Gene PAPL-4 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP100_AA protein Get Run
NvecP100_AA_88-316 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP5_pd Subfamily ACP5 94-297 5.8e-80 259.7 In-house 1-189 (189) alignment 
Range on Protein: 94-297
Range on HMM: 1-189/189.0
IFGDLGNKNARSLPFLQEEVQKGDYDAIIHVGDFAYDLFTNNGTYGDEFMRQIQPIAALVPYMTCPGNHESAYNFSDYKNRFSMPgnTNGMYYSWNIGPV
.|||||...|.||  |..| .....|.||||||.||.| ..|.. .||||..|.|.|. ||||...|||||..|||.||.|||||  .. ..||...|||
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp..sknewYsfdygpv

HFISISTEVYFSTYygydliDYQYAWLERDLKEATskeNRTLRPWIFAMGHRPMYCSNLDRDDCTNHLSIVRTGipekNKPGLEDLFYEYGVDVLLWAHE
||||.||||.||.       . ||.|||.|||||.   ||. .|||..|||||||||| |.||||.. ..||.|    ....||||.|.|.||..|..||
hfislstevdfslg......seqykWLekdLkean...nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkg....lresledllykykvdlalsgHe

HSYE
||||
HsYe
PAPL 93-296 5.6e-74 240.5 In-house 1-194 (194) alignment 
Range on Protein: 93-296
Range on HMM: 1-194/194.0
AIFGDLGNKNARSLPFLQEEVQKGDYDAIIHVGDFAYDLFTNNGTYGDEFMRQIQPIAALVPYMTCPGNHESAYNFSDYKNRFSMPGNTNGMYYSWNIGP
|.|||||..||.||. ||.|.|||.||||.||||.||.. ..|.. ||||||||.|.|| ||||..|||||..|||| ||.||||||...|...|.. |.
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgs

VHFiSISTEVYFSTYYGYDLIDYQYAWLERDLKEATSKENRTLRPWIFAMGHRPMYCSNLDRDDCTNHlsivrtgipEKNKPGLEDLFYEYGVDVLLWAH
 .. |..||... ......   ... .  ..|.|. .|.||. .|||..|||||||||| |.|||...         .| . .||||.|.||||. |..|
nsy.sfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckek.........akmlaaledllykygVDlvlaGH

EHSY
||||
eHsY
Metallophos Calcineurin-like phosphoesterase 91-296 8e-28 91.1 Pfam-A 2-200 (200) alignment 
Range on Protein: 91-296
Range on HMM: 2-200/200.0
RLAIFGDLGNKNARS---LPFLQEEVQKGDYDAIIHVGDFAYDLFTNNGTYGDEFmRQIQPIAALVPYMTCPGNHESAYNFSDYKNRFSMPGNTNGMYYS
| ...|||. ... .   |  |..  .... |.... ||. .     ..| ..   .. ..... .|.. ..||||| .  |.|. .  ...  .| .. 
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang

WNIGPVHFISISTEVYFSTYYGYDLIDYQYAWLERDLKEATSKENRTLRPWIFAMGHRPMYCSNLDRDDCtnhlsivrtGIPEKNKPGLEDLFYEYGVDV
.. .  ..| . |  .. ..   .  ...    |. |.|   ...|.| .......|.|...|    ||          | .. ... ||.|...||||.
eeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.........gselfgpdalekllekygvdl

LLWAHEHSY
.|..|.| .
vlrGHtHkp
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 320-381 3.6e-25 79.5 Pfam-A 2-61 (62) alignment 
Range on Protein: 320-381
Range on HMM: 2-61/62.0
APVHIITGSAGCseDHDKFKKDYGPWTAFRSEDYGYTRMTIHNKTHIYFDQFSVDKEKVIDS
|||||..|.||.   ..||.|   .|.|||..||||.|.|..|.||....... |. .|.||
ApvhIvvGaAGn..glskfskpqpewsafresdyGysrltvvNrthLhwefvrsddgqvlDs
ACP5 95-255 4.2e-08 25.1 In-house 4-171 (198) alignment 
Range on Protein: 95-255
Range on HMM: 4-171/198.0
FGDLGNKNARSLP----FLQEEVQKGDYDAIIHVGDFAYDLFTNNG---TYGDEFMRQIQPIAALVPYMTCPGNHESAYNFSDYKNRFSMPGNTNGMYYS
.|| |.|.. .       ... ..| |.|... .||  ||  ...       ..| .  .  .  ||.... |||.   | |   .  .   ... ... 
vGDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpslr

WNIGPVH-FISISTEVYFSTYyGYDLIDYQYAWLERDLKEATSKENRTLRPWIFAMGHRPMYCSNLDRD
...   . .... || . ...   .  . . .  |. ||. ... ..    |.. .|| |.|      |
yslskkevvtelftekkdeks.dqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgd
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 92-298 2.9e-07 22.6 Pfam-A 3-123 (156) alignment 
Range on Protein: 92-298
Range on HMM: 3-123/156.0
LAIFGDLGNkNARSLPFLQEEVQKgdYDAIIHVGDFAYdlftnngtyGDEFMRQIQPIaalvPYMTCPGNHESAYnFSDYK-NRFsmpgntngmyyswni
.||..||   | ..|  . |....  .|.|.|.||.            .|...... |    |  ...|||. |  . . .  ..               
iaiiSDlHg.nldaleavledike..vdlilhaGDlve.........peevvelledi....pvlavrGnhDeae.lpkelavel...............

gpvhfisistevyfstyygydlidyqyawlerdlkeATSKENRTLRPWIFAMGHRPMYCsnldrddctnhlsivrtgiPEKNKPGLEDLFYEYGVDVLLW
                                       . ..... . . . |.  .                    .....  |. |. |.|.|... 
....................................llaaaaleiegdrvllvhgtpls...................vqsseeelaellkeagadlvfl

AHEHSYER
.| | .. 
GHtHkpkv
PhoD PhoD-like phosphatase 44-175 1.8e-06 18.2 Pfam-A 58-179 (453) alignment 
Range on Protein: 44-175
Range on HMM: 58-179/453.0
NRTEYIHRVTLKDLTPTQSYVYHCGGP--DGWSEEFNFKARRDGVDWSPRLAIFGDLGNKnARSLPFLQEEVQKGDYDAIIHVGDFAYDLFtnNGTYGDE
....|. .|....| | |.| |.      .  |.  ...   ..   | |||....   . .   . ..| ..| |.|...|.||. |     .|||..|
serdytvkvevtgLepgqeyfYrfraeegesespvGrtrTlpeaaveslrlavvSCsnye.qGyfnayrelaekedlDfvlhlGDyiYeyg..egtykne

FM----RQIQPIAAlvpymtcpgnhesAYNFSDYKNRF
      |...|                ... .||..|.
ereekgrvvepeke.............ivtladYRkry