Gene PAPL-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP098_AA protein Get Run
NvecP098_AA_231-450 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP5_pd Subfamily ACP5 234-451 1.3e-67 219.4 In-house 1-189 (189) alignment 
Range on Protein: 234-451
Range on HMM: 1-189/189.0
VYGDMGVSAppgsVVTARLALQEVIANKAAFIFHVGDISYARGY--AYVWEQWHTLIEPYATLVPYMVGIGNHEQDHtsggA---Kdpsgapgdgfhpww
|.||.|||.      ... .|.|  ||.. .|.||||..||...  ..||.....||||.|. ||||| |||||.|.                       
vfgDlgvse....aaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesds....nfsay..............

gdfgddsggecgvpmYQRFRMPDNGNalwWYSFDYGSVHFVMMSTEHNFTRGSPQYEWLERDLRGV-DRKTTPWVILGGHRPMYTSEISPADY-----IV
                .||.||.. .   |||||||.|||...|||..|..||.||.|||.||. . .||.|||.|. ||||||.|. .  |.     .|
...............kkrfsmpskne...wYsfdygpvhfislstevdfslgseqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlv

SKGMQHAFEDLLSEYHVDLALWGHYHAYE
.||.....|||| .|.|||||.||.|.||
rkglresledllykykvdlalsgHeHsYe
PAPL 348-450 5.4e-34 110.0 In-house 92-194 (194) alignment 
Range on Protein: 348-450
Range on HMM: 92-194/194.0
RMPDNGNALWWYSFDYGSVHFVMMSTEHNFTRGSPQYEWLERDLRGVDRKTTPWVILGGHRPMYTSEISPADYIVSKGMQHAFEDLLSEYHVDLALWGHY
 .. . .  . |||...||||...|.|..... | |||||| ||. |.|. |||.|. ||||||.|. .  |   .. |..|.|||| .|.||| |.|| 
esnssesgsnsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvlaGHe

HAY
|.|
HsY
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 465-524 1.8e-23 74.0 Pfam-A 2-61 (62) alignment 
Range on Protein: 465-524
Range on HMM: 2-61/62.0
ATTHIIVGTAGWTLDPDRYWKMDWSMYHDNEFGYGRITVHNSTAMYWEWVRNRDNAVVDV
|..||.||.||  |..  . . .|| ......||.|.||.|.|...||.||..|..|.| 
ApvhIvvGaAGnglskfskpqpewsafresdyGysrltvvNrthLhwefvrsddgqvlDs
Metallophos Calcineurin-like phosphoesterase 230-450 1.8e-19 63.8 Pfam-A 1-200 (200) alignment 
Range on Protein: 230-450
Range on HMM: 1-200/200.0
FKFVVYGDMGVSAPPGSVvTARLALQEVIANKAAFIFHVGDISYARGYAYVWEQWH-TLIEPYATLVPYMVGIGNHEQDHTSGGAKDPSGAPGDGFHPWW
....| ||..         .... |.    .|. .... ||....  ..  ..     | .. .  .|... .|||| |.     .     ..| . ...
lrilvigDlHgglddled.lllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglan

GDFGDDSGgecgvpmyqrfrmpdngnalWwYSFDYGSVHFVMMSTEHNFTRGSPQYEWLERDLRGVDRKTTPWVILGGHRPMYTSEISPADYIVSKGMQH
|.  ...                     . . .  .|. ..  | .. .. .| |.|.|| .|. ..|. ....|| .|.|.. |. |  |      . .
geeeyenl....................k.itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgpd

AFEDLLSEYHVDLALWGHYHAY
|.|.|| .| ||| |.|| | .
alekllekygvdlvlrGHtHkp
PAPL 233-321 6.2e-19 60.9 In-house 1-87 (194) alignment 
Range on Protein: 233-321
Range on HMM: 1-87/194.0
VVYGDMGVSAPPGsvvtARLALQEVIANKAAFIFHVGDISYARGYAYVWEQWH--TLIEPYATLVPYMVGIGNHEQDHTSGGAKDPSGAPG
.|.||.|   .      ..   .|.  .|  .|.||||..|| ..   |....   .|||.|. ||||| .||||... . . |  .  ||
avfGDlGqtnass....lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpg
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 257-480 1.6e-06 20.2 Pfam-A 22-143 (156) alignment 
Range on Protein: 257-480
Range on HMM: 22-143/156.0
VIaNKAAFIFHVGDIsYARgyayvwEQWHTLIEPYatlvPYMVGIGNHEQDHTSGGAK--Dpsgapgdgfhpwwgdfgddsggecgvpmyqrfrmpdngn
 | .....|.|.||. ...      |. . |.| .    |  .  |||.....   ..                                          
di.kevdlilhaGDl.vep......eevvelledi....pvlavrGnhDeaelpkelavel.......................................

alwwysfdygsvhfvmMSTEHN----------------FtrgspqyewlerdlrgvdrkttpwvilgghrpmytseispadyivSKGMQHAFEDLLSEYH
                ......                                                               . ...... ||.|..
................llaaaaleiegdrvllvhgtpls.............................................vqsseeelaellkeag

VDLALWGHYHAYERtcpvynqkCQAGATTHIIVGTAGWTLDP
.||.. ||.| ..          . |.|... .|..|.  . 
adlvflGHtHkpkv........ekrggtlvvnpGsvgepreg
PhoD PhoD-like phosphatase 165-282 7.9e-06 16.1 Pfam-A 61-149 (453) alignment 
Range on Protein: 165-282
Range on HMM: 61-149/453.0
GYIHEVLLTGLRPDTVYQYSYGStennidggllsslitsfslfP-LQKMSAVRSFHTApiPGPD--VpFKFVVYGDMGVSAPPgsvvtaRLALQEVIA-N
 |. .| .|||.|.. | | . .                       .. | | .. |.  |. .    ....|.... . ..         |..|. . .
dytvkvevtgLepgqeyfYrfra....................eegesespvGrtrTl..peaaves.lrlavvSCsnyeqGy......fnayrelaeke

KAAFIFHVGDISYARGyayvWE
.  |..|.||. |..|    ..
dlDfvlhlGDyiYeyg....eg
ACP5 379-448 9.2e-06 17.4 In-house 132-197 (198) alignment 
Range on Protein: 379-448
Range on HMM: 132-197/198.0
RGSPQYEWLERDLRGVDRKTTPWVILGGHRPMYTSEISpadyIVSKGMQHAFEDLLSEYHVDLALWGHYH
| . . |.|.   . . ..|. |.|  || |.|.          .| ... .. ||..|.||. | || |
rekyaeeqlkwlekalakstadwkiVvGHhpvySigeh....gdtkelverllpllkkykvdaYlnGHdH