Gene PAPL-5 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP101_AA protein Get Run
NvecP101_AA_129-380 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP5_pd Subfamily ACP5 136-339 7.3e-79 256.1 In-house 1-189 (189) alignment 
Range on Protein: 136-339
Range on HMM: 1-189/189.0
IFGDLGNKNAKSLPFLQEEVQRGDYDAIIHVGDFAYNMDTDNALYGDEFMRQVQPIAAYVPYMTCPGNHEGAYNFSNYRFRFSMPgnTESLYYSFNIGPV
.|||||...|.||  |..| .....|.||||||.||.....|.  .||||....|.|..||||...|||| ..|||.|. |||||  ... .|||..|||
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp..sknewYsfdygpv

HFISISTEFYFFTDygleliDHQYAWLENDLKEAAapeNRTLRPWIFLMGHRPMYCSNTDHDDCTMHESRVRTGipelNKPGLEDILYKYGADVLIWAHE
||||.||| .|...      ..||.|||.|||||.   ||. .|||..||||||||||.|.||||..|..||.|    ....|||.||||. |.....||
hfislstevdfslg......seqykWLekdLkean...nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkg....lresledllykykvdlalsgHe

HSYE
||||
HsYe
PAPL 135-338 9.7e-74 239.7 In-house 1-194 (194) alignment 
Range on Protein: 135-338
Range on HMM: 1-194/194.0
AIFGDLGNKNAKSLPFLQEEVQRGDYDAIIHVGDFAYNMDTDNALYGDEFMRQVQPIAAYVPYMTCPGNHEGAYNFSNYRFRFSMPGNTESLYYSFNIGP
|.|||||..||.||. ||.|.|.|.||||.||||.||..|..|.  |||||||..|.||.||||..||||| .||||||..||||||..|. ..|.. |.
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgs

VHfISISTEFYFFTDYGLELIDHQYAWLENDLKEAAAPENRTLRPWIFLMGHRPMYCSNTDHDDCTMHESrvrtgipelNKPGLEDILYKYGADVLIWAH
 . .|..||...|.... |   ... .  ..|.|. |..||. .|||..||||||||||.|.|||. ...          . .|||.||||| |. ...|
ns.ysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekak.........mlaaledllykygVDlvlaGH

EHSY
||||
eHsY
Metallophos Calcineurin-like phosphoesterase 133-338 1.8e-28 93.2 Pfam-A 2-200 (200) alignment 
Range on Protein: 133-338
Range on HMM: 2-200/200.0
RLAIFGDLGNKNAKS---LPFLQEEVQRGDYDAIIHVGDFAYNMDTDNALYGDEFmRQVQPIAAYVPYMTCPGNHEGAYNFSNYRFRFSMPGNTESLYYS
| ...|||. ... .   |  |..  .... |.... ||. .  |  .   ..   ..|.......|.. ..||||  .  | | |.  ...  . |.. 
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang

FNIGPVHFISISTEFYFFTDYGLELIDHQYAWLENDLKEAAAPENRTLRPWIFLMGHRPMYCSNTDHDDCtmhesrvrtGIPELNKPGLEDILYKYGADV
.. .  ..| . |  .....   .  ...    |  |.| .|...|.| ....|..|.|...|   .||          | .. ... ||..|.||| |.
eeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.........gselfgpdalekllekygvdl

LIWAHEHSY
....|.| .
vlrGHtHkp
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 363-420 7.4e-21 65.7 Pfam-A 2-57 (62) alignment 
Range on Protein: 363-420
Range on HMM: 2-57/62.0
APVHIITGSAGCqeNHDPFKYHFGPWTASRSLDYGYTRMTIHNKTHIYFDQFSVDKFS
|||||..|.||.  ....|..   .|.| |. ||||.|.|..|.||....... |. .
ApvhIvvGaAGn..glskfskpqpewsafresdyGysrltvvNrthLhwefvrsddgq
ACP5 137-336 1e-07 23.9 In-house 4-197 (198) alignment 
Range on Protein: 137-336
Range on HMM: 4-197/198.0
FGDLGNKNAKSLP----FLQEEVQRGDYDAIIHVGDFAYNMDTD---NALYGDEFMRQVQPIAAYVPYMTCPGNHEGAYNFSNYRFRFSMPGNTESLYYS
.|| |.|.. .       ... ... |.|... .||  |.  ..        ..| . ..  .  ||.... |||.   | |      .   ... ... 
vGDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpslr

FNIGPVHFISISTEFYFFTDYGLELIDHQYAWLENDLKEAAAPENRTLRPWIFLMGHRPMYCSNTDHDD-CTMHEsrvrtgipelnkpgLEDILYKYGAD
...   ...          ..  .  ... .  |. ||.  .  ..    |.. .|| |.|   . .|  . ...              |. .| ||..|
yslskkevvtelftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdtkelver..............llpllkkykvd

VLIWAHEH
. .  |.|
aYlnGHdH
PhoD PhoD-like phosphatase 87-217 2.3e-06 17.8 Pfam-A 59-179 (453) alignment 
Range on Protein: 87-217
Range on HMM: 59-179/453.0
RTIYIHRVTLKGLKPTQAYDYHCGGP--DGWSEEFNFKARRDGVDWSPRLAIFGDLGNKnAKSLPFLQEEVQRGDYDAIIHVGDFAYNMDtdN----ALY
.. |. .|...||.| | | |.      .  |.  ...   ..   | |||....   . .   . ..| ... |.|...|.||. |.    .    .  
erdytvkvevtgLepgqeyfYrfraeegesespvGrtrTlpeaaveslrlavvSCsnye.qGyfnayrelaekedlDfvlhlGDyiYeyg..egtyknee

GDEFMRQVQPIAAyvpymtcpgnhegAYNFSNYRFRF
 .|  |.|.|                ... ..|| |.
reekgrvvepeke.............ivtladYRkry