Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_EYA_pd | Subfamily EYA | 21-290 | 5.5e-154 | 500.9 | In-house | 1-270 (270) | alignment | ||
Range on Protein: 21-290
Range on HMM: 1-270/270.0
RIFIWDLDETIIIFHSLLTGLFATKFGKDSPSSVALGLRMEEMIFNLADTHMFFNDLEDCDQVHIDDVAADDNGLDLSTYNFEADGFHAAATSANLCMAT
|.||||||||||||.||||| .|||..||..|.|||||||||.|||||||..||||||..||||.|||..|||| |||||||..|||||||||||||.|.
rvfiWdldetiiifrslltgsyatkyakdansvvalglrmeelifnladtklffndleeidqvhvddvssddngqdlstynfatdgfhaaatsanlclai
GVRGGVDWMRKLAYRYRKIKEVYSSYRNNVGGLLGAAKRETWLQLRMELESTTDSWLTLALKALSIIHSRTNCLNIMVTTTQLVPALAKSLLYGLGALFP
|||||||.|||||.||||.||.|.||.||||||||.||||.|||||.|.|..||||||||||.||.|.||.||.|..|||||||||||| ||||||..||
gvrgGvdvmrklafryrkvkelynsyknnvggllgpakreawlqlraeiealtdsWltlalkslslissrsncvnvlvtttqlvpalakvllyglgsvfp
IENIYSATKIGKEACFERILNRFGKKCTYIVVGDGRDEETASRQMNFPFWRVNTHSDLINLHHALDLGHL
|||||||||||||..||||..|||||.||.|.|||.|||||....|.||||...|||| .|..||||..|
ieniysatkiGkesvferivsrfGkkvtyvvigdgkdeetaakklnlPfWrisshsdlaalysaldleyl
|
|||||||||
EYA | 20-289 | 9.3e-108 | 349.4 | In-house | 2-273 (274) | alignment | |||
Range on Protein: 20-289
Range on HMM: 2-273/274.0
ERIFIWDLDETIIIFHSLLTGLFATKFG--KDSPSSVALGLRMEEMIFNLADTHMFFNDLEDCDQVHIDDVAADDNGLDLSTYNFEADGFHAAATSANLc
||...||||||.|...|||.| .| ||. || .|| |.|.|..|..|||.|.|....|.||.|..|||. ||.| |||.|.||.|||..|. . |
ervyvWdldetlillkslldGsyaekfdglkdhkksveigkrleklileladehffyeeieecdevflddvkedddGkdlsayefetdgfstasddlnk.
matgvrggvdwmRKLAYRYRKIKEVYSSYrnnVGGLLGAAKRETWLQLRMELESTTDSWLTLALKA---------------LSIIHSRTNCLNIMVTTTQ
|||||||||.|| | .. ...||. |.|.. .|| |.. |||||..||| |. |.|| |..|..||..|
............rklayryrkvkekyekg...leklldsekkealdelrseidkltdsWlssalklrlkkvcvreeadgkslleissrensvnvlvtsgq
LVPALAKSLLYGLGALFPIENIYSATKIGKEACFERILNRFGK-KCTYIVVGDGRDEETASRQMNFPFWRVNTHSDLINLHHALDLGH
|.||||| |||.|. ...|||.|||.|.||. ||.|| .||.| | ...|.||||.||||......||.....|.|| ....||.|.
liPalakvllyrldeilaienvysaikvGklqcfkrikerfdkpkvrfvviGdGreeetaakalklPfvkielhpdlsarfpalelkt
|