Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
|Domain||Domain Description||Range||Significance||Score||Source||Profile Range (length)||Alignment|
|Metallophos_C||Iron/zinc purple acid phosphatase-like protein C||40-102||8.4e-21||65.5||Pfam-A||2-62 (62)||alignment|
Range on Protein: 40-102 Range on HMM: 2-62/62.0 GTTNVVVGTAGYvlLLTPFPFERKPWSEYHSVHYGYGRATAVNSTALLWEWVKNYNHEVADRV ... .|||.|| |..|. ....||.... .|||.| |.||.|.| ||.|.. . .|.|.. ApvhIvvGaAGn..glskfskpqpewsafresdyGysrltvvNrthLhwefvrsddgqvlDsf
Range on Protein: 1-25 Range on HMM: 170-194/194.0 MQQEFEDLFYKYHVDLALWGHYHSY |....|||.|||.||| |.|| ||| mlaaledllykygVDlvlaGHeHsY
|subfamily_ACP5_pd||Subfamily ACP5||2-26||1.6e-09||30.0||In-house||165-189 (189)||alignment|
Range on Protein: 2-26 Range on HMM: 165-189/189.0 QQEFEDLFYKYHVDLALWGHYHSYE ....|||.|||.|||||.||.|||| resledllykykvdlalsgHeHsYe