVASQFNERNNLHFIAR
.   .|| |. |  ..   ..|.|||.||.|  ||.|| |   .|  .  |. |||||.|||  .|  . |   |    .||     .. .| .. .| |
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidlivr

AHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIF
|||.|  || .     ..||.||  |     | ||. 
ahqvveygyaffadrrlitvfsasryqielcnyaavv
Metallophos Calcineurin-like phosphoesterase 48-240 1.1e-41 136.3 Pfam-A 2-198 (200) alignment 
Range on Protein: 48-240
Range on HMM: 2-198/200.0
PVTICGDIHGQFYDL----MELFEIGGDVPQRSYVFLGDYVDRGFFSVETFLLL--LALKVRYPDRVYLIRGNHESRQITQVYGFYDDCL----------
.....||.||...||    ..|..|... .   ..||||.||||  | ||. ||  |.||...|..|.|.||||||......|||.. .|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKLSQLDEIrmidrkievphegpmcdllwsdpedieawam
                       ....  .... . ..|.. .|  |.|  ....||.||. .   | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGFLFGASVASQFNERNNLHFIARAHQL
    ...|||  . . . |....  . |.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 4-183 1.1e-39 129.3 In-house 17-202 (383) alignment 
Range on Protein: 4-183
Range on HMM: 17-202/383.0
CSDLDAQLEKLKRCELISEEQVVELCRKAREILVEEANVQPVQS----PVTICGDIHGQFYDLMELFE-IGGDVPQRSYVFLGDYVDRGFFSVETFLLLL
...... .|..|. .|.  . |... |.|...|..  |.. |..     ||.|||.||.. ||. ..   |   ....||| ||.||||  |||  |.||
kdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillill

ALKVRYPDRVYLIRGNHESRQITQVYGFYDDCLRKY--GSAHVWQLCTDVFDYISLSVLIDDEVFCVHGGLSPKlSQLDEIRMIDRK
|| . ||  ||| |||||   .   |||  .   ||   .... .|  ||| .. |. |||.... ||||.| | ..|. .  |.|.
alllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkiers
subfamily_PPP7C_pd Subfamily PPP7C 192-275 9.4e-17 53.8 In-house 237-321 (383) alignment 
Range on Protein: 192-275
Range on HMM: 237-321/383.0
MCDLLWSDPEDIE-AWAMSPRGAGFLFGASVASQFNERNNLHFIARAHQLVMEGYKWHFTEEVLTVWSAPNYCYRCGNIAAIFEY
. |.|||||.  |  .. . ||.|  ||. |.... .. ||... |.|.  .|||..   ..|||..|| ||     |  |    
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvkl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 18-70 1.7e-14 46.7 In-house 7-59 (317) alignment 
Range on Protein: 18-70
Range on HMM: 7-59/317.0
ELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGG
.|..|....||| .|||.. .|     ...||||.||||||| ||. |... |
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 18-70 5.6e-09 28.5 In-house 9-61 (339) alignment 
Range on Protein: 18-70
Range on HMM: 9-61/339.0
ELISEEQVVELCRKAREILVEEANVQPVQSPVTICGDIHGQFYDLMELFEIGG
.|.   .. |||..|||..  |  .  ...|. . ||||||| ||. .... |
dlfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_YNL217W_pd Subfamily YNL217W 49-121 1.9e-07 23.8 In-house 12-80 (235) alignment 
Range on Protein: 49-121
Range on HMM: 12-80/235.0
VTICGDIHGQFYDLMELFE--IGGDVPQRSYVFLGDYVDRGFFSVETFLLLlalkvrYPDRVYLIRGNHESRQIT
. . ||.|| . .|.||..  |||  ..   |..|| ...|  |||.  ..        | |. ..||||   . 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll