Gene PAPL-7 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP103_AA protein Get Run
NvecP103_AA_85-326 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PAPL 92-284 1.9e-74 242.0 In-house 1-194 (194) alignment 
Range on Protein: 92-284
Range on HMM: 1-194/194.0
AVYGDLGVGNPMALAKLQREVQSGHYDAILHIGDFAYDMASDMARVGDTFMNQIETMAAYTPYMVCPGNHEHACNFSDYRKRFSMPGGTEGIFYSWNIGP
||.||||  |. .|..||.|.|.|.||||||.||.||.. .. ...|| ||.|||..||..||||.|||||...||| |..||||||..|| ..|.. |.
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgs

AHIiSFSTEVYYFLQFGIEQLVQQYKWLQKDLEEANLPHNRAQRPWIITMGHRPMYCSNIIRTG--ITSLKLFPLEELFYKHGVDLQLYGHEHSY
... ||.||...|.... |. |..... ...|||.. . ||...||||.||||||||||  ..    .. .|. ||.|.||.||||.| ||||||
nsy.sfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvlaGHeHsY
subfamily_ACP5_pd Subfamily ACP5 93-285 9.3e-73 236.2 In-house 1-189 (189) alignment 
Range on Protein: 93-285
Range on HMM: 1-189/189.0
VYGDLGVGNPMALAKLQREVQSGHYDAILHIGDFAYDMASDMARVGDTFMNQIETMAAYTPYMVCPGNHEHACNFSDYRKRFSMPggTEGIFYSWNIGPA
|.||||| .. .||.|..| .....|.|.|.||.||..... ..|.|.|||.||..|...||||..||||.. |||.|.||||||  ..  .||...||.
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp..sknewYsfdygpv

HIISFSTEVYYFLQfgieqlVQQYKWLQKDLEEANlphNRAQRPWIITMGHRPMYCSNIIRTGITS-------LKLFPLEELFYKHGVDLQLYGHEHSYE
|.||.||||...|.       .|||||.|||.|||   ||...||||.||||||||||  .  .|.        .   ||.|.||..||| |.|||||||
hfislstevdfslg......seqykWLekdLkean...nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlalsgHeHsYe
Metallophos Calcineurin-like phosphoesterase 91-284 4.1e-24 78.9 Pfam-A 3-200 (200) alignment 
Range on Protein: 91-284
Range on HMM: 3-200/200.0
FAVYGDLGVGNPMA---LAKLQREVQSGHYDAILHIGDFAYDMASDMARVGDTFmNQIETMAAYTPYMVCPGNHEHACNFSDYRKRFSMPGGTEGIFYSW
..| |||. |.  .   | .|..  ...  |..|. ||. .         ..   .. . .....|.....||||  .  |.|  .  ...  .|... .
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

NIGPAHIISFSTEVYYFLQFGIEQLVQQYKWLQKDLEEANLPHNRAQRPWIITMGHRPMYCSNIIRTG--ITSLKLFPLEELFYKHGVDLQLYGHEHSY
. .  . | . |  . .    ..    . .  .. ||| ... .||. ...| ..|.|...|    .    .      ||.|..|.|||| |.||.| .
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgpdalekllekygvdlvlrGHtHkp
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 308-361 3.8e-21 66.6 Pfam-A 1-52 (62) alignment 
Range on Protein: 308-361
Range on HMM: 1-52/62.0
KAPVHLTSGSAGCkyCHDSFKRDYGPWTAFRSLDYGFTRMKIHNNTHLYFEQVS
|||||...|.||.   ...|..   .|.|||. |||..|....|.|||..|.|.
kApvhIvvGaAGn..glskfskpqpewsafresdyGysrltvvNrthLhwefvr
ACP5 94-283 1.3e-13 43.1 In-house 4-198 (198) alignment 
Range on Protein: 94-283
Range on HMM: 4-198/198.0
YGDLGVGNPMALA----KLQREVQSGHYDAILHIGDFAYDMAS---DMARVGDTFMNQIETMAAYTPYMVCPGNHEHACNFSDYRKRFSMPGGTEGIFYS
 || |  . .       .... ... ..|..| .||  ||      |  |. ..| .  .  .  .|..|. |||..  | |   .  .    .. . . 
vGDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpslr

WNIGPAHIISFSTEVYYFLQFGIEQLVQQYKWLQKDLEEANLPHNRAQRPWIITMGHRPMYCsnIIRTGITSLKLFPLEELFYKHGVDLQLYGHEHS
...  ....       .  .   ..  .. |  .. |.. .   .. .  |.| .|| |.|   | . | |.  .  |. |. |..||. | ||.|.
yslskkevvtelftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvyS..igehgdtkelverllpllkkykvdaYlnGHdHc
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 101-308 4.5e-08 25.3 Pfam-A 12-145 (156) alignment 
Range on Protein: 101-308
Range on HMM: 12-145/156.0
NPMALAKLQREVQSghYDAILHIGDFAYdmaSdmarvgdtfmNQI-ETMAAYtPYMVCPGNHEhacnfsdyrkR----------Fsmpggtegifyswni
|. || .. .....  .|.||| ||.     .          ... | .... |  ...|||.          .          .               
nldaleavledike..vdlilhaGDlve...p..........eevvelledi.pvlavrGnhD..........eaelpkelavel...............

gpahiisfstevyyflqfgieqlvqqykwlqkdlEEANLPHNRAQRPWIITMGHRPMyCSniirtgitSLKLFpLEELFYKHGVDLQLYGHEHSYERLYP
                                   .|..  .  .. .... |..   .         | . . |.||. ..|.|| ..|| | ..    
..................................llaaaaleiegdrvllvhgtpls.vq........sseee.laellkeagadlvflGHtHkpkvekr

VYQHKIYKGSEEEPYTNPK
  .. .. || .|| ....
ggtlvvnpGsvgepregde
PhoD PhoD-like phosphatase 41-175 7.9e-08 22.7 Pfam-A 56-180 (453) alignment 
Range on Protein: 41-175
Range on HMM: 56-180/453.0
VKKRTIWIHRAKLEGLVPSEGYDYRCGG--DHGWSAIYTFNASNAGSDWSPSFAVYGDLGVGNPMalAKLQREVQS-GHYDAILHIGDFAYDMAsdmarv
 .... .. .....|| |.. | ||     ..  | .  .   ....  | ..||...  . ...   .  ||. .  ..|..||.||. |  .      
atserdytvkvevtgLepgqeyfYrfraeegesespvGrtrTlpeaaveslrlavvSCsnyeqGy..fnayrelaekedlDfvlhlGDyiYeyg......

gdtfmN-QIETmAAYTPY--MVCPgnHEHACNFSDYRKRFS
     . . .. .. ..    | |  .... . .|||||..
.....egtykn.eereekgrvvep..ekeivtladYRkrya
subfamily_PAPL_pd Subfamily PAPL 212-283 6.5e-06 17.5 In-house 149-211 (212) alignment 
Range on Protein: 212-283
Range on HMM: 149-211/212.0
LVQQYKWLQKDLEEAnlphnraQRPWIITMGHRPMYCsnIIRTGITSLKLFPLEELFYKHGVDLQLYGHEHS
  .|..||...|...       .  ..|. || |..   . . | |.     |. |  |. |.  | ||.|.
aeeqwawleeeLkas.......eadylivaGhypvws..vaehGptkiLvkrLkPlLekynvtaylsGhDhn