Gene PAPL-11 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP107_AA protein Get Run
NvecP107_AA_284-502 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP5_pd Subfamily ACP5 288-503 4.3e-67 217.7 In-house 2-189 (189) alignment 
Range on Protein: 288-503
Range on HMM: 2-189/189.0
YADMGVSPtpgAEVTARYSLEEVKNGAELVLHFGDISYARGY--AYLWDKWHSLIEPYATRVPYMVGIGNHEQDHTTGASkdpsgagkgfhpswgnfgdd
..|.|||    |. .|... || .| ..|..|.||..||...  ...||....||||.|..||||| |||||.|... |                     
fgDlgvse...aaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsay....................

sggecgvpmFHRFHMPDNGNalwWYSFDYGSVHFVMMSTEHNFTRGSTQYKWLEADLKAV-NHKVTPWIVFMGHRPMYTSQLVQGLNPT---IALH-MQA
          .||.||.. .   |||||||.|||...|||..|..||.||||||.|||.. |.| ||||..|||||||.|.  ..   .   .. . .. 
.........kkrfsmpskne...wYsfdygpvhfislstevdfslgseqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglre

EIEDLLMEYSVDLALWGHYHSYE
..||||..|.|||||.||.||||
sledllykykvdlalsgHeHsYe
PAPL 400-502 8.1e-33 106.2 In-house 93-194 (194) alignment 
Range on Protein: 400-502
Range on HMM: 93-194/194.0
MPDNGNALWWYSFDYGSVHFVMMSTEHNFTRGSTQYKWLEADLKAVNHKVTPWIVFMGHRPMYTSQLVQgLNPTIALHMQAEIEDLLMEYSVDLALWGHY
.. . .  . |||...||||...|.|..... |.||.|||.||..|| ..||||..|||||||.|.  .  . . . .|.|..||||..|.||| |.|| 
snssesgsnsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdk.ddckekakmlaaledllykygVDlvlaGHe

HSY
|||
HsY
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 517-579 9.8e-21 65.3 Pfam-A 2-62 (62) alignment 
Range on Protein: 517-579
Range on HMM: 2-62/62.0
GPTHIIVGTAGFdvTLDPWPIPARSWSVYHSSNYGYGRVTVANATAMLWEWVINESDYVADRV
.|.||.||.||    |.... |  .||....|.|||.|.||.|.|.. ||.| ...  |.|..
ApvhIvvGaAGn..glskfskpqpewsafresdyGysrltvvNrthLhwefvrsddgqvlDsf
PAPL 287-366 1.2e-18 60.0 In-house 2-80 (194) alignment 
Range on Protein: 287-366
Range on HMM: 2-80/194.0
AYADMGVSPTPGaevTARYSLEEVKNGAELVLHFGDISYARGYAYLWDKWH--SLIEPYATRVPYMVGIGNHEQDHTTGASK
...|.|         ..|.. |. |.  ...||.||..|| ..   ||...   .|||.|..||||| .||||...   ..|
vfGDlGqtnass...lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnyk
Metallophos Calcineurin-like phosphoesterase 286-502 3e-16 53.3 Pfam-A 4-200 (200) alignment 
Range on Protein: 286-502
Range on HMM: 4-200/200.0
VAYADMGVSPTPG-AeVTARYSLEEVKNGAELVLHFGDISYARGYAYLWDKWH-SLIEPYATRVPYMVGIGNHEQDHTTGAS-------KDPSGAGKGFH
.. .|..  .      .. ..    ..... |||. ||....  ..  . .    | .. .  .|... .|||| |. . |.       ||. | ..|. 
lvigDlHgglddled.lllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

PSWGNfgddsggecgvpmfhrfhmpdngnalWwYSFDYGSVHFVMMSTEHNFTRGSTQYKWLEADLKAVNHKVTPWIVFMGHRPMYTSQL--VQGlnpTI
. . .                          . . .  .|. ..  | .. .. .|.|...|| .|  .. . ........|.|.. |    ...     
eyenl..........................k.itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...gs

ALHMQAEIEDLLMEYSVDLALWGHYHSY
 |..  . |.|| .| ||| |.|| | .
elfgpdalekllekygvdlvlrGHtHkp
PhoD PhoD-like phosphatase 239-338 1e-08 25.6 Pfam-A 61-153 (453) alignment 
Range on Protein: 239-338
Range on HMM: 61-153/453.0
GFLHDVLIADLKPATRYFYQYGSE--EAMGPMLNFTTApiPGADVP-VKFVAYADMGVSPTPgaevTARY-SLEEVkNGAELVLHFGDISYARGyaylWD
 .   | ...|.|...|||.. .|  |.  |. ...|.  |.|.|  ......... .         . |  | |  .  ..||| ||. |..|    ..
dytvkvevtgLepgqeyfYrfraeegesespvGrtrTl..peaaveslrlavvSCsnyeqGy....fnayrelaek.edlDfvlhlGDyiYeyg....eg

KWHS
....
tykn
subfamily_PAPL_pd Subfamily PAPL 422-501 2.1e-07 22.4 In-house 140-211 (212) alignment 
Range on Protein: 422-501
Range on HMM: 140-211/212.0
MSTEHNFTRGSTQYKWLEADLKAvnhKVTPWIVFMGHRPMYtSQLVQGlnPTIALhmQAEIEDLLMEYSVDLALWGHYHS
... .. .  ..|..|||..|||   .   ...  || |.. |   .|  ||  |  . ... || .|.|.  | || |.
legpvdvslaeeqwawleeeLka...seadylivaGhypvw.svaehG..ptkiL..vkrLkPlLekynvtaylsGhDhn
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 307-504 5.6e-07 21.7 Pfam-A 20-123 (156) alignment 
Range on Protein: 307-504
Range on HMM: 20-123/156.0
LEEVkNGAELVLHFGDISYaRgyaylwDKWHSLIEPYatrvPYMVGIGNHEQDHTTGASK--Dpsgagkgfhpswgnfgddsggecgvpmfhrfhmpdng
||.. ....|.|| ||.   .      .. . |.| .    |  .  |||.....  . .                                        
ledi.kevdlilhaGDlve.p......eevvelledi....pvlavrGnhDeaelpkelavel.....................................

nalwwysfdygsvhfvmmstehnftrgstqykwleaDLKAVNHKVTPWIVFMGHRPMYTSQlvqglnptialHMQAEIEDLLMEYSVDLALWGHYHSYER
                                     |.| . ... . |.. |.  .. |           ....|.. || |. .||.. ||.| .. 
....................................llaaaaleiegdrvllvhgtplsvq...........sseeelaellkeagadlvflGHtHkpkv
ACP5 427-500 9.6e-06 17.4 In-house 129-197 (198) alignment 
Range on Protein: 427-500
Range on HMM: 129-197/198.0
NFTRGSTQYKWLEADLKAVNHKVTPWIVFMGHRPMYTSQlVQGlnPTIAlhMQAEIEDLLMEYSVDLALWGHYH
. .| ... ..|.   ||.... . |.. .|| |.|.    .|  .|    .. ... || .| ||. | || |
vaerekyaeeqlkwlekalakstadwkiVvGHhpvySig.ehg..dtke..lverllpllkkykvdaYlnGHdH